Conserved Protein Domain Family
INCENP_ARK-bind
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pfam03941: INCENP_ARK-bind (This model is not part of the current CDD release)
Inner centromere protein, ARK binding region
This region of the inner centromere protein has been found to be necessary and sufficient for binding to aurora-related kinase. This interaction has been implicated in the coordination of chromosome segregation with cell division in yeast.
Links
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Statistics
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PSSM-Id: 515912
Aligned: 104 rows
Threshold Bit Score: 41.7837
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_009023488 1586 DdYDEDDGGDDDDEyesrarsrrrkmkknKKIPSWAQGSELVASLIRFfiYPIDVDELFGTVFAPDLNEMF 1656
EMG46736      579 Q-ILSDDEFGSTNN---------------RVLKSWANSPNLRREISSR--RTTNPANVLTYNPKIDMMQTF 631 
XP_002550074  707 T-ILSDDDLAVSNK---------------NVLQSWAQTPVLRRTIMNS--RSVDPTTVFRSHPKIDLKETF 759 
CCE84390      921 D-IPTDEEDLKSQK----------------ALQSWAESPQLRKILSQN--RNIDPVSIFGEVPRLDIDEIF 972 
XP_001482771  835 A-INTDDEDNGKHP----------------VLSPWAESPQLLKLVQQS--VDIDPVTIFGEIPKLRIEEVF 886 
Q6BSG3        935 D-IPTDDEDNQSHK----------------VLQSWAETPQLHKIVMQN--RTIDPVTIFGEVPRLNIEEIF 986  Debaryomyces hansenii
P38283        630 E-INTDSEDEASV-----------------TLAAWAKSPYLQEQLIRQ--QDINPQTIFGPIPPLHTDEIF 680  Saccharomyces cerevisi...
Q6CVR8        609 E-IISDDEGNNQVE---------------RTLTSWAEPEKLKQQLLLQ--QNWDIEQILGPIPPLHIDEIF 661  Kluyveromyces lactis
XP_004182139  584 E-IYSDSDDEDKNI-----------------YKSWGEKSILESQLINQ--QHLNPREIFGNIPIIDLDVIF 634 
XP_002493285  554 E-IFSESEDDAEGS----------------VLQPWAEFGQLKIALIKQ--QSLNPVSVFGSVLPLDMDAIF 605
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