Conserved Protein Domain Family
Sorting_nexin

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pfam03700: Sorting_nexin 
Sorting nexin, N-terminal domain
These proteins bins to the cytoplasmic domain of plasma membrane receptors. and are involved in endocytic protein trafficking. The N-terminal domain appears to be specific to sorting nexins 1 and 2.
Statistics
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PSSM-Id: 397658
Aligned: 9 rows
Threshold Bit Score: 57.9751
Threshold Setting Gi: 611968476
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_007244988   5 SVRNPPPF-LDSE--DQEPEYDTrELDSD--------DGEDIFTGSGNKlfAATPPETDPTTDIFseegsfTVEKNhppA 73  Mexican tetra
2_pfamImport   2 SERSPPPF-PESE--DPEPEPAAgDGDSD--------EGEDIFTGLVSE--GSMSCTQKQYSCFQ------PVRMS---T 59 
3_pfamImport   2 SDRIPPPF-PDTE--EPGVCDMA-DGDRD--------EGEDIFVGGGR---GLLPYESDRAGSLF------ISSAT---A 57 
1_pfamImport   2 SDRNPPPF-PTAEesEPGLCDMA-DADSD--------DGEDIFVSNVGSrfG---DTSNKLTCVFseeeeaASSTA---A 65 
O60749         3 AEREPPPL-GDGK--PTDFEDLE--------------DGEDLFTSTVSTl-ESSPSSPEPASLPAed--isANSNG---P 59  human
XP_007260838   3 EEREPPPLaGDAA--ETGFRELE--------------EGEDLFISTVSTieQLSPTSPEPASLPAed--isTNSNG---P 61  Mexican tetra
XP_015223974   3 AEREPPPL-GDAE--QTDFREVE--------------DGEDLFVSTASTl-ESSPSSPEPASLPTed--isVNSNG---P 59  spotted gar
Q13596        11 SERLPPPF-PGLE---PESEGAAgGSEPEagd--sdtEGEDIFTGAAVV---SKHQSPKITTSLL------PINNG---S 72  human
XP_007479610  12 SERLPPPF-PIPE--PPGPEGAAgGGGSEleagdsdaEGEDIFTGAASKslSLKRGSPPPIT------------NN---S 73  gray short-tail...
XP_007244988  74 KTNGVQSDEE---LDLF-A 88  Mexican tetra
2_pfamImport  60 KTNGLHSDDEe--QDIF-A 75 
3_pfamImport  58 KYNGVHSDDD---SDLF-A 72 
1_pfamImport  66 KANGVHSDDD---NDLFaA 81 
O60749        60 KPTEVVLDDDr--EDLF-A 75  human
XP_007260838  62 K-QEILLDDDq--EDLF-A 76  Mexican tetra
XP_015223974  60 KPTEILLDDDr--EDLF-A 75  spotted gar
Q13596        73 KENGIHEEQDqepQDLF-A 90  human
XP_007479610  74 KENGVHEEPDq-eQDLF-A 90  gray short-tailed opossum
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