Conserved Protein Domain Family
Ndc80_HEC

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pfam03801: Ndc80_HEC 
HEC/Ndc80p family
Members of this family are components of the mitotic spindle. It has been shown that Ndc80/HEC from yeast is part of a complex called the Ndc80p complex. This complex is thought to bind to the microtubules of the spindle.
Statistics
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PSSM-Id: 397740
Aligned: 48 rows
Threshold Bit Score: 120.065
Threshold Setting Gi: 221058004
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q6CNF3               71 SMRQSLRNSlprssiGPqQQQQMNSTQNSTYHNTARDPRPLRDKNF-----------------QNLLQQEIFSYLTDQKF 133 Kluyvero...
Q16QP7               55 RSQSATPAs---------RTPLRSNENIPIPSTVEKDKPPLENREW-----------------MMAQCERICDYLETipd 108 yellow f...
XP_002261510         36 KSRTSLNA-------------LSFYKSSASVYVKKV------DKTD-----------------KKENVKTLIRYLGWKNY 79  Plasmodi...
WGS:AFBI:EDEG_01459  10 QSRHSVNPn---------TSRASFIEEPRR-----RDLKHLRDKST-----------------INCSIQHLETFLKAHSF 58  Edhazard...
XP_002877991         28 QQRHLFNS---------------------------RDS----DASFassrpssiglggrasddRSSMIRFINAFLSSHN- 75  Arabidop...
XP_002177760         85 SRRSSFAGp---------DRRRSLLPPSSSSASAKVDPRPINDKSF-----------------QHNCSKALLTFLQESGY 138 Phaeodac...
2_pfamImport          1 SRRSSTYS--------------SRASLSGRSGARVLDPRPIGDRAY-----------------LHRCVRTLVEFLSEHPY 49 
EHB10380            280 ERKVSVFGKrts-ghRSwNSQLGIFSSSEKI----KDPRPLNDKAF-----------------IQQCIRQLCEFLTENVY 337 naked mo...
XP_002757141         51 ERKVSLFGKrts-ghGSrNSQLGIFSSSEKI----KDPRPLNDKAF-----------------IQQCIRQLCEFLTENGY 108 white-tu...
Q76I89               54 ERKVSFFGKrasgagGSrNSQYGMFG-TEKI----KDPRPLHDKAF-----------------IQQCIKQLCEFLVENGY 111 chicken
Q6CNF3              134 Dve--tnHPISLKSLKQ---------------PTQKDFIYMFKWLYLR-LDPGYVFT-KSLEHEVYSILRTIHYPYLATI 194 Kluyvero...
Q16QP7              109 ----lpqEFVERRNLRA---------------MSTKQFLVIMNHLFRQiGGNRYKLG-TNFIDDIMKTMIELEYPYT--I 166 yellow f...
XP_002261510         80 S------GSISPNLFKN---------------PSMTDLINIWNFIFKH-VDPQIEVNkDNYGEVVLSFYKDIGYPYT--I 135 Plasmodi...
WGS:AFBI:EDEG_01459  59 TanptnyRQTINATYNSqvtqnskplfnnpmcPSAKEVSSIFLFLFRF-FDANFAF--NKYEDDVINFMKILRYPFISEL 135 Edhazard...
XP_002877991         76 -------SLISIRANPV---------------PSVKDISETLKFILSK-LD--YPCDsIKWDEDLVFFLKSQKCPFK--I 128 Arabidop...
XP_002177760        139 D------YPISTKTLAR---------------PSGKDFANIVSFLLGQ-VDPEFSKGnVKFEDEVAMNFKAMGYPYP--I 194 Phaeodac...
2_pfamImport         50 D------QSLPAGLAKRg--------------PSKKEFFNILRFLFKQ-VDPTFEFG-VKVEEDVVVQFRNLRYPFP--I 105
EHB10380            338 A------YSVSMKSFQA---------------PSAKDFLKIFTFLYGF-LCPSYELPdTKFEEEVPRIFKDLGYPSA--L 393 naked mo...
XP_002757141        109 A------HNVSMKSLQA---------------PSVKDFLKIFTFLYGF-LCPSYELPdTKFEEEVPRIFKDLGYPFA--L 164 white-tu...
Q76I89              112 A------HNVTIKSLQS---------------PSVKDFIKIFTFIYGF-LCPSYELPdSKFEEEIPRVFKELGYPFP--L 167 chicken
Q6CNF3              195 NKSQISAVGGSN-WPKFVGMLHWLViinkK-LDECLEHLDVSINNQV 239 Kluyveromyces lactis NRRL Y-1140
Q16QP7              167 NKSMLKTPNVPHsVNHIIVMIGWLV----QlVPPINHEISHLKRDVD 209 yellow fever mosquito
XP_002261510        136 SKSTLVAPTTGLqYNTHLSALAWLC----QlLIFEAECFNDINEEKD 178 Plasmodium knowlesi strain H
WGS:AFBI:EDEG_01459 136 NKSQFIAV-TPHtWPILLAALVWII----G-LIEFYDTLIDKISKDS 176 Edhazardia aedis USNM 41457
XP_002877991        129 TKSSLKAPNTPHnWPTVLAVVHWLV----E-LARFHQHLSSNSTSEP 170 Arabidopsis lyrata subsp. lyrata
XP_002177760        195 SKTALVAAGSPHtWPSLLAALHWLM----EhLVIAKEARSEEMDETK 237 Phaeodactylum tricornutum CCAP 1055/1
2_pfamImport        106 SKTSLAAVGTPHtWPTLLLSITWLI----E-LLTYDEAIQEANETEE 147
EHB10380            394 SKSSMYTVGTPHtWLHIFAALIWLI----D-CIKIHNAMKESSLLFD 435 naked mole-rat
XP_002757141        165 SKSSMYTVGAPHtWPHIVAALVWLI----D-CIKIHSAMKESSPLFD 206 white-tufted-ear marmoset
Q76I89              168 SKSSMYTVGAPHtWPQIVAALIWLT----D-CFKLYAAMRENPSSFD 209 chicken
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