6MCP,6MCP,6MCQ,7K36


Conserved Protein Domain Family
Mob1_phocein
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pfam03637: Mob1_phocein (This model is not part of the current CDD release)
Mob1/phocein family
Mob1 is an essential Saccharomyces cerevisiae protein, identified from a two-hybrid screen, that binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Mob1 contains no known structural motifs; however MOB1 is a member of a conserved gene family and shares sequence similarity with a nonessential yeast gene, MOB2. Mob1 is a phosphoprotein in vivo and a substrate for the Mps1p kinase in vitro. Conditional alleles of MOB1 cause a late nuclear division arrest at restrictive temperature. This family also includes phocein, a rat protein that by yeast two hybrid interacts with striatin.
Links
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Statistics
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PSSM-Id: 515712
Aligned: 130 rows
Threshold Bit Score: 135.366
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6MCP_B         4 EATLGSG-NLRQAVMLPEGEDLNEWIAVNTVDFFNQINMLYGTi--tEFCteaSCPVMSAgpRYEYH---WADGtniKKP 77  human
XP_001323220  36 ALLKKYPnDIDRLVKCPEKLDKNSWIYASFRQFLKEINY-FAYehrfV-StaeTMPKMQFtiNGNFVecrSAAKn-pPAP 112
A0BPC0        36 ELIRADSsNIKQIITPPPEVDIHVWQYEHLRQFILELNL-LVTqlkgL-CtaqTCPKMKAteDWLYL---CAAHk-kAQE 109 Paramecium tetr...
XP_011406147  41 QLIRKDYkDVEAILDPPPVQDEASWKYEHLRQFCNELNS-LTVclleE-CdplVCKQMTAteQWIFL---CAAHr-qPKE 114
XP_015790436  43 QSIKRDPsNIDEILKPPEGQDEGTWKYEHLRQFCMDLNK-LAVklqtE-ClpsACVQMTAteQWIFL---CAAHk-tPKE 116
P34349        45 QTIKANPaDVATILTPPLDQDEGVWKYEHLRQFCIELNG-LALllqrE-CipeTCQQMTAteQWIFL---CAAHk-nPNE 118 Caenorhabditis ...
XP_020301250  46 QCIHKDPsDVDTILKVPPGQEEGVWKYEHVRQFCMQLNG-LTLllqdE-CkpdVCMQMTAteQWIFL---CAAHk-nPKE 119
EPB89947      46 QLIRLDYsDVQRIIELPENVDDEVWQYEHLRQVCLELSL-LVValetD-CtkqHCPEMKAd-GWLYL---CAAHp-sTQS 118
XP_025178038  71 SLIRANReNIDALVELPAGQDKETWQYEHLRQLCLELNY-LVIqleaE-CtsqTCPEMKAd-DWQYL---CAAHq-aPLN 143
7K36_H        45 qniradcsNIDKILEPPEGQDEGVWKYEHLRQFCLELNGLAVKl--qSEChpdTCTQMTAteQWIFL---CAAHk-tPKE 118 human

6MCP_B        78 ikCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQ------EEAHLN 151 human
XP_001323220 113 --VPAIDYITQTVDMATVAILDQTKFPSGV--I-NPDGLNLIMTYMRRLYRVFSYSYICHREVFDELE------EKTHLC 181
A0BPC0       110 --CSAIDYMIHNLDQSTSILTNIKTYPSRV-SINPQNATNNFAFIVRRLYRLFSHTYFNHKEIFEDFE------NEMFLC 180 Paramecium tetr...
XP_011406147 115 --CSALDYTLHTLHGAASLLNSNKHFPSRV-SI-KENSAQKLSSVARRIYRIFSHAYCHHRTLFNDFE------EKTYLC 184
XP_015790436 117 --CPAIDYTRHTLDGASCLLNNTKYFPSRV-TM-KESSVSKLGSVCRRVYRIFGHAYFHHRSIFDEFE------NSSHLC 186
P34349       119 --CPAIDYTRHTLDGAATLLNSNKYFPSRV-NI-KEISISKLGSVARRVYRIFSHAFFHHRKLFDEFE------NETHLC 188 Caenorhabditis ...
XP_020301250 120 --CSAIDYTRHTLDGAAALLNSNKYFPSRI-SI-KESSIAKIGSVCRRIYRIFSHAYFHHPELFENFE------TETHLC 189
EPB89947     119 --CPAIDYIIHTLDGATILLNNSKYFPSRI-SV-PEPSLKHFQSIARRLYRIFAHAYFHHREIYESFEasleflNETYLY 194
XP_025178038 144 --CCAIDYIVHTLDGATTLLNSHKYFPSRI-SI-PETSLKHYQSIARRLYRIFAHTWFHHREIFEAFE------NENMLY 213
7K36_H       119 --CPAIDYTRHTLDGAACLLNSNKYFPSRVSIK--ESSVAKLGSVCRRIYRIFSHAYFHHRQIFDEYE------NETFLC 188 human

6MCP_B       152 TSfkhFIFFVQEFNLIDRRELA-PL 175 human
XP_001323220 182 ER---FTRFAREFNLIQAQDIHiPD 203
A0BPC0       181 TR---FTEFALKFDLMSPKLIT-Ip 201 Paramecium tetraurelia
XP_011406147 185 KR---FTRYVIKYDLMTTDNLIvPL 206
XP_015790436 187 KR---FTIFVTKYNLMSKEHLIvPI 208
P34349       189 KR---FTTYVSKYNLMQQEHLIvPI 210 Caenorhabditis elegans
XP_020301250 190 RR---FTVFVKKYNLMANEHLIvPI 211
EPB89947     195 AR---FLLLSQTYGLIPPSLVSipd 216
XP_025178038 214 AR---FLKLSDRYELIAKNLLIiPY 235
7K36_H       189 HR---FTKFVMKYNLMSKDNLIvpi 210 human
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