6GMH


Conserved Protein Domain Family
Leo1
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pfam04004: Leo1 
Leo1-like protein
Members of this family are part of the Paf1/RNA polymerase II complex. The Paf1 complex probably functions during the elongation phase of transcription. The Leo1 subunit of the yeast Paf1-complex binds RNA and contributes to complex recruitment. The subunit acts by co-ordinating co-transcriptional chromain modifications and helping recruitment of mRNA 3prime-end processing factors.
Links
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Statistics
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PSSM-Id: 397901
Aligned: 125 rows
Threshold Bit Score: 121.529
Threshold Setting Gi: 163777239
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6GMH_U                485 FVKLPNFLSVEPRPFDPQYYED-E-FEDEEMlD---------------------------EEGRTRLKLKVENTIRWRIR 535
WGS:AACS:CC1G_00968   255 VIRTPNFVQVDSKPFHPDTYIGpEhDEDDAGtEt-------------------------lKQRSMSIKLRVESTIRWRWT 309 Coprin...
Q5KL25                122 QMKFPAYVNLDPKPFDPDLYRA-TqEEEPIDgAa-------------------------dPIAAKSMMIGVKNTIRWRWV 175 Crypto...
CCA66715               89 MLRLPQYLKVDSHPFHPDTFQG-YsDK-----D---------------------------KSQASAIKLELTNTIRWKWI 135 Serend...
EDP42428              132 LARLPNFVRYADRAFDPATW---NeDDEDEQqQqqqqqqqqqqssqqhqqpqqheydsvtGDQKARKFLRTMSTVRWRWK 208 Malass...
CCF49296              208 LARIPHFLRYVTTPFDADTWDE-EqEEKALLeEgfns--------------------qfgNDVGAASLLRTSNTIRWRYT 266 Ustila...
KDE07395              169 HARLPHFLGLETQPFDDLMWEP--------------------------------------PAAKQAHEIMDENLIRWRWS 210 Microb...
XP_007406386          129 DFRLPNFLELDSQAFTDQKFLN-EvKRSTTEeEg--------------------------NPSKSSSVFPDHNTIRWRWV 181 Melamp...
WGS:AAWC:PGTG_15728.3 119 DMRIPNFLSFNPLPFSDEEFLN-EnESSEKE-G---------------------------GESEAAKVLTDQNVIRWRWQ 169 Puccin...
GAC77398              198 LARIPHFLRYVTTPFEPDSWDE-EqEEDMLRdEgfns--------------------gfaHDEGATSLLRTSNTIRWRYT 256 Moeszi...

6GMH_U                536 Rdee--gnEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPL--------------------------------------- 574
WGS:AACS:CC1G_00968   310 Kden--grDVQQSNSRIIRWSDGSLSLRLGKELFDISKSIDtsaglprqlggs--------------------------q 361 Coprin...
Q5KL25                176 Tgpd--gePVRQSNARMLRWSDGSVTLQLGDDFYDVAPSQGatlarpsdpqp---------------------------- 225 Crypto...
CCA66715              136 Rkdd--gtMAKQSNARVIKWDDGTMSLQLGNEMFDISTTDEtttthrgtetpplsqsqsq-------------sqsqsqs 200 Serend...
EDP42428              209 Eagp--srVTPQSNARIVRWDDGTESLQIGSEFFDMTRHAEps------------------------------------- 249 Malass...
CCF49296              267 DqvdqdgaRIPESNARIVRWSDGTMSLQVGSELFDITQQTEkgrvstatntgtntpqmssssqaag-pssqllsqatqsm 345 Ustila...
KDE07395              211 Khel--dqVIKESNARIVRWSDGSLSLQLGSELFDMSVALDqsalltsssstipvm--------------------psst 268 Microb...
XP_007406386          182 Mgrd--gkPVKQSNSRVVSWSDGSKSLQVGSELFDMVFIHDhqnqntpqhdskp------------------------gs 235 Melamp...
WGS:AAWC:PGTG_15728.3 170 Kdse--gnPVKRSNARVICWEDGSQSLQVGSELFDMISTVDgrqnnntt------------------------------- 216 Puccin...
GAC77398              257 DeldqdgaRVPESNARIVRWSDGTMSLQVGSELFDITQQTEkgrvsvantgantpqlgassqsagpsssqqllsqatqsv 336 Moeszi...

6GMH_U                575 -----------QGDHNHLFIRqg--tgLQGQAVFKTKLTFRPH-STDSATHrkmTLSLADR-CSKT--QKIRILPMAGRD 637
WGS:AACS:CC1G_00968   362 pstqsqtplgkNQGLTYLVAQhkrsqvLQAEAVITGNMTLRPT-SMQSETHrmlVRAVGQK-HNKV--ARLKMADDPTMD 437 Coprin...
Q5KL25                226 -vrkrddkpatNSSTTFLCVGaaaervLVTERPIAGQLSLLPT-SMTSKTYlelVKHVGKQ-HTKH---SKMKMLEETQD 299 Crypto...
CCA66715              201 qsksqqtnsmrQHGVSYLVTQhsaqqlLQVEATITGSMSLRPAvGTQSTLHrqlVQAVAKK-------HSKVSKLRFASD 273 Serend...
EDP42428              250 ---------aqGTPLTYIYVPhaeegvLEAECPVRTSLSFKP--GLHSDTHsriASAIRHQrGMR---VVASSEMFGTMD 315 Malass...
CCF49296              346 pmgsrgssnrpAQSLSYLVVPhereqvMEAQGPIAGSLAFTPA-DIQSETHrriAKALRFQ-KTAR--VVATAAGEGALD 421 Ustila...
KDE07395              269 tslslttssdrAHGLTYLVAShdytelLEAQASVHGTLTFRPT-TLQSATHrklAGHIHARnLKS---VRTKIADLPAFD 344 Microb...
XP_007406386          236 lsqpkpdltpnTQGLTYLFVRqgesqvLESQTSITGQISLRPY-SLNSITHrn---lVANRsMNKTysQRQTQSVVVTVD 311 Melamp...
WGS:AAWC:PGTG_15728.3 217 ---tqqqpgatTQGLTYLFAQhselklLEAQASITGQVTLRPY-SLNSMTHrn---iVANRsLLKAnsQRQTSLRVITLD 289 Puccin...
GAC77398              337 pmgssgstnrpAQSLSYLVVPheaeqvMEAQGPIAGSLAFTPA-DTQSETHrriAKALRFQ-KTAR--VVATAAGEGALD 412 Moeszi...

6GMH_U                638 PECQRTEMI 646
WGS:AACS:CC1G_00968   438 PEREKMELV 446 Coprinopsis cinerea okayama7#130
Q5KL25                300 EEALQAlll 308 Cryptococcus neoformans
CCA66715              274 AMMREAERE 282 Serendipita indica DSM 11827
EDP42428              316 PEREKERIE 324 Malassezia globosa CBS 7966
CCF49296              422 PEVEKARIE 430 Ustilago hordei
KDE07395              345 PEKLKAQRE 353 Microbotryum lychnidis-dioicae p1A1 Lamole
XP_007406386          312 PEMEKLGKe 320 Melampsora larici-populina 98AG31
WGS:AAWC:PGTG_15728.3 290 PEKEKIDKe 298 Puccinia graminis f. sp. tritici CRL 75-36-700-3
GAC77398              413 PEIEKARIE 421 Moesziomyces antarcticus T-34
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