Conserved Protein Domain Family
Upf2

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pfam04050: Upf2 (This model is not part of the current CDD release)
Up-frameshift suppressor 2
Transcripts harbouring premature signals for translation termination are recognised and rapidly degraded by eukaryotic cells through a pathway known as nonsense-mediated mRNA decay. In Saccharomyces cerevisiae, three trans-acting factors (Upf1 to Upf3) are required for nonsense-mediated mRNA decay.
Statistics
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PSSM-Id: 515994
Aligned: 103 rows
Threshold Bit Score: 61.5961
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
GAC73050     1038 EE-----LAARR-------------EADDEFDRELARMMV--------ESSapgtataqssagaSTSQRPHQ----FfsR 1087
XP_002981454  985 EEdd--hVKLRCkske------vdpLEDADFEKELRALMQ--------ESV-------------DSRKSELRarptL--N 1033
5_pfamImport    1 DEdd--eVHVRQkvae------vdpQEEADFDRELKALLQarfslmlsESL-------------DSRKLELRarptL--N 57  
XP_002881640  986 DDd---kFRVRQkvvt------vdpEEQADFDQELKALLQ--------ESM-------------EQRKLELRgrpaL--N 1033
XP_010240152  990 DEe---sFQVRHkvvq------vdpKEQEDFDRELKALVQ--------ESL-------------ESRKSELRakptL--N 1037
XP_002111381  909 GEne-dvTILSGglka------mpcEEDDDFQKEYEKALA--------DDL-------------LTRRQHGPkvpsL--D 958 
2_pfamImport    1 ---esdgTVCSDktpiepvrrkiedPEDFEFLESFDKMVS--------DNI-------------QERTKEATrp-qT--E 53  
XP_011145321  969 MDvtelnAALPAgprr------vscPEDDDFLSALDKMVS--------DNI-------------QDRMRDSVkpqqV--D 1019
XP_015782828 1018 TEgekerMVLDDrsmpp---klvecPEDDLFRKEFDRIMS--------ESL-------------ISRGQEAIrgt--lnD 1071
XP_003533845  990 DEed--eVHVRQkmtq------vdpLEEANFDQELKAVVQ--------ESM-------------EQRRQELRgrptL--N 1038 soybean
GAC73050     1088 AALPSGGAsygpahshahahASGSSlseiGlPIKKKAAEQANGgveaEagSHMKFSLLSK-KGSKQVTHEVYVPATASIA 1166
XP_002981454 1034 MMMPMNLLe----------gTKDHGraqdPeSGDEGIDEHGSG-------HNVAFRVLVK-KGNKHQLKQLKIPRDSSLV 1095
5_pfamImport   58 MMIPMNVFeg--------stKDHHGrgveGeSGDEILDEEAGGs------KEVRVKVLVK-RGNKQQTKQMFIPRDCSLV 122 
XP_002881640 1034 MTIPMSVFegs-------gkDHHHFgrvvGeNGEDLLDEENGEq------REVQVKVLVK-RGNKQQTRQMLIPSDCSLV 1099
XP_010240152 1038 MTVPMNACd-----------GSKDPkatgAeSGQEITAEESGSagsgSk-VKVCVRVLVK-KGHRQQTKQMLIPGDCSLV 1104
XP_002111381  959 APLPFNRI------------CNFSV---------SFISNIYFNvgenLqtDDINFVLLTR-KSNKLQYKEVNIPVSDAVA 1016
2_pfamImport   54 ISIPFHLK------------KYSKK--------------TYEQlqntNedNSVNFILMLK-KGNKQTFKNLQVPVDSEMA 106 
XP_011145321 1020 ISVPLHVK------------STKKT--------------YEQLqerpTdnTTVDFVLMLR-KGNKQQYKNLAVPVSSELA 1072
XP_015782828 1072 IVIPMNKLv----------aAKKSVafsdIgSAASSKDEENSEklnnNetPTLNLMVMTRaKGNKPLLKPVQVPIDSDLA 1141
XP_003533845 1039 MMIPMNVFeg--------saKDHHGrgvgGeSGDEPLDEDTGGn------KEVQVRVLVK-RGNKQQTKQMFIPRNSSLV 1103 soybean
GAC73050     1167 INTRTKQLKEEAERRQLKQQILA 1189
XP_002981454 1096 QSTRQKEAAELEEKQDIKRLVLE 1118
5_pfamImport  123 QSTKQKEAAELEEKQDIKRLILE 145 
XP_002881640 1100 QSTKQKEAAELEEKQDIKRLVLE 1122
XP_010240152 1105 QSTKQQEAALHQEKQNIKQKILE 1127
XP_002111381 1017 ANIREKIAQEKADKEEMKRLVLS 1039
2_pfamImport  107 SNLKSQEMAEQAELRRVKQLTLD 129 
XP_011145321 1073 MNLRNREQEQKEEKERVKRLTLN 1095
XP_015782828 1142 LSLKQKEEAERAEKQQVKKLTLH 1164
XP_003533845 1104 QSTKQKEAAELQEKEDIKRLVLE 1126 soybean
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