7MQ8


Conserved Protein Domain Family
Mpp10

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pfam04006: Mpp10 (This model is not part of the current CDD release)
Mpp10 protein
This family includes proteins related to Mpp10 (M phase phosphoprotein 10). The U3 small nucleolar ribonucleoprotein (snoRNP) is required for three cleavage events that generate the mature 18S rRNA from the pre-rRNA. In Saccharomyces cerevisiae, depletion of Mpp10, a U3 snoRNP-specific protein, halts 18S rRNA production and impairs cleavage at the three U3 snoRNP-dependent sites.
Statistics
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PSSM-Id: 515964
Aligned: 46 rows
Threshold Bit Score: 317.306
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7MQ8_NA       25 PECFLTI----QEGLASKFTSLTKVLYDFNKILEng-rIHGS-PLQKLVIENFDDEQIWQQLELQNEPILQYFQNA-V-- 95  human
XP_004180331  12 PTDIL-------SKSSKGPLSLAKNYMDSVITLHkkeyPNSRnDIDTITTKGLDANQVWWQVKMVLDNVEGNLMDRi--- 81 
Q6CRE2        12 PVGLLSQ----DALESKEPLSAVKTYFDEVINLNknngNSKT-TLDEIVVDGLDANQVWWQSKIILDNVQGDIMEKi--- 83  Kluyveromyces l...
XP_003681862  12 PVEIL-------SQDSSSALQLVKSYLDEVITHAkkddISTD--IDEITVDGLDANQVWWQAKMVLDRVQGDLMERi--- 79 
XP_002551917  12 PISIISE----NEDTSTDSLRLVKTYIDDVILSQkaldGKVL--LDEIVVEGLDANQIWQQVRLVLENSGPKLMGKi--- 82 
CCE82181      13 PQNVFSLfpseSNQNENYFNKLTKEFLDPLSKDHs--------iLEQIHIDGLDSTQVFGQAKIVLDNVADQLLFSdI-- 82 
EMG50041      13 PQDVFKL----KEKNNNYFNSLAKSFIDPLAKQYs--------vLDEIYIDGLDSIQVYGQTKMVLDGVGEQLLGEkI-- 78 
XP_002839842  17 QHEFLQP----KSSLHSAALVLAKKYLDPLAASVaggkKSEV--LEKIYLDGFDVDQVWEQARLVVDAVESGVGEGkgvs 90 
XP_002173877  11 PTSFLFP----DESQG-------ASFLDECINAFssvsVPKKcPIQQIHTKGCDAWQIYNQLALATKYALDELp------ 73 
XP_013023134  11 PTSFLFP----NEQAS-------NQLVEEAIRYFsavkVPSSsPIQKVVTKNLDAWQVYNQLAIAAKHTLDDLPDL---- 75 
7MQ8_NA       96 ---------SETINDEdISLLPEs--------eEQEREEDGSEIEAD--------------------------------- 125 human
XP_004180331  82 ----------QELRELtTSNYISdse----rdiDLDDEQQNSSSEQMveseneseldin--------------ketedks 133
Q6CRE2        84 ----------AELKVDnENDMSEes------sgDEDDASNVENSNEMsadeapvsee-------------------saie 128 Kluyveromyces l...
XP_003681862  80 ----------------qELKIMTdsvdeavpspEGEDGSEYESEEEVseggemlppnfeetvsdne-aeeleesdaqyds 142
XP_002551917  83 ----------STIRTSlA---------------EVNESDEEISSSESseveenkeeelegmnefdsdesekvdaiittgq 137
CCE82181      83 ---------PKHVSHKgEDDINVkqy----devDSEDFSESESDADNindreyae----------------------nqs 127
EMG50041      79 ---------PSIMERLeEED-------------DEEDEDEEENE------------------------------------ 100
XP_002839842  91 wgvngdakggELANGKkRKAVAFe--------eDIDSASGTSSQSDS--------------------------------- 129
XP_002173877  74 ---------------------------------DVDVSDEEQGSDSVtgsaaevs----------------------dve 98 
XP_013023134  76 ---------------------------------DVEEDRPSDEESYAsedsqeen-----------------------qf 99 
7MQ8_NA      126 -----DKEDLEDLEEeevsdmgnDDPEMG------ERAEnSSKSDLrkspvfsdedsdlDFDIS--KLEQQSKVQNKGQG 192 human
XP_004180331 134 dgveiGNNGEGENIS--------RAESES------HSSEeELDSDEeerdlg-eaegedEGGVK--D------------- 183
Q6CRE2       129 eeeeeAENEELVLDE--------EQQFSEpeplelHEKEeDKLENEsdsepd-dqfveaQESPQ--AIED---------- 187 Kluyveromyces l...
XP_003681862 143 aeeelVENGSSEVEK--------EEPEII------GDANeEENSHEv--------------------------------- 175
XP_002551917 138 saglpINNSDDEYHS--------EVR---------EGHNsNRGSGDegseee-eggannSDGAE--EITVGPKKD----- 192
CCE82181     128 dfseeHDGNDDFSES--------EGSDEE------EEEEeDANDKYpgsedr-tstdfaKNDEE--ANVDQESKDANDNV 190
EMG50041     101 -----EENEEEENKE--------EFEEEN------EGFEgFEEDDVegseed-deeaeePEDVE--EGSDAETLINDTHT 158
XP_002839842 130 -----EEDEEVDDDE--------DLGEEE------YEEPmDEDGGIalpddd-ddeegiEEDSE--EGGEEFVQD----- 182
XP_002173877  99 ynedeEMSVDGENSE--------EEELDG------EEQEdEEDEDEfqgfdd-eadnaeVDVVE------KPKKD----- 152
XP_013023134 100 ealpaENPAEDVENE--------EEEFLGfsdrgdEENDhLSDENIenedle-tgnsneEDENEqvQEDQEPKKD----- 165
7MQ8_NA      193 ------KprekSIVDDKFFKLSEMEAYLENIEK--EEERKDDndeEEED------IDFFEDIDS-----DEDEGGlfgsk 253 human
XP_004180331 184 ------K----FGLNDQFFDIEEFNRQTIAADE--IDDMLDNdkeDEDE------VDYFADIPS-----EEDEEA----- 235
Q6CRE2       188 ------K----FGVNDQFFNLDEFNRQTLEAEN--RSQDADEedeDDEE------VDYFADVPS-----EEDEEA----- 239 Kluyveromyces l...
XP_003681862 176 ------L----SGVNDDFFNLEEFNKQTLEPEGgrAEQE------DDEE------IDYFENVPS-----DDEEEA----- 223
XP_002551917 193 ------S----FGLNDEFFDLEEFNRQTIDNEN--TAE-------PDNE------INYFEDVPS-----EEDEEV----- 237
CCE82181     191 egfsrdA----FGLNDGFFDIDKFNEQILDMED--ANA-------DDEE------IDYFEDLDE-----KDDEDD----- 241
EMG50041     159 k----dA----FGLNDGFFDIDHFNKQILSMEK--DNNINDE---DEEE------IDYFGSLSE-----SDDEED----- 209
XP_002839842 183 ------V----HGLNDGFFSIDDFNRQTRLLEM--QDERGELg-sDEEE------IDYDADPDQladndEVEDEGgivtv 243
XP_002173877 153 ------A----FGLNDQFFDIDAFNKQTLEMEE--QDESQTIalnDDEDeenedeIDVFGDVDE---------EEgp--- 208
XP_013023134 166 ------V----FGLNDKFFDIDEFNKQTLALEEqeDEQNHEIgeeEEDD------IDLFVDPEE-----EDEEEEggp-- 222
7MQ8_NA      254 kl-----------ksgkssRNLKYKDFFDPVEsDeditnvhd--------deldsnkeDDEIAEEEAe------------ 302 human
XP_004180331 236 ---------------------IYYDDFFDKPK-Enknkavskk-------ssdkegeeDFGNESYGEd------------ 274
Q6CRE2       240 ---------------------LYYDDFFDKPS-Nkkssqdrr--------pgpskkaeAEEDESFDEs------------ 277 Kluyveromyces l...
XP_003681862 224 ---------------------IYYEDFFDKPN-Tkkrttgg-----------dknslnTKKIDDLDEa------------ 258
XP_002551917 238 ---------------------LYYDDFFDKPS-Sskrkvtsg---------gdkqvkfGEHGEDFHEnsd---------d 277
CCE82181     242 -------------------EIAYYEDFFDRPN-KqdvsskekkdadnkfdfsdnsqseGEGEDENEE------------- 288
EMG50041     210 -------------------EMDYYDDFYDKPG-Qfkqkvshns------qdgdeddedDEGEEVFNEd------------ 251
XP_002839842 244 gnddydeedgdlhdsydnsNGIMYQDFFAPPA-KkgskkrlskvskpwnqrtkrleeeLEREGSNIE------------- 309
XP_002173877 209 -----------------qaDSIMYEDFFGPRN-Prdrrqqvqak----kraalkkkkrPVAEEPSDDeevanveedeeee 266
XP_013023134 223 -----------------raDSILYEDFFGPKS-AkgrrevskkkkrdadaskkkkakrVPKPEESDEeedqe-----epq 279
7MQ8_NA      303 eLSISETD---EDDDLQENEDnkqhkeslkrvtfalpDDAETEDTGVlnvkKNSDE-VKSSFEKRQEKMNEKIASLEKEL 378 human
XP_004180331 275 yYDAAMDA---AKLDLFEDET----------------DDEE-----El--tSNKPEkKLSTYEKQQLEIQKQIEILEEEA 328
Q6CRE2       278 eYDDAMEE---AKLDLFADED----------------DDFQGSDE------ETAEQ-PLSTFERQQLELKRQIESLEKEA 331 Kluyveromyces l...
XP_003681862 259 dYEAAVDS---AKLDLFAEEG----------------DDSEIDEDD-----KDVEG-KLSTYERQQIDIQNQIEQLEKDA 313
XP_002551917 278 eYDRAMES---AKLDLFAEVE----------------DDEMKPE-------VDPVS-KLSTFQRQQLDIQRQIAQLEKEA 330
CCE82181     289 -YSHAISS---ARKDLFDDDM----------------SEDDDKE-------SQKPA-NMSSFEKQQQQIQAEISKLESDL 340
EMG50041     252 dYDNAVGS---AMLDLFAEDD----------------KETK----------PKSAE-NLSTFEKQQRSIQAEIAKLEAEL 301
XP_002839842 310 ------SEmarVRRDLFDDDV----------------SEEGSDFDMDdd-lANPIS-HRSTHEKRQATIIEQIRQLEAAN 365
XP_002173877 267 dAAQTFER---VRQDLFASDS----------------EEEQDDGT------------GLSAYERQKLELTKQIRALEAEN 315
XP_013023134 280 nDDNTFER---VRKDLFADEE----------------EEEN----------ENSQQ-LLSSYERDKARISQQIKELESEN 329
7MQ8_NA      379 LEKKPWQLQGEVTAQKRPENSLLEE----TLHFDHAVRMAPVITEETTLQLEDIIKQRIRDQAWDDVVRKEKPKEDAYEY 454 human
XP_004180331 329 IAEKKWALKGEVKAKDRPEDALLTE----DLEFDRAAKPVPIITSEVTESLEDMIRRRIKNYEFDDLPRRTIHDITNKPF 404
Q6CRE2       332 VAEKKWALKGEVKARDRPEDALLTE----DLEFERTAKPVPVITAEVTETLENMIRRRIKEEDFNDLQRRVISDISGYNN 407 Kluyveromyces l...
XP_003681862 314 VAEKKWALKGEVGAQDRPADSLLTE----EVDFDRTAKPVPVITSEVTESLEQLIRRRIQEYNFDDLQRRVVSDLNLKKM 389
XP_002551917 331 VAEKKWALKGEVKAGDRPEDALLTE----DLDFERTSKPVPVITSDVTESLEDMIRRRIQQREFDDLARRVEANLNFSSA 406
CCE82181     341 VAEKKWTMKGEVSAKSRPQDSLLEDpeaiDLEFDRASKPVPIVTEDFSESIDDVIRRRIKEEQFDDLPKRYISDLEKHDR 420
EMG50041     302 VADKKWTMKGEITSNDRPQESLLDEt---DLTFDRTAKPVPVITEESTQTLEDLIRKRIKEDDFNDLPRRIITDISRFHK 378
XP_002839842 366 VAKKQWTLAGEARSTTRPLNSLLEE----DLDFERAGKPVPVITQEVTEDLEEMIKRRIIASDFDEVIRRRPDDISSRFR 441
XP_002173877 316 VAKKNWTLMGEASSKQRPQNSLLET----EVDFEQNAKPVPVVTEESTDTLEDLIKSRILDKNFDDIPRRLVSAVPDFKP 391
XP_013023134 330 VAKKPWTLIGEATSKSRPSNSLLDV----DIDFETGAKPVPVQTEETTSALEDVIKNRILEKRFDDVPRKAPSSLPEFRP 405
7MQ8_NA      455 KKRLTLDHEKSKLSLAEIYEQEYIKL-----NQQKTAEEENPEHVEIQKMMDSLFLKLDALSNFHFIPKPPV-PEIKVV- 527 human
XP_004180331 405 KPKFELSDTKSTKSLAELYENDYNGTk----DEDEISEELRMAHNEITDLFNDLCYKLDALSSAHFIPKPLK-KSLEVR- 478
Q6CRE2       408 KPRFELSDVKSSKSLAEIYEDDFKGVt----EDTEISEELQKSHDEISELYKDLVYKLDALSSAHFIPKPIK-KDLEVR- 481 Kluyveromyces l...
XP_003681862 390 KPQFELSDQKSSKSLADIYEDDYKNVp----QDVAVSEELKKSHDEISEMFSNLCYKLDALSSAHFIPKPAQ-KSLEIR- 463
XP_002551917 407 KPQFELSDSKSSKSLAELYENDYNNIp----QDSEVSEELKKSHAEISDLYSKLVYSLDALSSAHFIPKPAQ-KTLEVR- 480
CCE82181     421 RPAFELSQEKSKKTLAEIYEEEYSGA-----QDNSKSEETEKLHSEIGNLFENVTYMLDSLCSAHYIPKPHQtKTIEIK- 494
EMG50041     379 APKAEVSEQKSSKSLAELYEDEYNQId---aQQESLNEEVKKQHDEISELFTKVTHKLDALCSAHFIPKPHQlKTIDIKv 455
XP_002839842 442 RGRIELDDSKPQQGLAEIYEREHLQKidpenNPDIKDEKLAEAHREIGELFSDVSRKLDALSSWHFTPKPPK-PAISIV- 519
XP_002173877 392 SQLFDLDENKPQRSLAEEYEEEYLKKsdpttFQSKEDKKVEKEHEEIKGLFNSVAHILDSLSSWHYVPAPAE-ASVEVV- 469
XP_013023134 406 SELFELDENKPQQSLADIYEEQYMKKanpdtYQSGVDKKRQDDYNEIKTLFEDVSYTLDALSSWHYIPAPAE-ANVQVV- 483
7MQ8_NA      528 --SNLPA-ITMEEVAPVSV------SDAALLAPEEIKEKNKa------------------GDIKTAAEKTATD 573 human
XP_004180331 479 --VETAA-ISMEDAQPLTL------STSSTLAPQEIYKVGKsengne--------vrlknGVTISKDEMTRED 534
Q6CRE2       482 --VQTAA-ISMEDAQPLTM------SSGSTLAPQEIYKVGKsensne--------itlknGVVMSRDELSRED 537 Kluyveromyces lactis
XP_003681862 464 --VDSAA-ISMEDAQPLSM------SSASALAPQEIYKVGKsnntne--------irlknGVTMSRDELTRED 519
XP_002551917 481 --VQTPA-INMEDAQPLTM------STAPTLAPQEVYAPGAsrstne--------islknGVVMSRDELSKDD 536
CCE82181     495 --ASDAAeINLEDSQPAVV------GSGSTLAPQEIYSLKNkgnenkaa----nqislksGLSYSKDELPREE 555
EMG50041     456 tdSSSPA-ISMEDAQPLHV------SSESRLAPQEIYKIGDdvvkgdgvk-gksqvqlksGLSYSKDELSRED 520
XP_002839842 520 --VDAPA-ISMEEAQPSAVdggalaANISMLAPQEVYAPQKgravatigegggreivgksGAPVSTREMTRED 589
XP_002173877 470 --ANAPT-LSMEDVQPAAA------SETMALAPQEIYNATQgertde--------tvtrsGIAISKAEMNHQE 525
XP_013023134 484 --SNAPT-LAMEEAQPTAS------SDAMALAPQEVYQPSMdnrqne--------tversGIAVSKAEMDHSE 539
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