Conserved Protein Domain Family

pfam03966: Trm112p 
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Trm112p-like protein
The function of this family is uncertain. The bacterial members are about 60-70 amino acids in length and the eukaryotic examples are about 120 amino acids in length. The C-terminus contains the strongest conservation. Trm112p is required for tRNA methylation in S. cerevisiae and is found in complexes with 2 tRNA methylases (TRM9 and TRM11) also with putative methyltransferase YDR140W. The zinc-finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast. The crystal structure of Ynr046w has been determined to 1.7 A resolution. It comprises a zinc-binding domain built from both the N- and C-terminal sequences and an inserted domain, absent from bacterial and archaeal orthologs of the protein, composed of three alpha-helices.
PSSM-Id: 397869
Aligned: 69 rows
Threshold Bit Score: 36.3746
Threshold Setting Gi: 490186150
Created: 11-May-2020
Updated: 7-Aug-2020
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
2HF1_B   2 DAKFLEILVCPlCKG---PL---------------------------------------------V----FDKSKDELIC 29  Chromobacterium viola...
Q5V2N0   2 KEDLMEIICCPlDKH---DLdlevt-----------------------------------------erddgEILSGELTC 37  Haloarcula marismortui
Q9HQM5   2 KEDLLDIVCCPlDKH---DLtldad-----------------------------------------atedgEVMAGTLTC 37  Halobacterium salinarum
Q8TKW3   2 KKDLMDILACPvCKG---NLilnvv-----------------------------------------eeneeEVISGTLYC 37  Methanosarcina acetiv...
Q9YES6   3 RYYHIEMLACPeCRN---PRlilyvvrekrgamppqperlk---crrwcylfdrpastvplstcvSscveRDIEEGVLVC 76  Aeropyrum pernix
Q8ZZF9   2 KYRLMDVLACPyDKTf--PLrlvvikrtehperqytwprkpfceeycsyrdlkikehpkpdtlpcEechkWEIETGVIYC 79  Pyrobaculum aerophilum
Q980S2   2 KYRLMDLLACPmCKHf--PLkllvfsereidrklsqedkkpl--celyctyksaftkdldslppcEecirHEIEEGMLYC 77  Saccharolobus solfata...
Q976E5   2 KYRLLDLLACPiCKHf--PLkyyvfstrmvergigdekkpl---celycsyknqfikdmkeptpcEecikYEIVDGLLYC 76  Sulfurisphaera tokodaii
Q7NR33   2 KRELLAILRCPhCRG---ELhv-----------------------------------------agSgeneGEIDDGELHC 37  Chromobacterium viola...
Q74ER0   2 KRILLPLLICPaCLPkehPLdlsga-----------------------------------------geqaeDIVSGTLSC 40  Geobacter sulfurreducens
2HF1_B  30 KGDRLAFPIKDG 41  Chromobacterium violaceum ATCC 12472
Q5V2N0  38 TECSETFPIEDG 49  Haloarcula marismortui
Q9HQM5  38 TDCGETYPIEDG 49  Halobacterium salinarum
Q8TKW3  38 PVCKEHYPIDEG 49  Methanosarcina acetivorans
Q9YES6  77 PACGRWYPIVEG 88  Aeropyrum pernix
Q8ZZF9  80 PNCGRWYPIIEE 91  Pyrobaculum aerophilum
Q980S2  78 ESCNRWYPIIDE 89  Saccharolobus solfataricus
Q976E5  77 PNCKRWYPIIDE 88  Sulfurisphaera tokodaii
Q7NR33  38 AGCRRHYPVVQG 49  Chromobacterium violaceum
Q74ER0  41 RRCRRRYPIREG 52  Geobacter sulfurreducens
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