5OIZ,5LP4,2WAF


Conserved Protein Domain Family
PBP_dimer

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pfam03717: PBP_dimer 
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Penicillin-binding Protein dimerization domain
This domain is found at the N terminus of Class B High Molecular Weight Penicillin-Binding Proteins. Its function has not been precisely defined, but is strongly implicated in PBP polymerization. The domain forms a largely disordered 'sugar tongs' structure.
Statistics
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PSSM-Id: 427460
Aligned: 65 rows
Threshold Bit Score: 91.2295
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5OIZ_A         23 TVPAKRGTIYDRNGVPIAEDATSYN----VYAVID-ENYKSATGKIlyvektqFNKVAEVF-HKYLDMEESYVRE----- 91  Streptococcus ...
Q1WT97         69 EIKAKRGTIYDAANQPIAEDATTYS----IYIVLS-KSAVAYGKKEylp-dsqKKKAAKVL-SDNLNISYKRVLQ----- 136 Lactobacillus ...
jgi:Lreu_0587  66 IIQARRGDIYDSEGNPLATDTSKYT----LYAVLD-RTQKSSDGKPlyv--kdRKKTAKVL-SQYIDLTPKQIEK----- 132
Q7MWM8         61 DLAPIRGNIYATDGRAVAITAPYFRlyfdFQADPL-KAIKKDSLNKlld--tlALNISRKLsTQYEKIKPADLKKk---- 133 Porphyromonas ...
Q0PAZ1         47 yalALRGSIITKDNFTITSSKQIYR----AEIDLR-SINKDKFDL--------FLKLFQIY-SGISNDQVADIKK----- 107 Campylobacter ...
Q9KD08         58 RIDAPRGLMYDRFGYVVVDNELELS----LTYTSQ-SQTRDTEEMLd-----vARKLEQLI----EVDT-SKITErdrkd 122 Bacillus halod...
2WAF_A         55 tsSSARGEIYDASGKPLVENTLKQV----VSFTRS-NKMTATDLKEt------AKKLLTYVsISSPNLTERQLADyylad 123 Streptococcus ...
Q9CIL7         81 ieGAPRGNIYDATGKALASTVAVQA----VEFTRS-QNATADEIYQv------ANKLATIL-S--NNIDVADLTTrdkkd 146 Lactococcus la...
Q04EK2         71 tTEAPRGVIYDSTGKVLAGNKSIPS----ISFERLpSITSAEIYKS-------ATRLSKYL-T----IDTSALTEtqeid 134 Oenococcus oen...
Q38VZ5         65 TGNVPRGMVLDAKGRVLVGNSAKSA----ITYTKN-MNVLADKMYAe------ANQLTKYL----TIDKLDTLTErdqid 129 Lactobacillus ...
5OIZ_A         92 -----------------------------------------------------------QLSQPNLKQVSFGAKGN---G 109 Streptococcus ...
Q1WT97        137 ------------------------------------------------------------ILNPKDKNTYQVELENvgkN 156 Lactobacillus ...
jgi:Lreu_0587 133 -------------------------------------------------------------ILKPKGQAYQVEFGNagsN 151
Q7MWM8        134 -----------------------------------------------------------WREGMAKKSRYWPVINR---D 151 Porphyromonas ...
Q0PAZ1        108 ------------------------------------------------------------RMQNQKKRSYNFVLLQ---N 124 Campylobacter ...
Q9KD08        123 ywllqasreerlelvsleerkeidd----pqeeyaleleritdehlnslteederilaiFRQMNQGYALTPQRIKR---D 195 Bacillus halod...
2WAF_A        124 peiykkivealpsekrldsdgnrls-----eselynnavdsvqtsqlnytedekkeiylFSQLNAVGNFATGTIATd--P 196 Streptococcus ...
Q9CIL7        147 yflansknlekianslsekekkdkhgndlsgsqiydvelskvkdsdlnftaeqtfaaklFKEMNSTTTFNTTKIATg--S 224 Lactococcus la...
Q04EK2        135 yyltsskhsketikklglsnsavnkl---tssalyklevkylkknklelsssqknaaaiYNKMAQTTILSTTTLKSt--G 209 Oenococcus oen...
Q38VZ5        130 yylsnpknlkkwnarlpksrkvaadgskipdktvyqstidlveksftglsdkqkqaaaiFKIMSGAYQLSTVYIKNd--N 207 Lactobacillus ...
5OIZ_A        110 ITYANMMSIKKELEAa----------------eVKGIDFT-TSPNRSYPNGQFASSFIGLAQLH-------------ENE 159 Streptococcus ...
Q1WT97        157 ISLETKKKIDSYHLT--------------------GIKFT-PSQSRLYPNGVFASHLIGLAESE---------------- 199 Lactobacillus ...
jgi:Lreu_0587 152 LSVSTMQKIKNRHLP--------------------GINFI-ATPARQYPEGEFASQIIGMATPKvk----------nDNG 200
Q7MWM8        152 ISYLQMKELYDMAPLarvprk-------glgpiPRSIRPE-EKAKRMMPFGSLGSRTIGSVYGS---------------- 207 Porphyromonas ...
Q0PAZ1        125 LDSKQASYLKDLAKKlyiqgffkaftnnsgrveTRGLNIIeHEEDRIYMSKDSFTPIIGYTKMIl------------DPE 192 Campylobacter ...
Q9KD08        196 ISEEEAHSIAEKLDE------------------LPGVDIL-RDSRRKYPYGNSLRSVFGNTGSIpreql----nnylAKG 252 Bacillus halod...
2WAF_A        197 LNDSQVAVIASISKE------------------MPGISIS-TSWDRKVLE-TSLSSIVGSVSSEkaglpaeeaeaylKKG 256 Streptococcus ...
Q9CIL7        225 ITAEQQATIAEQEGD------------------LPGITIG-TSWDRSYAQ-NSLTPLMGTITSQksgipaedldaylKKG 284 Lactococcus la...
Q04EK2        210 VTTKEISEIGERLSQ------------------FSGVRIN-QGWTRYYPQGSSSKTLLGSLSGSssglpasslstylAEG 270 Oenococcus oen...
Q38VZ5        208 VTDKEIAEISEHLTS------------------LPGINVG-TDWERSYPNGDSMRSIIGHVSTEeqglpedginsllAQG 268 Lactobacillus ...
5OIZ_A        160 DGSKSLLGTSGMESSLNSILAGTDGIIT-YEKDRLGN-IVPG 199 Streptococcus pneumoniae R6
Q1WT97        200 --DKKLVGIMGLEKVFNKQLSGRDGINN-TATDSYGV-QLPG 237 Lactobacillus salivarius UCC118
jgi:Lreu_0587 201 TEETNLVGQLGLEGYFNKQLTGINGLRK-DKQDVYGY-QIAN 240
Q7MWM8        208 MEGGLSQGKNGIELFYDKQLRGEIGKASrVYVG--GRrILNT 247 Porphyromonas gingivalis
Q0PAZ1        193 SGILKNIGVKGLEKYYDACLSPVQNEKIqGLKDIGGN-IILN 233 Campylobacter jejuni
Q9KD08        253 YERSDIVGTSYLELQYEDVLRGQKAVVEsTTTSSAGD-MIEQ 293 Bacillus halodurans
2WAF_A        257 YSLNDRVGTSYLEKQYEETLQGKRSVKE-IHLDKYGN-MESv 296 Streptococcus pneumoniae R6
Q9CIL7        285 YQRNDRVGTGLLEKGYESELQGTHSISK-VKFDKNGD-VSGT 324 Lactococcus lactis subsp. lactis
Q04EK2        271 YSRTDSVGISGIEKEYEQTLRGISKKTQ-ITTNSQNK-IVSS 310 Oenococcus oeni PSU-1
Q38VZ5        269 YSRNDRVGTSYLEKQYESILHGSKSQTQ-VEVGNNNQ-ILSS 308 Lactobacillus sakei subsp. sakei 23K
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