Conserved Protein Domain Family
LPG_synthase_TM

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pfam03706: LPG_synthase_TM 
Lysylphosphatidylglycerol synthase TM region
LPG_synthase_TM is the N-terminal region of this family of bacterial phosphatidylglycerol lysyltransferases. The function of the family is to add lysyl groups to membrane lipids, and this region is the transmembrane domain of 7xTMs. In order to counteract attack by membrane-damaging external cationic antimicrobial molecules - from host immune systems, bacteriocins, defensins, etc - bacteria modify their anionic membrane phosphatidylglycerol with positively-charged L-lysine; this results in repulsion of the foreign cationic peptides.
Statistics
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PSSM-Id: 397664
Aligned: 70 rows
Threshold Bit Score: 52.3624
Threshold Setting Gi: 123496489
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q18DQ6              2 NIDDIRTTiigfgSVIIIFAalf--afaGVEELIATVRTANpqyVALV-IGATL------------TWLFA--------- 57  Haloquadra...
Q5LAE4             20 ILLPVLIG-----LSVVGWLf-------YWEFNPELFSGIR---FSWR-LVGGL------------LLAVLfmfgrdggl 71  Bacteroide...
jgi:HY04AAS1_1341   4 ILKAVALFafvagLSILYIIykt-----fnKYTIDVLYRLN---FRYV-LLALLlsflyqtfdvlrLFTLS--------- 65  Hydrogenob...
jgi:Hore_09870     24 VVISLVIS-----ALIVLLTf-------DKASFERALASINpqfMGVL-LFLLL------------INWLVagl------ 72  Halothermo...
Q8R8J2             11 YILGLAIGislisIVLVLKF----------TGITNIEKAFDiplFYIItIFAVI------------IASLVvdt-----l 63  Caldanaero...
Q03Z61              9 MIIVVVLT-----AIVVYFLtke--lsgKGHQLSVALENLD---WHWL-LFGLF------------TMIISifle---aa 62  Leuconosto...
WP_003527729       13 fnisllcLs---fGMIIYFCvk----dnNLAILIQSFSSLN---FFWL-IPAVL------------LIAGVwale---al 66  [Clostridi...
Q188H2             12 IQYGFLLFlicitTYLVLTTl-------DIKLIPKIIRLVN--------KTYIF------------LGILTiivymi--- 61  Clostridio...
WP_009242632        6 rileVTIF-----LLVMFLTfytlfsgkNLGEIANAVSKMS---VGYL-VPAAA------------LAIFFvcae---gy 61  [Ruminococ...
WP_012002369        5 IFLGVILSlg--aSGLISFLv-------SGNQIISALEKMN---LWYF-LLACF------------MYLLFlvld---sl 56  Pseudother...
Q18DQ6             58 -WsvslHTVLQTL-----DVHLSYAASFLVFAGAMFSNNVTPFGQAgGEPITAYLISRtADAEYETSLAAIAS-VDTLNL 130 Haloquadra...
Q5LAE4             72 mW----RFRF-IT-----DRELTWRQAFRVNMLCEFTSAVTPSAVG-GSSLIVLFLNK-EGINAGRSTALTIS-CLFLDE 138 Bacteroide...
jgi:HY04AAS1_1341  66 ------KAL---------NVKYPIFYGYIMSFINTFAATVTPLHIG-GELASVYMLKR-RGVHLHKTMSIVTM-KTLSGM 127 Hydrogenob...
jgi:Hore_09870     73 ----riKILVTTV-----GGNITLLDGIIIYLSGAFVSNVTPFATG-GGPFQVYFLHK-KGLNVGKASIVVVT-QFILRI 140 Halothermo...
Q8R8J2             64 rV----KDLLKKL-----GEDLCFSYLFKFNLATFFISYVTPFGS--GVLPLMIYLLNkKGVSANKALIVFTA-KLLFSG 131 Caldanaero...
Q03Z61             63 aT----RALLSKEd----RRHTSVLSLLRVPLLNLLGTGVTPFATG-GQPAQLYGLSR-SGVETGRAMSVILM-KFLVYQ 131 Leuconosto...
WP_003527729       67 lY----HLIVNSVy----PGQYSWKEAFRVTMVGQYFSAVTPFGVA-GQPMQLVALSR-QGVSSGVAVSVVVR-KFLIYQ 135 [Clostridi...
Q188H2             62 iesivtHLIINAV-----QKTKVKFIGIKMATMGFYYNLVTPFASG-SQPMQIYALTK-YDVSLSKSVAIVTN-KTVVFQ 133 Clostridio...
WP_009242632       62 mI----WYLLQAMkanrrKEGSSLIRCIQYSFIGFFYSGITPSATG-GQPVQLYYMSK-DGNRGSDSTVVLMT-VAVVYK 134 [Ruminococ...
WP_012002369       57 rT----KLLLSHA-----KINISYLKCFQNTLLGLYTSAVTPFSAG-GQPFQIYHLNK-NGVPVEAA--SMTIgVKFISS 123 Pseudother...
Q18DQ6            131 IPSITIALIGVGYFTTEVALGSRs--nILLGSIVVITLATTIL------IFAYTAWRYRYEIEHrvvyaltpmihwvadi 202 Haloquadra...
Q5LAE4            139 LFLVLACPFALLLFSFDDLFGNV----AILSSGIEVLFFLVYGvvtiwtFLLYLALFRRPEWVKrllltifr--lpllrr 212 Bacteroide...
jgi:HY04AAS1_1341 128 FFFIVAFPITAFYLYQKPKLGLN----VLKIFLVSFGIGFLIYigaklfFKSNILSDKRKLNIKytlrkyvatlriflri 203 Hydrogenob...
jgi:Hore_09870    141 FFFGILTPLFLIFFRWAISPGIIp--dYLFYTAFGFGILFSTI------IIIFSLVPGVTDTLLnylfsidkvkmffknn 212 Halothermo...
Q8R8J2            132 IFFVTIPPFLLIFFGRYLELGS-----FLMRLAIFVTFFLIGL------LILLLYIILRPHFLIeiverl-------eri 193 Caldanaero...
Q03Z61            132 IVVVVFFIIGYVSAEHFIYQQVNptfaTFIPFAIAIHAVVIIG------IILVMFWPSLTLRLVdlv------------a 193 Leuconosto...
WP_003527729      136 TTLSLYSLGVILLKSSFFESQIH----GFLPLALVGFLAQAAS------VLLLFLFSVSRTFTTkliqfffwllsklrlv 205 [Clostridi...
Q188H2            134 STVTVFCGILILLNKSLLMEQVHsv-kVLITFGMIMNVSMLLG------GLLIVFSPKQVKMIAevlinflskfktfkfl 206 Clostridio...
WP_009242632      135 FVLVILGAAILLFWYRPLYSELGkf-fPLYLFGLLLNVILVVV------IAGIMLMPNIMLRCAlffeklfv---kmsil 204 [Ruminococ...
WP_012002369      124 FTLMVFSTFFLLLIRGKSLLTTVg---STLLVYSGLVLTSSIY------LFFLLLIFSKPFAQKiimsr---------ff 185 Pseudother...
Q18DQ6            203 vpRLPDiaeaeietr--------iegffraieRVAANPRQLAVALGASTIGWICQMTALWLAFRAIGIELRTTFI----- 269 Haloquadra...
Q5LAE4            213 whKAIEtltdnl--------------vlssreMSQKSFTFWLKAFGITCLAWTSRYLVVNALLIAFTTSGSQLLAf---- 274 Bacteroide...
jgi:HY04AAS1_1341 204 kkS--------------------------------S----VFLAFFYSVMLYITFLSIAPVLIKAFGKNVDVVSSm---- 243 Hydrogenob...
jgi:Hore_09870    213 qrAKRLlvkarqelyd------frrslsllakYKGR----LLLAGLCTALYWSTLFMIMPIILGGLNLEPHFFRSy---- 278 Halothermo...
Q8R8J2            194 sfAKRYikedyfkktkee--illyhknfrnlfASFSGYRVFIWQFLYAVIYWMLFYSIAPLLLMAMKIPFDFLAVv---- 267 Caldanaero...
Q03Z61            194 ivVKKMmrrerferlianv-kqkidnfhtesrRVISSWQSLVGATFFTSLQ-------LITFYMIPYFVIRAFGYqsvnp 265 Leuconosto...
WP_003527729      206 krPEEKskrvhaql----------esylnnnkSMNHNWKLSLQLYGLTFLELTVLFSVPFFLYKAYHNPGAPYFDm---- 271 [Clostridi...
Q188H2            207 dsKRDRinhyiddyn---------ysikifikNVRI----LVLSILLTVLQLIAYFSIVYCVYKASNLRGVSYVHi---- 269 Clostridio...
WP_009242632      205 kpSEKRpekihefi----------gsyqnavsWLRTHKGKLLFIVLVTFLQRCSVFLLTYMVYLGFGLHGTGMMKv---- 270 [Ruminococ...
WP_012002369      186 trIVSIltkkdpkavwkkafdslsnyfellrgLWISSKLIVLITVIITFFNIIITASLPYIISISFGLSEIDYLQf---- 261 Pseudother...
Q18DQ6            270 ----LIIVPIATIAGVTPLPGGAGGIETVLVFLLLAAplphVTEAIAVTAVVIFRGAIY-WVPVILG 331 Haloquadratum walsbyi D...
Q5LAE4            275 ----VRQLILWVVMTISPTPGGSGVSEYMFREYYADFf---dVAGMALVVAFVWRIITY-YMYLLIG 333 Bacteroides fragilis NC...
jgi:HY04AAS1_1341 244 ----LRQLGLLYGIYMSPTPGGAGVGEIGGLEVFKAY----LSFYELGLFVILWRFVSQ-YFSAFIG 301 Hydrogenobaculum sp. Y0...
jgi:Hore_09870    279 ----IMQTIYYLVIPYMPTPGASGIAEIGFASLFVSF----IPGDLIGLVTCIWRFITF-YVVLTVG 336 Halothermothrix orenii ...
Q8R8J2            268 ----GRQIIFYDVLAYSFIPSGSGTVELGFAAIFSNI----LPTSYVGVFIGMWRFFTY-YVYLGLS 325 Caldanaerobacter subter...
Q03Z61            266 wlivTMNIMIVMVISLFPIPGGVGGAELSFQLLFSPFv---KNPATLILVILLWRFITY-YFGIFAG 328 Leuconostoc mesenteroid...
WP_003527729      272 ---vSAQAFVTMIAAYTPLPGAAGTSEGSFLVLFNLF----FQGETVKQAMLLWRFITY-YSTIVVG 330 [Clostridium] leptum
Q188H2            270 ---mTLQVFLYMAISPIPTPGNVGANEVTFFTMFSNI----IPKELLGYSVLLYSGFVYyFILIVSG 329 Clostridioides difficil...
WP_009242632      271 ---iLLQAAVYIAVDMLPLPGAQGITELMYQTVFAHV----FTGTYLIPSMLVSRGINF-YFLLIVs 329 [Ruminococcus] torques
WP_012002369      262 ---vCAFLTMSMVVYFVPTPGSSGGIEGAFYLMFKNL----SSSEFSVATMLIWRLITY-YAILIIG 320 Pseudothermotoga lettingae
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