2I7N,2I7P,7T1G


Conserved Protein Domain Family
Fumble
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pfam03630: Fumble (This model is not part of the current CDD release)
Fumble
Fumble is required for cell division in Drosophila. Mutants lacking fumble exhibit abnormalities in bipolar spindle organisation, chromosome segregation, and contractile ring formation. Analyses have demonstrated that encodes three protein isoforms, all of which contain a domain with high similarity to the pantothenate kinases of A. nidulans and mouse. A role of fumble in membrane synthesis has been proposed.
Links
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Statistics
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PSSM-Id: 515707
Aligned: 108 rows
Threshold Bit Score: 242.019
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2I7N_A          6 FGMDIGGTLVKL-----------------VYFEPkditaeeeqeevenlksir----kyltsntaygktgirdvhLELKn 64   human
Q18580         23 ICFDACSKTVKI-----------------VYSSSvplsht-----------------------------tlectrILSKq 56   Caenorhabditi...
KAF8355668     20 FSFDIGLRVIKV-----------------VYTSRihrh---------------------------------paivNEKFs 49  
A0DQ03         15 VCLDIGGTLTKL-----------------TFATKkgvslkc---------------------------qtkkelnIINEt 50   Paramecium te...
XP_004027672   21 VGIDIGGTLAKL-----------------CFALQkgsp---------------------------------vdfkHIEHl 50  
Q4U9L6        146 LSMDIGGTFVKIllnlpiknsenyhlfkdVYTSY---------------------------------------------- 179  Theileria ann...
Q384T6       1060 ISIDVGGTFAKL-----------------VYVQPpgdfkvphyvvkeaavlaeg--fnvrmldlldnaegmkrllNDDP- 1119 Trypanosoma b...
Q4Q8Q6       1048 VTIDIGGTFAKI-----------------AFIMPptggafptfpsiiheasslseklglrtfqffadeeaaeselRTRS- 1109 Leishmania major
XP_001913460   54 LSADMGGTMTKI-----------------VFWIPgdtdidlpkyvepeesvmsg---------------fdlypdpvlkv 101  Entamoeba his...
XP_001030111   64 IGIDIGGTLAKL-----------------CFALKknsq---------------------------------vdfeHIEHl 93   Tetrahymena t...

2I7N_A         65 ltmCG---RkgnLHFIR--------FPSCA---------MHRFIQMGSEKnfss------------------lhtTL--- 103  human
Q18580         57 s-----edR---IYCIQ--------VQYPD---------FPLILNFFGENcpll------------------kgtTVd-- 91   Caenorhabditi...
KAF8355668     50 kegGT---R---LHCIH--------FPFTD---------LDKVCEYIAQKvgnls----------------gktvQF--- 87  
A0DQ03         51 e-----dyE---IHFIS--------HPNS----------LDKLIENLEGIgfivdg--------------ksyiqNF--- 87   Paramecium te...
XP_004027672   51 airSYsdfD---VFFQT--------FQTND---------VESLIDFIDQLnmnf------------------itkKF--- 89  
Q4U9L6        180 ------------LHSIYisdrfselFGSTYkvnvenqrdLEDVLEFLHSIflsikvrdrvlvfkyfplsdfengyNIegr 247  Theileria ann...
Q384T6       1120 ---FStvgT---LQFAK--------MSSKC---------IPDFMSYIVESqmlsyy-------------tkeyrnTL--- 1160 Trypanosoma b...
Q4Q8Q6       1110 ---HSlvgT---LRFLK--------IPSQQ---------VPRFTDYLAGShainnf-------------kpqyttKV--- 1150 Leishmania major
XP_001913460  102 tmnskgenE---LCFMK--------FPTSQ---------IPEFIHYAKTSklkeiy-------------gignlqIL--- 145  Entamoeba his...
XP_001030111   94 minSYqefD---IYFKT--------FESRN---------VEDMIDFIESLdmnf------------------itkEF--- 132  Tetrahymena t...

2I7N_A        104 --CATGGGAFKFEEDFRMIA-D--LQLHKLDELDCLIQGLLYVD-SvgfNGKPECYYFE----Np--TNPELcQkkPycl 171  human
Q18580         92 -fVVTASQNAEIEEVIRKVL-D--VELRHVDAFNGLVNGTSFLL-R---NIEAECFTYS----FdesQEYEFqTlnN--- 156  Caenorhabditi...
KAF8355668     88 --TSTHKDSEECVRIIRDTL-R--VKMERVNDMRCHVKGTNFLL-S---NILDEVFVYDh--hNv-dCRYFFqTclN--- 152 
A0DQ03         88 --YITGGGSFKYYDQI-----SnyGKIIRINEFDALKFGFKLLDsI---KCKNTYFTFNngie---------ylqlT--- 145  Paramecium te...
XP_004027672   90 --YITGGGAHKFEELFQKRL-K--VEIIKVQEFESLRMGFLLLDqL---TPNDTVFTYSk-------QKGQQyIvkN--- 151 
Q4U9L6        248 clNFTGGGAYKYTEFLNSTFvKhnVKVNVMDEFSAIVEASKFL--T---KMDKSAVRYDl-------IHRIPeVvsL--- 312  Theileria ann...
Q384T6       1161 --RVTGGGAFKYAALA-KKM-D--LNFSVMREMSAVVHGLGVVI-G---RAPETIFTVDpatgErhpHRLKSpPgeP--- 1227 Trypanosoma b...
Q4Q8Q6       1151 --RATGGGAFKYASVARNVL-G--IEFDVVKEMDAVVKGLNLVL-R---VAPESVFTVDpstgVhhpHQLVS-NgdG--- 1217 Leishmania major
XP_001913460  146 --NVTGGGAYKFANLLKDEM-D--LEVRQQDEMRCLVLGVNFLLlC---CQEKLCFRFv--------NKTKLyRevT--- 206  Entamoeba his...
XP_001030111  133 --YITGGGAHKFDELFQERL-K--VNVIKVQEFESLKMGFQLLEqL---SPNDSIFNFSk-------QKGKDfFkgQ--- 194  Tetrahymena t...

2I7N_A        172 DN---PYPMLLVNMGSGVSILAVYSKD-NYKRVTGTSLGGGTFLGLCCLLTGCETFEEALEMAA---KGDSTNVDKLVKD 244  human
Q18580        157 DS---MFPYLLINIRTGVSVVLVEGEN-QFKRLGGSSIGGGSFLGLTELITGVSDIEEMMDRAL---QGSPDEFDIFIRD 229  Caenorhabditi...
KAF8355668    153 SPhssVYPYVLVNVGTGMSIVRVNSES-DFEYIGGSHCGGGAFFGLAQLLIGSADMDELLVMAE---DGDHRKVDSLVSD 228 
A0DQ03        146 AS---IYPFILVNIGSGVSILKFDNED-QFARISGTSLGGGMFLGLSHLFTGINDFDELLKMTK---QGSNAHTDLLMDE 218  Paramecium te...
XP_004027672  152 KS---LFPFLLVNVGSGVSIIKFLDEG-TIQRVNGTSIGGGFFLGLAHLLTGENNFNSLLDISN---KGDNQNLDLYVSD 224 
Q4U9L6        313 EP---VYPFIISNIGSGTFYLKVESEN-ENKHVFGTSISGGTSFGLVNYLLPLKERRSFTKIFK---TGKYIYYDIIL-- 383  Theileria ann...
Q384T6       1228 FS---PYPCLLVNIGSGISIIKCLGPDgSHVRIGGSPMGGATFWGLVRTMTAVTSWEEITETMRldgPGDNRNVDLLVGD 1304 Trypanosoma b...
Q4Q8Q6       1218 FS---PFPYLLVNIGSGISLIKCTGADgSHVRVGGSPIGGATFWGLIRTMTNLTSWEEVMEIMRldgPGDNKNVDLLVGD 1294 Leishmania major
XP_001913460  207 PE---IFPYLLVNVGSGVSILKVTAPE-KYERVSGSLIGGGTFWGLCCLLTNYKSFDEMLQAAQ---YGQHQNVDLYVKD 279  Entamoeba his...
XP_001030111  195 GG---LFPFVLINIGSGVSMIKFEGEG-VFTRVNGTSIGGGFFLGITHLLTGERNFDKLLEMSN---QGDNRNVDLYAND 267  Tetrahymena t...

2I7N_A        245 IY-GG---DYERFgLQGSAVASSFGNMMSKEkrdSISK------------------------------------------ 278  human
Q18580        230 IY-GD---RASNFnMDPHLLAASFGRVTRGEtvrRAENfde------------------------------------qsk 269  Caenorhabditi...
KAF8355668    229 IY-GM---KYEGLgLPPDLIAGSFGKCSNTKfadQVKNdpd-------------------------------------yr 267 
A0DQ03        219 VHlGF---QSPTRnKNEKHVAVSMGKLDQNIninK--------------------------------------------- 250  Paramecium te...
XP_004027672  225 IF-GQ---SNAPKdIHGDALCVSMGKMTQKLkegQDVNk----------------------------------------- 259 
Q4U9L6        384 IK-G-------QIvLIHSLIIKARTTIRMRKfkkEEIKtdce-----------------------------------lyp 420  Theileria ann...
Q384T6       1305 IY-GYnakDLPPM-LSVDTVASTFGKLGTERfyeSQGNvdrlyasssedlsgavssspdsnptlhdavaptlashgktse 1382 Trypanosoma b...
Q4Q8Q6       1295 IY-GYnakDLPAM-LSSETVASTFGKLGTERfydMKRNictahfadddaageilspkgs-kspsviselpvrngtkaasa 1371 Leishmania major
XP_001913460  280 IY-GR---CYDSVgLAADMMASSFGKIQKVPcgeAKNHys---------------------------------------e 316  Entamoeba his...
XP_001030111  268 IY-GQ---VVPPEdIHGDALCVSMGKMSAKLkegEDVNk----------------------------------------- 302  Tetrahymena t...

2I7N_A        279 EDLARATLVTITNNIGSIARMCALNENIDRVVFVGNFLRINMVSMKLL----AYAMDFWSKGQ-----LKALFLEHEGYF 349  human
Q18580        270 NNAILSLLRMILYNVSQLAYMLSEISNVKRVFFNGFLVRNRPIVMKTL----SFACNYWSSGK-----LRAYFLRHENYT 340  Caenorhabditi...
KAF8355668    268 KDCIRSLLLMISNSIGQVVSLVLNNEKTNRLFFNGFMVRNHPIIMRTL----SYAINFWSKGA-----LQAHFLRHEAFN 338 
A0DQ03        251 SDLVKSLLYMTTYNISQIAFLHSKLHNIERVFFSGHFIRNHEETLQCI----NEAFSYFSKLDqq--nRHPYFIKHDGFI 324  Paramecium te...
XP_004027672  260 QDIVKSLLLMTSFNLSQIAFNQAKLEGIQNIIFAGNFVRNHPDTMDCI----DHAIDYFNQAQskqnqNQAFFVKHDGFI 335 
Q4U9L6        421 GELYKSLIDMVAYNKGCLGYVIAKANGVKRIIYNGNFICKN--TMDSIvagfAFTSDVYRDKS-----IELCFPLHGPYI 493  Theileria ann...
Q384T6       1383 IDIVRSLLNMISSNVTQLAYLHSRVQDVHNIFFAGGFVRNNPIVWSHI----SSFMAYWSKGE-----CHAHFLGHDSHL 1453 Trypanosoma b...
Q4Q8Q6       1372 IDIVRSLLNMISSNVTQLAYLHARLHGVPNIFFAGGFVRDNAMIWSLI----STTMKYWSSGE-----CHAHFLEHDGYL 1442 Leishmania major
XP_001913460  317 ADIAQGLMMMVCGSIAHLGFELTKLHHINRIFYTGGFVAHNPVVWEAI----TTMLTTWSSGS-----VDANFLEYDGYF 387  Entamoeba his...
XP_001030111  303 NDLVKSMLLMASFNLSQIAFIQSKLEGINNIIFAGNFVRNHQDTMDCI----NTAIEFFNQNEdannqRKAFFVKHDGFI 378  Tetrahymena t...

2I7N_A        350 GAVGA 354  human
Q18580        341 TGLGA 345  Caenorhabditis elegans
KAF8355668    339 AAIGA 343 
A0DQ03        325 GSLGS 329  Paramecium tetraurelia
XP_004027672  336 GALGS 340 
Q4U9L6        494 AALGS 498  Theileria annulata
Q384T6       1454 GALGA 1458 Trypanosoma brucei
Q4Q8Q6       1443 GALGC 1447 Leishmania major
XP_001913460  388 GSIGA 392  Entamoeba histolytica HM-1:IMSS
XP_001030111  379 GALGS 383  Tetrahymena thermophila SB210
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