2YXH


Conserved Protein Domain Family
MazG

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pfam03819: MazG 
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MazG nucleotide pyrophosphohydrolase domain
This domain is about 100 amino acid residues in length. It is found in the MazG protein from E. coli. It contains four conserved negatively charged residues that probably form an active site or metal binding site. This domain is found in isolation in some proteins as well as associated with pfam00590. This domain is clearly related to pfam01503 another pyrophosphohydrolase involved in histidine biosynthesis. This family may be structurally related to the NUDIX domain pfam00293 (Bateman A pers. obs.).
Statistics
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PSSM-Id: 397753
Aligned: 46 rows
Threshold Bit Score: 54.509
Threshold Setting Gi: 74534172
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2YXH_B  22 QSIETLLEALASEIEEVAEAVKK----------NDLANLEEEIGDXIYDALLVAAVaqrdYGIDLESAIQKVVEKISHRK 91  Thermotoga maritima MSB8
Q87I30  25 KGVETYLEAIGKEVDEVREEIRE----------DRLCHLEDELGDVLWNYLNVLKTlereKGIDPEKVLERACTKYEQR- 93  Vibrio parahaemolyticus
Q9KM96  25 LGSSTYLAEIKQEVDEVVEEIPK----------NRLCYLEDELGDVLWDYLNTILSlekeAGVKIESVVQRACRKYEER- 93  Vibrio cholerae
Q8TT97  21 RGGKATMLWLVEEVGELAEAIRR----------EEPENIEEELADCFAWIGALANL----YGIDLEEAF---LKKYPGVC 83  Methanosarcina acetiv...
Q8TWI5  21 RGPERTLLWLVEEVGELAEAVRK----------NDRQAVREELADVVAWTFSLANV----LGIDVEEVL---KEKYPGRC 83  Methanopyrus kandleri
Q8A2P1  22 FSELTNMAVLTEEVGELARVMARkygdqsfkegEK-DNLDEEIADILWVLLCIANQ----TGVDITKAFRESLEKKTKRD 96  Bacteroides thetaiota...
Q9RVK5 208 FPPLLLLARLAEETGEIARVIAHqngkt-pkpgEDVGDLEMELADLLFVAICLANE----RGLSLERGFARMMDKIEQRD 282 Deinococcus radiodurans
Q8EQD2  27 FSPLALMARLSEETGELAREINHyygekpkkqtENIKTVEEEVGDILFVLACFANS----LDFQLSDAFQQSIEKFETRD 102 Oceanobacillus iheyensis
Q9KC94  25 FSPLAMLARLSEEVGELSREVNHfygekpkkdsEEERTMEQEMGDILFVLICFANS----LEIDLEEAFTLVMNKFHTRD 100 Bacillus halodurans
Q2G254  23 FSPLANLARLTEEVGELAREINHtygekkkkdsEEANTIKAELGDNLFVLLCLANS----MGIDMTESFNETMEKFNTRD 98  Staphylococcus aureus...
2YXH_B  92 PWLF 95  Thermotoga maritima MSB8
Q87I30  94 ---V 94  Vibrio parahaemolyticus
Q9KM96  94 ---V 94  Vibrio cholerae
Q8TT97  84 PTCS 87  Methanosarcina acetivorans
Q8TWI5  84 PKCG 87  Methanopyrus kandleri
Q8A2P1  97 NKRH 100 Bacteroides thetaiotaomicron
Q9RVK5 283 KDRW 286 Deinococcus radiodurans
Q8EQD2 103 KNRW 106 Oceanobacillus iheyensis
Q9KC94 101 KDRW 104 Bacillus halodurans
Q2G254  99 KNRF 102 Staphylococcus aureus subsp. aureus NCTC 8325
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