5Y31,5Y31,5Y31,5Y31


Conserved Protein Domain Family
EPTP
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pfam03736: EPTP (This model is not part of the current CDD release)
EPTP domain
Mutations in the LGI/Epitempin gene can result in a special form of epilepsy, autosomal dominant lateral temporal epilepsy. The Epitempin protein contains a large repeat in its C terminal section. The architecture and structural features of this repeat make it a likely member 7-bladed beta-propeller fold.
Links
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Statistics
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PSSM-Id: 515770
Aligned: 172 rows
Threshold Bit Score: 30.8816
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5Y31_B         490 KFVKFQELNVQ-APRSFTHVSINKRNFLFASSFKGNTQIYKH 530 human
XP_003441909   425 KFDRRTDIPDMeDVFSIKHFRVQGDLFICLTRFIGDSKVMRW 466
125_pfamImport   1 QFAFHSQIPNAvDVQMVKHFRVLKDLYLCLTRFIGDSKILRW 42 
XP_040051203   409 QFAFFSQITELaDVQMVKHFWVRKVLYLCLTRFIGDSKVLRW 450
109_pfamImport   1 QFVPQGEVGEVlDVQMVKHFRAKREQFLCLSRYIGDSKVVRW 42 
Q4R4H3         410 QFVAQGEVTQVpDAQAVKHFRAGRDSYLCLSRYIGDSKILRW 451 crab-eating macaque
XP_064421587   354 QFVQQGEITDMmDVQVVKHFKYKKDIYLCLTRFIGDSKVLKW 395 coelacanth
NP_001072088   404 QFVFWSQITDLaDVQMVKHFWVRKVLYVCLTRFIGDSKILRW 445 torafugu
NP_001233219   407 QFERRTDIPEMeDVYAVKHFHVKSDLFICLTRFIGDSKVMRW 448 torafugu
XP_056703261   403 KFTPRTDIPDMdDVYAVKHFKVKEDVYICLTRFLGDSKVMHW 444 tarantolino
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