1OLT,2QGQ,4JXC,1R30,6DJT,2FB2,7JMB,5HR7


Conserved Protein Domain Family
Radical_SAM

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pfam04055: Radical_SAM 
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Radical SAM superfamily
Radical SAM proteins catalyze diverse reactions, including unusual methylations, isomerization, sulphur insertion, ring formation, anaerobic oxidation and protein radical formation.
Statistics
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PSSM-Id: 427681
Aligned: 491 rows
Threshold Bit Score: 37.5056
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1OLT_A  58 HIPFCHKLCYFCGCNKIvtr----qqhKADQYLDALEQEIVHRAPLFAG--RH--VSQLHWGGGTPTY-LNKAQISRLMK 128 Escherichia coli K-12
P73538  84 KSGNCSENCGFCSQSSHhp-------dPNSPIYGLKTEAEILEQARAAAa-AGakRFCLVSQGRGPKYhSPKDREFEQIL 155 Synechocystis sp. PCC...
Q58014  42 WYCNLKQPCKFCYMATQkn-------kIKDPRKARRRLESVLAEAILMK--RIg-WKLEFISGGYGYTpKEINDIAEMVA 111 Methanocaldococcus ja...
Q55948 124 RYRDESTVCQFCAIEKSl---------DAGRTITRKLPEQLAEVTEAAv--RLdgIEQVIMTTGTPNSgDRGAAYLTKCA 192 Synechocystis sp. PCC...
Q9WY85  28 LGERCVYNCLYCAQSRSst-------sPSHFLSRVTWKEVSEDLLGKLn--DRf-KRVCIQVVSYPSYgKDLRLIIPRFR 97  Thermotoga maritima
Q97Z26  44 YPDGCKANCSYCGQAREvangpecktlIRVEWPLRPLNEVLKRIYERQGnpEYglQRICIGQLAHPRAsPDAIEITRRIR 123 Saccharolobus solfata...
O67770  51 YPSGCHATCAYCGLQKAreiey-skknFIRVEWPTVKTDEIIERTKQVGh-A---ERLCISQITHPRAiRDTKYILEKVH 125 Aquifex aeolicus
O27507  74 LTNRCCNDCRYCINSS-------------CEMPVELSPEEIARVFLDYYe-RRy-VDGLFLSSGVSHDpDETMERLIETL 138 Methanothermobacter t...
Q9A5W5  68 LTNFCIYDCAYCINRIS-----------SNTPRARFTVQEVVDLTLNFYk-RNy-IEGLFLSSGVIRSgDYTMEEMVRVA 134 Caulobacter vibrioides
Q9K942  88 LATGCMGHCHYCYLQTTl--------gSKPYIRTYVNLEEIFAAADQYIheRE--PEITRFEAACTSDiVGIDHLTHSLK 157 Bacillus halodurans
1OLT_A 129 LLRenf-qfNADAEISIEVDPREIE--LDVLDHLRAEGf--NRLSMGVQDFNKE--------------VQRLVn-ReQDE 188 Escherichia coli K-12
P73538 156 ATVr-----QIIQETNIKPCCALGEvtPEQAQQLKEAGv--TRYNHNLEASATY--------------YDKIV--StHTW 212 Synechocystis sp. PCC...
Q58014 112 Y----------VQKCRQYLNVGVID------LDNINLDv-iEGVVGAVETVSKD--------------RDWIC--PgKPL 158 Methanocaldococcus ja...
Q55948 193 AAIk----aRVNIPIQAQCEPPDD---FIWFERMKAAGv--DSLGMHLEAVDPDv------------rAKIMPgkAeVPV 251 Synechocystis sp. PCC...
Q9WY85  98 ------------IPVSVSVRAVS----IEEVVEYFELGa--DRVGIAVDVPNKTl-------------FEKIR--G-GKY 143 Thermotoga maritima
Q97Z26 124 NA---------GIELQISELVTATYtfKHHMIEMRKAGa--DMIDVAIDAANEKvfe--------elrGKKAR--SmHSW 182 Saccharolobus solfata...
O67770 126 REL------GDKIFISILLNATGHT--YEDLEDYKRLGa--ETLTVALDAATPElfe---------klRGRPMn-SpHRW 185 Aquifex aeolicus
O27507 139 RILrle-gyGGYIHLKIIPGSSM--------DSIKRAMelaSRVSINIETATPDgldelsstkdygvdILRRMr-WiHRL 208 Methanothermobacter t...
Q9A5W5 135 KSLrldhdfRGYIHLKLIPEASP--------ELAAEAGlyaDRVSINIELPRDDslkalap-ekdptdIKRAMgrMrLAI 205 Caulobacter vibrioides
Q9K942 158 KTIehi-gqTEYGRLRFVTKYHHV---NHLLDANHN-Gk--TRFRFSVNADYVV--------------RHFEP--GtSSL 214 Bacillus halodurans
1OLT_A 189 EFIFALLNhaREIGFT----STNIDLIYGLPKQtpESF 222 Escherichia coli K-12
P73538 213 QDRVDTVKnlKAAGIQa--cTGGILGMG-ETWEdrIDL 247 Synechocystis sp. PCC 6803 substr. Kazusa
Q58014 159 DKIKDNLLkaKELGLKt---GITIILGLGEKEEdiEKL 193 Methanocaldococcus jannaschii DSM 2661
Q55948 252 SYYYEAYEaaVKVFGWgq-vSTYLLAGLGDSFEtlVEA 288 Synechocystis sp. PCC 6803
Q9WY85 144 ERHLHILEkvSEM-FPgr-iTTHVIVGLGESDKdiVDF 179 Thermotoga maritima
Q97Z26 183 KRYLEAIDeaVEVFGKk---NAGIHLIIGLGESe-KDA 216 Saccharolobus solfataricus
O67770 186 ETYWKVLEwcADIMGDgh-vGAHLIVGLGETEEemVRT 222 Aquifex aeolicus
O27507 209 RKR---HPelAPSGQS----TQLMVGAVDETDEdiVKR 239 Methanothermobacter thermautotrophicus str. Delta H
Q9A5W5 206 DDHAEPGRkaRRRAFArsqsTQLIVGADEAKDGdiLSR 243 Caulobacter vibrioides
Q9K942 215 SERLEAAKkvAEAGYPlgfiVAPIILHDGWQRGy-REL 251 Bacillus halodurans
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