1T5J


Conserved Protein Domain Family
ADP_ribosyl_GH
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pfam03747: ADP_ribosyl_GH 
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ADP-ribosylglycohydrolase
This family includes enzymes that ADP-ribosylations, for example ADP-ribosylarginine hydrolase EC:3.2.2.19 cleaves ADP-ribose-L-arginine. The family also includes dinitrogenase reductase activating glycohydrolase. Most surprisingly the family also includes jellyfish crystallins, these proteins appear to have lost the presumed active site residues.
Links
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Statistics
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PSSM-Id: 397700
Aligned: 682 rows
Threshold Bit Score: 34.4421
Threshold Setting Gi: 270510641
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1T5J_A               12 GSVFGAVIGDALGMPTEN---LTKE--EIKKLYGFVDs--YVEPKNYLAGK----LNKGEW----TDDTEQAICLIKSLT 76  Methanoc...
Q39Q85               27 GAVWGQFVGDAACLGSH----WIYElaELERRFQGGVvgfETPADGHYHTG----KHSGEL----THYGDGALVMLRSVA 94  Geobacte...
jgi:Dester_0467      10 GATLGAAIGDALGTLVEE---MDRD--TVKKAYGGAI----IGFTEPSPLSvcpyLKKGQY----SHETQIFLLALEVFA 76  Desulfur...
jcvi:cds.PERMA_1427   7 GALVGAAVGDSMGMCVEE---IPFD--EVILHYGDKItniCEPHPASPASY----LKAGET----SSEFEIVKIVAQSLS 73  Persepho...
O66816               11 GAVLGAAVGDALGKSVED---ITEE--EVFEFYGDRI----RDFVTPHPSS----PAYGQLpeetSDETTIFRLLLESLV 77  Aquifex ...
WP_012963137          8 GTLLGAALGDAIGKCVED---ITKE--EVYDFYGSRVegfVEPHPLSPSYG----SHPEEI----SDETKITLILLESVV 74  Hydrogen...
WP_012992414         11 GTLLGGAIGDALGKDVED---LTEE--EVRDLYGGRI---------ENYVG----PNPGET----SDETTISLLLLESIL 68  Thermocr...
Q111G6               11 GALLGAVLGNYIGSHFEY----QVR--KNRGNYKLFI-----NQHKCYLSN----SQKNYL----QKWGEATFNCAKSLI 71  Trichode...
WP_012062344         45 GTMISLAIGDAIGSHLEG---QYSK--EIEQ------------ISHFLKGE----KTAISLn--tTNITESTILFSESLI 101 Alkaliph...
jgi:Clos_2156        45 GALVSLAIGDAFGSLWEGqrgTEVE--HINLYLKGE-----------KNTA----YMKG------TWQTKATILFAESLI 101 Alkaliph...

1T5J_A               77 K-EGIDIKKFANClIawknknppdigltslmaid--------------------klenndysgvdssscgaaMRIYPLGI 135 Methanoc...
Q39Q85               95 ErGHFDPQDFGRRfVelfgsdsyrgyldhatrdtlthwra--------ftethpgdpynfqdgadddqpataTRLVPVVI 166 Geobacte...
jgi:Dester_0467      77 EkGRFDEELYINKlIewvkdekshrypagshinaal---------------ayasgadgaearvksadidgaIPALAAGI 141 Desulfur...
jcvi:cds.PERMA_1427  74 EkKILDIKDIIERyIqweekeelhsyvdpyfllai------------------dalkngreierggssiegaLPAIPLGM 135 Persepho...
O66816               78 EkKALDVRDFLNRlMewydreemhrypdpmlltaid---------------llsrginpsthgltsfsvegiLRSVALGL 142 Aquifex ...
WP_012963137         75 DkKAIDPQDFYKRlIlwredekshrypdpalltald---------------llssgisleeagfssasvegiLRCIVVGL 139 Hydrogen...
WP_012992414         69 SrKRIDPYDFFQRlYswrlqeekhrypdpalltaid---------------llsagvslteagfyscsvegiLRCTVVGL 133 Thermocr...
Q111G6               72 SqQEFNEENWQKV-YiewknkwedqkdytgepnkikdspieleklvrrvndkesnfqyinddvliptasnaiIASLPVSL 150 Trichode...
WP_012062344        102 InQGFHPEDFANRlIrspiipigktmsafvsnyr-------------------drrmfwyesgvasagngaaIRCAPVAL 162 Alkaliph...
jgi:Clos_2156       102 InQGFNPEDLANRfArqhivnpdkemekflekyr-------------------elrfawyqcatpslatgaaIRGIPAAL 162 Alkaliph...

1T5J_A              136 VFHNNLKKLKEEVIKASKITHNNKTAIAGALAIAFFVSSALKDRKDFSLLDEcynyikdideefakkll----------- 204 Methanoc...
Q39Q85              167 AHW-RDASLLRVVETATRVCQNNDGAVDYLKCHALILRELFNGTDLHEAFHRaatemergsgfgpevadgir-------- 237 Geobacte...
jgi:Dester_0467     142 FRWDSSYESYEEGAKIASITHNDETLIDTAGVLAVAASEVIGGRVILSTKEDrigfvevlrsfaqteivrayld------ 215 Desulfur...
jcvi:cds.PERMA_1427 136 YHYTNPVLAVEGTKAVVMLTHRNEIVIDAASVIAVAIGELLQGKFYLEDEYPyfikllktfvqkdetkfyldr------- 208 Persepho...
O66816              143 YHYYNPELAAEGSKVVSLLTHRSDVISDASAILGALIAHLVRGDFYLEDFREklrlietlkdyakeekhkkild------ 216 Aquifex ...
WP_012963137        140 FHFYNPLLASEGARLVSIMTHRSPEVYDASAVLAVMISNLIRDAYHLDNLDErvklleelklfvkhdrhktyld------ 213 Hydrogen...
WP_012992414        134 YHFNSPYVAAEGGRLVSLITHRSKEIYDTSAMLSAFVSYLVSQDSCSLSWEEalsllheiksfarypqhakvid------ 207 Thermocr...
Q111G6              151 MYHEDELKLQQKLRQWGNVWQNCLEVNLSNLVIGYTIAQALTERLDPRTIIPkiinyigekesivdqlrqveklinqgan 230 Trichode...
WP_012062344        163 IHYGDFEGLKFVAGIQAFITHNDQMALASSILMNTALAHLLNTEPYTLDRKEeklkflevcakgikgietqlypsnhsde 242 Alkaliph...
jgi:Clos_2156       163 INYGDFHALNLIGIIQTAITNTDETAIAASILFSTAIAYLLSTPAYSLDHIEkinlfleticrsirgietkvypigknge 242 Alkaliph...

1T5J_A              205 --------------eiknfnnldyiydyfgtGVKTDEVVPSAIATYLL-TdNFKEGMLKCIN----AGGDTDSLASMYGA 265 Methanoc...
Q39Q85              238 ------------kacasltlsvrdatlafgqSCPLSSSFPAAVHCALRhSvDFAAAVLDTAN----AGGDSAGRAALIGS 301 Geobacte...
jgi:Dester_0467     216 ---------mvtqvilkgiesiddlivllgnGSFAPEAFSIALFIAMEnNnSYRKGVLKAVNsygdFGGDTDAIAFITGG 286 Desulfur...
jcvi:cds.PERMA_1427 209 -----------vealikrdasyeeavnelgnGSYALEALSQALFIFLKtPeNTENVIIHAVNsygnYGGDTDSIGLIAGA 277 Persepho...
O66816              217 ----------rvaellmesadletaintlgnGTFAFEAFPLALYIFLSnVeNPEEALFQAVNsygeFGGDTDAIGFLVGA 286 Aquifex ...
WP_012963137        214 ----------rvaellqegadleraintlgnSTYVFESLPLSLFIFLSnIdEPMKALWDAVNsygdFGGDTDAIGYLVGA 283 Hydrogen...
WP_012992414        208 ----------rvvdllsegadledaiktlgnSTHVLEAFPLSLFIFVRrIgEPLEALYDAVNcygpFGGDTDAVGYLVGS 277 Thermocr...
Q111G6              231 l--daainifsknvsffdngqisnegqqksqSCTFFIPISLALYCFLStPeDFGLAVLCSAR----TAWSTQ-VCAIVST 303 Trichode...
WP_012062344        243 vanlyirlardlpealevdmgieafknrwgtGAYALESIPLALYLFLKsPdDYEKILKDSLM----CNR-PDALSSLTLM 317 Alkaliph...
jgi:Clos_2156       243 itnlyiamnktlrgwvendlsidevrerwgnGSNILEVLPLAIYIFIKgSsDYEKTLKECLS-----IRENDTMVILTLA 317 Alkaliph...

1T5J_A              266 MAGAYYGFKNIPKE 279 Methanocaldococcus jannaschii
Q39Q85              302 WLGAFHGIAGISAA 315 Geobacter metallireducens GS-15
jgi:Dester_0467     287 LIGGYLGVSAIPQD 300 Desulfurobacterium thermolithotrophum DSM 11699
jcvi:cds.PERMA_1427 278 FAGAYNSEESIPSR 291 Persephonella marina EX-H1
O66816              287 MLGAYYGEEAIPYH 300 Aquifex aeolicus
WP_012963137        284 YLGAYLGQEIFPLD 297 Hydrogenobacter thermophilus
WP_012992414        278 YLGALHGDEIFPRH 291 Thermocrinis albus
Q111G6              304 LSGAYNSIAGVPVE 317 Trichodesmium erythraeum IMS101
WP_012062344        318 LAGAYLGFSNIPKg 331 Alkaliphilus metalliredigens
jgi:Clos_2156       318 LLGAYLGFNNIPKg 331 Alkaliphilus oremlandii OhILAs
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