1M0W


Conserved Protein Domain Family
GSH_synth_ATP

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pfam03917: GSH_synth_ATP 
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Eukaryotic glutathione synthase, ATP binding domain
Statistics
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PSSM-Id: 397825
Aligned: 96 rows
Threshold Bit Score: 506.328
Threshold Setting Gi: 212529138
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1M0W_B                8 KDQLNELIQEVNQWAITNGLSMyp--pkFEEN---PSNASVSPV--TIYPTPIPRKCFDEAV-QIQPVFNELYARITQDm 79  baker's ...
XP_002144726         12 PDHLNSILTQIKDYQTTHGSLL------KVIGsetPHSVHLQPIsaSVFPTLFPLRLFNEAAgELQLVYNQLYCKLAED- 84  Talaromy...
XP_007798163          8 DDEINAILSELEDYQLTHGSLLki--prGFAKdidSPIAIARPIgiSVIPTAFPRAQFQHAV-RIQGAFNELYAKVAED- 83  Eutypa l...
EME43161             18 DDNLERLTSEVKDYQITHGSLL------KLVGyeaESTVPARPVnvSLAPTAFPATALRNAL-DLQPLYNELYMKAASD- 89  Dothistr...
XP_002340757         23 PDQIHSLLTQIKDYQSTHGSLL------KVIDseiPHSVHLQPVsvSVFPTVFPRRVFHEAIdELQLAYNELYGKIAED- 95  Talaromy...
P35669                8 PEQIEELGKGARDFAFAHGVVFt----eLSVSkegRNIATQIPI--TLFPSVIPHGAFVEAV-SVQKAYNKLYAKIAND- 79  Schizosa...
XP_002172601         11 SSEIDDLSYTARNYAVSNGLVFl----nNDEKsseATTLTQIPV--TLFPTVIPREAFVEAL-SVQQAYNKLYAKVSND- 82  Schizosa...
CCA76407             12 QAQLDELLLQATTYALAHGLLYlppnssNLPPpaiPASAIHAPF--ALFPTPFPRHLFEHAM-KLQRIYNVLYTRVASD- 87  Serendip...
XP_007329727         15 EAQLEELSVYATTYALSHGLLYlp---pAPSLpkvPTAAIHAPL--ALFPSPLPRKLFEQAT-RLQRIYNVLYSRVALD- 87  Agaricus...
WGS:AACS:CC1G_04993  24 PEQLNELVSTASAYSLAHGLLYlp--pgYPLDsppPQAAIHAPL--SLVPSPFPRDLFESAK-RLQTIYNVLYSRIAMN- 97  Coprinop...
1M0W_B               80 aqpDSYLHKTTEA---LAL--SDsEFTGKLWSLYlatLKS---AQY-K-----K-QNFRLGIFRSDYLIDKKKG------ 138 baker's ...
XP_002144726         85 ---VEWLYAVTGP---LRK--TE-PLVDALWSVY---EEVqmrRQDeGmq--yIrQRVHAGVFRSDYMLHVQSEsaaesd 150 Talaromy...
XP_007798163         84 ---HAWLEGILEE---LRRktTAdGFVAKLWGIW---ERVv--REDgGe----EvQPWRCAVWRSDYMLQASREildfqn 148 Eutypa l...
EME43161             90 ---ERWLAEILGP---LIQ--HD-EFIAALWGIW---LKV---KEVgA-----V-QPIVCGIFRSDYMLHSELGy----- 143 Dothistr...
XP_002340757         96 ---KEWLYAVTGP---LRK--TE-PLVDALWCVY---EEVq--RQRrKvq--yIeQNVHAGLFRSDYMLHVLSDsdndd- 158 Talaromy...
P35669               80 ---YEFLRLHLQS---ITK--YD-EFMNKLWNLY---QKH---REAvAhlkenQfQPLSLGVFRSDYMVHQDDS------ 138 Schizosa...
XP_002172601         83 ---HRFLERCLKD---MCG--QD-EFISKLWKVY---EES---RAHfAtlkkpCqQPVSLGIFRSDYLVTDSKE------ 141 Schizosa...
CCA76407             88 ---EAFLDQILSAetgVGK--VD-EFVGNLWRIW---KDV---RTE-Gl----V-QPLQLGIFRSDYLLHGEEG------ 143 Serendip...
XP_007329727         88 ---DEFLDQVMGVetgVGK--VD-DFIGQLWRGW---KAL---RDE-Gi----D-QSLHLGIFRSDYLLHSPNG------ 143 Agaricus...
WGS:AACS:CC1G_04993  98 ---IPFLDEVMGAeqgVGR--VD-DFIGELWRGW---KRL---RDEgKl----P-QPLHLGLFRSDYLLHIPGD------ 154 Coprinop...
1M0W_B              139 -----------------T-EQIKQVEFNTVSVSFAGLSEKVDRLHSYLNRANK------YDPKgpi--------yndQN- 185 baker's ...
XP_002144726        151 d----------dgenwgQnLCLKQVEFNSFSCAGGCHADKVAHMHRFLARRGVy----dFVYTssesqdellintkmLPs 216 Talaromy...
XP_007798163        149 radggnkggegdvrnvfRdAQLKQVEFNTFSCAGGSHATIVANAHRYLASRG--------AHGag----------riTRe 210 Eutypa l...
EME43161            144 -------------------TGLKQVEMNTFSVAGACHGERVAGMHRHLRRVRTveetftPGGE----------------- 187 Dothistr...
XP_002340757        159 ------------dedwiQsLCLKQVEFNSYSCAGGCHADKVADMHRFLALRGVy-----NCPSidekq-----dmriLPs 216 Talaromy...
P35669              139 -----------------F-IGCKQVEFNTISVSFGGVSKAVSNLHAYCSQSGLy-----RKPL--------------TTn 181 Schizosa...
XP_002172601        142 -----------------G-PSCKQVEFNTISVSFGAASKVVKNMHNYLSDYGLy-----HDRL--------------TPn 184 Schizosa...
CCA76407            144 -----------------QdMTIKQVEFNTISASFGALSQAVDGLHRYLLASTG------YFSCshil-------kasN-- 191 Serendip...
XP_007329727        144 -----------------EtPELKQVEFNTISSSFGPLSQRVSELHRYLLSTTG------YFNTspyl-------sleN-- 191 Agaricus...
WGS:AACS:CC1G_04993 155 -----------------QkPSLKQVEFNTISISFGCLAQRVAELHRYQLAATS------YFDSspyl-------qrdN-- 202 Coprinop...
1M0W_B              186 -MVISDSGYLLSKALAKAVESYksQQSSSTTSDPIVAFIVQRNERNVFDQKVLELNLLEKFGTKSVRLTFDDVNdklf-- 262 baker's ...
XP_002144726        217 sLPRNNTINGIASLLVSAHKMYgsKPYSPTASHTAVLMVVQPNNFNIADERPIEYALWNWTDNNGDDNPIPIYRiewqlv 296 Talaromy...
XP_007798163        211 kLRSNDSLDSIVRLLEAAHRAYgsPVSHDAKQTAIMMTVQGRNINICDERPVEYALSECDPPILLYRVEFGEKTmqsck- 289 Eutypa l...
EME43161            188 -LSGNDNTQFLVRVLQKAHQVYndLRITTSRLCILMIVQPSNFNVADERPLEYSLWDNHVPCYRCEWQEILTRTtis--- 263 Dothistr...
XP_002340757        217 sLPLNNTIHGIASLLVLAHKRYgsTPYNSAASHTAVLMVVQPNNFNIADERPIEYALWNWADDNPIPTYRIEWQdvlhrt 296 Talaromy...
P35669              182 yLTVNTSVSGICTGISNAVDAYrdYVKNITSKMNIASDNTKPIVLFVVKGGERNITDQRTLEYELLNRFHVISKridiae 261 Schizosa...
XP_002172601        185 hLTINTSTTGIVMGLNKAYCVYkqQAEQLLKEQNNELPDKTAAQVIVLFIVDRNERNIMDQCALEIELNNRFKVpsariy 264 Schizosa...
CCA76407            192 -LPVNDTLTQLVKGLVMAHEAY--LQSTASSSAPTPPPNVRAPRILFVVQPNERNVFDQRPLEYALLHQHGIHVlrrtfd 268 Serendip...
XP_007329727        192 -LPPNQTISGVAAGLAAAHSAY--SASTSNARILVVAQDNERNVFDQRWLEYELLNKHSIRMIRRTLTQLQKVAkvdstt 268 Agaricus...
WGS:AACS:CC1G_04993 203 -FPPNESISGLAEGLATAHKAYvsQGGNPRSKILFVIQPGERNVFDQKWLEFELLEKHSIHVLRQTFDDLITSAk----- 276 Coprinop...
1M0W_B              263 --------------------iddKTGKLFIRDTEQEIAVVYYRTGYTTTDYTSEKDWEARLFLEKSFAIKAPDLLTQLSG 322 baker's ...
XP_002144726        297 iqytkl------tqtgellffppENGGSREVQPVEISVIYHRAGYEPHEYSEDIDGKEIRIRLELSRAIKCPSILGHITT 370 Talaromy...
XP_007798163        290 ------------------fganrELLFLPPSGGPPLEISVVYHRAGYSEGEYDDKGIEARYMLECSRAIKCPTILSQISG 351 Eutypa l...
EME43161            264 --------------------pdrTLHFTPRPNGPCLEVSVVYYRAGYQAIEYDEPGTEGRLRLELSRAIQCPDVLTHLTT 323 Dothistr...
XP_002340757        297 ql-------------tetgellfFPPESGGRTPVEISVIYHRAGYEPQEYSDEIKGKDIRIRLELSRAIKCPSILGHITT 363 Talaromy...
P35669              262 ln-------------slihdkssNKLYMKTSFTTYEVAVVYYRVGYALDDYPSQEAWDMRLTIENTLAIKCPSISTHLAG 328 Schizosa...
XP_002172601        265 fdel---------dksatldnktNKLFVKVKGKVYEVAVAYYRTAYALSEYTSEADWNARLTVEKSLAIKCPSIAFHLAG 335 Schizosa...
CCA76407            269 elalatvseddgrrlyvrdsalcSADEGEKAKEAIEISVIYFRAGYTPTDFPTHAQFETRKMLERSRAIKCPSIAIQLAG 348 Serendip...
XP_007329727        269 ------------------rklfiDVPKDLEASGSIEISVIYFRAAYTPHDFPTPAYYATRFLLERSTAIKCPSLALQLAG 330 Agaricus...
WGS:AACS:CC1G_04993 277 -----------------------VENETLTVSSTTEISVVYYRSGYMPHEYPTPAHYTVRLILESSKAINCPTIALQLAG 333 Coprinop...
1M0W_B              323 SKKIQQLLTDEGVLGKYisd-----------aeK----KSSLLKTFVKIYPL--D-Dtkl-----------greGKRLAL 373 baker's ...
XP_002144726        371 IKKVQEALTVPGTLERW----------------LtterADSIRRTFVEIRSLehFiS-----------------SKNPVR 417 Talaromy...
XP_007798163        352 FKKVQQELARPGVLERF----------------LtpdkSALLRQVFMPMYPLddSpEgq--------------hAREIAL 401 Eutypa l...
EME43161            324 FKAVQEALTTPGALERF----------------LspgtAQRVRETFMPMQVLnaStAgl--------------kARARAI 373 Dothistr...
XP_002340757        364 IKKVQQALTVPGTLGRW----------------LtsdkADRIRGTFVEIYSLneFdF-----------------SEK-IH 409 Talaromy...
P35669              329 SKKIQQVLAESNALERF----------------LegdeLQAVRSTFADMYPLd---Dtpr-----------gkeGIKLAF 378 Schizosa...
XP_002172601        336 SKKIQQELAVEGVLENY----------------LsgneLKAIRYTFADMYPLd---Esea-----------glkGRKLAL 385 Schizosa...
CCA76407            349 SKKVQAVLSDPGVVEKFllptssagnqvlddnvFspkeVEELRASWMEMYSLdaP-N-----------------AIERTL 410 Serendip...
XP_007329727        331 GKKVQEVLTQAGVLERFladgk------kyhevFskeeIQELRDSFMAMWGLdvGdDlltpdgqa-iqagkenfGVRKAR 403 Agaricus...
WGS:AACS:CC1G_04993 334 GKKVQEVLTRPGVVEKFlp-------------eFsaeqIAELRGSFMDMWGLdeDsQdavgstetggqgkseplGTTKAR 400 Coprinop...
1M0W_B              374 sEPS---KYVLKP-QREGGGNNVYKENIPNFLKGIE--ERHWDAYILMELIEPElNENNIILR-DNK-----------SY 435 baker's ...
XP_002144726        418 -NAElaeNYILKPaSLEGGGNNIYGADIYAFLKTLSaeATEKSAYILMQRIRSPmDVYGMLMSsSRG-----------VV 485 Talaromy...
XP_007798163        402 -SEDmaaDYILKP-NMEGGGNNIHGCNIPDFLLALP--PERWSDYILMRRIEPP-LVHGVLVSpKF------------GY 464 Eutypa l...
EME43161            374 -RREtarNCVLKP-NLEGGGNNVHGEAIVDFLKTVP--EEGWGKYVLMKQIETP-GEEGCLMMlDG------------IY 436 Dothistr...
XP_002340757        410 -DEKlteNYILKPaSLEGGGHNIYGSDIPSILQTLLe-NEKSRAYILMQKIRSPqNIYGMLMSsSRG-----------VV 476 Talaromy...
P35669              379 eKPE---DFVLKP-QREGGGNNTYGKDIPGLLSKMP--QEEWDSYILMRYINAV-PSQNYILK-GER-----------PE 439 Schizosa...
XP_002172601        386 eSPE---HYVLKP-QREGGGNNVYGADIPKFLEKTE--KKNWSSYILMRHIDAI-PSTNYILK-GKK-----------AV 446 Schizosa...
CCA76407            411 tQHA---DMVLKP-QREGGGNNVYKAHIPPFLEKLE--EKEREAWIAMKLIRVPkGARNWLARsGTG-----------GV 473 Serendip...
XP_007329727        404 eEAQ---VLVLKP-QREGGGNNVYKQDIPAFLDTLP--PQERQAWIAMQLIVTPaDVGNYLIRaGSTtgss---diqaPV 474 Agaricus...
WGS:AACS:CC1G_04993 401 kEFA---SLVLKP-QREGGGNNVYKDDIPAFLDKLP--PEEREAWIAMRLIEVPqGVRGWLLRaGSVgyssdtlsahnAV 474 Coprinop...
1M0W_B              436 NEPIISELGIYGCVL---------FNDE-------------QVLSNEFSGSLLRSKFNTSNEGGVAAGFGCLDSIIL 490 baker's yeast
XP_002144726        486 VDEVVSELGIFGGCLwerkessseGERC-------------QVIENRVVGWSFKTKEVSVDEMSVVKGYGCFDAPFL 549 Talaromyces...
XP_007798163        465 QGPTISELGILGTCMwarn--dlgGGSL-------------DIGIDSHGGWTFKTKPSHVEEMSVVMGYGCFDSPCL 526 Eutypa lata...
EME43161            437 QGGVVSELGVLGTCLwe-----reRGSV-------------QVLSSETAGWTFKTKPEDVKEMSVVKGYGCFDSPNL 495 Dothistroma...
XP_002340757        477 VDEVVSELGVFGGCIwek---nesSSGL-------------DMIENRVVGWSFKSKERSLDEMSVVKGFGCFDTPLL 537 Talaromyces...
P35669              440 KFDVVDEIGILGTIVw-------nIKTD-------------EVVQNGQSGFICRTKPKKTNEGGVATGYASLSSIEL 496 Schizosacch...
XP_002172601        447 KFETVDELGILGTLVy-------nSKTG-------------EELQNTQVGYICRTKPINVSEGGVATGYASLSSVHL 503 Schizosacch...
CCA76407            474 LANVVSELGTFGWAL---------FGRSspsstsqpeaksmMELREGGGGYLLRTKGEDSDEGGVATGFSVLDSVVL 541 Serendipita...
XP_007329727        475 RTNVISELGIFGWSI---------FGKEgg----------hSHVKEDTMGWLVRTKGTDSNEGGVATGFSVLDSLLL 532 Agaricus bi...
WGS:AACS:CC1G_04993 475 EAEVVSELGIFGWAL---------FGKDge----------kEKIEEKEVGWLVRTKGKDSNEGGVATGFSVLDSLVL 532 Coprinopsis...
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