Conserved Protein Domain Family
Phage_holin_4_2

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pfam04020: Phage_holin_4_2 
Mycobacterial 4 TMS phage holin, superfamily IV
These proteins are predicted transmembrane proteins with probably four transmembrane spans. The 1.E.40 is represented by the mycobacterial 4 phage holin, but it also contains many cyanobacterial. proteobacterial and firmicute proteins. Holins are encoded within the genomes of Gram-positive and Gram-negative bacteria as well as in those of the bacteriophage of these organisms. The primary function of holins appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis. When chromosomally encoded the enzymes are therefore autolysins. Holins may also facilitate leakage of electrolytes and nutrients from the cell cytoplasm, thereby promoting cell death. Some may catalyze export of nucleases.
Statistics
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PSSM-Id: 397915
Aligned: 452 rows
Threshold Bit Score: 28.8821
Threshold Setting Gi: 504248209
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
jgi:Arth_4030          3 SFILRVLINGLALGIASWIL-PGLDIsTTatteavaqggvtqgtdplgvILAYLF-IGLIFGLVNALVRPIVS-LLS--- 76  Arthrob...
WP_014441909           3 SIVVTVILSALALGATVA-LmPGISAeNGw----------------------AVLgAAIILGLLGALLRPLLVrLLSrvg 59  Actinop...
goetting:Curi_c01320  16 AILIRVITTIVVVGIAAFLT-PGFSIr-N--------------------IWSLIV-ASIVIALVDYIIAKLTG-VDA--- 68  Gottsch...
WP_015926235          14 HLVLRVVIGAVILAITAFLT-PGFSIs-S--------------------WFSLLL-AAVVLAVLDWAVNKITG-VNA--- 66  Ruminic...
jgi:Cthe_2067         30 HFLIRLVVGAVVLAVTAALT-PGFSIt-G--------------------FWPLIL-GAIVLAALDYIALRFLG-IHA--- 82  Hungate...
jgi:Clocl_3982        15 HFIIRLVVGAIVLGVTAALT-PGFTIs-G--------------------IWPLLL-ATVVLAVLDYLALKLLG-VNA--- 67  Hungate...
WP_012448036           3 RLAIRFVVSALVLMVLSFIL-PGFAVv-G--------------------FGGALL-AAVVIALLGYGAEYFLG-ENA--- 55  Natrana...
CCY99696               8 QFIGRFITSILILGITAFFT-PGFTLs-N--------------------IWILAL-AIILLSVIDFAIGNFTK-LYF--- 60  Clostri...
CDA59514              19 QVILRFVTSAVILAITAFFT-PGFTIn-N--------------------IWALAL-AAVVLTVIDFLLVKFTG-LHA--- 71  Clostri...
CDE10373              19 QILWRLVTSAVVLAITAFFT-PGFSIn-N--------------------LWTLAI-AAIVLSIMDYIITKFTG-LHA--- 71  Clostri...
jgi:Arth_4030         77 -LPItilTLGLFTIVINAAMLFLTSwlssYTP-VHFTIDSFfWTAVLAAIIITVVSLV 132 Arthrobacter sp. FB24
WP_014441909          60 wAGV---VAGW--LVAQALLVWAA-----LWLaPGVHVDGF-WGAFAASWLGAVLmsi 106 Actinoplanes missouriensis
goetting:Curi_c01320  69 -TPfg---rGIVGFVVSALILYATK----YLVa-gFDIS-V-WGAIIGALIIGVIDAI 115 Gottschalkia acidurici 9a
WP_015926235          67 -TPfg---rGISGFILAAIIIYVIK----FIVp-gYNIS-L-FAAVIAALVYGVVDAI 113 Ruminiclostridium cellulolyticum
jgi:Cthe_2067         83 -SPyg---rGITGFVLAAVIIYITQ----FFVa-gYSVT-L-LGAVIGALVYGIIDAI 129 Hungateiclostridium thermocel...
jgi:Clocl_3982        68 -TPfg---rGIAGFILAAVIIYVTQ----FFIv-gYNVT-L-VGSIIGALIYGIIDAI 114 Hungateiclostridium clariflav...
WP_012448036          56 -SPng---rGVISFVIAAVVIYVAQ----FLVp-dMSVS-I-LGAALAAIVIGIVDLF 102 Natranaerobius thermophilus
CCY99696              61 -HPfv---kFFIGFVLSGITLFLVQ----YFTi-gYTLS-L-LSIILGAIVYGLVDYM 107 Clostridium sp. CAG:793
CDA59514              72 -SAfg---kGFVGFVLAAVVLYATQ----FFVa-gYSIS-W-IAAMIGALIYGVVDYF 118 Clostridium sp. CAG:245
CDE10373              72 -SSfg---rGIVGFALAVATLYATQ----FFVa-gYTIS-W-MAAIIGALIYGVVDYF 118 Clostridium sp. CAG:354
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