7MQ8,7AJT,6RXV


Conserved Protein Domain Family
Nrap

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pfam03813: Nrap (This model is not part of the current CDD release)
Nrap protein domain 1
Members of this family are nucleolar RNA-associated proteins (Nrap) which are highly conserved from yeast (Saccharomyces cerevisiae) to human. In the mouse, Nrap is ubiquitously expressed and is specifically localised in the nucleolus. Nrap is a large nucleolar protein (of more than 1000 amino acids). Nrap appears to be associated with ribosome biogenesis by interacting with pre-rRNA primary transcript. This domain has a nucleotidyltransferase structure.
Statistics
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PSSM-Id: 515824
Aligned: 128 rows
Threshold Bit Score: 88.8197
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7MQ8_NH       178 VDVALTMPREILQDKDGLNQRYFRKRALYLAHLAHHLAQDPLfgsVC-------FSYTNGCHLKPS--LLLRPR------ 242  human
XP_004995438  285 VDVCIQMPRALLQHQDRKRFRYLYKRAAFLAHIAGIAAKLDG---IHsv----tYERFQGDELKPV--LCITPLksaats 355 
XP_002117055  129 VDVTVEIPQECLNSRDHINARYYYRRALYLAHLAYHLNQ-------SdicqevqYSTMNGDPLKPI--LVIKAA------ 193 
XP_067747077  137 VDLAVEMPQDCFLPKDFANYRYTDKRNLYVGVLAAELQAHGdlfq------dvtLQAWHGDYEKPValLKVSAAf----- 205 
Q0WVM5         98 VDLLVHLPKECFYEKDYMNHRYHAKRCLYLCVIEKHLLSSSS---IEkv----vWSTLHNEARKPV--LVVFPAkkl--- 165  thale cress
XP_044387716   95 ADLLVRLPKECFHEKDFLNHRYHAKRCLYLCVIEKSLRSSPL---IRkv----sWSTFQDEARKPV--LHVYPAtei--- 162 
XP_004232410   99 VDLFLHLPKECFYEKDYLNYRYHAKRFLYLCKIKEQLTKSPL---IKav----rWSSFQNEARKPI--LLVYPAvkl--- 166 
XP_003516574   99 VDLIIRLPKECFHEKDYLNYRYYAKRCLYLCLMKNYLEKSPS---IDrv----eWSTLQNEARKPL--LVVYPAakl--- 166 
3_pfamImport    1 VDVSIVMGKTFFHKKDYADEKYLRKKAFYLYCLAKELMKIPF---MIdnd-dlqFSFGSHSYYLPA--LIVKPIgt---- 70  
XP_008201939  181 IDILVEMPENLFSKIDSKNYRYMRKKAIYLAYITSKIGKdlae--------tksFIG---NHSNPI--LKIVPTgk---- 243 
7MQ8_NH       243 --------------------------GKdE-----RL-VTVRLHPCPPPDFFRPCRLLPT-KNNVRsawyR------GQ- 282  human
XP_004995438  356 arpkpgqrkaakgagddnddndgngnTA-DgeprpSR-FRIVIHAIAPKDFFKPNQLGPK-HNTLD----WpdlhllYPq 428 
XP_002117055  194 -----------------------------Per-fnRY-FTIRLYPCINQSAFKLSQLKPT-KDNIRyefyPt----iESk 237 
XP_067747077  206 --------------------------LA-EnglkgAN-VCVRVIPVATPGLFKLAKLAPS-RNNVR-----------HEp 245 
Q0WVM5        166 ---------------------------------dqFPgFSIRLIPSATS-LFSVAKLSIS-RNNVRs------------- 197  thale cress
XP_044387716  163 ---------------------------------aeLPgFYVRIIPTASS-LFDLSKLNLStRNNIRa------------- 195 
XP_004232410  167 ---------------------------------igNAeFVVRIIPAATS-LFSPTKLRLE-RNNIHt------------- 198 
XP_003516574  167 ---------------------------------veVPgFFVRIIPSAKA-IFSIAKLNLK-RSNIHn------------- 198 
3_pfamImport   71 ---------------------------------lgKK-CCFCLRVVPERDIYSLLKFSPS-TSNINcqwyFn-----TSv 110 
XP_008201939  244 ---------------------------------lgSK-FVVHVHVVVQETSLPPNKFTPE-KNNVKpnwfFk-----At- 282 
7MQ8_NH       283 -----SpaGDGSPEppTPRYNTWVLQDTVLESHLQLLSTILSS 320  human
XP_004995438  429 hkdldF--GTQTTGtaTPRYTLRILQDVLMMEHAKFVANATKD 469 
XP_002117055  238 l---nE--ETQRLGppTPHYNHGILVDMSFGRHLREIYQATRQ 275 
XP_067747077  246 n---mT--EQEMKQcsTPMYNNSILEDMMVRRHTRELHAALKE 283 
Q0WVM5        198 -----V--TADGVPepTPTYNSSILEDMFLEENSEFLKKTFSE 233  thale cress
XP_044387716  196 -----Y--TKDGINqpTPRYNNSILEDMFLEENAEYTGSTFAN 231 
XP_004232410  199 -----L--KQGDALqaTPRYNNSILEDLFLEDNAEFVKRTFSG 234 
XP_003516574  199 -----L--SDGTALlaTPKYNSSILEDMFI-EDVEFINNYFLG 233 
3_pfamImport  111 e---nG--NIDSKNnsTPYYNSLILQDLVMDESESLLKEIFDI 148 
XP_008201939  283 -----D--KNTDNNppTPYYNSAILHDLTALKANTQNVKLIKE 318 
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