Conserved Protein Domain Family
Glyco_hydro_81

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pfam03639: Glyco_hydro_81 
Glycosyl hydrolase family 81
Family of eukaryotic beta-1,3-glucanases. Within the Aspergillus fumigatus protein ENGL1, two perfectly conserved Glu residues (E550 or E554) have been proposed as putative nucleophiles of the active site of the Engl1 endoglucanase, while the proton donor would be D475. The endo-beta-1,3-glucanase activity is essential for efficient spore release.
Statistics
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PSSM-Id: 397619
Aligned: 92 rows
Threshold Bit Score: 168.955
Threshold Setting Gi: 548846625
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EPE09474      24 HPEE-PKG--INrhATPGPIQTNKFYANLLLGGQELPAYVIPYTVSW-NKGrgpthgwGLAVSYATPeqrvfgptdgacn 99  Ophiostoma pice...
Q6H5B5        27 DPARfFAPalLS-----SPLPTNSFFQNFVLKNGDQPEYIHPYSVRS-AAA-------ALTLCYPAR------------- 80  Japanese rice
XP_002436404  31 DPSRfFAPalLA-----APLPTNSFFQNFVLKDGDMPEYIHPYSIRSpGAG-------ALDVCYPSR------------- 85  sorghum
XP_004956715  86 DPSRfFAPplLA-----APLPTNSFFQNFVLKNGDQPEYFHPYSIRSpGGA-------ALDVCYPTR------------- 140 foxtail millet
XP_003555070  76 EPSNfFSSnlVS-----NPLPTNSFFQNFVLKNGDQPEYIHPYLIKS-SNS-------CLSLSYPSR------------- 129 soybean
XP_002282971  80 DPSPfFSPdlLT-----APLPTNSFFQNFVLKHGDQPEYIHPYLIKS-SSS-------SLSLSYPSQ------------- 133 wine grape
Q9LFT3        67 DPSRfFSHdlLS-----SPLPTNSFFQNFTLNNGDQAEYFHPYIIKP-STS-------SLSISYPSL------------- 120 thale cress
XP_002305966  75 DPSLfLSPslLS-----SPLPTSSFFQNFTLKNGDQPEYIHPYLIKS-SLS-------SLSVSYPSQ------------- 128 black cottonwood
XP_006338286  61 EPSDyFSSqlVS-----TPLPTNSFFQNFVLKNGDQPEYIQPYLIRS-ANS-------SISISYPSQ------------- 114 potato
1_pfamImport   1 NPKL----------LADVPFPTGAWWTNLVLAEGKSAIASLPYVFKIlSEK--------LHVSYPFR------------- 49 
EPE09474     100 hpsrpasyYYSPPI-----IQNMVLDAAELmGSQTT----LTVEQPRDMSLMVNLHaapGL-PPTIRFPIVQGQGFVTGL 169 Ophiostoma pice...
Q6H5B5        81 --------NHSPSFviqtfVEDLTVSAASD-AAAAAagqrHRVAAFDDLSVTLDV-------SPSLRAFLVRGCPFVTVA 144 Japanese rice
XP_002436404  86 --------IHSASSitqafVADLTVSDASA-GAGTGtaqrHVVSAFDDLSVTLDV-------SPSLRAHLVRGCPYVTLA 149 sorghum
XP_004956715 141 --------NHSPSFviqtfVPDLTISDAAGsa------qrHRISAFDDLSVTLDV-------SPSLRAHLVRGCPYVTVV 199 foxtail millet
XP_003555070 130 --------FMNPSFiyqvfNPDLTISSSQK--SHPsh-lnHTISSHNDLSVTLDIP------SSNLRFFLVRGSPFLTLS 192 soybean
XP_002282971 134 --------FLTSVFiyqifNPDLTISASNK--TDPDsqrrHIVSSFSDLSVTLDLP------SSNLRFFLVRGSPFLTCA 197 wine grape
Q9LFT3       121 --------SHNSAFiyeafNADITITGSDG--PDPHsrksHLISSFSDLGVTLDFP------SSNLRFFLVRGSPFITFS 184 thale cress
XP_002305966 129 --------SHNSSFiyqvfVVDLTISATNK--TDPNpgksHVISSYSDLSVTLDMP------SSNFRFFLVRGSPFLTCL 192 black cottonwood
XP_006338286 115 --------NISSDFieqifRPDLTISASKN----PKpnqrHVISSYSDLSVTLDLP------SSNLRFFLVRGSPYLTFA 176 potato
1_pfamImport  50 --------VVTPTDivegfIAQMVFSSQP--SGLSSlpmaHHVVDFDDFSTTVRFS---QGqTEAFRVFLVRGSPYITME 116
EPE09474     170 ---YH-GAMPVLRSATAIKSFahy-dmPTKTSSGS-W------V--RRFALQLGDSSTWLVYARnlpRTPNLELvHdehN 235 Ophiostoma pice...
Q6H5B5       145 tadAA-GPVD-----ISVASV------HAFIEVAScD------DalTKWRLRMNSGQTFLLYAs---APIRLAQ-----S 198 Japanese rice
XP_002436404 150 t-tAA-GPID-----ISVASV------HAFVEVGAtSchchhgSsgTKWRLRMDSGQTFLLYAs---APIHLTQ-----A 208 sorghum
XP_004956715 200 ---TTaGPVD-----VSVASV------HAFIEVAPcD------DdgTKWRLRMNSGQTFLLYAs---APIRLEQ-----A 251 foxtail millet
XP_003555070 193 ---VT-QPTP-----LSITTI------HAILSFTS-S------EslTKHTFHLNNGQTWFLYAs---SPIRLSH-----G 242 soybean
XP_002282971 198 ---VS-GGTA-----LSITTI------HAILSFSP-S------SsrTKYTIKLNNGQTWLLYTs---SAINLTH-----D 247 wine grape
Q9LFT3       185 ---V---NSS-----ITISTI------HAVLSLSG-N------TssTKYTVKLNNNQTWLIYAs---SPINLTK-D---G 233 thale cress
XP_002305966 193 ---IT-GNTE-----ITISTI------HAILSFSS-S------NslTKYTVKLNNNQTWLIYSs---SPINLSH-----D 242 black cottonwood
XP_006338286 177 ---VN-GNTS-----ISISTV------DPILKLSC-D------SsfTKYTIRLRNRQTWILYAs---APIHLTD-----N 226 potato
1_pfamImport 117 ---FR-HSRPLIEAMDGLQIVhfkrllGLKLMNGD-E------VpfATFAAELNNGQTWYVYASd--STLELQL-N---R 179
EPE09474     236 GAIVRMQRPFYGSVQVARMInsgNPQEW--QAYD--------SAAGVFATGIQLKGkTSYEGkT-----GNYTFVFEKGd 300 Ophiostoma pice...
Q6H5B5       199 SVTQLSAPGFSGVIRVAYLP-----DPSmeAVLD--------QYSRCFP---------TAGEaSl---nRPFCVEYTWRk 253 Japanese rice
XP_002436404 209 TATQLSAPAFAGAIRVAYLP-----DASmePVLD--------RYSRCYP---------TAGHaTlnpndRPFSVDYSWRk 266 sorghum
XP_004956715 252 GTTQLSAPRFAGAIRVAYLP-----DASmePVLD--------RHSGCFP---------TAGDaAl---nRAFCVDYAWRk 306 foxtail millet
XP_003555070 243 LSEIT-SDAFSGIIRIALLP---GSDWKheAVLD--------RFSSCYP---------VSGEaVf---aRPFCVEYKWEk 298 soybean
XP_002282971 248 ISSIT-SDAYSGIIRIAILP---DSNPRfeSILD--------RFSSCYP---------ISGKaEl---sKPFCLEYRWDk 303 wine grape
Q9LFT3       234 VSSINCGDGFSGIIRIVVLP---NPNPYfeTILD--------GFSCSYP---------VSGDaDf---tKPFALEYKWEk 290 thale cress
XP_002305966 243 LSSIT-SEGFSGIIRIAVLP---DSDPKyeAILD--------RFSSCYP---------ISGDaSf---tKPFCLEYRWEk 298 black cottonwood
XP_006338286 227 VSTIK-SGGFSGVIRIALLA---DSDSQfeKILD--------KCSSTYP---------VSGSaIl----GSFALKYKWDv 281 potato
1_pfamImport 180 NRQLTTDMEFTGVLRVAL-------------CLDailwphllESASVYAVGGEVVH-SMDPQdPe---kALLDFQWKTR- 241
EPE09474     301 vagePEFm----------ARt-pLLMFALPHHYSAFG----------RTTQAAMQsYVALLTtTKGLARAVLADSWTMEE 359 Ophiostoma pice...
Q6H5B5       254 ------------------QGwgdLLMLAHPLHLRLLS----------EDCCVRVLdDFRYRS-IDGDMVGVVGDSWVLRT 304 Japanese rice
XP_002436404 267 ------------------EGhgeLLMLAHPLHLRLLAlaaaanddddENRAVRVLdGFRYRS-IDGDMVGVVGNSWALRA 327 sorghum
XP_004956715 307 ------------------EGpgeLLMLAHPLHLRLLS----------DDCAVRVLdDFRYRS-IDGDLVGVVGDAWSLRA 357 foxtail millet
XP_003555070 299 ------------------RGwgdLLMLAHPLHIQLLAd--------sGSEDVSVLsDFKYGS-IDGELVGVVGDSWLLKT 351 soybean
XP_002282971 304 ------------------KGwgdLLMLAHPLHLRLLS----------ADDEVAVLdDFKFNS-IDGELVGVVGDSWKLKL 354 wine grape
Q9LFT3       291 ------------------RGygdLLMLAHPLHLKLLSt---------NDCSITVLdNFKYNS-IDGDLVGVIGDSWVLKP 342 thale cress
XP_002305966 299 ------------------KGwgdLLMLAHPLHLRLLSs---------KDSDVTVLdDFKYNS-IDGELVGVVGDSWVLKT 350 black cottonwood
XP_006338286 282 ------------------KGagkLLMLAHPLHLRLLSk---------ADASVTVLeDVKYSS-MDGELVGVIGDTWDLEA 333 potato
1_pfamImport 242 ----SFStfhgqtdevtaEEndkLLMLTLPHHLDVMQvqkg--agtlKEGKNRLLpKLKYIC-IRGPMQGIFGAVWHMEE 314
EPE09474     360 PELPADvgflpWNP 373 Ophiostoma piceae UAMH 11346
Q6H5B5       305 DPVSPT-----WHS 313 Japanese rice
XP_002436404 328 DPVLPT-----WHS 336 sorghum
XP_004956715 358 DPVSPT-----WHS 366 foxtail millet
XP_003555070 352 DPVSVT-----WHS 360 soybean
XP_002282971 355 DPVSIT-----WNS 363 wine grape
Q9LFT3       343 DPVSVT-----WHS 351 thale cress
XP_002305966 351 DPVSVT-----WHS 359 black cottonwood
XP_006338286 334 ESIPVS-----WHS 342 potato
1_pfamImport 315 TLTPVE-----WNY 323
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