Conserved Protein Domain Family
YjeF_N

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pfam03853: YjeF_N 
YjeF-related protein N-terminus
YjeF-N domain is a novel version of the Rossmann fold with a set of catalytic residues and structural features that are different from the conventional dehydrogenases. YjeF-N domain is fused to Ribokinases in bacteria (YjeF), where they may be phosphatases, and to divergent Sm and the FDF domain in eukaryotes (Dcp3p and FLJ21128), where they may be involved in decapping and catalyze hydrolytic RNA-processing reactions.
Statistics
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PSSM-Id: 397779
Aligned: 52 rows
Threshold Bit Score: 87.6744
Threshold Setting Gi: 118765373
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q2H9J8          375 EEMMTENAGRGLAEvTLTALSdpaikvrhagsvdpatgAPPPQTVVVLAGNN------KSGSRAIAAARHL--RNKGIN- 445 Chaetomium g...
A0EFJ7           49 KAQLAEIGGQSVAE-YILYLSr---------------iDVPLKRVIFIIGQDfsgssfQNGYFGLAAARYL--AQRKVE- 109 Paramecium t...
Q0UCS2          536 EDMIAENSGRGIAE-VALTAInpggrr------larenPNARPVIVVLAGNH------LGGARAVAAARHL--QARGPK- 599 Parastagonos...
Q502M5          300 LERRLEMTGVCASQmALTLLGgpnrl--------tpknVHQRPTVALLCGPH------VQGAQGISCGRHL--ANHEVE- 362 zebrafish
O94752          235 TDIVVENAAQLLSQfVFSVLGghkrl--------ssrnHNSQPLVCILVGSH------DHASAAVAAGRRL--CAIGIK- 297 Schizosaccha...
XP_001387318    269 SAVMAEVCATNLSS-LIAKSIlggstr-----lsnrknHNLPPLVLLLIGSA------RCGSRAFATGRHL--TNHGVR- 333 Scheffersomy...
EDO16830        323 SQIVLENYALSASF-FIRQKLggrvr-------lhsqnSNAEPLVVIMTSDTs-----RTGPRAIALGRHL--CQTNAIr 387 Vanderwaltoz...
P39998          305 SAGLLENFAVNASF-FLKQKLggrar-------lrlqnSNPEPLVVILASDSn-----RSGAKALALGRHL--CQTGHIr 369 Saccharomyce...
jgi:OSTLU_86160  45 LEALMRAAGRAAAT-ATLDAF-------------------GGTDFVVLCGPG------NNGGDGLALAREVatRRRDAR- 97  Ostreococcus...
A8BQZ5           33 IEQLMEIAGTAVAQ-ATTHYIes-------------tsSVSKAGVLVVCGPG------NNGGDGLVAARHL--SSGSMSs 90  Giardia lamb...
Q2H9J8          446 VLVcvVGLERGErDLLEDVQQQVRLYRNLGGRVFAKSDFFEHIRKisipmltidtpraslsslanpapVMLIIDALLGL- 524 Chaetomium g...
A0EFJ7          110 VDVv-LLYPNDP-LRSRLAMQCKSHSATLHFDILQ-NLQEQLNVQmtknil-----------anwlndYDLVVDAISLSs 175 Paramecium t...
Q0UCS2          600 VMValLGFERAA-DWDKDVRRQVDLFRKFGGSVRAWKETEEALKRlq-------------------apPELIIDALLGRh 659 Parastagonos...
Q502M5          363 VVL----FLPNFvKMLEAITSELALFGKTGGRLVSNVKDLPETP------------------------VDLVINCLDSHe 414 zebrafish
O94752          298 VVL--RLLTPFN-----VDNRQLLMFQAAGGYIPTENFDQFLNKLts--------------------pIELVVDVLTGFh 350 Schizosaccha...
XP_001387318    334 VLA--FLINS-D-DQDKDLLQQWKLFENCGGKIITSNVHELLDIVnhql----------------etpVELIIDALQGYd 393 Scheffersomy...
EDO16830        388 VITv-FTGLQEE-ILDKQVAEQLDIYKKCGGKLV--TSVAALENAiskl----------------nspVEIIIDGIQGFd 447 Vanderwaltoz...
P39998          370 VITl-FTCSQNE-LQDSMVKKQTDIYKKCGGKIV--NSVSSLESAmetl----------------nspVEIVIDAMQGYd 429 Saccharomyce...
jgi:OSTLU_86160  98 VSV------WYP-KGAGTNELYGELVRECRETANVEFVDEDAVLGmmrera-----------tsaaatPRCFVDALFGF- 158 Ostreococcus...
A8BQZ5           91 ATV--RVWLPKE-PSSSVNKRMLSIAKHAGVVFIKDTNEEALHAIlefi---------------nsceSFYLVDAIFGF- 151 Giardia lamb...
Q2H9J8          525 ----------------AISfGELRNgdqAtVYELIEWANRN-------EAF-VLAVDVPSGV--DPS-SGKVS------- 570 Chaetomium g...
A0EFJ7          176 i--------------eQPK-TPVRE-----FMHAFSEVNKK-----------VLAINLPVGW--HTD-NGNLYn-----v 216 Paramecium t...
Q0UCS2          660 ke------------feALG-DQDRR---T-VLSIVGWANKS-------RAA-CLAVETPSGV--GGS-TGEVAilegepl 711 Parastagonos...
Q502M5          415 ---------------nGFL-RDQPW-----YKAAADWANQN-------RAP-VLSIDPPV--------SGQAHa------ 451 zebrafish
O94752          351 --------------------PSIDK---N-SHALIQWANDL-------NVL-ILSVDIPSGYtvQKK-NTAIL------- 390 Schizosaccha...
XP_001387318    394 dhl----------edvFFQ-DEDQQ---E-LRSLMKWCNEPh-----qQNK-IMSFDVPSGI--DGG-SGTLSdd---sl 446 Scheffersomy...
EDO16830        448 ctlreifdsesyynikNEG-ESIKK---R-TIDLITWANSNq-----nSRKqIWSLDLPSGY--DSG-SGLSSei----- 509 Vanderwaltoz...
P39998          430 ctl---------sdlaGTS-EVIES---R-IKSMISWCNKQr-----gSTK-VWSLDIPNGF--DAG-SGMPD------- 479 Saccharomyce...
jgi:OSTLU_86160 159 ----------------SFK-GAVRA---P-FVNVL-NALVAltngdarETF-TVSLDIPSGW--DVD-AGAPDdg----- 207 Ostreococcus...
A8BQZ5          152 ----------------SFHgGPIKP---P-YDTVINTLLQMqtsmaigPKTrIVSVDVPSGWsvDAQeWGLNTd------ 205 Giardia lamb...
Q2H9J8          571 VvdgnrlyVKPRYVVAVGAPKRG 593 Chaetomium globosum CBS 148.51
A0EFJ7          217 Y-------V-PQFVISLGLPLKG 231 Paramecium tetraurelia
Q0UCS2          712 E-------VRAKYIVCLGAPRTG 727 Parastagonospora nodorum SN15
Q502M5          452 --------VEAKWSLSLGLPLPL 466 zebrafish
O94752          391 ----------PKWTLALGAVTTT 403 Schizosaccharomyces pombe 972h-
XP_001387318    447 K-------LNSRWCVSMGLPITG 462 Scheffersomyces stipitis CBS 6054
EDO16830        510 -------sINSTGILSTGWPLQC 525 Vanderwaltozyma polyspora DSM 70294
P39998          480 Iffs--drIEATGIICSGWPLIA 500 Saccharomyces cerevisiae S288C
jgi:OSTLU_86160 208 ------diFVPDLLVSLTAPKQC 224 Ostreococcus lucimarinus CCE9901
A8BQZ5          206 KelipdglLRPDALISLTVPKNC 228 Giardia lamblia ATCC 50803
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