8AFZ


Conserved Protein Domain Family
Sorting_nexin

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pfam03700: Sorting_nexin (This model is not part of the current CDD release)
Sorting nexin, N-terminal domain
These proteins bins to the cytoplasmic domain of plasma membrane receptors. and are involved in endocytic protein trafficking. The N-terminal domain appears to be specific to sorting nexins 1 and 2.
Statistics
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PSSM-Id: 515741
Aligned: 8 rows
Threshold Bit Score: 62.6207
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
8AFZ_A        11 SERLPPPF-PGLE-PESEGAAgGSEPEagd--sdtEGEDIFTGAAVv---SKHQSPKITTSLL------PINNG---SKE 74  human
2_pfamImport   2 SDRIPPPF-PDTEePGVCDMA-DGDRD--------EGEDIFVGGGRg---LLPYESDRAGSLF------ISSAT---AKY 59 
3_pfamImport   2 SERSPPPF-PESEdPEPEPAAgDGDSD--------EGEDIFTGLVSe--gSMSCTQKQYSCFQ------PVRMS---TKT 61 
O60749         3 AEREPPPL-GDGKpTDFEDLE--------------DGEDLFTSTVStl-eSSPSSPEPASLPAed--isANSNG---PKP 61  human
XP_007260836   3 EEREPPPLaGDAAeTGFRELE--------------EGEDLFISTVStieqLSPTSPEPASLPAed--isTNSNG---PK- 62 
XP_015223974   3 AEREPPPL-GDAEqTDFREVE--------------DGEDLFVSTAStl-eSSPSSPEPASLPTed--isVNSNG---PKP 61 
XP_007479610  12 SERLPPPF-PIPEpPGPEGAAgGGGSEleagdsdaEGEDIFTGAASkslsLKRGSPPPIT------------NN---SKE 75 
XP_007244988   5 SVRNPPPF-LDSEdQEPEYDTrELDSD--------DGEDIFTGSGNklfaATPPETDPTTDIFseegsfTVEKNhppAKT 75 
8AFZ_A        75 NGIHEEQDqepQDLFA 90  human
2_pfamImport  60 NGVHSDDD---SDLFA 72 
3_pfamImport  62 NGLHSDDEe--QDIFA 75 
O60749        62 TEVVLDDDr--EDLFA 75  human
XP_007260836  63 QEILLDDDq--EDLFA 76 
XP_015223974  62 TEILLDDDr--EDLFA 75 
XP_007479610  76 NGVHEEPDq-eQDLFA 90 
XP_007244988  76 NGVQSDEE---LDLFA 88 
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