Conserved Protein Domain Family
RasGAP_C
?
pfam03836: RasGAP_C (This model is not part of the current CDD release)
RasGAP C-terminus
This domain can be found in the C terminus of the IQGAP family members, including human IQGAP1/2/3, S. cerevisiae Iqg1 and S. pombe Rng2. Some members function in cytoskeletal remodelling. Human IQGAP1 is a scaffolding protein that can assemble multi-protein complexes involved in cell-cell interaction, cell adherence, and movement via actin/tubulin-based cytoskeletal reorganization. IQGAP1 is also a regulator of the MAPK and Wnt/beta-catenin signaling pathways.Iqg1 and Rng2 are required for actomyosin ring construction during cytokinesis.
Links
?
Statistics
?
PSSM-Id: 515844
Aligned: 106 rows
Threshold Bit Score: 86.0734
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Q5AH02       1413 YHELKKMCLEIILKLESMGELTRKNSFQTLLNQIAMDIKTKDSQRQCRWQQLQVSQKTIKKLSEKENYLKTQLHNYKKHV 1492 Candida albic...
XP_003031654  556 LVRKGIKVKEMLRELEELHVIDSSDGYKLMQDEVAAELAHLGNLREKVVLETKSLEAVYKTICDHNNYMRSQLEQYKAYL 635 
XP_006960028  545 LVKKGIKVKEMLRELEEIGIIDRSDEYNLMQEEVQAELAHLGNIREKVLVESKSLDSVYKTICDHNNYLRSQLESYKAYL 624 
EKD04042      595 LVRRGIKVQNLLSELEAAGVLDRTDNYKLLQDEVRTELVHLGNAHEKVLLETRSLEEVFHAICNHNQYLRNQIDSYKAYL 674 
GAA95323      546 LVRKGIKVQEMLRELEELKLVDRKDGYKFITEEVTGELTHLGNLKEKVILESRSLDAVFKTICDHNNYLRSQLEQYKAYL 625 
CCG80715      527 MVRKGLKALEMLRELSEQNLVDSRDRYNPLTEEVEQELVHLGSIRDKVVLETKSLHSVYKTICDHNEYLKGQIDTYRAYL 606 
XP_002173585  564 FMHKGLRALQYLEELSKLSVVDPLNRYAPLVSEVEHEFQNLDAVYQRLKTERDALFMVHKTISEHNEYLRSQLDIYRNYL 643 
XP_013021907  548 LIRKGLKAIQLLERLSDLNLVFKENNYEPLASEVEKEYLSFDKIIRRIQVERDALKDVHKAICDHNEYLRTQLEIYASYL 627 
XP_007872104  541 LVRKGIKAIEYLKELSELKLIDPNDFYNPLAEEVEHEIAHLGSLYEEVLRETESLESVYKTIEDHNEYLRGQLEQYKSYL 620 
XP_025178290  576 LVRKGIKVKEMLRELEEAHVINRRDGYKLMTEEVAQELVHLGNLREKVNEEIKSLETVYKTICDHNNYLRSQLDSYKAYL 655 

Q5AH02       1493 ESVLLEL-------------------------QSKSksndknwkrrlfnimvipvfskqyfyhrelrkHNRLPKFGSYKY 1547 Candida albic...
XP_003031654  636 QNVRLTAtkdkgsstg--------vgvvtvggKEKK--------------------------------PTKPVTLGPYRF 675 
XP_006960028  625 ANVRINSskdskssag-------gvgvvtvggKEKK--------------------------------PAKSHILGPYRF 665 
EKD04042      675 FNSRMMMskdkgagg---------vgvvsfngKDKK---------------------------------ARSQSLGPYRF 712 
GAA95323      626 QNVRQTSgaqkgktgg--------vgvvsvdgKDKK--------------------------------VVKTQALGPYKY 665 
CCG80715      607 LNVRGQSsvtkhseanr------gigvvaisgKQKK---------------------------------AGKLLLGPYRY 647 
XP_002173585  644 QNARVQSsitkhsdlknvsrgvgvvgfkgkqqKQTN----------------------------------------ASKF 683 
XP_013021907  628 TNARNQMsssngeskklsr-gvgvigikpkhnKTNE----------------------------------------VVRF 666 
XP_007872104  621 HNVRIHSgrneskigvm-----ggvgvvslggKEKK--------------------------------QKKQQVLGPYKY 663 
XP_025178290  656 LNVRQQDakggpga-----------svvklggKEKS---------------------------------QKIKVLGPYKF 691 

Q5AH02       1548 SAKKLIDQKVLIDfSTAN 1565 Candida albicans SC5314
XP_003031654  676 THAQLEKEGIIVE-SNVP 692 
XP_006960028  666 THYQLEKEDIIRQ-SNVP 682 
EKD04042      713 THQQLEKEGVVKS-SAVP 729 
GAA95323      666 THAQFEKDGIIVD-SNVP 682 
CCG80715      648 THAELEQRGIIAE-SNVP 664 
XP_002173585  684 SHAHLVKEQVIAE-CLFP 700 
XP_013021907  667 SALQMKKESMLLD-FSFT 683 
XP_007872104  664 THFQLEKELVIAE-SNVP 680 
XP_025178290  692 THTNLEKDGIIVE-TSVP 708
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap