Conserved Protein Domain Family
AfsA

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pfam03756: AfsA 
A-factor biosynthesis hotdog domain
The AfsA family are key enzymes in A-factor biosynthesis, which is essential for streptomycin production and resistance. This domain is distantly related to the thioester dehydratase FabZ family and therefore has a HotDog domain.
Statistics
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PSSM-Id: 486612
Aligned: 11 rows
Threshold Bit Score: 125.547
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q82KU4             33 LVHRSSIAEVFVTDGVRT---GENAFSVGAQWPRDHALYHPD---ENGLNDPLLFAETLRQAHFYGAHTYF-GVPVGSRF 105  Streptomy...
WP_012015345       18 AVHRRHADTVFLADVHPD---GTDGYVATALLPESHTYYSAHtaeANRRLDPMLLLEACRQVVIYIGHNSL-GLANDTRF 93   Salinispo...
Q7AKF0             28 LVHRTRVQDAFPVSWIPK---GGDRFSVTAVLPHDHPFFAPV---HGDRHDPLLIAETLRQAAMLVFHAGY-GVPVGYHF 100  Streptomy...
WP_015037150       16 FVHRADPADIIPTDWTQL---RQNRFSVSARWPASHPFFSPV---AGARHDPMLVAETIRQTSMLVAHAEL-GVPLDEQF 88   Streptomyces
Q2JB50            158 AVGRASSVNTILVDPVQF----AGGATATIRVPVDNRSMFDH---ALDHFPGMVLTEAARQLCLWSGADLL-GVPA-TAA 228  Frankia c...
Q82KU4            205 RVGRLRWKDCVLERDRPD-------QDWRLRVDRDHAVLFDH---PTDHVPLMVMLEGFRQLGHLTVHEASrRTLGDRAF 274  Streptomy...
WP_011039545      201 tVGFHDDLHVLLATAQGL-----PDTAWQLRLRRDHPVLFDH---ESDHISGMALLEACRQAATALTPPAP-GAFGPRQV 271  Streptomy...
Q7NCZ7           1048 LVHKDYDHNVLLARLSRA---DENTVLAEMVQDPAHPFFYEH---PKDHVPGLYLVEAARQLVTALSHVYH-GVAMGKAF 1120 Gloeobact...
Q8KCQ7            136 LVHKHVEANVLVSEPFTA-----GRLRYFNIFSETAELKFDH---QSPHVQGLLILEALRQAGIASAHYQG--LPLDGKL 205  Chlorobac...
jgi:Cpha266_1803  163 YVHKKNSSNVLISDYFSA-----GRMLYFNMLASTEEISFDH---VSDHVQGLLMLEALRQAGVATAHIQG--LSFDGGL 232 
WP_012645614       24 FVHKAKDENVVISDICRRedlGPDIYQCFLTYDDQLPFFFEH---YLDHVPGLLVIEAARQMGTATVHKFY-DVDFDTIF 99   Geotalea ...
Q82KU4            106 IGQDVSFEITDPTALRVga-aPLAVVLNGTWTEERdrRGRPAGARLDVTLTVDGRPCGRGHTRGLM 170  Streptomyces avermitilis
WP_012015345       94 LMDSCEISVPADAYVQRpdggSTTLTMRVTVAAVRv-GSRLRAFTSRYELSLGAVPIGSTVITSSV 158  Salinispora tropica
Q7AKF0            101 LMATLDYT-CHLDHLGVsg-eVAELEVEVACSQLKfrGGQPVQGQVDWAVRRAGRLAATGTATTRf 164  Streptomyces coelicolor...
WP_015037150       89 VMWDLSYS-ADSEALTVdg-lSSDVTVDVVCSDITrrGSRLRNLRTTVVLTRDDRLLATGSGTARC 152  Streptomyces
Q2JB50            229 TVVAFDLAFTRFAELDV----TTTVAAVHQHEDVV------GGSTFAVSFQQNDAVIAAGTMTICP 284  Frankia casuarinae
Q82KU4            275 ALAGLSLDCAAFGELGE----TILLSLEKGPSEGV----PTEECALRVAAHQGERLLARADMTWKC 332  Streptomyces avermitilis
WP_011039545      272 ALTAVASSYQAFGELDS----PVTITTLPAAHGHS---PDSGTRTLQLTARQGSRTLITATVTTTt 330  Streptomyces sp. NRRL_B...
Q7NCZ7           1121 ILDEIQARFLRLAETDA----PVFLIARSRAPVYS--RGELLQMHNDLCLLQNEAVVAEMSCLFRV 1180 Gloeobacter violaceus
Q8KCQ7            206 ALLNYNTSFYHFLEQES----PIICRCYTDFTSSK--TSDDAEACIYMQVFQWGRLCADAILKGFA 265  Chlorobaculum tepidum
jgi:Cpha266_1803  233 ALLNYNTNFFHYLENDV----PVVLRVYCSFTADE--TSEDKDAPIYIQVLQYGRVVADATLKAFA 292 
WP_012645614      100 ILDVVNCSFTNFLECQE----PVVIQIAIIAPNGP--DRVRKAFSSVVTIFQHSESKGTIEFNCTC 159  Geotalea daltonii
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