Conserved Protein Domain Family
YadA_anchor

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pfam03895: YadA_anchor 
YadA-like membrane anchor domain
This region represents the C-terminal 120 amino acids of a family of surface-exposed bacterial proteins. YadA, an adhesin from Yersinia, was the first member of this family to be characterized. UspA2 from Moraxella was second. The Eib immunoglobulin-binding proteins from E. coli were third, followed by the DsrA proteins of Haemophilus ducreyi and others. These proteins are homologous at their C-terminal and have predicted signal sequences, but they diverge elsewhere. The C-terminal 9 amino acids, consisting of alternating hydrophobic amino acids ending in F or W, comprise a targeting motif for the outer membrane of the Gram negative cell envelope. This region is important for oligomerization.
Statistics
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PSSM-Id: 397812
Aligned: 52 rows
Threshold Bit Score: 35.987
Threshold Setting Gi: 122545416
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CAK27532        817 PEVslaqDEPVRCGFGAGGWGSQYSVAGGCAARVADRLHVNGAIAYtpsvdyefGSTPSVGGRVG--FSF 884  Synechococcus sp. RCC307
Q5F6U9           40 AQLg--kNDKFAFSLGFGSYKNAQAVAMGAVFKPAENVLLNVAGS---------FAGPDRAFGAGvfWKF 98   Neisseria gonorrhoeae...
Q2NDN8         1053 PALp--aGANFGLSGGIGYFEDRAAGTIAMSARVSENATVSAGVGVg-------FDSGEVGARGGfqIAW 1113 Erythrobacter litoral...
Q0C0A4          540 QVLq--pDQTFAVSANLGHFDNSSAAGFGAIGKVHENVFVNVGVGTg-------FRSGTVGARAGvsWGW 600  Hyphomonas neptunium ...
WP_010944725    197 VQPn--gVGKTSVSAAVGGYRDKTALAIGVGSRITDRFTAKAGVAFn-------TYNGGMSYGASvgYEF 257  [Haemophilus] ducreyi
Q9JXK7          303 FQPy--nVGRFNVTAAVGGYKSESAVAIGTGFRFTENFAAKAGVAVg------tSSGSSAAYHVGvnYEW 364  Neisseria meningitidi...
WP_012132307    282 FQPy--sVGKFNATAALGGYSDKQAVAVGIGYRFTDNVAGKMAVA---------AGGDSVSWNTGisLEF 340  Citrobacter koseri
RUNMC:MCR_0329  755 FQPy--sVGKFNATAALGGYGSKSAVAIGAGYRVNPNLAFKAGAAIn------tSGNKKGSYNIGvnYEF 816  Moraxella catarrhalis...
Q8RFK4          115 LSKt--pADKFRVGAGVGHSAKNQAVAVGIGYAPTERLRLNTKISTttn---stKSSRSNGISIGasYDl 179  Fusobacterium nucleat...
Q28QS1          288 PNPr--aQAPLSLSLGLGTYEGETAAAMGLLWRMSDTSHMQFSVAG--------SDQTTPQTAISfrIVW 347  Jannaschia sp. CCS1
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