3FLO,6HV9,6P1H


Conserved Protein Domain Family
DNA_pol_E_B

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pfam04042: DNA_pol_E_B 
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DNA polymerase alpha/epsilon subunit B
This family contains a number of DNA polymerase subunits. The B subunit of the DNA polymerase alpha plays an essential role at the initial stage of DNA replication in S. cerevisiae and is phosphorylated in a cell cycle-dependent manner. DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition, DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast. The largest subunit of DNA polymerase epsilon is responsible for polymerase epsilon is responsible for polymerase activity. In mouse, the DNA polymerase epsilon subunit B is the second largest subunit of the DNA polymerase. A part of the N-terminal was found to be responsible for the interaction with SAP18. Experimental evidence suggests that this subunit may recruit histone deacetylase to the replication fork to modify the chromatin structure.
Statistics
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PSSM-Id: 397933
Aligned: 27 rows
Threshold Bit Score: 136.274
Threshold Setting Gi: 159112740
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3FLO_G     151 IVTCGPYFAnDNFSLELLQEFIDSIN---NEVKPHVLIMFGPFIDITHPLIASGKLPnfpq------fktQPKTLDELFL 221  baker's yeast
Q7S126     490 VIIGELNLD-QPRSLQALRKILGLYAsdpEGCTPMTFVLAGNFTQHAVMARGGSGGS-------------IEYKEFFDAL 555  Neurospora crassa
NP_955875  346 MIACGPYTPsESLTYDPLLDLITIIN----KDRPDVCILFGPFVDSKHEQIEKNQV---------------TETFETIFK 406  zebrafish
Q21625     324 WFACGPYTAtDNCGYEHLCELLDKVV----AEKPDILMLAGPFVDKKNTFLNKPTF---------------NITYDNLLE 384  Caenorhabditis e...
O94263     333 VCISEVHLD-NHQTFYALEKIFQKYEs--SEAVPFCIILCGSFMSSAFHNSGSSI----------------QYKEGFNKL 393  Schizosaccharomy...
6HV9_B     401 ILGANLFLD-DLKIMTALSKILQKLN----DDPPTLLIWQGSFTS----------VPvfasmssrnisssTQFKNNFDAL 465  baker's yeast
Q19196     277 VFLSDVFLD-DKKVMKAVFKLLQGYK----DQPPVAIVFCGNFCSRPRQTDTID-----------------LLDRGFRWL 334  Caenorhabditis e...
Q7Q7P2     285 VFLSDCWLD-NPIVMEKLEQLLRGYD----DFPPVAIVLMGPFARSIENVY--------------------TLKGHFVKL 339  Anopheles gambia...
Q9VRQ7     287 VFLSDVRLD-LPVVMEKLRQLFVGYD----SCPPQAIVLMGPFTASTRNHH--------------------ELRHHLDAL 341  fruit fly
Q500V9     285 VILSDIWLD-DEEVMRKLETVLDGFEs--VETVPSLFVFMGNFCSRPCNLSFGSYS---------------SLREQFGKL 346  thale cress
3FLO_G     222 KLFTPILKTIS-PHIQTVLIPSTKDAISNh------AAYPQASLIRK-ALQLPKRN------------------------ 269  baker's yeast
Q7S126     556 ASTLADFPSLL-TTATFVFVPGDNDGWVSafsggaaTPLPRKPVPDL-FTSRIRRVfaaanaeaglanpgketekdagkr 633  Neurospora crassa
NP_955875  407 RCMDSIVEGTKgTACKLVFVPSQRDVHHH-------YIYPQPPFNLT--ISKEDTAr----------------------- 454  zebrafish
Q21625     385 DLLLKVKETLVgTKTQVIIQPNASRDLCVp------PVFPSAPFQQNrKLDKIKKE------------------------ 434  Caenorhabditis e...
O94263     394 AASLEKFPKIC-EKTKFIFVPGPNDPWTTng----iSLMPKHSIPLH-FVNRIQRVck---------------------- 445  Schizosaccharomy...
6HV9_B     466 ATLLSRFDNLT-ENTTMIFIPGPNDLWGSmvslgasGTLPQDPIPSA-FTKKINKVck---------------------- 521  baker's yeast
Q19196     335 ANQLTPLRKDY-EKTQFIFVPGPDDPFVD-------TVLPRPHLPSL-LFKHISPIi----------------------- 382  Caenorhabditis e...
Q7Q7P2     340 GEILSSCEKLK-SQTDLVIVPSIDDPAAA-------NILPRPPVPEA-LAGELKKRfp---------------------- 388  Anopheles gambia...
Q9VRQ7     342 GGLAAGCEQLK-KQTDLILVPSSEDPTAP-------NILPRAPIPEC-LAAGLLKAwp---------------------- 390  fruit fly
Q500V9     347 GRMIGNHPRLK-ENSRFLFIPGPEDAGPS-------TVLPRCALPKY-LTEELRNIip---------------------- 395  thale cress
3FLO_G     270 ----FKCMANPSSFQIN--EIYFGCSNVDTFKDLKEVIKGGTTS------------------------------------ 307  baker's yeast
Q7S126     634 rggeAVWTTNPSRITLFgpSHEMVLFRDDISARLRRASVRLKNTskasvepepptngnddsamdnqcppsslpdapdadd 713  Neurospora crassa
NP_955875  455 ----VTLAPDPCTLLIG--NVTFGLTSTDILFHMGAEEISSGT------------------------------------- 491  zebrafish
Q21625     435 ----LIFVADPCIFRIS--GVEVAMTSSEPIQALSNTEFHRSANq----------------------------------- 473  Caenorhabditis e...
O94263     446 ---hTIFASNPCRIIFF--SQEVLIYRDDISGRFQRNSLKFGKTpqgtsnin---------------------------- 492  Schizosaccharomy...
6HV9_B     522 ---nVVWSSNPTRIAYL--SQEIVIFRDDLSGRFKRHRLEFPFNesedvytendnmmskdt------------------- 577  baker's yeast
Q19196     383 ---sCTFASNPCRIQFA--SQEIVVFRSDLIKKTCRHSINSITV------------------------------------ 421  Caenorhabditis e...
Q7Q7P2     389 ---rTILTTNPCRLQYC--TQQIVVCRADLVTKLCRNTIHFPKe------------------------------------ 427  Anopheles gambia...
Q9VRQ7     391 ---rTQLATNPCRLQYC--TQQIVVCRLDLMAKFCRNTLHFPED------------------------------------ 429  fruit fly
Q500V9     396 ---nAIFSSNPCRVKFY--NQEIVFFRQDLLYRMRRSCLVTPSSe----------------------------------- 435  thale cress
3FLO_G     308 ----------------------------------SRYRLDRVSEHILQQRRYYPIFPgsirtrikpkdvstkketndmes 353  baker's yeast
Q7S126     714 edmadttmtdamdvdsapapnqkttmpppssipyDVLAARKLVKTILDQGYLAPFRQ----------------------- 770  Neurospora crassa
NP_955875  492 ----------------------------------GTERFSRIMKHMLTQRSYYPLYPp---------------------- 515  zebrafish
Q21625     474 ---------------------------------eNIDRVARLSSHLLTQQCMYPLEP----------------------- 497  Caenorhabditis e...
O94263     493 ---------------------------siplaeqQVHQQRKLVKTVLDQSHLSPFPS----------------------- 522  Schizosaccharomy...
6HV9_B     578 -----------------divpidelvkepdqlpqKVQETRKLVKTILDQGHLSPFLD----------------------- 617  baker's yeast
Q19196     422 -----------------------------------ESIPSRYARSVLSQAHLCPLPQ----------------------- 443  Caenorhabditis e...
Q7Q7P2     428 -----------------------------------GLLEEHFARTIINQNTLAPLTP----------------------- 449  Anopheles gambia...
Q9VRQ7     430 ----------------------------------TSQIEQHFARTIVCQGHLVPIHP----------------------- 452  fruit fly
Q500V9     436 ---------------------------------eTNDPFKHLVYTITHQSHLCPLPL----------------------- 459  thale cress
3FLO_G     354 keekvyehisgADLDVSYLGLTEFVG-GFSPDIMIIPS-ELQHFAR 397  baker's yeast
Q7S126     771 -----------AIRPVHWDYTSAMYL-YPLPTAMVLVDtTAPPFCV 804  Neurospora crassa
NP_955875  516 ----------aEEVNMDYDKFQQFSQmSLTPDILVAPS-ELRYFIk 550  zebrafish
Q21625     498 -----------TEVPASMGDLLDVCCiGSTPHIVFAPT-KLAPSAK 531  Caenorhabditis elegans
O94263     523 -----------RTRPILWDFDYALSV-FPLPSCMGLIDsESSAFDV 556  Schizosaccharomyces pombe 972h-
6HV9_B     618 -----------SLRPISWDLDHTLTL-CPIPSTMVLCDtTSAQFDL 651  baker's yeast
Q19196     444 -----------HITPVLPDFSHSLSL-HPLPDLLITAD-RFETFTE 476  Caenorhabditis elegans
Q7Q7P2     450 -----------IAFPTHWNYDAALSL-YPLPDLIVIGD-PCQGFHT 482  Anopheles gambiae str. PEST
Q9VRQ7     453 -----------IAMPVHWDYDPALWL-YPLPDLIVMGD-SCQSFSs 485  fruit fly
Q500V9     460 -----------MVQPIIWNYDHALRL-YPTPHTIVLGD-KSEQevc 492  thale cress
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