8A3Y,7XN7


Conserved Protein Domain Family
Leo1

?
pfam04004: Leo1 (This model is not part of the current CDD release)
Leo1-like protein
Members of this family are part of the Paf1/RNA polymerase II complex. The Paf1 complex probably functions during the elongation phase of transcription. The Leo1 subunit of the yeast Paf1-complex binds RNA and contributes to complex recruitment. The subunit acts by co-ordinating co-transcriptional chromain modifications and helping recruitment of mRNA 3prime-end processing factors.
Statistics
?
PSSM-Id: 515962
Aligned: 120 rows
Threshold Bit Score: 121.142
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
8A3Y_Q       1553 YFVKLPNFLSVEPRPFDPQYYEDEF-EDEEmldee---------------------------grtrLKLKVENTIRWRIR 1604 human
CCG84473       79 YLAKLPSFLDINALPYDPDVLLTEIqQSTAmtadn--------------------------dermtKKRSLVNTLRWRHK 132 
XP_002174284  115 iHAHMPNFLSMEQRPFDHEVYRTEAeADAEmiehnm-------------------------ewgqmIKHKVDNTIRWRFD 169 
XP_013020924   96 FHARMPNFLSVEQSPFDSEKYAVEAeADETllehdv-------------------------qwgqrVKHKVDNTIRWRLD 150 
Q9P6R2         89 FHAHIPNFLSVEQTPYDPEQYAAEAeADAAllehda-------------------------hwgqrIKHKVDNTVRWRLG 143  Schizosacchar...
XP_007873049  122 YYIKMPNFLTVVEKPFDSNSYLEEAcSEYEettvns------------------------ydnyqrIRLRIENTIRWRYV 177 
CCJ31330      131 YYVKMPNFLTIVQKPFDRESYLEEAqSEREettihq------------------------ydtnqrIRLKVENTIRWRYV 186 
XP_001729642  131 LLARLPNFVRYADRAFDPATW--NEdDEDEqqqqqqqqqqqqqssqqhqqpqqheydsvtgdqkarKFLRTMSTVRWRWK 208 
GAC77398      197 WLARIPHFLRYVTTPFEPDSWDEEQeEDMLrdegfnsg--------------------fahdegatSLLRTSNTIRWRYT 256 
XP_006678228  139 FLIKPPNFLHIEPIPYDRATYA-QLdNDLEkdedg---------------------------srerARLHVENTIRWRYD 190  Batrachochytr...
8A3Y_Q       1605 RDee--gN---EIKESNARIVKWSDGSMSLHLGNEVFDVYKAPL------------------------------------ 1643 human
CCG84473      133 AT-----PdgfESRQSNARFVRWSDGTMSLQVGEELFDVPIKNM------------------------------------ 171 
XP_002174284  170 En---------GKKVSNAQLVQWSDGTYSLRIGNDIFDAQSKPV------------------------------------ 204 
XP_013020924  151 Ea---------GNQESNTQVVQWSDGSYSLRIGNDIYDAQSKMI------------------------------------ 185 
Q9P6R2        144 Ps---------GSYQSNAQIVQWSDGSYSLRIGNDIYDTQNKLI------------------------------------ 178  Schizosacchar...
XP_007873049  178 KNs----Dg-tYSKESNARFLKWSDGSLSLLLGSELFSVVIKNS------------------------------------ 216 
CCJ31330      187 KNk----Dg-tYSKQSNARFIKWSDGSLSLLLGSELFSAVTKNS------------------------------------ 225 
XP_001729642  209 EAgp--sR---VTPQSNARIVRWDDGTESLQIGSEFFDMTRHAEps---------------------------------- 249 
GAC77398      257 DEldqdgA---RVPESNARIVRWSDGTMSLQVGSELFDITQQTEkgrvsvantgantpqlgassqsagpsssqqllsqat 333 
XP_006678228  191 Akh-------pDQKNSNARLVRWEDNSFSLLVGEEQFEVAVTSL------------------------------------ 227  Batrachochytr...
8A3Y_Q       1644 --------------QGDHNHLFIRqg--tgLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRcsk-tqKIRILPMAGRD 1706 human
CCG84473      172 --------------SREHSYLTLMhadeglLRGVQRFSNSMTFQPFGLSSKSHAELKADIARRaitskgRTVKLHTEMID 237 
XP_002174284  205 ---------------SQPTFLTVSheaqhlLRVQASFKQSLTFLPSAINTAKTARAPAMRYFNtpp-rtRGVQEIITEKD 268 
XP_013020924  186 ---------------TQPTFLTTSheaqhlLRVQTAFQRSFTFLPSAISTATTSKLPSMRMRGaql-ssRGVQEIITEKD 249 
Q9P6R2        179 ---------------SQPTFVTASheaqhlLRVQTSFKSSFTFLPSAINTATRSKLPSMRLTTvqv-psRSVQEIIIEKD 242  Schizosacchar...
XP_007873049  217 --------------ISDYMYLSIShetqslLMSRKRFTKNMTFLPIDTRSSTHKRLTEAILRGnm--kkSSIIEFINIED 280 
CCJ31330      226 --------------FSEHTYLCLShesqnlLMSRKRFTKNMTFLPIDTGSSTHKRLTEAILRGnm--kkCSIVEFVNVED 289 
XP_001729642  250 ------------aqGTPLTYIYVPhaeegvLEAECPVRTSLSFKP-GLHSDTHSRIASAIRHQrgm-rvVASSEMFGTMD 315 
GAC77398      334 qsvpmgssgstnrpAQSLSYLVVPheaeqvMEAQGPIAGSLAFTPADTQSETHRRIAKALRFQkta-rvVATAAGEGALD 412 
XP_006678228  228 --------------QNQHHYLAVQhseegyIQNRARFNKLMSFRPFSAQSLTHKRVTMAIVGKhs--kkNRTRLITTTED 291  Batrachochytr...
8A3Y_Q       1707 PECQRTEMI 1715 human
CCG84473      238 PADFQKQAI 246 
XP_002174284  269 PELLKRETE 277 
XP_013020924  250 PELLKREAE 258 
Q9P6R2        243 PELLKRQAE 251  Schizosaccharomyces pombe 972h-
XP_007873049  281 PEKVKREAE 289 
CCJ31330      290 PEKVKREAE 298 
XP_001729642  316 PEREKERIE 324 
GAC77398      413 PEIEKARIE 421 
XP_006678228  292 PEKAKQLVE 300  Batrachochytrium dendrobatidis JAM81
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap