6SXA


Conserved Protein Domain Family
Rad10

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pfam03834: Rad10 (This model is not part of the current CDD release)
Binding domain of DNA repair protein Ercc1 (rad10/Swi10)
Ercc1 and XPF (xeroderma pigmentosum group F-complementing protein) are two structure-specific endonucleases of a class of seven containing an ERCC4 domain. Together they form an obligate complex that functions primarily in nucleotide excision repair (NER), a versatile pathway able to detect and remove a variety of DNA lesions induced by UV light and environmental carcinogens, and secondarily in DNA interstrand cross-link repair and telomere maintenance. This domain in fact binds simultaneously to both XPF and single-stranded DNA; this ternary complex explains the important role of Ercc1 in targeting its catalytic XPF partner to the NER pre-incision complex.
Statistics
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PSSM-Id: 515842
Aligned: 103 rows
Threshold Bit Score: 84.0693
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6SXA_G       100 SIIVSPRQRGNPVLKFVRNVPWEF--GdVIP-DYVLGQSTCALFLSLRYHNLHPDYIHGRLQSLGK--NFALRVLLVQ-- 172 human
XP_013058199   1 -MRVSELQKGNILITHIKRVPIEYk---YTVfDYEPGEYFGVLHITLHLHISSPQYIFNRIERIKdtksTRVPIILLLin 76 
XP_004350864 186 SLIVSERLRGNGIIQFLNLVKWEYnsN-IKP-DFLMAHDSCGLFLSLKNHRLQPAQLGERNKAISS--VHELRVLFVL-- 259
XP_002639231  41 LVVNRRRQEGNPVLKYVRNVRYEW--GdIGP-DFECGPTFGVVYLSFKYHKQHPEYVYTRINGKAEn-RYRNKVLLGY-- 114
XP_001416142   8 TLLVNVLHKTHPLLALLE---VGYrlEnIDC-DFIY-EHTSIVYCTLRLHTLNADLSTQRLKKASS--VLANVVVLCL-- 78 
Q4UII7        11 NLIISPRQRKNPILRFIKNVP--YieGdIAP-DFIISSDIYVLFLSLKYHRVNINYIKNRLESLSq---YKIKNLFIIcq 84  Theileria annulata
XP_002140582  42 IIVASNRQKGNPLIQYIKNTIYEF--SsLVP-DFLVGKYDAVIFISIKYHKLHNTYLKRRIMSLEK--NYKVRVVLCM-- 114
Q7R9F7        21 YLIISPRQKLNPVLKKINRVQYKF--NeIVP-DFLIGKNNACLFISMKYHRLKPNYLKARIETLTN--KYNNRILLCL-- 93  Plasmodium yoel...
XP_001583144   4 PIVISNRQKDNPMIELLKGIPCNWieDdCA--DYIVGSDIGVLFLSLKFHRQYPRYLEERVKKFQG--NFKSRVLLTL-- 77 
XP_002507180  23 LLIISRSQTGNGLVHRLHNVCWAI--DyINP-DFVFSSSSCALFASLKFQSLHPTHLHTRVCGLSD--SYALRIVVCL-- 95 
6SXA_G       173 VDVKDP---QQALKE----------LAKMCILADCTLILAWSPEEAGRYLETYK 213 human
XP_013058199  77 QDITTLs-tSSVFTK----------LQIDCISLNIRIIPAYTPVECAKYIENMH 119
XP_004350864 260 VDVEEAs-aVPLLEE----------LSHWCIVYNLTLVVGWSLIEVARYIQTFK 302
XP_002639231 115 CNMEEP---RHVLRE----------LNMICFREAWTLVVVYTVEEAAEYIELFK 155
XP_001416142  79 VDSEDS---FQALIS----------LNRVCAASNCVLVCVYTLREAISYIHALC 119
Q4UII7        85 IDVSDY---NQLLSKfldlqwtivnLLTITFGYGCKILLSWNARESAAIVEILN 135 Theileria annulata
XP_002140582 115 VDVSSSaglDTTILD----------ITNICFNTNMTLLLVWTPQEAAAVLEAMK 158
Q7R9F7        94 VDIDNI---ENPLGE----------INQLAFCYNMTLILCWDNNECARIIEDYK 134 Plasmodium yoelii yoelii
XP_001583144  78 VDVEDP---DLAISK----------LTRTAQGSYMTLVLAFKYDEVARWLISMY 118
XP_002507180  96 VDDEDE---NSSLPE----------VNRSAGLGDCALVCAWSLDEAARYIEFFH 136
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