Conserved Protein Domain Family
TMEM33_Pom33

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pfam03661: TMEM33_Pom33 (This model is not part of the current CDD release)
Transmembrane protein 33/Nucleoporin POM33
This is an integral membrane protein family. Family members include TMEM33/Pom33 proteins. Budding yeast Pom33 is a transmembrane nucleoporin that contributes to proper distribution and/or efficient assembly of nuclear pores. Proteins in this entry also include Tts1 from fission yeasts, Kr-h2 (krueppel homologue 2) from flies and TMEM33 from vertebrates. Tts1 is required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator. Kr-h2 is a member of the dosage-dependent hierarchy effective upon white gene expression. TMEM33 regulates the tubular structure of endoplasmic reticulum by suppressing the membrane-shaping activity of reticulons.
Statistics
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PSSM-Id: 515727
Aligned: 19 rows
Threshold Bit Score: 196.347
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_018651118  12 QQQNTLLSRLKSDYINTAMYFARLGTLFCCVVFFFaPIFSRshPSDlevWYRRALLASAATSALRLHQRIkSLNtGFSRE 91 
EFX72489       8 TGFGVLTAHIGRNKIDFALWCTRFATIVFTFNYLI-PIFGS--GYN---MYYKALLANSATSALRLHQRL-PQV-QLSRE 79 
Q9XWV0        33 PAYSSISQYVSANTMECVLFAARVLTVFFALNYMI-PFIGLvpAHS---AYYKIFAASAATFALRLHTRIqGQF-ALNAQ 107 Caenorhabditis ...
1_pfamImport   4 QTYSSISQYVSAHTMECVMFAARVLTVFFALNYMI-PFIGFipPHS---AYYKLFTASAATFALRLHTRIqGRL-ALNAQ 78 
XP_004348619 121 AARRSLVQFAIANKLQLIAWIANLLCLINVLAFIV-PIGMDpsPIS----YYKVFRRGAVAYIVMLYQRH--GL-VFSRN 192
4_pfamImport   4 TSLKSFLIGSKINMFQLFQFALRSLLLLYFVSFWI-PVLLS--SYVayvNFFKVALINHASYLAFIHG----VP-RWSAM 75 
XP_007407318  14 SSK-------RMSYMHLAWSLGHILVLLSTIWTFLgALFFKsrSTS----YYIACSGAILSWSIVVYKSL-GIP-SFSRA 80 
EEC16272      15 RGFSEVINHLSIHKIESLLWFTRMCTVVFTLLYII-PILGAn-PYT---CYQRALISNAATSALRLHQRM-PTI-QLSRM 87 
Q803C2        14 PPQAGAAQFLLSNKLETAMWLSRLFTVYCSIMFIL-PLLGPqaAAN---FYQRALLANALTSALRLHQRL-PHF-QLSRA 87  zebrafish
XP_036764477   9 pQGAGAVQFMMANKLDTAMWLSRLFTVYCSALFVL-PLLGLheAAS---FYQRALLANALTSALRLHQRL-PHF-QLSRA 82  Chinese pangolin
XP_018651118  92 VLEVLISEDSSHYLLFSIMFAVLPPVTVSLVPIFLFALLHVASFTRVLLNasvslnsggtsdgsdapVGSSNMS--CVHH 169
EFX72489      80 FLGKVFLEDSAHYLLYSMIFFYSPPVTWVLLPVFLFALLHISSYSLGLIE-----------------ILGPTAL--GVVR 140
Q9XWV0       108 FIQRLIIEDSFHYLVYSVVFLMAAPVSMAALPVTIYAALHACTFMTKILR-----------------ETGHTSS--IIPK 168 Caenorhabditis ...
1_pfamImport  79 FLQTLVVEDAFHYLIYSVVFLMAAPVSMAALPVTIYAALHSSTFFVKIMR-----------------STGHNLP--LLQK 139
XP_004348619 193 YLNSIIPDENFAYIMYCVVFSFADVHAAAVLPMAIFALYGFATFTPNVASail------------pqNLRSTIV--PRIR 258
4_pfamImport  76 YAERLFLDPATQALFFCLVFFFSPPYSLAMVPVFLQDMVHYSTYLQSLLQ-----------------VLGLADTk----- 133
XP_007407318  81 YFQRAAMDENVQYLAVALYWFFSKPIYVTLLPFAIFSTFHSLTFVRTSLLpkipspkkdatgastssGTGSEGPqqVAIA 160
EEC16272      88 FLSQLLIEDSCHYLFFSLIFLFAQPMTLVLLPVFLFALLHSASFTLTLLD-----------------KFGGRSG--FLGT 148
Q803C2        88 FLAQALQEDSCHYLLYSLILVNSYPITMSIFPVFLFSLLHATTYTKKVLD-----------------TMGPNSL--MFVR 148 zebrafish
XP_036764477  83 FLAQALLEDSCHYLLYSLIFVNSYPVTMSIFPVLLFSLLHAATYTKKVLD-----------------AKGSNSL--PLLR 143 Chinese pangolin
XP_018651118 170 ILqklIVKVNAHDQN---IL------------------------RIIALNEI-MLMVICIFMAVSGPRIFILPFI-YYPF 220
EFX72489     141 MA---IGIVEVQSVK---LL------------------------KTIALSEI-FLFPLLILSLFGGRATLMTLFV-YYRF 188
Q9XWV0       169 LE----QFTAHQTQN---AL------------------------GIIACSEI-FLVPLLVSLIFSGKGSLLLPFA-YYRF 215 Caenorhabditis ...
1_pfamImport 140 IE----QFNTAQTQN---AL------------------------GIIACSEI-FLVPLLVSLIFSGKGTLLLPFA-YYRF 186
XP_004348619 259 GLvarLTAVGDQAKI------------------------------AAARLEL-ILVPILFIGLFSGE---FLPLIsYANF 304
4_pfamImport 134 ----vVTLVASKALVpltALiirdpsfptlatsakwvklysripQVAANIDL-AIGFAMIVELLLPSRNFLLLVL-YWQV 207
XP_007407318 161 VSrsiQNWVKQNYES---AM------------------------YLVAIIEVvVIQGRVTVGALLFQNSFLHPLF-FAHF 212
EEC16272     149 WL---VLLLEHQSNN---IL------------------------RLVAFTEI-FLMPLTIFSLLSGRSSLVTPFV-YYRF 196
Q803C2       149 NF---LNKLTSNQQN---IL------------------------KFIACNEI-FLMPATVFMLFSGQGSLLQPFI-YYRF 196 zebrafish
XP_036764477 144 SM---LDKLSANQQN---IL------------------------KFIACNEI-FLMPATVFMLFSGQGSLLQPFI-YYRF 191 Chinese pangolin
XP_018651118 221 LKMRYNSRRNPYTRNAFSELRVALQNVAYHTKCPALISRIIYGLINIVSRLGTS 274
EFX72489     189 LTLRYSSRRNPYTRNTFGELRLLVESYAQNPSCPAVIRNLVSKLVSFISRLAPP 242
Q9XWV0       216 LSLRYASRRNPSTRQAFAQMRGSLQNVAMSSSCPRPISSLIYRAIDFISARAPP 269 Caenorhabditis elegans
1_pfamImport 187 LSLRYASRRNPSTRQAFYQMRVSLENVAQSTSCPGPVRGFIHRAIGFISSRAPP 240
XP_004348619 305 LNLRYV--QSAHTRRLLSDLKILGFQLTGHPRCPPIIGAAFVKLVGLLERMDPN 356
4_pfamImport 208 MRVRYM--ISPQLQEAFRSLHASIFTIVNHPRCPAVIPSIYEKIRAFVAKTG-- 257
XP_007407318 213 LRLRFY--LSPQTRAALSAVNTTIDHYLNHPSCPGAAKTGVNVVRNLIIQYads 264
EEC16272     197 LSLRYASRRSPYSRTVFHELRLVTEHYASRPGCPAFLSRLLYKTIGLICQLSPP 250
Q803C2       197 LTLRYSSRRNPYCRTLFTELRILLEHFVMKPSCPVFFRRMCLNSIAFVSRLAPT 250 zebrafish
XP_036764477 192 LTLRYSSRRNPYCRTLFNELRIVVEHVIMKPACPLFLRRLCLQSIAFISRLAPT 245 Chinese pangolin
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