2JR5


Conserved Protein Domain Family
Sdh5

?
pfam03937: Sdh5 
Click on image for an interactive view with Cn3D
Flavinator of succinate dehydrogenase
This family includes the highly conserved mitochondrial and bacterial proteins Sdh5/SDHAF2/SdhE. Both yeast and human Sdh5/SDHAF2 interact with the catalytic subunit of the succinate dehydrogenase (SDH) complex, a component of both the electron transport chain and the tricarboxylic acid cycle. Sdh5 is required for SDH-dependent respiration and for Sdh1 flavination (incorporation of the flavin adenine dinucleotide cofactor). Mutational inactivation of Sdh5 confers tumor susceptibility in humans. Bacterial homologs of Sdh5, termed SdhE, are functionally conserved being required for the flavinylation of SdhA and succinate dehydrogenase activity. Like Sdh5, SdhE interacts with SdhA. Furthermore, SdhE was characterized as a FAD co-factor chaperone that directly binds FAD to facilitate the flavinylation of SdhA. Phylogenetic analysis demonstrates that SdhE/Sdh5 proteins evolved only once in an ancestral alpha-proteobacteria prior to the evolution of the mitochondria and now remain in subsequent descendants including eukaryotic mitochondria and the alpha, beta and gamma proteobacteria. This family was previously annotated in Pfam as being a divergent TPR repeat but structural evidence has indicated this is not true. The E. coli protein, YgfY also acts as the antitoxin to the membrane-bound toxin family Cpta, pfam13166, whose E. coli member YgfX, expressed from the same operon as YgfY.
Statistics
?
PSSM-Id: 397843
Aligned: 265 rows
Threshold Bit Score: 42.3919
Threshold Setting Gi: 221052453
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2JR5_A         7 KARIKWAC-RRGMLELDVVIMPFFEECFD--SLTESEQDDFVALLESDDPDLFAWVMGH-GRCENLGL---AAMVDKI 77  Vibrio cholerae
XP_002956425   2 vNKLLYRSkQRGFLELDLLIGLWAEVNIP--KMDFAELKQMALVLEEENPDLFKWLTGQlQPPDRMSG---NAVFEAL 74  Volvox carteri f....
EFN53019      12 vNRLLYRSrQRGFLELDLLVGMWAEKELP--QMSVEQMREFEVVLGQENPDMFKWLTAQaEAPEELRH---NRTFAAl 84  Chlorella variabilis
Q01G94        38 INRALYRArQRGFLELDIVVGAWATRTLDpeTASMEFLDAFDEVLRAENPELFKWLTGQeRAPRAMAEnaayaslaeh 115 Ostreococcus tauri
XP_002257802  29 klRCKFKS--VGMLELDTLINNYLNTNIN--SMNKEKAKLLYNLMDIDTTNLLKLFYFY----SNKENqkvEKLAQYL 98  Plasmodium knowle...
Q4FLY7         9 KNKITYRAnYRGTKEMDKLLGSFTKKYID--QFNEQELTLLCDLLDLDDDNLYKFNQGQ-NPTIQIEL---NKVTEMF 80  Candidatus Pelagi...
CAQ41870     122 fEKVLYKCtTLGYIELQNIISTFVSHEKN--TFTGEDICALDNFLNLPEKEILDYLNGDeLIPQDHLD---ASVIKRL 194 Plasmodium knowle...
XP_001617028 114 lEKVLFKCtTLGYIELQHIISTFVSHEKG--TFTGEDICALDNFLNLPEKEIFNYLSGDeLMPQHHLD---ASVIKRl 186 malaria parasite ...
WP_006459049  14 wrQLAIAA-RRGNAESEQLLAPFIARLAQddRLLSQYGQALAGLLNNEEQDLLIWLLDPaLAPSKWQ-----ALLKQI 85  Thiomicrospira ae...
Q31E06        10 IKAIRLNC-RRGNSETELLLQAYIDHLAE--KSDPEALHELSTLVAENDQDLFHWLMTPtDAPQYYQ-----TLIERI 79  Hydrogenovibrio c...
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap