Conserved Protein Domain Family
Glyco_hydro_79n
?
pfam03662: Glyco_hydro_79n (This model is not part of the current CDD release)
Glycosyl hydrolase family 79, N-terminal domain
Family of endo-beta-N-glucuronidase, or heparanase. Heparan sulfate proteoglycans (HSPGs) play a key role in the self- assembly, insolubility and barrier properties of basement membranes and extracellular matrices. Hence, cleavage of heparan sulfate (HS) affects the integrity and functional state of tissues and thereby fundamental normal and pathological phenomena involving cell migration and response to changes in the extracellular micro-environment. Heparanase degrades HS at specific intra-chain sites. The enzyme is synthesised as a latent approximately 65 kDa protein that is processed at the N-terminus into a highly active approximately 50 kDa form. Experimental evidence suggests that heparanase may facilitate both tumour cell invasion and neovascularization, both critical steps in cancer progression. The enzyme is also involved in cell migration associated with inflammation and autoimmunity.
Links
?
Statistics
?
PSSM-Id: 515728
Aligned: 26 rows
Threshold Bit Score: 501.408
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
EEF50783      30 VVQVTVRGLTSRASTDENFICATLDWWPDTKCDYGQCPWGQAGILNLDLENKILANAIKAFDPLRIRIGGSLQDQLVYQV 109
XP_002284470  24 DAIIKVDGATTVAETDANFICATLDWWPHDKCNYNHCPWGYSSVINMDLSHPLFAKAIEAFKHLRIRIGGSLQDQVLYDI 103
Q8L608        26 RTTLVIDGSRRIAETDENFICATLDWWPPEKCNYDQCPWGYASLINLNLASPLLAKAIQAFRTLRIRIGGSLQDQVIYDV 105 thale cress
Q9FF10        29 RASIVIQGARRVCETDENFVCATLDWWPHDKCNYDQCPWGYSSVINMDLTRPLLTKAIKAFKPLRIRIGGSLQDQVIYDV 108 thale cress
XP_002321464  24 RATISIDGTIAVAVIDDNFICATLDWWPHDKCNYNQCPWSYSSVTNLDLSHPLLAKAIQAFRNLRIRIGGSLQDQVLYDV 103
XP_006345162  24 EIVLTIDASTKVAWTDANYICATIDWWPKEKCNYKQCPWGSASIINLDLTHPYLENAIRAFKGLRLRLGGSLQDQVIYGV 103
XP_006354764  23 DTEFLIDGTVKIAETDDNYVCATLDWWPKEKCNYNECPWGSASLINLDLSHPFLANSIQAFNHLRLRLGGSLQNRIIYDV 102
EFJ22005       3 RVVLQINTTSPVARISENFICATLDWWPPEKCDYGYCSWGRASLLNLDLWNPRLVNAVKGLSPLLLRLGGSLQDQIIYEV 82 
EFJ22004       1 --tlaLDASIPVATVDEHFVCATIDWWPQGKCNYGSCSWFHSSILNLDLTNRLLAEAVTALAPLLIRLGGSLEDQIFYDV 78 
XP_040871815  24 HGSILVDGIQAIAETDDNFICATIDWWPHDKCDYNYCPWGDSSAVNLDLSHPFFAKAIQALKPLRIRVGGSLQDQVLYEV 103 soybean

EEF50783     110 G--NYIKKFPHFKRRdgDDYLFGFTRGSLPMDRWDQINALFNQTGVKLTFGLNALIGKQKskdDGSILWVGDWDPQNARD 187
XP_002284470 104 G--SLRSPCHPFRKM--NDGLFGFSKGCLRMSRWDELNRLFSQTGVILTFGLNALYGRYQ---IRKGAWAGVWDSSNTQN 176
Q8L608       106 G--DLKTPCTQFKKT--DDGLFGFSEGCLYMKRWDEVNHFFNATGAIVTFGLNALHGRNK---LNGTAWGGDWDHTNTQD 178 thale cress
Q9FF10       109 G--NLKTPCRPFQKM--NSGLFGFSKGCLHMKRWDELNSFLTATGAVVTFGLNALRGRHK---LRGKAWGGAWDHINTQD 181 thale cress
XP_002321464 104 E--SLKAPCHPFRKM--KGGLFGFSKGCLHMNRWDELNHLFSRTGAIVTFGLNALYGRHQ---IRKGVWGGAWDSSNACD 176
XP_006345162 104 G--NLKSPCSSFTQQ--KDGLFGFSRGCLPMQRWDELNNLFKKTGALVTFGLNALYGRQP---TNRHAWVGNWDSSNALD 176
XP_006354764 103 G--NLESPCHPFTKQ--GDELFGFSNGCLHMDRWDELNSFFNKTGALVTFGLNALRGRQR---TSKRVWEGNWDSSNAHD 175
EFJ22005      83 G--VRPGPCLPLQKQ--PSAMFGFTGGCLNMSRWTELNSFFEKTGALVAFGLNALYGRTK---FEDNGFKGSWKSSNARD 155
EFJ22004      79 GssATTTTCKTFTTQ---NHRFGFSTGCLNMSRWQQLNEFFQRTGSLVAFGLNALHGKER---IDNT-FQGPWNSSNARD 151
XP_040871815 104 G--SLKSPCHPFQKM--KGGLFGFSKGCLQMKRWDELNHFFDETGALVTFGLNALHGRHQ---ISHTVWGGDWDPSNAKD 176 soybean

EEF50783     188 FMKYTISKGYHIDSYELGNELCGSGVSARLDAVEYGNDVIALRKLVNELYPDP-NSRPAVLGPAGFYDQQWFNTFLMTVg 266
XP_002284470 177 FIKYTISKGYQIDSWEFGNELSGSGVGASVNAEQYGKDLINLKAIINKLYNNS-NVKPLLVAPGGFYEQDWYAKLLQVSg 255
Q8L608       179 FMNYTVSKGYAIDSWEFGNELSGSGIWASVSVELYGKDLIVLKNVIKNVYKNS-RTKPLVVAPGGFFEEQWYSELLRLSg 257 thale cress
Q9FF10       182 FLNYTVSKGYVIDSWEFGNELSGSGVGASVSAELYGKDLIVLKDVINKVYKNSwLHKPILVAPGGFYEQQWYTKLLEISg 261 thale cress
XP_002321464 177 FMNYTVLKGYKIDSWEYGNELSGSGVSASVSAELYGKDLIKLKDVVNNLYKNS-DLKPSLVAPGGFFDKQWYAKLLQVTg 255
XP_006345162 177 FIKYTVAKGYQINSWEFGNELSGSGIGASVDAAQYGKDVIQLHNLLNQVYQNT-PVRPLLLAPGGFYDPGWFGKLLQVSg 255
XP_006354764 176 FIYYTVSKGYQIHSWEFGNELSGKGIGAKVDAEQYGEDVIHLNNLIDQLYKHF-QPRPLLLAPGGFYDKEWFETFLEVSg 254
EFJ22005     156 LMKFSLDHGFPIVAWELGNELSGSGVGTSISAKQYAADIKELRSVVDQVYARS-TIKPQVVAPDGFWDYGWFHDFLQSTg 234
EFJ22004     152 FIAYTASKRYPIKAWGLGNELSSSFSGVTLDSRNYAADVDELQQIIDEIYGT--GQKPVLVAPDGFFYAYWYSQVLQQTr 229
XP_040871815 177 FINYTISKGYKIDSWEFGNELSGKGIGARVGAAQYGKDLIKLKEILRTLYKNS-TFKPSLVAPGGFYNKEWFDKLLQVTg 255 soybean

EEF50783     267 PN-VVDGVTHHIYNLGAGVDKALINKIQDPYFLDQIAQTFKDVSDSVRQFGPWSGPWVGESGGAYNSGGKDVSHTFANGF 345
XP_002284470 256 SS-TVNVVTHHIYNLGAGVDPNLVSKILNPHYLSRVEETFKSLDKTLQTWGPWASAWVGESGGAYNSGGHLVSNTFVNSF 334
Q8L608       258 PG-VLDVLTHHIYNLGPGNDPKLVNKILDPNYLSGISELFANVNQTIQEHGPWAAAWVGEAGGAFNSGGRQVSETFINSF 336 thale cress
Q9FF10       262 PS-VVDVVTHHIYNLGSGNDPALVKKIMDPSYLSQVSKTFKDVNQTIQEHGPWASPWVGESGGAYNSGGRHVSDTFIDSF 340 thale cress
XP_002321464 256 SG-IVNFVTHHIYNLGAGMDPNLVNKILDPHYLSKVSETFSNLSQTIQQNGPWASAWVGESGGAYNSGGRHVSDTFVNSF 334
XP_006345162 256 RG-TVNVLTHHIYNLGPGSDSKLVDKILNPEYLSRTEGTFSSLTQTILRNGPWASAWVGESGGAFNSGGPDVSNAFVDSF 334
XP_006354764 255 PG-TVDALTHHIYNLGPGSDLNLVNKILNPLHLNKIADTFSNLIQTIEINGPWTSAWVGESGGAFNNGGPNVSNTFVNSF 333
EFJ22005     235 PN-VVNACSHHIYNLGPGVDTHLIEKIVSPSYLSQEAGTFEGVEKLMKAYG--TEAWVGEAGGAYNSGHHNVTDRYVFSF 311
EFJ22004     230 TDpALRAVSFHVYDLGPGDGKNIAARILSAAHTDR----YQQVQRVLRQYGNGAKAWVGEAGGIYNGGQHLVSDAFVFSF 305
XP_040871815 256 PG-IVNVLTHHVYNLGPGSDEHLDRKILDPECLSKVESIFSNLSETIQKYGPWSSAWVGEAGGAFNSGGRSVSNTFVNSF 334 soybean

EEF50783     346 WYLDQLG 352
XP_002284470 335 WYLDQLG 341
Q8L608       337 WYLDQLG 343 thale cress
Q9FF10       341 WYLDQLG 347 thale cress
XP_002321464 335 WYLDQLG 341
XP_006345162 335 WYLDQLG 341
XP_006354764 334 WYLDQLG 340
EFJ22005     312 WYLDELG 318
EFJ22004     306 WYLDQLG 312
XP_040871815 335 WYLDQLG 341 soybean
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap