6GMH


Conserved Protein Domain Family
Paf1

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pfam03985: Paf1 
Paf1
Members of this family are components of the RNA polymerase II associated Paf1 complex. The Paf1 complex functions during the elongation phase of transcription in conjunction with Spt4-Spt5 and Spt16-Pob3i.
Statistics
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PSSM-Id: 397885
Aligned: 38 rows
Threshold Bit Score: 235.281
Threshold Setting Gi: 388583757
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6GMH_V       112 VCRVKYCNSLPDIPFDPKFITYPFDQ---NRFVQYK-ATSLEKQHKHDLL-------TEPDLGVTIDLINPDTYRIdp-- 178
XP_002498888   8 IAKIRYDNRLPAPLLPPRLLKYTINP---EEEAD---SSELITSLYTKTSvtp-likVNEDLGMPLDLMKIPGMLDhmdt 80  Zygosaccharomyc...
CCF55803       8 IAKIRYENNLPPPTVPPKLLNYQINP---DEDVD---SPQLITSLYTRTNvtp-lvdINGDLGMPMDLMEIPGLLNkndt 80  Kazachstania af...
XP_001644317   8 IAKISYQNNLPPPLLPPSLLKFQDNE---NENAD---SPQLITSLYTKTNvns-lvnLDSELGMPLDLFKIPGLLNnsdt 80  Vanderwaltozyma...
XP_004199563  13 ISKVRYINDLPPPPLNPKFLEYNTTE---RSSTKTE-SEQVISSLFRKENfhsliecIDEDMGMNLNLLNNKGFLDende 88  Pichia farinosa...
XP_013021989   9 ILRVRYHNPLPPPPFPPRLINISNPV---KQYALPNfVSNLIQEKKIAIE-------NDAELGMPMDLAAVDGFFEgdts 78  Schizosaccharom...
Q9US06         9 ILRVRYHNPLPPPPFPPKLINIPNPV---KQYALPNfVSTLVQEKKIPIE-------NDIELGMPLDLAGITGFFEgdts 78  Schizosaccharom...
CCD51508      14 IARIRYSNALPPPPNPPKLLDIPNTGlasGQYTTPGfATRLARDQPLNIE-------ADAELGMPLDLVGMPGIFDgdes 86  Botrytis cinere...
CCE27944      18 IARIRFSNALPPPPNPPKLLDIPNTGlasGQYTTPGfASRLAREQPLNIE-------ADAELGMPLDLVGMPGVFDgder 90  Claviceps purpu...
EHK48006      18 IARIRFSNALPPPPNPPKLLDIPNTGlasGQYTTPGfASRLAREQPLNIE-------ADAELGMPLDLVGMPGVFDgder 90  Trichoderma atr...
6GMH_V       179 ----------------nVLLDPADEKLLEEEiqapTSSKRSQqHAKVVPWMRKTEYISTE-FNRYGISN--EKPEVKIGV 239
XP_002498888  81 ky---------lydfdgVKLQPEDRMLLRDP----GVDKLPKtDISKVSFLRRTEYISTTi---------tSHHHSQIEE 138 Zygosaccharomyc...
CCF55803      81 ry---------lysfdnVKLDPKDRILLRDP----RVDRLTKtDMSKVKFLRRTEYVSST---------------IAASN 132 Kazachstania af...
XP_001644317  81 kf---------lngfenVRLHADDRILLRDP----RVDRLTKtDISKVSFLRRTEYISTSi---------sSHSDSLTSN 138 Vanderwaltozyma...
XP_004199563  89 svigmflneknkkdnkpVTLHERDRELLRDA----GIERIAR-SELGVSFLRRTEYISEKqFMKPSANGveNGAHKLTKg 163 Pichia farinosa...
XP_013021989  79 wn---------qsdmsgMNLEPVDRSLLKVAggs-------gsSHVEVPFLRRTEYISAE-------VGrnSSTRGNLRL 135 Schizosaccharom...
Q9US06        79 wm---------hsdlssVNLDPIDRSLLKVAggs-------gsTHLEVPFLRRTEYISSE-------VAraASNRGNLRL 135 Schizosaccharom...
CCD51508      87 si---------qaplhpPQLHPHDRALLRPL----ATLGKPKfSDTGVSFLRRTEYISSGfTSKARMEGttSAKGLVDTR 153 Botrytis cinere...
CCE27944      91 si---------qapvqtPAVHPHDRPLLRPI----AALGKPKvAEANVSFLRRTEYISST-TPKRLd---aSHPRALLPK 153 Claviceps purpu...
EHK48006      91 si---------qapsqpLAVHPHDRALLRPI----AALGKPKvAEANVSFLRRTEYISSL-IPKRFe---aNHPRALLAK 153 Trichoderma atr...
6GMH_V       240 SVKQqf----tEEEIYKDRDSQITA-IEKTFEDAQKSIS-----QHYSKPRVTPVEVMPVFPDFKMWINP--CAQVIFDS 307
XP_002498888 139 TKKRaas-emeDEEELLNAPQLLEK-VENTFDCMTNDLSk---lQHPVKKKLRAVKTWNLLPDTASMDQN--YFLLKMVG 211 Zygosaccharomyc...
CCF55803     133 TKKRprnrledDDDKVLNPAEIVTR-VENTFEAMTDDLSk---lRHPVKRHLKATKVWNLIPDTASMDQN--YFTLKLVG 206 Kazachstania af...
XP_001644317 139 KKRTrdsshdeDDDRILNSHEISEK-VEGTFEKNSEDLSs---fRHPIKKKLQAVKSWKLLPDTSSMDQN--YFTLRLVG 212 Vanderwaltozyma...
XP_004199563 164 k---------eDNQEKLDADAQLQA-VEKTFADAQKTLQdfqniKHPRRKNLKAVAAWPILPDTSMLDSK--FLNVKFFG 231 Pichia farinosa...
XP_013021989 136 TASTskaiaeqRGRSLREIPNQIQA-IEQTFSAVQQPLEn---lKHPTKPELKPVGAWNFLPNDSMAGIQ--HLMLRVSD 209 Schizosaccharom...
Q9US06       136 TASTskalaeqRGRSLREVPKQLEA-INESFDVVQQPLEq---lKHPTKPDLKPVSAWNLLPNTSMAGIQ--HLMLRVAD 209 Schizosaccharom...
CCD51508     154 KPKPv-----qNLPADRESPAYIKAqVEKGFETAAANLKdrtrvRHPTKRNVQLVNAVPLIPDLDAFPDAggYVLLKFLT 228 Botrytis cinere...
CCE27944     154 ARRPlr----tAPDAAADSPLAIKRkIDRSFETAEQDIKdvkrvKHPTKKHLKVVEAIPMLPDLEAFPDSgaYVTIKFLT 229 Claviceps purpu...
EHK48006     154 SRRPv-----kRPEPAADSPQAIKRkIDKGFEVAEQDLKdpkriKHPSKKHLKLVDALPLVPDLDAFPDSgaYVTIKFLT 228 Trichoderma atr...
6GMH_V       308 DPAP----KDTSGAAA--------LEMMSQAMIRGm-MDEEGN---------------------QFV--AYFLPVEETLK 351
XP_002498888 212 SALLdkkeKE--------------NLALSTAIFRPveLEED-----------------------EWI--SMYTTEPKDSN 252 Zygosaccharomyc...
CCF55803     207 SAALdkreKE--------------ALALKTTIFRPveLEED-----------------------EWM--SMYTTDMKDSE 247 Kazachstania af...
XP_001644317 213 SATLskqeKN--------------TLALQTTIFRPveLEED-----------------------DWI--SMYTTDVKDSK 253 Vanderwaltozyma...
XP_004199563 232 SASFsremQLLKRQEKekydeqfqKNSLETSIFRP--ITSDDG---------------------EWI--SLYQSKDPQRT 286 Pichia farinosa...
XP_013021989 210 NLTDrtptSSTPGEEDv-------SNRHKVALFMP--SSAEGE---------------------QYL--SYYLPSEESAE 257 Schizosaccharom...
Q9US06       210 DLSErshsYSSLVNLQegh---nlTKRHEVALFMP--SSAEGE---------------------EFL--SYYLPSEETAE 261 Schizosaccharom...
CCD51508     229 NPVPpsstYD---------------ARVESSVLRPadPTEAELemkeaarqayeldphnnpppdEKIqyEMFMPDTVTDA 293 Botrytis cinere...
CCE27944     230 NPVSsaneYD---------------TRLLSGLFRPieRTEAEEaayeaaleaheqdpennpsphNLMnyDFYLGQSSTVA 294 Claviceps purpu...
EHK48006     229 NPVSssneYD---------------NRLRSGLFRPidRTAAEEaaleaameaynqdpvsnpkpaNLMnyDFYLGQSRADA 293 Trichoderma atr...
6GMH_V       352 KRKR-------------DQEEEMDYAp-dD-----VYDYKIAREYNWNV----KNKASkgy----eenYFFIFRE----- 399
XP_002498888 253 ILGG-------------EVEKNLEDNlqdDpnadkVYKFKRLRDFALKQvppqGHSGSfg-------eLSLVLNDek--- 309 Zygosaccharomyc...
CCF55803     248 TLEK-------------SIERVIDENltaDds-nkVFRFRRLRDFDMKQakstDSSLSe---------LAIVLNNek--- 301 Kazachstania af...
XP_001644317 254 ILSN-------------ELEKKIDDSsngLek--kVYKFKRLRDFDMKQiqtmENMGPsqqt--qlndLALIFNDek--- 313 Vanderwaltozyma...
XP_004199563 287 QILKdklnssekekqvyVLDEEEDAE---------EYKFEHIKEYDMSFqrynKPYEE----------LAIKFASegepn 347 Pichia farinosa...
XP_013021989 258 KIQ--------------QASNNSSSTe-------gPFLYNLFRNFDASM--------LvnpsgledlcLSICTDQenp-- 306 Schizosaccharom...
Q9US06       262 EI---------------QAKVNDASAdvhE-----PFVYNHFRNFDASM--------HvnstgledlcLTFHTDKdhp-- 311 Schizosaccharom...
CCD51508     294 KNIKrkfdvldpehddrDLYSQFDEEtgkG-----AFRLKRLRGYETVQ------TSGgtddkydeyvVIAMHDG----- 357 Botrytis cinere...
CCE27944     295 RNFRrkfdiedadrdntDLYTHQGETg--P-----YFQFNRVRAYETAD----ERELDhptky-sdeiIVAYNDV----- 357 Claviceps purpu...
EHK48006     294 DRFRrkfdvddadrdeeDLYTHRGDTg--G-----YFQFNRIRAYETAQ----ETELDhptky-edeiILSINEK----- 356 Trichoderma atr...
6GMH_V       400 -Gd-----GVYYNELETRVRLSKRRAKagv----------qsgTNALLVVKHRDMNEKELEAQEARKAQ---LENHEPEE 460
XP_002498888 310 -------gIAYYKPLRSRIELRRRRVNdvikp------lvrehNLDQINVTLRNPTTQEAKARDKLRMQfdpIDFANVDD 376 Zygosaccharomyc...
CCF55803     302 -------gVAYYKPLRTRIELRRRRVNdvikp------lvtehNIDQLNISLRNPTTSEVNTRDRLRMKfdpINFVPVDE 368 Kazachstania af...
XP_001644317 314 -------kAVYYKPIRSKIELRSRRVNdvirp------lvrehNLDQINISLRNPTTQESNLRDKLRTKfdpIDFPYVDE 380 Vanderwaltozyma...
XP_004199563 348 sKgdrkrkAAYYYPVTGKIDLKKHRAStnaein----rfirdsAYDIVNYKLREPNTNEMRRMDTIRSEfdpMEYEGEEE 423 Pichia farinosa...
XP_013021989 307 -----knnKALYTPIYARSTLKRRHVRapv----------npdTIDGIELTLREPNREESVQLKRARYDsfaMGDVEALE 371 Schizosaccharom...
Q9US06       312 -----eanQVLYTPIYARSTLKRRHVRapv----------sldAVDGIELSLRDLNDEESLQLKRARYDtfgLGNIKDLE 376 Schizosaccharom...
CCD51508     358 -TdglhqkAAHYYPVVQRSSIRPQRTKniqkmrhn-isgeeeeVLDMVDLSIVDPGAETKQVMEGFKTWpygENHE---D 432 Botrytis cinere...
CCE27944     358 -DayprqkAMYYYPIMQKSTIRPQRTKniartig--inadeeqMVDQLDITVEDPTEEMLDAMKKYKNHplgWEQEPDEE 434 Claviceps purpu...
EHK48006     357 -DtdasqkAVFYYPIMQRSTIRPQRTRniartnyglaeddepqVVDQLDLTVDEPTEEMRAAMKMYARHpmgWEQD---- 431 Trichoderma atr...
6GMH_V       461 EEEeemeteekeagGSDEEQEKGSSSEK-EGSEDEHSGSESEREEGDRDEA---SDKSGSGEDESS 522
XP_002498888 377 EEE-----------EQEQP-------QEqEQEQEPNNESQQPEQSEQSESK---PEESQSKPEEPE 421 Zygosaccharomyces rouxii
CCF55803     369 EEE-----------EKEEESR---EDDMsKEKHDDNEQHKHEDLDSTQNQI---TGKADSKEDEVE 417 Kazachstania africana CBS 2517
XP_001644317 381 DED-----------ENEKGVE---SSQQpGEQHDSDGEESLPLSAQSHDSL---PLSAQEHGSQGI 429 Vanderwaltozyma polyspora DSM...
XP_004199563 424 VAE-----------TNETQPN-----EEeQEKKDQDNGSSINNDQENNGET---KPEDDSSLKNQE 470 Pichia farinosa CBS 7064
XP_013021989 372 KEE-----------QEIAEEQAGEENELnEIEEQHQDENPLPNPSENPQPL---PTEESGQLSTKN 423 Schizosaccharomyces cryophilu...
Q9US06       377 EEE-----------EKLRSVEGSLNEELsEEEKPAESREQLESAEQTNGVK---PETQAQNMSASE 428 Schizosaccharomyces pombe 972h-
CCD51508     433 DAE-----------RDAAEVE------------DALSEADAEGEDDDLNSPvrpSLGGKTIASRVQ 475 Botrytis cinerea T4
CCE27944     435 DIA-----------AGATQEQ------GpDADGDADADVEVDGEADADAEA---GADADPEPDADV 480 Claviceps purpurea 20.1
EHK48006     432 -----------------EEDELHQGVERsIEEGDVDADGDAEGEDADRNGA---SSPAEKYHERSP 477 Trichoderma atroviride IMI 20...
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