6G3U


Conserved Protein Domain Family
IDH

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pfam03971: IDH (This model is not part of the current CDD release)
Monomeric isocitrate dehydrogenase
NADP(+)-dependent isocitrate dehydrogenase (ICD) is an important enzyme of the intermediary metabolism, as it controls the carbon flux within the citric acid cycle and supplies the cell with 2-oxoglutarate EC:1.1.1.42 and NADPH for biosynthetic purposes.
Statistics
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PSSM-Id: 515936
Aligned: 129 rows
Threshold Bit Score: 1312.86
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6G3U_A          3 ITYTFTDEAPALATYSLLPIVKAFAASAGIDVETSDISLAGRILANFADRLEADQRIEDDLARLAVLATSPDANIIKLPN 82   Pseudomonas a...
WP_012082209    6 IVWTKIDEAPALATYSLLPIVKAFTKDSGVEIELRDISLAGRVIAEFSDRLPEDKKQADELAYMGELVLKPEANIIKLPN 85   Nitratiruptor...
WP_013638725    7 IIWTKVDEAPALATYSLLPIMRAFVKHADVDIEVRDISLAGRILAQFG-------YVPDDLAYLGELVWKPEANIMKLPN 79   Desulfurobact...
WP_012676672    6 IVWTKIDEAPALATYSLLPIMRAFTKDADINIELRDISLAGRIIAQFPDILPEDKRIPDELAYMGELVWKPEANIMKLPN 85   Persephonella
Q30RQ6          4 IIWSKIDEAPALATYSLLPIVNAFTKAAGVEVVTSDISLAGRVISKFSDRLKPEQRINDELAELGNVVLQPDGNIIKLPN 83   Sulfurimonas ...
WP_013553321    7 IVWSKIDEAPALATYSLYPVVKKYVGKAGVNMRLSDISLAARTLAAMG-------KHEDELAQLGELVHKPEANIIKLPN 79   Nitratifracto...
XP_002178894   76 ILYTETDEAPALATFSLYPVISKFSALANVDIVPCDISVAGRVLAAFPECLKPSQRVPDNLSYLGKKALEADCAIVKLPN 155 
XP_003063226   18 IWWTLTDEAPALATHAFLPVVRRFCGGVGVSVESADISLASRVLAAFPERLTPAQRKTDVLAKLGELATTERANIIKLPN 97  
XP_002507787   21 IWWTLTDEAPALATHAFLPVVRRFLGPSGVSVETADISLAARILAAFPERLTPAQRRVDVLAKLGELAKTSRANIIKLPN 100 
Q7UX35          8 IVYTHTDEAPALATRSLLPILQAFTSGSGLSFETKDISLAGRILAGFADRLPADKQVPDALAELGELVTKPEANVIKLPN 87   Pirellula sp.
6G3U_A         83 ISASVPQLKGAIAELQGLGYKVPDFP----EDPQTDEEKEVRARYAKILGSAVNPVLREGNSDRRAPAAVKAYARKHPHS 158  Pseudomonas a...
WP_012082209   86 ISASIPQLVATIKELQAQGYDIPDFP----EEPKTAEEVELRNRFAKLLGSAVNPVLRQGNSDRRLSKAVKEYAKKFPHK 161  Nitratiruptor...
WP_013638725   80 ISASIPQLIDAVKELQSQGYDLPDFP----ENPQTEEEKEIRAKYDKCIGSVVNPVLRQGNSDRRIAPPVKEYAKKHPHR 155  Desulfurobact...
WP_012676672   86 ISASVPQLKEAIKELQEQGYPLPDYP----ENPQTEEEKKIKERYDRCVGSVVNPVLRQGNSDRRLAAVVKEYAKKHPHR 161  Persephonella
Q30RQ6         84 ISASVGQLIECITELQAQGYDVPNYP----EDAKTDEEKALKEIYSTCLGSAVNPVLREGNSDRRAAAAVKRFAQKNPHK 159  Sulfurimonas ...
WP_013553321   80 ISASLTQLKECIAELQEHGHDIPDYP----ENPQTEEEKQIAAKYATCLGSAVNPVLREGNSDRRSALAVKRYAQKHPHR 155  Nitratifracto...
XP_002178894  156 ISAPLNQLLECVNELRHKGYDVPLYP----HEPSNVEETDVKHRYDKLMGSAVNPVLREGNSDRRVAAPVKAYAQKNPHR 231 
XP_003063226   98 VSASVPQLESCVAELKSKGYDLPKYPgkanAETMDAETLSIATRYAKVIGSAVNPVLREGNSDRRVAPPVKDFAKKNPHR 177 
XP_002507787  101 VSASVYQLEQAISELNRKGFDVPKYPs---GDALSPEDAAIKARYGKVIGSAVNPVLREGNSDRRVAGPVKDFARANPHR 177 
Q7UX35         88 ISASIPQLVEAITELQAQGYDIPDFP----QDPKTDEEKSVRATYAKVLGSAVNPVLREGNSDRRVAAPVKAYAQKNPHS 163  Pirellula sp.
6G3U_A        159 MGKWSMASRSHADYMRG-GDFFSSEQSITMA--KAGDVRIEFVGK----DGKVEV-KKQLSLQEGEVLDSMFMSCGKLRD 230  Pseudomonas a...
WP_012082209  162 MRDVSPDSKSYVAHMDK-NDFYQNEQSFISD--KDQTVKLVFEGQ----DGKTEVlKE-VEVKKGEVFSASFLNRKTLRE 233  Nitratiruptor...
WP_013638725  156 MRDVSPKSLSYVAHMKS-GDFYENEKSVTLK--KDTKIRYEFVDK----EGNVTVlKE-IELGMGDVVDGTYMSRKKLKE 227  Desulfurobact...
WP_012676672  162 LKEVSPHSKSHVAHMKE-GDFYQHEKSVIIE--KDTKIKYVFEDK----NGNQTVlKE-VEVGKGDVVDATYMNRKKLRE 233  Persephonella
Q30RQ6        160 LRAFESPSKAYVAHMNG-GDFFSNEKSVIVE--GNAPVTIELNGK---------VlKTLNDVVDKEIMDATFMSAKALQA 227  Sulfurimonas ...
WP_013553321  156 LKPFAENSQAKVAHMNGdGDFYGNEQSIINP--KAQTISIKLNGK---------TlKE-IEAETDEVLDATFMSVRKLRD 223  Nitratifracto...
XP_002178894  232 MGLWSKASRTHVAHMET-GDFYETEQSAVMA--LPTSVSIVLATK----NEGEIVlKAETPLEEGEVVDASRMSVKSLRD 304 
XP_003063226  178 LADWRADSSTRVASMSD-GDFYGSEKSWTNEsrEPATLRVELHAKgdggGGVIQTlKRSVVALPGEIVDVATMSAEKLAA 256 
XP_002507787  178 LKDWSGDSKTEVKSMPG-DDFFGSEKSSVRT--NAGSLRVELHAA----DGSVTVlKDSIPVEADEIFDAARLSRAKLTD 250 
Q7UX35        164 MGDWTADSKSHVAHMSE-GDFYGSEKSVILD--SDDSLRIEHVDQ----DGNVTVlRDGLTVIAGEIVDSARLSVRQLRA 236  Pirellula sp.
6G3U_A        231 FFEKTLQDCKETGVMWSLHVKATMMKISHPIVFGHAVSVYYKDVFDKWGQLFEELGVNPNNGISSVYDKI-KSLPASQQE 309  Pseudomonas a...
WP_012082209  234 FYECVINDAKEKDILFSLHVKATMMKISDPVLFGDAIRVYFKELFDEYGKELEEIGFDPNNGLVDLENKL-CKLPEGVQK 312  Nitratiruptor...
WP_013638725  228 FFEEVINDAKEKDILFSLHVKATMMRVSDPAIFGDAIRVYYKELFEKHGKELEEIGFDPNKGLIDLENKL-SKLPPEKQE 306  Desulfurobact...
WP_012676672  234 YFAEVIDRAKEDDILFSLHVKATMMRVSDPVIFGDAIRVYYSKLFERHADAIEKLGWKPEFGMQELENRI-ESLPEEEKN 312  Persephonella
Q30RQ6        228 FYQKTLDDAKKNGVLWSLHLKATMMKVSDPIMFGHAVKVFFKDVFAKYGDELTAIGYNANMGLGDLYKKL-EK--SSKKA 304  Sulfurimonas ...
WP_013553321  224 FYQKTIEEAKEKDLIWSLHLKATMMKISDPIMFGHAVQVFFKDVFEKYGDEFKRLGVNPNQGLGDLYEKL-QN--SDKKE 300  Nitratifracto...
XP_002178894  305 FYEREMQDAKDSELMLSLHLKATMMKVSDPIMFGHAIRVFFQDAFDKHGEVLASIGANPNGGLGSVYETIkSKLPADQAA 384 
XP_003063226  257 FAEETLRQAAKDDVMVSLHLKATMMKVSDPVLFGTVVRTYFADAFEKHASALESVGANADNGLGAVLDAI-KNLPDADRA 335 
XP_002507787  251 FVEAELQRAAKDGVMVSLHLKATMMKVSDPILFGAVVATYFKKAFEKHADSLASVDANPNNGLKSVLDAV-KSLPNA--A 327 
Q7UX35        237 FYAEQIADAKSTGVLFSLHLKATMMKVSDPILFGHCVAVMYDRLFQEHGDVLTAAGVDPDQGLASVFAKV-QDLPSDQRA 315  Pirellula sp.
6G3U_A        310 EILHDIHEVYSH--RPEMAMVDSVKGITNLHIPSDVIVDASMPAMIRNSGQMWGKDGKQKDTKAVMPESTYARIYQEMIN 387  Pseudomonas a...
WP_012082209  313 DIKDKIQEILKK--NARMYMVDSDAGITNLHAPNDVIIDASIPAVVKNGLQGWGPDGETADTVITVPDRTYARMYKEIVA 390  Nitratiruptor...
WP_013638725  307 EIKKTIEEIYKK--QPRLYMVDSDNGITNLHRPNDVIVDASVPAVIKNGLQGWGPSGETDDCVITIPDRSYATMYSEIVE 384  Desulfurobact...
WP_012676672  313 AIKKTIEEIYKE--RPRMYMVDSDKGITNLHMPNDVIIDASVPAVIKNGLQGWGPDGETDDTVLCIPDRSYATMYKEIIE 390  Persephonella
Q30RQ6        305 EIIAAIEATYDI--QPPMAMVDSDKGITNLHASNDIIIDASMPVVVRDGGKMWNRDGKVQECVSVIPDASYAFFHKAMVD 382  Sulfurimonas ...
WP_013553321  301 EIEAAIKDVILNg-KPDLAMSDSDKLITNLDAPNLVIVDASMPVVVREGGKQWDKNGEARETLAVIPDSSYARFYEAMME 379  Nitratifracto...
XP_002178894  385 TIQADFEACFED--RPWLAMVDSDKGITNLHAPNDIIIDASMPVVVRDSGKMWNKLGELEDVKCLIPDRCYATMYQEVLS 462 
XP_003063226  336 EVEASIAATYASsnRPRVAMVDSDKGITNFHVPSDVIIDASMPAMIRDGGRMWNADGELEDVVCVIPDRSYAAVFAACVD 415 
XP_002507787  328 EIAADFAACYTQpdRPKVAMVDSDKGITNLHVPSDVIIDASMPAMIRDGGKMWNKDGELEDVVCLIPDRSYASVFQTCID 407 
Q7UX35        316 LVEGTLVEIQSN--LPEIAMVDSDKGITNLHVPSDVIIDASMPAAIRAGGKMWGADGKLHDMKAVIPDRCYAGVYQATID 393  Pirellula sp.
6G3U_A        388 FCKTNGAFDPTTMGSVPNVGLMAQKAEEYGSHDKTFEMTADGTMRVVL--ADGSVLMQHKVETGDIWRACQTKDAPIRDW 465  Pseudomonas a...
WP_012082209  391 DIVKNGQFDPAKVGTVQNIGLMAKKAEEYGSHDKTFFPPEDGYIKTID--EDGNTLMCHEVEEGDIWRAYSAKDEAIVDW 468  Nitratiruptor...
WP_013638725  385 DIKVRGQFDPTKVGSVSNVGLMAMKAEEYGSHDKTFFPPADGVIRIVD--EDGNVLMEHEVEEGDIYRSCVTKDIAIRDW 462  Desulfurobact...
WP_012676672  391 DIKARGQFDPTKIGTVQNVGLMAMKAEEYGSHDKTFFPPADGKMKVVD--EDGNVLMEHCVNEGDIYRSCITKDIAIRDW 468  Persephonella
Q30RQ6        383 DCVANGQYDVTTMGNVANVGLMAQKAEEYGSHPTTFEIAENGSVEVK---QNGKVLMSHNVEAGDIWRMSRVKDIPIQDW 459  Sulfurimonas ...
WP_013553321  380 DCKKNGQFDVTTMGRVSNVGLMAKKAEEYGSHPTTFEVAEDGVMEVVS--ETGEVLMKHEVEKGDIWRLVRAKDDAIRDW 457  Nitratifracto...
XP_002178894  463 YVKTKGQFDVATMGSVANVGLMAKKAEEYGSHDKTFEIPSDGRVVVKDn-NTGEVYFEHVVNAGDVWRMCQTKDVAIRDW 541 
XP_003063226  416 DCKKRGKFDVSTMGSVSNVGLMARKAEEYGSHDKTFVIERDGVVKVFNgdDDDDVVFEHAVSEGDLWRMCQTKDEPIRDW 495 
XP_002507787  408 DCKANGKFDVSSMGSVANVGLMAKKAEEYGSHDKTFQISADGVVKVVAd-DSDEVVFEHDVAAGDIWRMCQTKDEAVRDW 486 
Q7UX35        394 DCIANGKFDVTQMGSVANVGLMAKKAEEYGSHDKTFRVPADGKVRVVN--SAGTELMSHDVEKGDIWRACQTKDVAVKDW 471  Pirellula sp.
6G3U_A        466 VKLAVTRARQSDTPAIFWLDPERAHDRELRKKVELYLKDHDLTGLDISIMGYNEAIRVSMERLIRGKDTISVTGNVLRDY 545  Pseudomonas a...
WP_012082209  469 AKLAVRRAKESGYPIVFWLDSNRAHDANLIKKVVSVLKDEDLSGVEFHIMAPEKAMRYTLRRFRAGEGTISVTGNVLRDY 548  Nitratiruptor...
WP_013638725  463 VKLAVNRAKESGEPIVFWLDHMRAHDRQLIEKVKEELQKYDLSDVEWYIKPPREAMKFTLERFRKGLNTISVTGNVLRDY 542  Desulfurobact...
WP_012676672  469 IKLAVNRAKESGYPIVFWLDEYRAHDRNLIEKVKEELPKYDLSDVDWYIKAPADAMKFTLARFRNGENTIAVTGNVLRDY 548  Persephonella
Q30RQ6        460 VRLAVERARLTGSPAVFWLDKNRAHDANMIKKVNEYLKNHDTTGLELPIMDVASAAKYTNARVRKGEDTISVTGNVLRDH 539  Sulfurimonas ...
WP_013553321  458 VRLAVERARIEGVPAVFWLDKNRAHDANMIKQVEKYLKEYDTTGLELPIMDVTEATYYTNERARAGLDTISVTGNALRDY 537  Nitratifracto...
XP_002178894  542 VRLAVERARATGDRTIFWLDKRRAHDASLIKKVNTYLKDHDTDGLDISIMRPVDAVRISMERATDGKNTISVTGNVLRDY 621 
XP_003063226  496 VKLAVNRARATGAPAVFWLDPNRAHDVALTSKVRLYLADHDVADADVSIKSPVDAIDFSMTRARAGQDTISVTGNVLRDY 575 
XP_002507787  487 VKLAVQRARLTNTPAVFWLDSSRSHDSVLIDKVNAYLKDHDTSGLDISIKTPKEAIEFSMARARKGEDTISVTGNVLRDY 566 
Q7UX35        472 VRLAVVRSRATGSPAIFWLDENRAHDQNLIGKVNEYLKDHDAAGLDIQILAPADATRHACGRAREGKDTISVTGNVLRDY 551  Pirellula sp.
6G3U_A        546 LTDLFPIMELGTSAKMLSIVPLMAGGGMYETGAGGSAPKHVQQLVEENYLRWDSLGEFLALAVSLEETGIK------TGN 619  Pseudomonas a...
WP_012082209  549 LTDLFPIIEVGTSARTLSIVPLLAGGGVFETGAGGSAPKHVEQFLKEGHLRWDSLGEFMALVESLKLAVKQ------GAS 622  Nitratiruptor...
WP_013638725  543 LTDLFPIIEVGTSARALSIVPEIAGGGLFETGAGGSAPKHVQQFVKEGHLRWDSLGEFLAFVEALKLAYKQs----gSTN 618  Desulfurobact...
WP_012676672  549 LTDLFPIIEVGTSARSLSIVPLIAGGGVFETGAGGSAPKHVEQFIKEGHLRWDSLGEFLAFDESLRLAYKQlktlheKDN 628  Persephonella
Q30RQ6        540 LTDMYPILELGTSAKMLSIVPLLAGGGVFETGAGGSAPKHVDQFLEEGHLRWDSLGEFLALAESLRFIAQK------NSD 613  Sulfurimonas ...
WP_013553321  538 LTDMYPILELGTSAKMLSIVPLLAGGGLFETGAGGSAPKHVEQFLKEGHLRWDSLGEFLALAESLRMEYMK------SEN 611  Nitratifracto...
XP_002178894  622 LTDLFPILELGTSAKMLSIVPLLAGGGLYETGAGGSAPKHVQQFVKEGHLRWDSLGEYLALAVALEGLADT------AGN 695 
XP_003063226  576 LTDLFPIIELGTSAKMLSIVPLLRGGGLFETGAGGSAPKHVQQFTEENHLRWDSLGEYLALAVSLEDLAHK------TRN 649 
XP_002507787  567 LTDLFPIIELGTSAKMLSIVPLLAGGGLFETGAGGSAPKHVQQFTEENHLRWDSLGEYLALAVSLDDLALK------TRN 640 
Q7UX35        552 LTDLFPILELGTSAKMLSIVPLLEGGGLFETGAGGSAPKHVEQIMSENHLRWDSLGEFLALAVSLEDLAEK------TGN 625  Pirellula sp.
6G3U_A        620 AKAKLLGKALDEATGKLLDNNKSPSRKVGDIDNRGSHFYLAMYWAQALAAQNEDAELKAHFAPLAKALTEQEATIVAELN 699  Pseudomonas a...
WP_012082209  623 EKTTIIAEALDRAVGKYLNNDKTPKRKVGELDNRGSHYYLATYWAEELASCG-ESELEAKFAPVAEKLKANEEQILAEIK 701  Nitratiruptor...
WP_013638725  619 KRILIMADTLSKAVGKYLDNDKTPKRKVGELDTRGSHYWLARYWAEELAAQDTDAELAKIFEPVAAALIENEEKILEEIR 698  Desulfurobact...
WP_012676672  629 PRILVIADALSKAIAKYLDNDKTPKRKVGQLDTRGSHFYLALYWAEALATQNEDKELAEKFSKVYADLKENEEKILSEIA 708  Persephonella
Q30RQ6        614 DKLAAVTTALDIANAAYLDNNKAPSRKAGEPDNKASHFFLAQYWAKALS-EGKNAELAAKFAPIAKALTENEAKIIEELL 692  Sulfurimonas ...
WP_013553321  612 EKIGVMADTLDKANEAYLENDKSPSRKCCEPDNKASHYWLARYWAEALSTQTVDKELSDTFTPVADALAKNEEKILEELL 691  Nitratifracto...
XP_002178894  696 PKAKILGDCLNKAVGRILTNRKSPSRVVNQIDNRATNFYVSLYWADFL--QQEDPSYKAIF----ESLTENRGKIVEEFS 769 
XP_003063226  650 PKIKTLAKGLTTATGKLLDENKSPGRKVGEPDNRAAHFYVAMWWAEAVSRA------LPSFKQLASDLAASEDVIVRELT 723 
XP_002507787  641 PKIKILAKGLTSATGKLLELNKSPGRKCGEPDNRAAHFYIAMWWAEAVARS------FPSFKALASKLKESEDVIVKEMT 714 
Q7UX35        626 EEFAVLAKTLDDATGRFLDNDKSPSRKVGELDNRGSHFYLALYWAEALAGCAHEG-LKARFAPVAKALSENESTIVGELN 704  Pirellula sp.
6G3U_A        700 AVQGKPAEIGGYYRSNPELTSKVMRPSATFNAAID 734  Pseudomonas aeruginosa
WP_012082209  702 AAEGKPVDIGGYYHPDDCKAETAMRPSKIFNEIID 736  Nitratiruptor sp. SB155-2
WP_013638725  699 ATEGSPKDIGGYYHPDDAKAEAAMRPSATLNSIID 733  Desulfurobacterium thermolithotrophum
WP_012676672  709 ASEGKPTDIGGWYHPDDEKAEKAMRPSETFNRIID 743  Persephonella
Q30RQ6        693 SIEGKAQDIGGYYHPDDKKAEAAMRPSATLNKIVD 727  Sulfurimonas denitrificans DSM 1251
WP_013553321  692 SVEGKEQDIGGYYDPDELKAEKAMRPSQTFNEIID 726  Nitratifractor salsuginis
XP_002178894  770 QCQGTAVDLGGYYLFDPAKTKAAMNPSPTLNKILS 804 
XP_003063226  724 ECQGSSVDVGGYWLPDVDEAERAMRPSETFNALVD 758 
XP_002507787  715 DCQGKAVDIGGYWLPDVEKCTLAMQPSATFNALID 749 
Q7UX35        705 DAQGVAVDLGGYYHPDETKANAAMRPSPTLNAIID 739  Pirellula sp.
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