Conserved Protein Domain Family
PMEI
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pfam04043: PMEI (This model is not part of the current CDD release)
Plant invertase/pectin methylesterase inhibitor
This domain inhibits pectin methylesterases (PMEs) and invertases through formation of a non-covalent 1:1 complex. It has been implicated in the regulation of fruit development, carbohydrate metabolism and cell wall extension. It may also be involved in inhibiting microbial pathogen PMEs. It has been observed that it is often expressed as a large inactive preprotein. It is also found at the N-termini of PMEs predicted from DNA sequences, suggesting that both PMEs and their inhibitor are expressed as a single polyprotein and subsequently processed. It has two disulphide bridges and is mainly alpha-helical.
Links
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Statistics
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PSSM-Id: 515989
Aligned: 585 rows
Threshold Bit Score: 30.2721
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Q9FGA7         28 TYIDAICqS-VTDKAFCAKTLNAYpaagSATsq--------fQA--ATATLNLAISYAdksagftGN---AAKEnptlkt 93  thale cress
XP_006586830   35 arlYSLCkP-TTNVGLCYRTILPEvlglPRFn----------yYkaLEVEMLVTQKQVektskliSVllaRPGNskdlgd 103
XP_004962765   66 DIVRSLC-LkTDYPDLCTSSISKQ----LQPqlpggkrleapDV--LRLAMAAVRAKAgeakaaaAAlanDPKTqplarg 138
KQJ86323       57 DIVKSLC-AkADDPAQCVSSVSK------QPapaagkkldgpAV--LRMAMGAVRAKAaeakaraLAlaaDPKTpklavg 127
73_pfamImport   1 PVVKTMC-AkTDHADLCESSIGQ------LPeeppa-qldglGV--LKLAMDALRAKVqetinmaTDrmgAPGMdpqskd 70 
EES10240      417 PVIKSVC-AkTEYPVDCEASIGG------LPgaasaaatdsvGV--LKLAMEAVRQKVivamnaaTDrmnAPGVdgttkd 487
XP_003547320   33 trLYSLCkP-TTNMDLCYKTILPEvvglSRFs----------nYkaLEVEILATQKQVettskliTSllaKPGNskdlte 101 soybean
XP_003546245   39 SDITEFCkK-TTNPAVCAQTIQPHfl-kNNLd----------pLkaLDVEVDATLASAkktlidiQTlesKKGItksikd 106 soybean
XP_003519742   63 PMILKFCtG-TENPTLCAETIAPYlt-gT-Fd----------pIqaLETEINATLEKAeeiagniKKmldDPTTtknamd 129 soybean
XP_006588562   64 PEILKFCsG-TEHAALCAETIAPYla-gE-Fd----------pLkaLEMEINASMEKAkeiggniKKmldNPATekkaid 130 soybean

Q9FGA7         94 qFAASQDAFVTISkslksaaselki--------spdtanydvmvCSDSiatvknlvekntdnssktVMTm-TLM------ 158 thale cress
XP_006586830  104 sLQICKEQYGNIMdsmaeaknqvaqrnviearfkfssvvsyyesCNDSf-----------------TKG---TSpiveea 163
XP_004962765  139 pLHDCVESFDDIAysldeaekalaggdrdttgtmldtvrtdvdtCDQGfeere--------eltpvMAKq-DAE------ 203
KQJ86323      128 vLRDCAESYDDVPysldnadkamasgdkdttgtmldtvrtdvdtCDQGfedre--------elpklMAKq-DAE------ 192
73_pfamImport  71 aMNDCLEMYDDMKqnldsaeaalkkgdkdtartmldsahtdvdtCENGftere--------glkplMADl-DKI------ 135
EES10240      488 aLDSCTSSYSDIKtsldsvddalkrgdvdtahtnldsvetdlttCDDGfqehg---------ipsvMTDh-DQE------ 551
XP_003547320  102 sLQICKEQYGNILdsieesknqvaqrnviearfkfsaaislqvsCNDSf-----------------TAG---TSpivkea 161 soybean
XP_003546245  107 sFDTCKDQYGSMLdaiketkaaiakkdiitakfkfsavlsyqgaCKDAf-----------------ESG---KIpfseds 166 soybean
XP_003519742  130 aLGICQSQYDNILdniketvelvgnqnvvdawyrfssvlsykeaCEDAf-----------------KESpgVDMpfpedn 192 soybean
XP_006588562  131 aLGICQSQYDDMVdsmkegvdlvrqqnvvdaryklssvlsyksaCDDAf-----------------TESpgVHIpfpedi 193 soybean

Q9FGA7        159 --MEKLLTIA 166 thale cress
XP_006586830  164 qgVYDLAGNC 173
XP_004962765  204 --LAKLASNC 211
KQJ86323      193 --LAKLASNC 200
73_pfamImport 136 --LAELSSNT 143
EES10240      552 --LQKLASNL 559
XP_003547320  162 qdVFDLAGNC 171 soybean
XP_003546245  167 daVYNLGGNC 176 soybean
XP_003519742  193 tkLFQLSGNC 202 soybean
XP_006588562  194 tkLFQLTSNC 203 soybean
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