Conserved Protein Domain Family
Solute_trans_a

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pfam03619: Solute_trans_a 
Organic solute transporter Ostalpha
This family is a transmembrane organic solute transport protein. In vertebrates these proteins form a complex with Ostbeta, and function as bile transporters. In plants they may transport brassinosteroid-like compounds and act as regulators of cell death.
Statistics
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PSSM-Id: 397604
Aligned: 269 rows
Threshold Bit Score: 104.939
Threshold Setting Gi: 746846317
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ESS28380       38 GSVCALVASLLSGISIFLHLAHYAFPSLQKYVVRILLFVPVYAVSSLVILFMPS--QFVyiEALRDMWEAVVVYSFFCLI 115  Toxoplasma go...
PDM83402       72 ATTTSLATVGLAALQLIYINAYVTHTTRRSLIMFLASTAPFVSVTALVSLFMPRawFFS--HLSGFMYFTLALYVIICLL 149  Pristionchus ...
CAP27306       40 ACVFVGITFVLSFFHLYFVLKYVSNERIRNDMYALIFMFPITTFASLVGMFIPR--AAVflYAVSLVYFMFTLFIMVTLL 117  Caenorhabditi...
EFO26895       50 ATAFTVIVLLLAAVHWFHVWMYVAEEKRQNKLYFLLSLFPVSTMCCYIGMISPR--TSMviSSLGLLYFLTCLFVLISLI 127  eye worm
CAP24986       54 ASVSTIIVLILSLIHWFYVYRYVSIEKRRNKLYWLIAVFPVACTCSYIAMCVPR--TAVilTCIGVLYYLMCLFVIVSLA 131  Caenorhabditi...
Q17EA4         50 TIVLSFATFVICGKNIRQVL-RYTPKRFKSKTIVVLIIYPIVTTLAIISTLIPK--SYFicDTASHIYFMISAYVFYSLI 126  yellow fever ...
XP_001845253   47 TIALSLVTFVICGKNISQVL-RHTPKRFKTKTIILLSIYPTVTALAMVSVLVPK--SYFvcDTVSHIYFMICAYIFYSLV 123  southern hous...
XP_011053482   42 GSIILVLTIYFFASACRNILSQKDSEFYKTNAIIILSIYPITSVCSLMAIAIPR--GQLlsEAITQIFLMISLYRLYLLL 119  Panamanian le...
XP_001949206  107 GAVIVAMIFYLYVDTLRCII-KNAPPMVKTHSAFILSVYPVVAVATYCAILVPR--AHLlaEAMTQGMFMASMYQLFCLF 183  pea aphid
XP_550843      49 TVLLSIGTFSIFFKNAYHIL-HRTPKQFKTKSILLLTIYPLITLFGVVSISVPR--AFFlcDTVMHVYFMICAYVFFSLC 125  Anopheles gam...
ESS28380      116 LARCGGEDACAGALSRdpgsvrhpqPVpfllrlwKKil-----rlPpteaaaltppagrcfgpeapthatarptssdksa 190  Toxoplasma go...
PDM83402      150 LNLFNGRQGIESRLAEq--------KVs------IEtstppfccfFp--------------------------------- 182  Pristionchus ...
CAP27306      118 FNIFGGRQEMSAYLLQrni----rvNFtv---ppLC---------Fc--------------------------------- 148  Caenorhabditi...
EFO26895      128 RHLFGSRDAFATVLLLdkr---kidFQsp---pfCC---------Cc--------------------------------- 159  eye worm
CAP24986      132 RHLFGGRESFSTCLQYddr---pidFRsp---pfCC---------Ii--------------------------------- 163  Caenorhabditi...
Q17EA4        127 VDYIGGEEAFIRSSDTqtf----naRTpp----cCC---------Cl--------------------------------- 156  yellow fever ...
XP_001845253  124 MAYVGGEDGFIKSSDTetf----nvRTpp----cCC---------Cv--------------------------------- 153  southern hous...
XP_011053482  120 LDV--GRRKI--SETPalm----lrVGpc----cCW---------Pc--------------------------------- 145  Panamanian le...
XP_001949206  184 MAYCGGEANLIASVKPqsl----dmQVpp---ccCW---------Pc--------------------------------- 214  pea aphid
XP_550843     126 MQYVDGEDALIKSTDSqsf----slRTpp----lCC---------Fv--------------------------------- 155  Anopheles gam...
ESS28380      191 qrerrtagetnfyvrepsrrevygrqtrrhsgaaccfgedsmfLCREDLPTDLAFVKCCKRWILQFIFVKPTMALVSLIM 270  Toxoplasma go...
PDM83402      183 --------------------------------------------CMPKLPADYRTLGMVEWMVLQAPLVRLLATIVSLFI 218  Pristionchus ...
CAP27306      149 -------------------------------------------KFLPTVESTDQNLRRIEWLVFQTPIIRTLLELVSVVV 185  Caenorhabditi...
EFO26895      160 -------------------------------------------SFLPKAKSTARNLRQLEWLVLQAPVVRAIIVTFNVIA 196  eye worm
CAP24986      164 -------------------------------------------PKLPTARSTEKNIRRLEWCVLQAPIVRSIIIFLDVVA 200  Caenorhabditi...
Q17EA4        157 -------------------------------------------PFLQRSAVTKNRLLFTRLLILQLPIVQSLLFVGLNVV 193  yellow fever ...
XP_001845253  154 -------------------------------------------PFLKRSPVTKNSLLFTRLLILQLPIIQSILFFGLNIV 190  southern hous...
XP_011053482  146 ------------------------------------------lPF-PNLQMTDANLSWIGILALQLPITQSLLYFILLYI 182  Panamanian le...
XP_001949206  215 ------------------------------------------cCFLPKFTLTKKHLRHLRMLVLQLPVVQGFVYMVLLVM 252  pea aphid
XP_550843     156 -------------------------------------------PLFKRAPVTKNRLRFVRMLIMQLPVVQTALFLALNVV 192  Anopheles gam...
ESS28380      271 -----FSvgkYHSFCfQV-----PYMIIYN-ISICGALYALGLFYLATRKlpALlQ-FHPVAKFLAMKLVIVATWYQAFF 338  Toxoplasma go...
PDM83402      219 -----YF-----EYAtDgftalkVIDFLAL-PSLLIGIYGMHILVTTACKleEL-SsYRYVVVFRLIDLFLAFFGIQHGV 286  Pristionchus ...
CAP27306      186 smeqeGR---RESi--wF-----VFSQLLalLSMCIAFYGCYVMVPLGREk--Ha-pYRFDFLFRTCDIAQCIYTIQKFV 252  Caenorhabditi...
EFO26895      197 iaewrEA---ANk---yI-----HFSETIsvASLLLAIFGVHTLARLTSDk--Lg-qYEFMTIFRVVDIALLFFTAQQPM 262  eye worm
CAP24986      201 vaemrEE---ATp---yI-----RYSDMAslCSLLLAIFGVHTLARVTSNk--Ls-aYCFMSMFRLVDISLLFFSAQQPM 266  Caenorhabditi...
Q17EA4        194 fvedaEN---FNRi--iL-----YFVPFIv-lSIIIGVWGLNIIVRMVNPl--Ys-eFKVMGKYVVLQAVLILCKVQPLV 259  yellow fever ...
XP_001845253  191 fledlDN---FNRi--iL-----YFVPFIa-gSILLGVWGLNILVRMIAPl--Ye-eFKIMGKYVVLQAVLILCKIQPVV 256  southern hous...
XP_011053482  183 eaedpML---TTQy--vT-----FLQPVVv-iSILLGIYSLTITTKTLHTa--Vp-eVKLYYKTLVLQLVLLFSKLQTGI 248  Panamanian le...
XP_001949206  253 waeeeSL---YQVn--yM-----YMQPFIv-iSIICGMWGISMTMRVLGDi--Lk-dHSIQGKFVVLQLVLVLAKLQGLA 318  pea aphid
XP_550843     193 fvenyPN---FNRi--iL-----YFVPMIv-iSILLGVWGLNILVRMLAPl--Ys-dLKLMGKYFVLQAVLILCRIQPLI 258  Anopheles gam...
ESS28380      339 L--GIIDGmtVrdvtkwT-------------------NWLLCVEMPLFALLNAYAYPV 375  Toxoplasma gondii VEG
PDM83402      287 F--DFFAR--A------GafgcgmgnlapletaffwkNVLVTIESFIVVLLSTillqp 334  Pristionchus pacificus
CAP27306      253 F--EFAAAvgLitsdrfLpaaaka--------lwwasFMCT-WEMMLLSALCSYClrp 299  Caenorhabditis briggsae
EFO26895      263 IfeNILIRfnVlkcgplLsahgna--------rfvcnFVII-VEMLLLSLFISfmvap 311  eye worm
CAP24986      267 IfqNVLLRfnLiscgplLnaqena--------yfvcnFIIT-CEMLLLSLLATWllap 315  Caenorhabditis briggsae
Q17EA4        260 I--MGLVTyvTpscafpMtlqvqk--------navfqMCLC-AEMLVLSLWAFqlyka 306  yellow fever mosquito
XP_001845253  257 I--MVIVTyvTprcdfpLvlqvqk--------navfqLCLC-GEMVFLSLWAfqlykt 303  southern house mosquito
XP_011053482  249 I--KALPAagVfpckppItpaiya--------nvmcnALML-VEMMMLCYAAWYVYYV 295  Panamanian leafcutter ant
XP_001949206  319 F--RGVVWagWlpckppIsptvya--------nliynSTML-WEMLVLAALARKlykk 365  pea aphid
XP_550843     259 I--AAIVSssIsdcafpNtlqvqk--------naifqLCLC-FEMMVLSCWASllyks 305  Anopheles gambiae str. PEST
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