5MVI,7BR9,7BR9,7BRA


Conserved Protein Domain Family
MmgE_PrpD_N

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pfam03972: MmgE_PrpD_N (This model is not part of the current CDD release)
MmgE/PrpD N-terminal domain
This entry represents the N-terminal domain of 2-methylcitrate dehydratase EC:4.2.1.79 (PrpD) that is required for propionate catabolism. It catalyzes the third step of the 2-methylcitric acid cycle. This enzyme consists of two domains: a large domain with an all-helical fold and a smaller domain that folds into an alpha/beta domain. Cis-aconitic acid decarboxylase (CAD) shares high identity with proteins of the MmgE/PrpD family. Citrate/2-methylcitrate dehydratase from Bacillus subtilis is involved in the tricarboxylic acid (TCA) and methylcitric acid cycles as it has both 2-methylcitrate dehydratase and citrate dehydratase activities. This entry represents the N-terminal domain of 2-methylcitrate dehydratase PrpD, which has an all-helical fold.
Statistics
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PSSM-Id: 515937
Aligned: 171 rows
Threshold Bit Score: 129.927
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5MVI_E        17 VDIVDYVMNYEITSk--VAYDTAHYCLLDTLGCGLEALEYPACKKLLGpIVPGTVVPN-GARVPGT-Q-F-QLDPVQAAF 90  Salmonella ente...
XP_030126785   8 GNFAKVIHGLNANHltdQVIQRSKRMILDTLGVGLLGTSTEVCHKVAQ-YSKIYSSDL-SSTIWGHlD-F-RLPPVYAAF 83 
XP_002712978   8 ESFANMIHGLKVGHltdPVIRRSKRMILDTLGVGFLGTNTEVFHIASQ-YSKIYTSSV-SSTVWGQpD-I-KLPPTYAAF 83 
XP_003218727   8 GNFANVIHGLTTSHltdVVIQRSKRMILDTLGVGLLGTRTDVFQKMVQ-YSKVYSSDT-SSSVWGH-P-YlKLPALYAAF 83 
NP_001071075  40 SSFGRFIQSVQPKNltpTVLQRSKRMVLDSIGVGLVGSTTEVFDLALQ-HCQHMYASDdISFVYGR-Q-GvKLSPTLAAF 116
XP_025752996  37 ASFGKFIGEIKPQHlspVVLHRSKRMVLDSIGVGLIGSTTDVFELALQ-HCQNMYAPGdTSSVYGR-K-GiRLSPILAAF 113
XP_040028729  37 ASYGKFISEVKPQHlspVVLHRSKRMVLDSIGVGLIGSTTDVFELVLR-HCQHMYAPDhISSVYGR-GgT-RLSPILAAF 113
7BR9_A         8 ESFAGMIHGLKVNHltdGIIRRSKRMILDSLGVGFLGTGTEVFHKVTQ-YSKIYSSNT-SSTVWGRpD-F-RLPPTYAAF 83  house mouse
7BR9_B         8 ESFAGMIHGLKVNHltdGIIRRSKRMILDSLGVGFLGTGTEVFHKVTQ-YSKIYSSNT-SSTVWGRpD-F-RLPPTYAAF 83  house mouse
XP_064422783  61 SSFGAFIQGIPMDQlseTVRSRSKQMILDNIGVGLVGSTTEVFEIALQ-YCQQMYapdpvCSVYGRpG-R-KLSPVLAAF 137 coelacanth
5MVI_E        91 NIGAMIRWLDFNDTWLAAeWGHPSDNLGGILATADWLSR----N----AvaagkapltmKQVLSGMIKAHEIQGCIA--- 159 Salmonella ente...
XP_030126785  84 VNGVAVHSMDFDDTWHPA-THPSGAVLPAVIALSEAFPQ----KkkisG----------LDLLLAFNVGIEVQGRLL--- 145
XP_002712978  84 VNGVAIHSMDFDDTWHPA-THPSGAVLPVITALSEALPQ----SpkfsG----------LDLLLAFNIGIEVQGQLMhfs 148
XP_003218727  84 VNGVAIHSMDFDDTWHPA-THPSGPVLAALLATSEAISK----NqrisG----------QDLLLAFNVGIEVQGRLM--- 145
NP_001071075 117 VNGVAAHSMDFDDTWHPA-THPSGAVLPALLAISDMLHS----NskpsG----------LDFLTAFNVGIEIQGRLM--- 178
XP_025752996 114 VNGVATHSMDFDDTWHPA-THPSGAVLPAVLALSDMMPA----NnkpsG----------LDFLLAFNVGIEIQGRLL--- 175
XP_040028729 114 VNGVATHSMDFDDTWHPA-THPSGAVLPAVLALSDMLPA----NskpsG----------LDFLLAFNVGLEIQGRLL--- 175
7BR9_A        84 VNGVAVHSMDFDDTWHPA-THPSGAVLPVLTALSEALPQtpkfS----G----------LDLLLAFNVGIEVQGRLM--- 145 house mouse
7BR9_B        84 VNGVAVHSMDFDDTWHPA-THPSGAVLPVLTALSEALPQtpkfS----G----------LDLLLAFNVGIEVQGRLM--- 145 house mouse
XP_064422783 138 VNGVAVHAMDFDDTWHPA-THPSGAVLPALLATAQMLPP----NskpsG----------LDFLLAFNVGIEVQGRLM--- 199 coelacanth
5MVI_E       160 -LENAFNR---VG----LDHVLLVKVASTAVVAEMLGLTRDEILNAVSLAWVDGQSLRTYRHAPNTGTRKswAAGDATSR 231 Salmonella ente...
XP_030126785 146 -HFSREAR---NIprrfHPPAVVGTMGSAAACAKLLALDQQECKNALAIAASYAGAPLANAATQIKPLHV----GNAAKH 217
XP_002712978 149 kEANNIPK---RF----HPPSVVGALGSAAAASKLLGLSLTKCQEALAIAVSHAGAPMANAATQTKPLHV----GNAARF 217
XP_003218727 146 -HFSKEAS---NVpkrfHPPSILGTLGSAAATAKLLGLDQFKCKEALAIAASYAGAPLANAATQTKPLHV----GNASRH 217
NP_001071075 179 -RFSNEAH---NIpkrfHPPSVVGTLGSAAACARLLSLDRNQASNALAIAASLAGAPMA--NAATQSKPL--HIGNASRL 250
XP_025752996 176 -RFSNEAH---NIpkrfHPPSVVGTMGSAAACARLLSLDPTQSSHALAIAASLAGAPMA--NAATQSKPL--HIGNASRL 247
XP_040028729 176 -RFSNEAQ---NIpkrfHPPTVVGTMGSAAACARLLSLDHSQCGHALAIAASLAGAPMA--NAATQSKPL--HIGNASRL 247
7BR9_A       146 -HFSKEAKdipKRf---HPPSVVGTLGSAAAASKFLGLSLTKCREALAIAVSHAGAPIANAATQTKPL----HIGNAAKH 217 house mouse
7BR9_B       146 -HFSKEAKdipKRf---HPPSVVGTLGSAAAASKFLGLSLTKCREALAIAVSHAGAPIANAATQTKPL----HIGNAAKH 217 house mouse
XP_064422783 200 -RFSGEAH---NIpnrfHPPSVVGTLGSAAATAKLLSLNQTQCRNALAIAASLAGAPMANAATQAKPLHI----GNATRL 271 coelacanth
5MVI_E       232 AVRLALMAKTGEMGyP--SALTA---KTWGFYDVSFKGETFRFQ 270 Salmonella enterica
XP_030126785 218 GLEAACLALQGLQG-N--KQILD---EESGMGAFYTDY-NPQTL 254
XP_002712978 218 GVEAAFLAMLGLQA-N--KQILD---LKVGFGAFYDNY-SPKVL 254
XP_003218727 218 GLEATTLASLGLQA-N--KQILD---LESGFGVFYTEY-LPQTL 254
NP_001071075 251 GLEAALLASRGLEA-S--PLVLDavpGVAGFSAFYEDYAPRPIG 291
XP_025752996 248 GLEAALLASRGLEAsPlvLDAVA---GVAGFSAFYEDYVPQPLQ 288
XP_040028729 248 GLEAALLASQGLEA-S--PLILD---AVAGVAGFSAFYEDYVPQ 285
7BR9_A       218 GMEATFLAMLGLQG-N--KQILD---LGSGFGAFYANYSPedlp 255 house mouse
7BR9_B       218 GMEATFLAMLGLQG-N--KQILD---LGSGFGAFYANYSPedlp 255 house mouse
XP_064422783 272 GLEAALLASKGIEA-S--SQILDyipGCSGFSAFYSDYHPKALR 312 coelacanth
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