Conserved Protein Domain Family
MYG1_exonuc

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pfam03690: MYG1_exonuc (This model is not part of the current CDD release)
Uncharacterised protein family (UPF0160)
This entry includes MYG1 exonuclease from human and its orthologues. MYG1 is a 3'-5' exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. It is involved in regulating spatially segregated organellar RNA processing, acting as a coordinator of nucleo-mitochondrial crosstalk. In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, it processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins. Overexpression of MYG1 has been associated with the autoimmune disorder vitiligo, suggesting that MYG1 may play some role in human innate immunity. Studies in yeast suggested a potential antiviral function of MYG1.
Statistics
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PSSM-Id: 515737
Aligned: 169 rows
Threshold Bit Score: 259.363
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q4CZB7        32 VIGTHNGSFHCDEAMACGLLRCSqnFGQSNILRSRDPNALE------RCNIVVDVGSVYDEATLRFDHHQPSFHDTMKTP 105 Trypanosoma cruzi
XP_013058029  12 TIITHDGAFHLDDVLACFMLKKI--YPHANIVRTRNEDIIK------TGDIVVDVGGVFDPANFKYDHHQRGFNQTYNDN 83 
EJW03508       2 yLITHNGKFHLDEILACVILEKL--YPNSTLLRTRDRKEIKrlvdenKHVAVFDVYDQFDHSLRLYDHHQRCFNDTFSSD 79 
XP_008075638   2 KLATHNQRFHLDEVTSTAILKKI--FPDATLKRTRDPKDFE------EADIVYDVSGVYDPTRGRYDHHQRGFTHTFSEA 73 
EED43680      13 TLITHSGSFHYDELLATAFLMEL--FDDVILLRTRDPKIIK------TGTIVYDVGFEFDPANKRFDHHMKWFSEVFSED 84 
XP_007603960   2 KLVTHDGNFHYDEILATAVLLKI--YPDAEVIRTRVREVIN------TGDIVYDVGQTYDPSKYRYDHHQNTFHDTYSPQ 73 
Q8SUU4         2 ILVTHDGKFHLDEVMATAVLLKI--YPDSEIVRTRSSAVVR------SGDIVYDVGRSFDPEANRYDHHQESFNETFSPK 73  Encephalitozoon...
Q8SW07         2 KLITHNERFHYDEVLASCILLRI--YPDAEIVRTRDKTLID------SGDIVYDVGGVFDPGLGRFDHHQRTFFETFSPK 73  Encephalitozoon...
EOB13648      10 KLITHDERFHFDEVLSTAILKRI--YPNATVIRTRDNEIIK------TGDIVYDVGGIIDPSLGRFDHHMNFFTETYSDK 81 
XP_024330143   2 KLVTHDGKFHYDEVLASSILLFI--YPNAELIRTRDLVEIS------KGDIVYDVGSEFNPSTKRFDHHQHSFKETYSNK 73 
Q4CZB7       106 kaaYQTRLSSAGLVYKHFGREIIQGYvesalaspyrvklldatkwgTdkkkLSEQELDILFDIVYKNFVEHIDGIDNGVN 185 Trypanosoma cruzi
XP_013058029  84 ---YDIKMSSAGLVYKYHGMQFIKALg------------------lDv---HPDFDYLLLLGLLYETYFVSVDANDNGVD 139
EJW03508      80 ---YDVKLSSAGLIFKYYGKQFILAFfs----------------diE----LSSEILEYLYIKIYEEYFLYEDAIDNGID 136
XP_008075638  74 ---FPIKLSSAGLIYKHYHKQLFKYYg------------------lVa---E-----DWIVDEVYEEYFKYVDACDNGVD 124
EED43680      85 ---YNVKLSSAGLIYKYYHEAVFKKYg------------------lHs---NDILIFNYIKNKMYKELFLATDAIDNGIE 140
XP_007603960  74 ---YNIRLSSAGLIFKHFHDKLFERYgf----------------------trQSTIFEEIVEKVYFEFFLPADAIDNGYD 128
Q8SUU4        74 ---HKIKLSSSGLIYKYYGEKFLEKYgl----------------------nrTDECFPRVLEEVYTAYFMSADAIDNGYE 128 Encephalitozoon...
Q8SW07        74 ---YSVKLSSSGLIFKYFHRKLLSLYgi----------------------esSSRTYDLVVDKIYSEFFLYADAIDNGQD 128 Encephalitozoon...
EOB13648      82 ---YKIKLSSSGLVFKYFTEEIMETFnv---------------------kkVDDDLYDWLISKVYERYFLPADAVDNGVD 137
XP_024330143  74 ---YNFKLSSAGLIYKYFQKELFQYFei----------------------ydTHPLYERLTDKVYNEFFLGADCVDNGID 128
Q4CZB7       186 -AYGPaetegeegavpvsssspsCVKKYNVST-TLSARIGNLMP---------------WWNEe---------------- 232 Trypanosoma cruzi
XP_013058029 140 -----------------------ISDDVRYNErTLDNVIRSFVPfdipe------------------------------- 165
EJW03508     137 -----------------------VGQKYKIR--SLPDMVDNMYK------------------------------------ 155
XP_008075638 125 -LQCT------------------IVPR------TMVDLVSCFNVqetgvkedtkngqmkNEVGgattagssarvhssctv 179
EED43680     141 -ITYS------------------IKPR------TIQDIIKLFNTsyi--------------------------------- 162
XP_007603960 129 sVFGA------------------IRAR------TVADVVKNFNVys---------------------------------- 150
Q8SUU4       129 -IFGE------------------IVPR------SLSHVVESFNAl----------------------------------- 148 Encephalitozoon...
Q8SW07       129 -IYGE------------------IKPR------SIADLVNLFNVd----------------------------------- 148 Encephalitozoon...
EOB13648     138 -IYGE------------------IKPY------TIYDLVENLNNh----------------------------------- 157
XP_024330143 129 -IWNI------------------VKPR------TIYDVVNDLNVd----------------------------------- 148
Q4CZB7       233 --------gNGKVENENAAFLQAMELATSEFFDSV--HY-HVFAWMPARGIVRAAFLE--AmnvhPSG--RIVVF---KD 294 Trypanosoma cruzi
XP_013058029 166 -----gesiEYGDKVRYEAFEKAMEYIGSDLVRHC--KY-LMHQINKDKMPILQSFNQmkD----PRS--RYIIM---GS 228
EJW03508     156 ----------GSSEKSEEIFFNAKKFVRNDFYLYLnsKRkDIALISELRAIVKKTDKN------------DFFIYvgeNK 213
XP_008075638 180 plsdtlkdfVLSDNYNDYNFLCALNLISIDMDNYF--RQ-K-KQLVEMVSANHDLIRS-------ATGdiLVIGP---DR 245
EED43680     163 ------ddmDEYNVAQDSQFHKALEFVKMDLKNYL--NN-LFNNFLPGFRKAIDLLQN-------NKDpdIIVIT---DN 223
XP_007603960 151 --------eNTMTRDENLRFETALDFVSMDLDNYL--KY-VLCEYALSYEHFYNVLKD-------FAG--DIFVT---DK 207
Q8SUU4       149 --------dFSDSDRQNKRFLEAVQFVSKDLDNFI--SA-IVNRWVPSYKYLNKLIAE-------VNG--DILYV---DR 205 Encephalitozoon...
Q8SW07       149 ---------GSGRDAETEGFYEALRIVDKDLDNYM--KR--IKLWTDNYEHMENKIKE-------TSG--PILVL---DK 203 Encephalitozoon...
EOB13648     158 --------eDLVCEKQTEQFYKAVEIVSLDFENFM--TK-LLNCWYYKFIEIEKLLSN-------HDD--YILVS---DT 214
XP_024330143 149 --------nDCFSEAQTKNFYEAVKIVSDDFIRYM--YK-VKDYWLKYYSECEEKIKN-------LSG--HILQS---DK 205
Q4CZB7       295 CfCPWKEHLLELE--EEHGkvGHVLYVLFaD-----KKGWRVQAVPKEASGFENRKSLP--WRGLRDEELSQASGIEGGI 365 Trypanosoma cruzi
XP_013058029 229 GaYPAKELIQYYN--TSLN--RNVSIIIY-KirsreGTIYKLLCIPKKGIRYTPEIPLCeeWRGLRNEQMRRFPKLKKAS 303
EJW03508     214 N-CSSIIHFL--E--KKYD--RDFKFIIQ-Ke----EEQFRVYAIAITALSFKTKCPLQekWRGLRNEELQRISGIDDAL 281
XP_008075638 246 D--LSREALFILE--KIWK--KDFLFIVY-Ds----SEHVRMYGTIKERNSYAIKVPLCleWGGLREEELRARSGIEGST 314
EED43680     224 Y--ISISAIVEAE--RFTS--RDLKYMIF-Kk----NNEYRIYCFNIPEHDFQPKVPLKqeWRGKSQEELKTISQIPGIR 292
XP_007603960 208 K--VATDLLY--ElnEKLQ--KNIKFIIV-Kn----DNDFRIITIPVERGKFAIKYPLHpkWRGLSGTNLDEVSGINGCV 276
Q8SUU4       206 Y--CFVDVIPEIE--KKYK--KDVKFVLN-Rk----ESSVSILTVPKDRKRFESKVPLKkeWRGLAGGKLETVSGIDGCN 274 Encephalitozoon...
Q8SW07       204 H--YSTDLVLEIE--AQNG--KDFKFMVF-Ph----RGAYRVIAIPKHKGTFETKNPLRkeWRGLVNEELVEASGIEGCT 272 Encephalitozoon...
EOB13648     215 Y--IYPNLILDVE--RRLN--KNILFLVF-Ps----MGKYKIRAINEDKKTFKSKLPLKaeWRGKREEELKDL--IEGGF 281
XP_024330143 206 Y--YDVDLILDIE--KQYN--KDVYYLVY-Pq----NNQYRIRAINVESKTMASKLPLKeeWRGKRGKELNDL--FEGAI 272
Q4CZB7       366 FVHVSGFIGGNKTYEGALQMAVKAL 390 Trypanosoma cruzi
XP_013058029 304 FVHATGFCGSAMDLETAEYMAQKSI 328
EJW03508     282 FVHSTGFLGITKSYDNAVKMCELSy 306
XP_008075638 315 FVHSSGFTGGAKDLKSALEMCRRSI 339
EED43680     293 FVHATGFTGSVDTLDSAIMMCHESL 317
XP_007603960 277 FVHASGFTGGNSTLEGAVEMCRKSL 301
Q8SUU4       275 FVHASGFVGSNKTIEGAMEMCRISI 299 Encephalitozoon cuniculi
Q8SW07       273 FVHSSGFMGINSTLENALKMCTESL 297 Encephalitozoon cuniculi
EOB13648     282 FVHSSGFIGVNRTLEGAIKMCRETf 306
XP_024330143 273 FVHYSGFIGIHKTKEGALKMCENTI 297
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