Conserved Protein Domain Family
ADP_ribosyl_GH

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pfam03747: ADP_ribosyl_GH (This model is not part of the current CDD release)
ADP-ribosylglycohydrolase
This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.
Statistics
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PSSM-Id: 515779
Aligned: 563 rows
Threshold Bit Score: 51.8691
Created: 13-Feb-2025
Updated: 25-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002679880   59 GALFGVTWGDVIGCPVEG-WRQE--EIEELFGDENmlklfdfktiiekrndgslklqnitkdgidflfpsddlissklkt 135
XP_004988411    6 ACVVGGLLSDAATTPLH--WVYDvaKLSTFLKENGivd------------------------------------------ 41 
XP_002955014   10 AALLGSFVADAATSSLH--WIYNr-NILRETLTKPvdrt----------------------------------------- 45 
Q4FLA6          6 HIFLGATVADAAARPLH--WVYDekKLKSYIKGKKni------------------------------------------- 40  Candidatus Pel...
WP_013695978    6 HIFLGATVADAAARPLH--WIYDqkTLQKHIKGKKdf------------------------------------------- 40  Candidatus Pel...
XP_002116030    6 IAVMGSIVADAAAQPLHYiADSD--SIHKILEQNNavd------------------------------------------ 41 
25_pfamImport   1 GAIIGAAAADAATQPMH--WIYNpdTLKEVLSDLEpc------------------------------------------- 35 
56_pfamImport   1 GAIIGAAVADAAAQPLH--WIYDlkMLHTILSNEPcp------------------------------------------- 35 
27_pfamImport   1 GAIVGSAVADAAAQPLH--WVYDlqKLQAILAQHPip------------------------------------------- 35 
XP_006010516   10 GAIIGAAVGDAAAQPPH--WIYDlqKLDGLLSESPfp------------------------------------------- 44  coelacanth
XP_002679880  136 lstesdekknkrkKSPFESFLSRCRFPGIHSDDTQQGMALINSIVQY-----CELNPsGKYFGEiWGE------------ 198
XP_004988411   42 ----------epeFCSKPQCPFYEAKVGDLSPYGGEYVAMLNGLAKTdaankGTLDP-KAVEKE-MCE------------ 97 
XP_002955014   46 ---------sepeFFDPPSCPFYTCEVGDLSPYGQELLPLVKFLAAT-----GSC-E-PQAWAQfFAE------------ 97 
Q4FLA6         41 ------------aFFKQNRSPFYSIKTGEVSGYNDVGQVMFKTLTK-------TTNH-KEVIKLfKKNivknf----gpg 96  Candidatus Pel...
WP_013695978   41 ------------aFLKENKSPFYSIKTGKVSGYNDVGQVMFRSLKE-------DQNE-KDILSVfKKNivknfgpgslyw 100 Candidatus Pel...
XP_002116030   42 -----------peFLPVSANPRYKIDTGQQSCYGDQLMVFMDSLANH-----GIIDV-KDLIRR-IVR------------ 91 
25_pfamImport  36 -----------peFRPESANPFYRRATGEQTCYGDQAYVLLESLSRC-----GDVNV-EDLTKRiYK------------- 85 
56_pfamImport  36 ------------eFRPQSANPFYRRETGQQSCYGDQAFVLLESLTEC-----GGLNV-DDLKQRtYK------------- 84 
27_pfamImport  36 ------------eFISESANPFYRRQTGQQSCYGDQAFVLLESLSEC-----GGLNV-DDLTQRtLK------------- 84 
XP_006010516   45 ------------eFRAQSANPFYLQETGQQSCYGDQAFVLLKSLAEC-----EGFDA-KDLTRRtYN------------- 93  coelacanth
XP_002679880  199 --WLVRgFetcsckypmksgqveeigrGVQAFRDYG------------------ANSSKAFTNL--KK-NI-PAHEAGSS 254
XP_004988411   98 --FFA------------------------SWKGYKN------------------HVTKTLEANA--AK-GA-TYPDTADK 129
XP_002955014   98 --YFAT----------------------TDPPLAYM------------------NHSAKSMRDAvlEG-GR-TWPECGDA 133
Q4FLA6         97 skYWKNlSlrkkyk--------kikwkTAMKGPWIH------------------QNILETIKNI--KL-KK---TITGG- 143 Candidatus Pel...
WP_013695978  101 knL----Tlrkkyk--------kikwrSKIKGPWIH------------------QNIMETIKNV--KK----KKKITGGI 144 Candidatus Pel...
XP_002116030   92 --YFG--Pn------------------SEYEPKDPTerplp--------cplrtSAISDIISNS--LRyGL-DGQNLGPt 138
25_pfamImport  86 --FFG--Pgtvyelp-----rpkailpI-------Dgpw-------------rnSSLKAFIRNV--DA-GK---EETGKK 130
56_pfamImport  85 --FFG--Pgs----------------eY----DTPGprpqlpi-----egpwrhASLKSFLKNF--EA-GK-TDTGCEV- 130
27_pfamImport  85 --FFG-------------------------PGSDYD------------------TPLNNPYREK--LP-IEgPWRHASLK 116
XP_006010516   94 --FFG--Pgs----------------eYDTPINNPDrpkgeprpqlpikgpwrqGSLKSFLKNV--EA-GK-KETGCDr- 148 coelacanth
XP_002679880  255 --------------SSGIGGIMRGAIAtAVFSLFshesDDEKA-IQ-MIEKFSfeqnLTTHATIEGAATCFATSLCAYMF 318
XP_004988411  130 --------------DDNQANGMAKAPL-IAAAFG----KADDF-VA-TAKAAV----ALMQSRPSAVQYGLAAAIITKNV 184
XP_002955014  134 l------------dSQANCFVKSPAVV-ALFGGVg---DGGVA-LRtAVDVAV----RAQQNNDTAVELAWAAARVLERV 192
Q4FLA6        144 --------------TKVNESDGYCASL-PFYFSN----NSDHKtKQ-IIRTVA--------NGKISEQFALAKLKIIDLA 195 Candidatus Pel...
WP_013695978  145 k-------------VNESDGYCAVLPY-FLYYQ-----SFKNI-KR-VVSAVA-------NTK-LSMEYALAKLMIIDLA 195 Candidatus Pel...
XP_002116030  139 -------------dDYNADCLCKLAPVvGMFA------GQRNM-LA-SVEKVA----RITQNNTKSLAICLAAARILEHY 193
25_pfamImport 131 --------------KKKMDGVTKLAPV-VAMYA-----GRPEM-LE-KVEKAV----RVTQNDDMCVAVTLAAARFLEHY 184
56_pfamImport 131 --------------DNQIDGIAKLAPIvALYA------GKPEL-LE-KVKVAI----CVTQNSDTCVAVTLAAARFLEYY 184
27_pfamImport 117 sflknvdsgkeetgRSEIDGITKLAPI-VAFYA-----GKPDM-LD-KVEQAV----RVTQNNDACVAETLAAARLLEHF 184
XP_006010516  149 --------------DQQIDCITKLAPI-VSLYA-----GKPEM-LE-KVEEVV----RVTQNTDICVALALAAARLLEHY 202 coelacanth
XP_002679880  319 -LKLGQERAIEWIldnladrvkkaedkwwnnsrittereeqekeekkpkkkayvpnanqvvnktpenelkwkiyktlpsv 397
XP_004988411  185 -LDGATVGDAIKAaessdsldattkadi---------------------------------------------------- 211
XP_002955014  193 iTSGDSVEAALLWllgpegglsesskardavqev---------------------------------------------- 226
Q4FLA6        196 -DKGDKDPVNSFLrkniknkyfknvieni--------------------------------------------------- 223 Candidatus Pel...
WP_013695978  196 -DKGLKNP--VDAflkqnknksyfkgvivk-------------------------------------------------- 222 Candidatus Pel...
XP_002116030  194 lLKGYDKDVFTIVqnelknpqrtlptdedr-------------------------------------------------- 223
25_pfamImport 185 -ILNGSDSNALDAvlaqlndpkrqnpqel--------------------------------------------------- 212
56_pfamImport 185 iLHGPDQRALDVVldqlknqnsmnpqnldg-------------------------------------------------- 214
27_pfamImport 185 iLNGPDPKAVDSVldqlsdpnrkqpqdld--------------------------------------------------- 213
XP_006010516  203 -ILNGPDSSALDViikqlqdpkrknpqdldrgvi---------------------------------------------- 235 coelacanth
XP_002679880  398 naasevlqelfviiktlratekentllvelrnkisdlarvykpekknmRAHVNQGFCLLAGMHAIACILLpenpeiifhy 477
XP_004988411  212 ---------------------------------tdvlankdgdiaalsKKWGISCSYPGAFKLSLLVILQs--------- 249
XP_002955014  227 ---------------------------lankdvdprslmyqegpdvqfGPWRAGCGNPGCLKAALLVALQa--------- 270
Q4FLA6        224 ---------------------------------kkvkkvkskphnfvvKKFGKACSYPGTFNGGIHAIITs--------- 261 Candidatus Pel...
WP_013695978  223 --------------------------------ikevkalkkkphnmvvKKMGMACSYPGTFCGALHAIITs--------- 261 Candidatus Pel...
XP_002116030  224 --------------------------------nvadmiqsivdmksrsH-VNVVSHVGHIFQCSLHVLLTa--------- 261
25_pfamImport 213 ---------------------------------dravivsrrnvcsplKQGEGSAALPGAFQGALHGVLKl--------- 250
56_pfamImport 215 --------------------------------pvygwwinfvmfdtcfRD--HSERLPGAFQAALHGVLTe--------- 251
27_pfamImport 214 --------------------------------ternernknhvqqfmfYVYFHFSSLPGAFQAALHGVLTa--------- 252
XP_006010516  236 ---------------------------ghlhqvkanvskphkevtttvF-QN-NUVLPGAFQAALHCVLTe--------- 277 coelacanth
XP_002679880  478 hkstpEtptpsydsadifnnfPNLLLRSTVTLGYDTDTIGAILGYLLGSRFGTSWIPLQ 536
XP_004988411  250 ----sS---------------FKEAVRTNIKLGGDNCSRAAFIGGVFAAAS-PDQVPEE 288
XP_002955014  271 ----pD---------------FQAGVRHNLLLGGDNCSRAILVGALLAAKGGASSIPTA 310
Q4FLA6        262 ----kS---------------FKTAVIKTIKAGGCNCSRANFVGAYFAAYKGLKGIPQD 301 Candidatus Pelagibacter ubique HTCC...
WP_013695978  262 ----kN---------------YKSAVLKTIKAGGCNCSRANFVGAYFAAFKGIKSIPKE 301 Candidatus Pelagibacter sp. IMCC9063
XP_002116030  262 ----kS---------------YIDGVRNTLIAGGCNCSRATFIGACLAAQFGIDAIPMQ 301
25_pfamImport 251 ----kQ---------------LDEAVRDTMRCGGCTASRASFIGACFGAQNGLQGVPES 290
56_pfamImport 252 ----tV---------------FEQAIRNTMSCGGCTSSRSSFIGACLGAQVGLSGIPDS 291
27_pfamImport 253 ----kH---------------YEQAVRDTMSCGGCTCSRGSFIGACLGAQIGFEGIPAA 292
XP_006010516  278 ----kV---------------FDQAIRNTMSCGGCTCSRSSFIGACLGAQLGISGVPDS 317 coelacanth
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