6DJ4,4D8M,1W99


Conserved Protein Domain Family
Endotoxin_C
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pfam03944: Endotoxin_C 
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delta endotoxin
This family contains insecticidal toxins produced by Bacillus species of bacteria. During spore formation the bacteria produce crystals of this protein. When an insect ingests these proteins they are activated by proteolytic cleavage. The N-terminus is cleaved in all of the proteins and a C terminal extension is cleaved in some members. Once activated the endotoxin binds to the gut epithelium and causes cell lysis leading to death. This activated region of the delta endotoxin is composed of three structural domains. The N-terminal helical domain is involved in membrane insertion and pore formation. The second and third domains are involved in receptor binding.
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Statistics
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PSSM-Id: 397849
Aligned: 80 rows
Threshold Bit Score: 58.8474
Threshold Setting Gi: 8469156
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6DJ4_A  443 ITQIPLVKAHTLqs-gtTVVRGPG-FTGGDIl-RRTSGGPfAYTIVNingQLPQRYRARIRYASTTNLRIYVTVAGERIF 519  Bacillus thuringiensis
4D8M_A  450 LKGFPFEKYGSEynnrgISLVREW-INGNNAvkLSNSQSV--GIQITn--QTKQKYEIRCRYASKGDNNVYFNV--DLSE 522  Bacillus thuringiensis
Q45760  540 TMGFPFEKASYg-----GTVVKEW-LNGANAmkLSPGQSI--GIPITn--VTSGEYQIRCRYASNDNTNVFFN-VDTGGA 608  Bacillus thuringien...
P56955  540 TMGFPFEKASYg-----GTVVKEW-LNGANAmkLSPGQSI--GIPITn--VTKHNYQVRCRYASNSDNPVFFN-VDTGGA 608  Bacillus thuringiensis
Q8KZM2  545 LKGFPAEKGYGGs----IEYVSEP-LNGANAakLTLNQIL--YMQVTn--LTTQKYQIRLRYATKNDTTASVWFHIIGPN 615  Bacillus thuringien...
P56956  551 LKGFPAEKGYGDs----IAYVSEP-LNGANAvkLTSYQVL--QMEVTn--QTTQKYRIRIRYATGGDTAASIWFHIIGPS 621  Bacillus thuringiensis
Q45754  485 IKGFPAEKGYIKnqgimKYYGKPEyINGAQPvnLENQQTL--IFEFHa--SKTAQYTIRIRYASTQGTKGYFRLDNQELQ 560  Bacillus thuringiensis
Q45743  484 FTVSPIHATQVNnqirtFISEKYG--NQGDSlrFELSNPT-ARYTLRg--NGNS-YNLYLRVSSIGSSTIRVTINGRVYT 557  Bacillus thuringiensis
P57092  555 FTISPLHLDTVNinsylYIQENYG--NNGDSlrVIN-RAI-IKYRLSa--ARSVIYRLVLRVSGTASSIVAIYENYPVGS 628  Paenibacillus popil...
Q45358  575 FTVSPLHPSANTit--sYIKENYG--NSGDSlhLKGQGYL--HYMLSg--NGQDRYRLVLRLSG-AANQIKLQSPTTSIY 645  Paenibacillus popil...

6DJ4_A  520 -------AGQFNKTMDTgdP---LT--FQ-SFSYATINTAFTF-PMSQ-SSFTVGADTFSSgnEVYIDRFELI--PVT 580  Bacillus thuringiensis
4D8M_A  523 npf--rnSISFGSTESSvv---gVQgeNG-KYILKSITT-----VEIPaGSFYVHITNQGSs-DLFLDRIEFV--PKI 586  Bacillus thuringiensis
Q45760  609 npi--fqQINFASTVDNnt---gVQgaNG-VYVVKSIATTDNSfTEIPaKTINVHLTNQGSs-DVFLDRIEFI--PFS 677  Bacillus thuringiensi...
P56955  609 npi--fqQINFASTVDSnm---gVKeeNG-VYVVKSIKT-----VEIPaGSFYVHVTNQGSs-DLFLDRIEFV--PKI 672  Bacillus thuringiensis
Q8KZM2  616 nqdiinhSPDIPPRSNNkm---fVQgeNG-KYVLDTLVDS----IELPsGQLTILIQNINPdqDLFLDRIEFV--PIP 683  Bacillus thuringiensi...
P56956  622 gndltneGHNFSSVSSR--NkmfVQgnNG-KYVLNILTDS----IELPsGQQTILIQNTNSq-DLFLDRIEFIslPST 691  Bacillus thuringiensis
Q45754  561 -------TLNIPTSHNGy-----VTgnIGeNYDLYTIGS-----YTITeGNHTLQIQHNDKn-GMVLDRIEFV--PKD 618  Bacillus thuringiensis
Q45743  558 a------NVNTTTNNDG------VLdnGA-RFSDINIGNVVAS-ANTN-VPLDIQVTF-NGnpQFELMNIMFV--PTN 617  Bacillus thuringiensis
P57092  629 a-----nQINTGTDNEG------VIdnDS-KFIDLIFNTPFSV-SGTA-RELQLQVSGATTssPLDIMNIILI--PIN 690  Paenibacillus popilliae
Q45358  646 -------AFDTSTNNEG------ITdnGS-KFKDFAFSTPFVI-PEQKeIVLYFeg-----vgSLDLMNLIFL--PAD 701  Paenibacillus popilliae
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