Conserved Protein Domain Family
Endotoxin_N

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pfam03945: Endotoxin_N 
delta endotoxin, N-terminal domain
This family contains insecticidal toxins produced by Bacillus species of bacteria. During spore formation the bacteria produce crystals of this protein. When an insect ingests these proteins they are activated by proteolytic cleavage. The N-terminus is cleaved in all of the proteins and a C terminal extension is cleaved in some members. Once activated the endotoxin binds to the gut epithelium and causes cell lysis leading to death. This activated region of the delta endotoxin is composed of three structural domains. The N-terminal helical domain is involved in membrane insertion and pore formation. The second and third domains are involved in receptor binding.
Statistics
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PSSM-Id: 397850
Aligned: 5 rows
Threshold Bit Score: 255.532
Threshold Setting Gi: 470241202
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFA76887      78 ETLITnnssNKGGYISG---VTDIFFTYLIEn---DKAINNSVKsyrSMLIAIVDKNITQYDDAALKASIYGCALSLKDF 151  Heterostelium ...
XP_004352176 405 LSLIP----EVGGVLSF---GADLIFSHFSQ----DNSTAELIN---KEVQKAINEKLGNYNYVDLNDQLEVISSSIATF 470  Cavenderia fas...
EFA76885      49 LTMVP-----YGPVVSG---IADVFLTYLIEtfneDKSIIRy----qTLCNDLIQNSLYQYDDNQTKAIFKACSLAFKDY 116  Heterostelium ...
WP_015892933  78 SSFVP----FVGPVIGFfipIIDLIW---------PPSQPDLFDilrQQIQDLINQALTTDTLNKLQALLQGWKNELDVL 144  Brevibacillus ...
Q54BL0        58 LSMIP----TIGNPLSI---LVSAVWAHIISn--tNETTYEVYNsyrEMIKATIDNSIDMYDASTIKAVLTKLNALVIDY 128  Dictyostelium ...
EFA76887     152 QSHVLNLRGHPNNASlKQ----MVRIAFMNLENDIecKYIFDCtkqkYLIEELPMYTYFATAHLSLLREAAIYG-KDWGF 226  Heterostelium ...
XP_004352176 471 RRTVSNFKANPTDDN-KSfmiaQYDSTYNSLKNDI--RFLHDT----YSISEAPLFVLMASTKLMFLADGIVNA-EEYHI 542  Cavenderia fas...
EFA76885     117 RQHWKELQADPKNEAlKE----VMRVSFQNLENEIatKYIYQCrkggFEVNELVLFSMFATDHLIILRDCIYSGnKEWGM 192  Heterostelium ...
WP_015892933 145 ATEVKNL-TDPKTSTiGS----TVNTIHLQFVHDIpqFTLKD-----YAAYALPLYVQAATMHLGLLKEAISKQ-TDWGI 213  Brevibacillus ...
Q54BL0       129 TKAKKNYKLTPNQAPvKKdlvdAHNLLYIELRGSL--LPLSDLrkegYEAQELGAFALMATLHLLLLKEGSTNG-KIWGI 205  Dictyostelium ...
EFA76887     227 DdATIKYYIDKFAARHNDYVDHCQAAYDDGYAKItk-stANNKYTYDQWNALNKYRNFMITTVFDFVNIWWLFD 299  Heterostelium album ...
XP_004352176 543 S-GQVNILIDDFRDSLDKYIRYSLPIYEKGLAKM-----AKTKDPVKDYNDRTEYFNQMLLGLYDTVNIFWAMD 610  Cavenderia fasciculata
EFA76885     193 HpDSVKIYSDKFNKLIVDYAEYCVTTYNQGITTIskrpeANMKM---RWNRLNRWRNYNIICVFDFVNLWFAMD 263  Heterostelium album ...
WP_015892933 214 SdSDKTNFLTYLKQWIVKHSENVYTLFVTGLQNIqddesSQISS--------ADFIYTSTLYGFDIAALWPTFD 279  Brevibacillus brevis
Q54BL0       206 SeSKIETFEQEFNKNMVEYAQHCKLAYYKGVAKIk----ALGIDGVMQFNKLNTFRSFCARYVFDYVNLWSGFN 275  Dictyostelium discoi...
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