3KVN,3QQ2,7AKV,1UYN


Conserved Protein Domain Family
Autotransporter
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pfam03797: Autotransporter (This model is not part of the current CDD release)
Autotransporter beta-domain
Secretion of protein products occurs by a number of different pathways in bacteria. One of these pathways known as the type V pathway was first described for the IgA1 protease. The protein component that mediates secretion through the outer membrane is contained within the secreted protein itself, hence the proteins secreted in this way are called autotransporters. This family corresponds to the presumed integral membrane beta-barrel domain that transports the protein. This domain is found at the C terminus of the proteins it occurs in. The N terminus contains the variable passenger domain that is translocated across the membrane. Once the passenger domain is exported it is cleaved auto-catalytically in some proteins, in others a different protease is used and in some cases no cleavage occurs.
Links
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Statistics
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PSSM-Id: 515812
Aligned: 432 rows
Threshold Bit Score: 53.537
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3KVN_X         360 FVGGGGQRLD--FDSQDSAASGD--GNGYNLTLGGSYRI-DEAWRAGVAAGFYRQKLEa-----------GAKDSDYRMN 423  Pseudomonas ...
WP_039104297   540 WINLTHQYED--NDSKRGIAGYK--YSANGFLLGYDKSI-QDDWLIGAAFGYSDGNYKd----------kSAVSNDSNIK 604  Frischella p...
Q9CM43         826 FVKYLNGKQKygSNLSFIDYGYDfnASYSGVMLGGKVWQ-SERGNHALYTALNKTSYKvt---------pKAVDGETKAK 895  Pasteurella ...
Q9ZD91        2066 WGMSFYGKIK--QNSKNSASGYQ--SNTGGGIIGFDYNI-DNSIVIGAAYTMADSKVKhk---------nDKNGDRTKAK 2131 Rickettsia p...
29_pfamImport    2 WSSGTLGSSQ--QKSKADSNGYS--SRMAGGSIGADTHF-ENDLLLGASFSKIRSSIKeqsggdlsdlqnQDQNTKTKYD 76  
Q9ZE66          72 WISGLYGVNK--QGVWKNIPKYQ--GRTTGLTIGADAEFiNNHDVIGIAYSNLESKIKy-----------NKKLGKTAVH 136  Rickettsia p...
WP_011944685   379 QGNIFTSKSS--QEENEELKKYD--AGINGVFITVNKYV-NENTIVGATGLYSNLNIQyde-------niKHIFNKTDCK 446  Orientia tsu...
Q9F287         488 FITPYAGEYR----RDPVTSGYS--GQRYGVLLGQNQHF--GDFQLGWHGGYESASTDfn---------gTSVGRKEEIN 550  Yersinia pestis
Q6AKC6         489 FAMPYYSNVS----NNASPMGYD--ADIYGATAGYNHWI-DSDLILGFHAGYGSGDINyt--------gkGYEQKKENLK 553  Desulfotalea...
O06653        1376 WAKPFYTDAH--QSKKGGLAGYK--AKTTGIVIGLDTLA-NNNLMIGAAIGITKTDIKhq---------dYKKGDKTDVN 1441 Rickettsia j...

3KVN_X         424 SYMASAFVQYQ---ENRWWADAALTGGYLDYdDLKRKFALGGge----rsEKGDTNGHLWAFSARLGYDIAQq---ADsp 493  Pseudomonas ...
WP_039104297   605 NYQVQLYSRYKl--SNDIFTTAYFGYTYGDIeLKQHDGay---------lAKEDFLSHTWNVGGNLGYSWHAl---PS-- 668  Frischella p...
Q9CM43         896 YHSWGGSINWHsnlPHNLIVDLSAGYQKHKGdi----------------eHAGHVKGYTFNIGADLGYRYQWm---KN-- 954  Pasteurella ...
Q9ZD91        2132 SNIYSIYGLYNw-lTNNFFVEAIGVYGRNKIkNYEKRITTITdq-----iAIGKFINTFYSYELLGGYNYLIs---HR-- 2200 Rickettsia p...
29_pfamImport   77 TYILSLYGLSQv--GGNMSISVIGSAGLSKGkKAGSDTrd--------veSGNKPRSKLFSLELHLNYKIALl---KE-- 141 
Q9ZE66         137 GHLLSVYGLKEl--VKGFSLQSITSYGHNYI-KNKSKNLNKI---------IGKYQNNNFQTLLNYKYRTK-----YN-- 197  Rickettsia p...
WP_011944685   447 TFSLSLNGRYYp--QDNVFTQGIIGFITYDG-KTEYIAn----------kPSSEISGKGYYVDFMLGGDLNSiaynPK-- 511  Orientia tsu...
Q9F287         551 TLMLGVQGGMKl--SESLFIAATSTWFSSDTdYSDSNTYYGVg------sQSGSYDSSGLYTDVSVGNSWQLn---RN-- 617  Yersinia pestis
Q6AKC6         554 AGSLGVQSLYRf--ADDWLLQSIASFYYSSNdYSDNNP-Ln--------rEQGDYHGYGVNANLDLDYVFSF----TN-- 616  Desulfotalea...
O06653        1442 GFSFSLYGAQQf--VENFFAQGSAIFSLNQVkNKSQRYFFDAngnmskqiAAGNYDNMTFGGNLTVGYDYNAm---QG-- 1514 Rickettsia j...

3KVN_X         494 WHLSPFVSADYARVEVDGYSEKG-----ASAtALDYDDQKRSSKRLGAGLQGK-YAF---G------SDTQLF-AEYAHE 557  Pseudomonas ...
WP_039104297   669 LTLTPSVGLTYVYTENSAHNVKYn----QAK-LIKYGTASNSALFIPMDVTAD-YSVl-qH------ADIDLS-VKAKVG 734  Frischella p...
Q9CM43         955 AFITPMVGLHYLYASLSDVNDQA-----NKA-LL--KYNNFNALKTNLGVDVN-YRIgkfE--------VKGLlSYDMYQ 1017 Pasteurella ...
Q9ZD91        2201 TTITPMFGMRYATFKNNGYKENNt----TFQ-NLSIKKNYYDKFETILGLNSV-THYlsqD------IIIKPE-LHWFIN 2267 Rickettsia p...
29_pfamImport  142 VNLIPHIGLKYEYENANRHKEKIt----NDC-AIERPKKSYQALNTEIGNRVI-FAPiklTgstasiMSITPT-AHFSVE 214 
Q9ZE66         198 LHFIPSIGFKYDYSRASNYKEYNv----DIE-NLMIQKKSNQSFESSIGAKIV-SKPiisKn----nIILTLS-AHGNIE 266  Rickettsia p...
WP_011944685   512 LTVSPIVGIRYNKFNNSSYKLFN---------DVNVSDAEHHILEARAGGTVK-YVIdnkN------ISIIPE-VYAFIH 574  Orientia tsu...
Q9F287         618 YAMTPMVGLTHIWQQRDGYTVSSnnknyDLI-DTRYSSYSDHAVALHAGVRLD-GRYpltNe-----TLLKPF-FNVGFQ 689  Yersinia pestis
Q6AKC6         617 NRLVPSVGLRYLWQHVDSYTAYNl----DNA-DVNYGDMDENQLYANLGLDWY-GDYrteSn-----WQIVPS-LGLGVE 684  Desulfotalea...
O06653        1515 VLVTPMAGLSYLKSSDENYKETGt----TVA-NKQVNSKFSDRTDLIVGAKVAgGTMnitD------FAVYPE-VHAFVV 1582 Rickettsia j...

3KVN_X         558 RE-YEDDTQDLTMSLNSLPGn-Rf---TLEGYTPQDHLNRVSLGFSQKLA-PELSLRGGYN 612  Pseudomonas aeruginosa
WP_039104297   735 YA-FNLTDDEFDNDITINGIngLn---KMSARTSGRSKNQFNMGTGIALKfNQFDFDIDYH 791  Frischella perrara
Q9CM43        1018 QKtRQLYVDDVAYKQGKLADtlHln-tQFVAHLTPRFAFSTEVGFQHARNkGQSSFAVGAH 1077 Pasteurella multocida
Q9ZD91        2268 YQ-CKNKLPNIDARLDGIDEplTt---IRF--KPAKITYNLGGGISTKN--NMIEFGIRYN 2320 Rickettsia prowazekii
29_pfamImport  215 RR-IGSRGKSHPCTLTY-SElgQtigaGSISANTQNDRTSLNTGIGLIASrKNIKLELLLN 273 
Q9ZE66         267 RH-FNNKNTKVNAKATFKKQtlQe--tIII---PKQPKLGYNIGNNILMSiKNINVLLEYN 321  Rickettsia prowazekii
WP_011944685   575 SNlPTNSSNIKLEY--VASSnsSt---VDIKP-AKMHTLFGQLGGTVTIYrGPIRFGASYS 629  Orientia tsutsugamushi
Q9F287         690 QMlYGDEITIDQSIp------nSp--vVGVSTKDKTTQGTFDLGMALVSD-NGVSASLQLS 741  Yersinia pestis
Q6AKC6         685 QA-LTDNEFGNSMGv------gSi--iIPVTNSMDKTSVSARASIEFVK--DSYALSAGYA 734  Desulfotalea psychrophila
O06653        1583 HK-VTGRLSKTQSVLDGQVTpcIs---QP--DRTAKTSYNLGLSASIRSD-AKMEYGIGYD 1636 Rickettsia japonica YH
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