6SXA


Conserved Protein Domain Family
Rad10

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pfam03834: Rad10 
Binding domain of DNA repair protein Ercc1 (rad10/Swi10)
Ercc1 and XPF (xeroderma pigmentosum group F-complementing protein) are two structure-specific endonucleases of a class of seven containing an ERCC4 domain. Together they form an obligate complex that functions primarily in nucleotide excision repair (NER), a versatile pathway able to detect and remove a variety of DNA lesions induced by UV light and environmental carcinogens, and secondarily in DNA interstrand cross-link repair and telomere maintenance. This domain in fact binds simultaneously to both XPF and single-stranded DNA; this ternary complex explains the important role of Ercc1 in targeting its catalytic XPF partner to the NER pre-incision complex.
Statistics
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PSSM-Id: 397767
Aligned: 115 rows
Threshold Bit Score: 83.6697
Threshold Setting Gi: 122045993
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6SXA_G           100 SIIVSPRQRGNPVLKF--VR-NVP-WEF-GD-----VIP-DYVLGQSTCALFL-SLRYHNLHP-DY---IHGRLQSLG-- 161 
XP_652464         15 ikanLIQKKNYKLLDF--IRkR---VEYdPG-----IKQgDFIVGNMTKIFYL-TYKYHSTNI-KY---LEECIVPLIe- 78   Entamoeba ...
jgi:OSTLU_119485   8 TLLVNVLHKTHPLLALleVG-----YRL-EN-----IDC-DFIY-EHTSIVYC-TLRLHTLNA-DL---STQRLKKAS-- 67   Ostreococc...
Q4E1D8             8 TVMVSEACKGGKIIRL--MQrHRYvVEGmDN-----DVC-DFVC-GRTCVLYVnDL--NRLCDeSYraaVSQRISFANa- 75   Trypanosom...
EHY65186           1 -mksNELQRGNALIKY--IK-KTP-IEY-KY-----TVF-DYEPGEYFGVLHI-TLQLHMSSP-QY---IFGRIERIKs- 62   Nematocida...
EIJ88593           1 -mrVSELQKGNILITH--IK-RVP-IEY-KY-----TVF-DYEPGEYFGVLHI-TLHLHISSP-QY---IFNRIERIKd- 62   Nematocida...
PDM84175          20 vVINRKRQQGNPLLQY--IR-LVR-YEW-GE-----VSC-DIEIDSTIGIVFL-ALAYHKLHN-QY---IHTRLTGKAe- 82   Pristionch...
CAP24618          41 lvVNRRRQEGNPVLKY--VR-NVR-YEW-GD-----IGP-DFECGPTFGVVYL-SFKYHKQHP-EY---VYTRINGKAe- 103  Caenorhabd...
CCH60426         117 TVLVNSTQRENPLLNH--LK-NTN-WRYyKPpagtkIYY-DYFL-HGRSVLFL-TLSYHKLYN-DY---ITRRMKPFTss 185  Tetrapisis...
CCF55735          90 SVLVNTTQKENPLLNS--LK-NTN-WRYiSStggkkIYY-DYFI-RNRSILFL-TLSYHKLYP-DY---ITRRMASLSk- 157  Kazachstan...
6SXA_G           162 ---KN---FALRVLLVQVDVKD---PQQALKELAKMCILA-DCTLILAWSPEEAGRYLETYK 213 
XP_652464         79 --qSN---EYLNIVLFVIDCKIneiNEEIIQDVNIKLFKK-KCTLIIAQSYSDAAHYIEEFs 134  Entamoeba histolytica HM-1:IMSS
jgi:OSTLU_119485  68 ---SV---LANVVVLCLVDSED---SFQALISLNRVCAAS-NCVLVCVYTLREAISYIHAlc 119  Ostreococcus lucimarinus CCE...
Q4E1D8            76 ---QVitaGSRIVLLLLVDSTDp--RPDVLAWLNLHCSVElRCAVMLCWTEEECASYLEGla 132  Trypanosoma cruzi
EHY65186          63 ---SNskrVPIIILLLSADITSa-sAASAFTTLQIDCMAT-GVRIIPAYSPVECAKYIETMh 119  Nematocida sp. 1 ERTm2
EIJ88593          63 ---TKstrVPIILLLINQDITTl-sTSSVFTKLQIDCISL-NIRIIPAYTPVECAKYIENMh 119  Nematocida parisii ERTm3
PDM84175          83 ---NK---YATKILLVVDNVTE---SRHSLRELSLLCFRM-EWTLIVAKGIEEAAEYIESIK 134  Pristionchus pacificus
CAP24618         104 ---NR---YRNKVLLGYCNMEE---PRHVLRELNMICFRE-AWTLVVVYTVEEAAEYIELFK 155  Caenorhabditis briggsae
CCH60426         186 snnSD-----NNILIFVVDDSN---SEDTVKDLTKICMFN-GFTLLLAFNFEQAAKYIEYLN 238  Tetrapisispora blattae CBS 6284
CCF55735         158 ---ND-----DNILIFVVDTTN---SEETLNELTKQCMFS-GFTLLVVFNFEQAAKYIEYLN 207  Kazachstania africana CBS 2517
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