8D9D,3FLO,6V8P,3E0J,6WJV


Conserved Protein Domain Family
DNA_pol_E_B
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pfam04042: DNA_pol_E_B (This model is not part of the current CDD release)
DNA polymerase alpha/epsilon subunit B
This family contains a number of DNA polymerase subunits. The B subunit of the DNA polymerase alpha plays an essential role at the initial stage of DNA replication in S. cerevisiae and is phosphorylated in a cell cycle-dependent manner. DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition, DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast. The largest subunit of DNA polymerase epsilon is responsible for polymerase epsilon is responsible for polymerase activity. In mouse, the DNA polymerase epsilon subunit B is the second largest subunit of the DNA polymerase. A part of the N-terminal was found to be responsible for the interaction with SAP18. Experimental evidence suggests that this subunit may recruit histone deacetylase to the replication fork to modify the chromatin structure.
Links
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Statistics
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PSSM-Id: 515988
Aligned: 29 rows
Threshold Bit Score: 132.8
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
8D9D_D       188 VLVACGPYTTs---DSIT----YDPLLDLIAV-----IN--------HD-RPDVCILFGPFLDAKHEQVENCL----L-- 240 human
XP_001706598 182 VLFVAGMDLGwe---------aSHAARAVLFA-----TAlg----tpPFsSVKQVVLCGGTYAPVDAGPAAAA----Clg 239
Q19366       186 IAFVSGLDLTgdleDDRLtisgLEFMADWMNV-----QVgn----enQCpPIDRLVVIGPLVETKSNGCDVQS----Vvr 252 Caenorhabditis ...
P46957       214 IALVSGLNLNn---TSPDrllrLEILREFLMG-----RInnk---idDIsLIGRLLICGNSVDFDIKSV----------- 271 Saccharomyces c...
Q9W088       175 LVLASGLDQLq---AHKFve-aLNLFQYWLAG-----SLgn----nkEAgSMVRLIVAGNSVRASAMAHVPTL----Qva 237 fruit fly
O35654       196 VLLVSGLGLGg---GGGEsllgTQLLVDVVTG-----QLgdeg-eqcSAaHVSRVILAGNLLSHNTQSRDSIN----Kak 262 house mouse
XP_961110    231 IALVSGLEFSn---ADTSyameLNLLLEYLLG-----EAldpsvqrdELsHITRLIIAGNSISTTAAEQAKPA----Aaf 298
P87324       186 IAAVSGLGLSn---DGIEgi-qVHQLVDFLRG-----TLphv--ssfSPsSIKRLIILGNCLAPSIEIADSAS----Asv 250 Schizosaccharom...
6V8P_F       221 IALVSGLNLNn---TSPDrllrLEILREFLMGrinnkID--------DIsLIGRLLICGNSVDFDIKSV----------- 278 Saccharomyces c...
3E0J_A       200 drfvllvsglglgggggesllgtQLLVDVVTG-----QLgdeg-eqcSAaHVSRVILAGNLLSHSTQSRDSINkakyLtk 273 human

8D9D_D       241 -------------------TSPFEDIFKQCLRTIIEGTR----SSgSHLVFVPSLRDVHHEPVYPQPPFSYSDLSREDKK 297 human
XP_001706598 240 n----------------alSPTTGFLDLQASYDLVDTILarvaAA-RPTILVPGQSDPTPR-LWPQAPVPSIVLPRCSLT 301
Q19366       253 tlt------------lsraEKHSSTASLITVDKIINSIAek-pLV-NTVDVTPGVGDPCSS-MWPLPPIHRVCLPRCGMS 317 Caenorhabditis ...
P46957       272 -------------------NKDELMISLTEFSKFLHNIL----PS-ISVDIMPGTNDPSDK-SLPQQPFHKSLFDKSLES 326 Saccharomyces c...
Q9W088       238 r---------------tqaNANDTVQAVSQLDQWFASWA----RS-LPVDIMPGPYDPANF-MLPQQPFHKCMFPQAAQL 296 fruit fly
O35654       263 yl--------------tkkTQAASVEAVKMLDEILLQLS----AS-VPVDVMPGEFDPTNY-TLPQQPLHPCMFPLATAY 322 house mouse
XP_961110    299 dtttvtnkfqpqikkygydSSSYNPVPSQLLDSFLSDLL----PT-MPVTLLPGALDPANA-SYPQQPIHPAMFPQSRTY 372
P87324       251 pigkkk------vkrygydTSAYNPNPTFQLDNFLDQVC----SS-IDVTLMPGPYDYSST-ILPQQPLHPALLTKSKVW 318 Schizosaccharom...
6V8P_F       279 -------------------NKDELMISLTEFSKFLHNIL----PS-ISVDIMPGTNDP-SDKSLPQQPFHKSLFDKSLES 333 Saccharomyces c...
3E0J_A       274 ------------------kTQAASVEAVKMLDEILLQLS----AS-VPVDVMPGEFDPTN-YTLPQQPLHPCMFPLATAY 329 human

8D9D_D       298 q---------------------VQFVSEPCSLSINGVIFGLTSTDLLFHLGAEEISSSSG-----------------TSD 339 human
XP_001706598 302 n--------------------sLISAPCPAKLLTRDKQLVWVIDGTVLTYLAALIPASLT-------------------- 341
Q19366       318 dk-------------------kVNLVTNPYEFEVNGLRVMTMSGENVSELLRTSLKWTG--------------------- 357 Caenorhabditis ...
P46957       327 yfngs-------------nkeiLNLVTNPYEFSYNGVDVLAVSGKNINDICKYVIPSNDNgesenkveegesndfkdDIE 393 Saccharomyces c...
Q9W088       297 a--------------------tFQAVTNPYSCRLDEALVVGTSGQNVSDLLRSTSLDSA--------------------- 335 fruit fly
O35654       323 s--------------------tLQLVTNPYQATIDGVRFLGTSGQNVSDIFRYSSMEDH--------------------- 361 house mouse
XP_961110    373 mpppkagagkdrdvpgeeepgwFDNVTNPWEGEIEGWRVLGTGGQNLDDVFKYVESEDR--------------------- 431
P87324       319 lg------------------ssLQTVTNPTWLSLGNHFVLATSGQNINDLRKYHPKKSS--------------------- 359 Schizosaccharom...
6V8P_F       334 yfngs-------------nkeiLNLVTNPYEFSYNGVDVLAVSGKNINDICKYVIPSNDNgesenkveegesndfkdDIE 400 Saccharomyces c...
3E0J_A       330 s--------------------tLQLVTNPYQATIDGVRFLGTSGQNVSDIFRYSSMEDH--------------------- 368 human

8D9D_D       340 RFSRILKHILTQRSYYPLYPpqEDMAIDYESFYVYAqL-PVTPDVLIIPS-ELRYFVK 395 human
XP_001706598 342 -VPALVATLLQVAHLCPQSP--LFFDVQPLQLDAFV-LdEP-PQYIVVSN--HPQTTT 392
Q19366       358 --ADAIENIIKWQHVAPNCPd-TLDAFPVAERDPLI-M-DITPHVIICGNqPHAEFRH 410 Caenorhabditis elegans
P46957       394 HRLDLMECTMKWQNIAPTAPd-TLWCYPYTDKDPFV-L-DKWPHVYIVAN--QPYFGT 446 Saccharomyces cerevisiae S288C
Q9W088       336 --LEALRCTLTWGHVAPTAPd-TLACYPYIESDPFI-L-RECPHVYYAGN--CESFAT 386 fruit fly
O35654       362 --LEILEWTLRVRHISPTAPd-TLGCYPFYKTDPFI-F-PECPHVYFCGN--TPSFGS 412 house mouse
XP_961110    432 --LGMMEAMCRWRCVAPTAPd-TLWSYPFQEDEPFV-I-KECPHLFFVGC--QPEFGT 482
P87324       360 --LQCMENTLLWNHITPTSPd-TLWCYPFTDKDTFV-M-EEMPDLYLCGN--QPKFGC 410 Schizosaccharomyces pombe 972h-
6V8P_F       401 HRLDLMECTMKWQNIAPTAPd-TLWCYPYTDKDPFV-L-DKWPHVYIVAN--QPYFGT 453 Saccharomyces cerevisiae S288C
3E0J_A       369 --LEILEWTLRVRHISPTAPd-TLGCYPFYKTDPFI-F-PECPHVYFCGN-T-PSFGS 419 human
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