Conserved Protein Domain Family
Virul_fac_BrkB

?
pfam03631: Virul_fac_BrkB 
Virulence factor BrkB
This family acts as a virulence factor. In Bordetella pertussis, BrkB is essential for resistance to complement-dependent killing by serum. This family was originally predicted to be ribonuclease BN, but this prediction has since been shown to be incorrect.
Statistics
?
PSSM-Id: 486518
Aligned: 79 rows
Threshold Bit Score: 72.6584
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Q7USG3         30 SKDRCSTLAAALAYYTAFALPPLLYLMMTVLtfslsvmydseqATEKAQGILQTQASQMi--------GNp-------AA 94  Pirellula sp.
WP_011321826   20 RSDRITFLAASLAYYGLVSLVPLLVLALVAAsv---------vGEGQLIEALVVAVGDA---------LGe------qAG 75  Natronomonas p...
P37642         62 ndrLGNQFGAAITYFSFLSMIPILMVSFAAGgfv-------laSHPMLLQDIFDKILQN---------ISdp-----tLA 120 Escherichia co...
Q4JTJ2         48 TEQGGNQYAAGITYFSVMTIFPLMMLTLAVLamila---gnerLLNDVMDKVANMgd--------------------gNM 104 Corynebacteriu...
WP_010907877   31 dERNGSFFAAGLTYYTIFALFPMLMVSFSVVglv-------lfRRPELLTTIDDHIRSA---------VSs------qLG 88  Mycobacterium ...
Q5Z1A9         32 QRQRGDYFAAGITYFTVLSLFPLLMVAFAIAgfvla---gnqdLFTELQNKIVEN-------------IPg-------EF 88  Nocardia farci...
Q9KZA0         41 DRVKWSRLAAAMTFTSFVALFPLLSLAAAVAaa---------tLNKQQQDKLQDKLAEQ---------IP---------- 92  Streptomyces c...
2_pfamImport    1 GEARGNVLAGGIAYFAFFSIFPALAVGLTVLglvmr---ntpeVRDVVVDNLIAGVNQYapdlvhrgvKPan-----gTG 72 
jgi:Arth_1124  46 NLQHGPLMAAGIGFRMFFSITGLLATGLSLAglvls---gqpaLLDQVIKSIAKA-------------APglmkvdggEG 109
Q0RRI5         40 TADGGDRLAASATYFAFLSFFPIVALAFAVTgfvvd---aypdVQDSLTKQINDY-------------LP---------- 93  Frankia alni A...
Q7USG3         95 vEQIETIM-E-NHEQTSgkwWKTLLSFAGILvGATGVVSALQAALNQ----VWEVkpDP-EnSgikdMIAKRFLSFGMIL 167 Pirellula sp.
WP_011321826   76 -DVLGDAL-T-GAAGRG---GATLLGLAVFLwSGLKLFRGLDIAFSE----VYGT--AG-PeS----LLSGIRNA----V 134 Natronomonas p...
P37642        121 -ATLKNTInT-AVQQRT---TVGLVGLAVALySGINWMGNLREAIRAqsrdVWERspQD-QeK----FWVKYLRDFISLI 190 Escherichia co...
Q4JTJ2        105 gGVLQTIIeQ-SIEQRK---SVFSIGLLLALwTGLGWMAHLRLGVSE----MWKVdgKPaG------FVSGKVKDLIGLI 170 Corynebacteriu...
WP_010907877   89 -QELVDLMnR-AIDARA---SVGVVGLATAAwAGLCWMSHFRAALTK----MWWEhhID-PsS----LLRNKLSDLLAMV 154 Mycobacterium ...
Q5Z1A9         89 gTQVNDLVdQ-AVESRG---TVGVLGLITGLwTGLGWMANLRAALTE----QWEGkhEDgN------WFLTKLSDLGALV 154 Nocardia farci...
Q9KZA0         93 --GISDQLnIqGLVDNAg--TVGVISALLLLfTGMGWIEATRGCLRA----VWELpdEDeN------PVLHRAKDAGVLV 158 Streptomyces c...
2_pfamImport   73 -IYIDEFIqGtALT------WSLVVSTATFLfTGLGWMDGMRESIRA----VFGDppGGgN------LVVVRLRDLLGML 135
jgi:Arth_1124 110 lVDPYQLLnPsGLG------WAAVIAAAVTVfTALGWISGIRDGVRG----MMQLgpRGmN------PVLQILRDAGILL 173
Q0RRI5         94 --GLADRLdVtSIGNAKv--GVGIVGLLGLLlAGLAWIDALRDALRL----IWHQdiDVgN------IIMRRLRDITVLA 159 Frankia alni A...
Q7USG3        168 GLGFLLLVSLVVSSVLTA--LGDQvggwigMSETV----------AHLANFAVQALVV-FVIFASIFKFMPDAITKWRDV 234 Pirellula sp.
WP_011321826  135 VTLGAVGLGVTATVAA-----GAAi----aVLGVDaave-----gvaLVGTLGLFVAL-TVAFLPLYYFLPGTDVSLSEA 199 Natronomonas p...
P37642        191 GLLIALIVTLSITSVAGSaqQMI-------ISALHlnsiewlkptWRLIGLAISIFAN-YLLFFWIFWRLPRHRPRKKAL 262 Escherichia co...
Q4JTJ2        171 GLLVSLIAAFAITTIGNSglTTQL------LDAVGladvpgiryiTFAVALLVALIAN-FCVFFWMILYLPRTKVPRRSA 243 Corynebacteriu...
WP_010907877  155 GTFVVFLTTLALTVLSHQapMAAIl----rCIGIThffv--fgviFQGASVLVSTLVS-WLLFTWMIAWLPRKSVNLVAS 227 Mycobacterium ...
Q5Z1A9        155 GLGVALVLSLGLSAVGSSdlGERV------LDGLGlggvpgarllLTAVSILLALVAS-WAVFAWIIARLPREPVTLASA 227 Nocardia farci...
Q9KZA0        159 GLGGALLITVGISTVASAlvGWI-------IRTIGlaqggvggvlLYVAAF-AVAVLAdFLLLLYVLTLLPGVQPERRRL 230 Streptomyces c...
2_pfamImport  136 VVGSGVALSVASVVVTNGagGYL-------LSALGfepstwsrwlLGAAGFLVAFAID-TCTFLLVFRVLPNADVPLHDL 207
jgi:Arth_1124 174 LLGVALVLSAAASLIFGTaaGWV-------TEQLQldpvmawpltTAIKVG-VPLALG-WVTALIMFRLAAGLKLSRQAL 244
Q0RRI5        160 GLGLTLLASLVVTSLSTSatGTF-------LDWIGlsgstaaawvTGILALLVALAID-TAVFLYLFWRLPG-QTDRSRS 230 Frankia alni A...
Q7USG3        235 AVGAAVTTILFLVGRYA---MQ-LYFSM-SEPGAQLGaAAASLAVLLVWVYYTAMIVLLGAEATQVYAVRY 300 Pirellula sp.
WP_011321826  200 VPGAAFAAIGWTALQTG---FR-IY-AGaTDAYAAYG-ILGGVLLLVTFLYLGALVLLLGAVLNAVLAGRS 264 Natronomonas pharaonis
P37642        263 IRGTFLAAIGFEVIKIV---MT-YTLPSlM--KSPSGaAFGSVLGLMAFFYFFARLTLFCAAWIATAEYkd 327 Escherichia coli K-12
Q4JTJ2        244 VKAAIIGAVLFEVFKQF---AT-VFFSNaL--SNPAGaAFGPVIGVMVLMYFIWRILLYCSAWAATTPESL 308 Corynebacterium jeikeiu...
WP_010907877  228 MRGGLIAAVGFELFKQV---GS-IYLQIvL--RSPAGsVFGPVLGVMVFSYFTAYLVLFAASWAATAElcm 292 Mycobacterium leprae
Q5Z1A9        228 AKAALLAALIFEVFKFV---AS-IYLRTvL--RSPAGaTFGSIIGLMVFSYVTYRIILFATAWAATAEENR 292 Nocardia farcinica
Q9KZA0        231 VVAALIGAVGFELLKLL---LS-GYIQGvAa-KSMYG-AFGVPVALLLWINFTAKLVLFCASWTATGSKAQ 295 Streptomyces coelicolor
2_pfamImport  208 LQGAVLGGIGLGLLKQFgtaFA--RRSAeG--NAFLG-AAATLVVLLVLMNLISRLILLAAAWAATRAEDS 273
jgi:Arth_1124 245 LEGTILSAVGTTVLQIF---STeLLASAgR--NPILA-PFAIIIGLLIWFNLVSQVYLVSAAWSAVREEDL 309
Q0RRI5        231 ARGAVLGAVGLEILKVV---GTwLIGKTtG--NPVYG-TFAVIVGLLIWINIVMRWTLFAAAWTVTAPYAS 295 Frankia alni ACN14a
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap