7EN0


Conserved Protein Domain Family
SLAC1

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pfam03595: SLAC1 (This model is not part of the current CDD release)
Voltage-dependent anion channel
This family of transporters has ten alpha helical transmembrane segments. The structure of a bacterial homologue of SLAC1 shows it to have a trimeric arrangement. The pore is composed of five helices with a conserved Phe residue involved in gating. One homologue, Mae1 from the yeast Schizosaccharomyces pombe, functions as a malate uptake transporter; another, Ssu1 from Saccharomyces cerevisiae and other fungi including Aspergillus fumigatus, is characterised as a sulfite efflux pump; and TehA from Escherichia coli is identified as a tellurite resistance protein by virtue of its association in the tehA/tehB operon. In plants, this family is found in the stomatal guard cells functioning as an anion-transporting pore. Many homologues are incorrectly annotated as tellurite resistance or dicarboxylate transporter (TDT) proteins.
Statistics
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PSSM-Id: 515683
Aligned: 393 rows
Threshold Bit Score: 44.9109
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7EN0_A        196 RFPIGCFGVCLGLGSQAiLWgal-----------aaS--PAMRFlrvtpmINLAVWLLAAAVLAATSvTYALKCVFYFE- 261 stiff brome
WP_014136929   18 RLGPNWYAAVMGTAITGnAAaalp--------vrvpG----RTV------FAEAVWTLSLLMLAALLaGRAVHLSRHRE- 78  Kitasatospora
WP_015032418   30 HLGPNWYASVMGTAIVAtAGaslp--------ldlpG----LRT------ACAAVWALSLAMLLVLLcARTVHWVRHRD- 90  Streptomyces
WP_358944384   38 HLGPHWYAPVMGTAIVAsAGaglp--------ldlpG----LRT------ACASVWALALLALVTVLgARALHWTHHRD- 98  Streptomyces s...
WP_020938975   19 HLGPNWYAAVMGTSVVGtAGaalp--------lrveG----LRE------VGTAVWALALVLLVVLLaGRALHWTHHRD- 79  Streptomyces c...
O88074         32 HLGPNWYACVMGTAIVGtAGaalp--------ghvaG----LRA------ACTAVWALSLVLLVVLLtARSLHWLHHRD- 92  Streptomyces c...
Q828E8         25 HLGPNWYASVMGTAIVAtAGaglpsgsaaglpgdlpG----LRT------ACTAFWALSLIMLVTLLgARALHWIHHRD- 93  Streptomyces a...
18_pfamImport   1 HLGPNWYATVMGTAVVAtAGaalp--------vrvpG----LRG------ACVAVWALASVLLVVVLaARAGHWALHRD- 61 
WP_012936319    2 KVAPNWFTAAMGTGIVAnAAvllp--------rdaaW----LRA------LALAAWLAAALLLLRLAaVAVEQWRRGRRv 63  Conexibacter w...
22_pfamImport   1 HVPPNWFATVMGTGILAvAAhg-------------lGhgTLLTA------LSIVFWLLACLVYLGVIaATVLHWRRHRD- 60 
7EN0_A        262 -----------AIRREFFH----PVRVNFFFTPSIAaMFLAIGLprALAPADG---RAMHPAVWCa---SVAPLFALELK 320 stiff brome
WP_014136929   79 -----------QARRTLLDd---PSAAVFYGCPPMAlLAVGYGA--LTVGGPVlgeRPALALDALlwtvGTAYALAVAAG 142 Kitasatospora
WP_015032418   91 -----------QARAHLLD----PAVAPFYGCLSMAlLAVGGGA--MIVGRDWiglPAAVALDTVlftaGTVVGLAAAVG 153 Streptomyces
WP_358944384   99 -----------QARAHLLD----PAVAPFHGCLSMAlLAVGAGA--LVVGRDWigvRAALALDVVlfgaGTVTGLAAAAV 161 Streptomyces s...
WP_020938975   80 -----------QARADLLD----PAMAPFYGCLSMAlLAVGGGA--VTVGRDWigvRAAVALDWVlfpaGTLIGLAAAVA 142 Streptomyces c...
O88074         93 -----------QARAHLLD----PSAAPFYGCLSMAlLAVGGGA--LALGRDWigtPAAVALDTVlftaGTVIGLAAAVA 155 Streptomyces c...
Q828E8         94 -----------QARAHLLDpttgPTTAPFYGCLAMAlLAVGGAT--LTVGRDWlgtTAAVVLDAVlftaGTAVGLAAAVA 160 Streptomyces a...
18_pfamImport  62 -----------QARAHLRD----AAVAPFYGCLSMAlLAVGAST--LAVGRDAigrPAAVAVDSVlfvlGTAAGLGAAVV 124
WP_012936319   64 rdcagrrvrggAADGSAGD----LAMAPFWGAPPMAaMTVGAGA--LLVGGDAigqDAALAVASAlwalGTLGGLAASVT 137 Conexibacter w...
22_pfamImport  61 -----------AARAHLQH----PVIAHFYGAVPMAtLTVGTST--LVAGVHVigpSAALVIDVVcftlGTLGGVATALL 123
7EN0_A        321 IYGQWLSGGk-------RRlcKVANPSSHLSVVGNFVGAILAARVg-----------WVEAGKflWAIGVAHYIVVFVTL 382 stiff brome
WP_014136929  143 LPYLMITRHr------lSV--LEANPTWLLPVVAPMVSAALGPALvphlpegaarqaLLYACVamFGASLLATLALLPVV 214 Kitasatospora
WP_015032418  154 IPYLMVVHHk------iES----ASPVWLLPVVAPMVSAALGPLLvphlpagqaqetLLLACWamFGVSLLATLVMLPLV 223 Streptomyces
WP_358944384  162 LPYLMIVRHr------iDP--AGITPVLLLPLVAPMVSAALGPLLvpylpagqarqtLLLGCLalFGLSLLATLLVLPLV 233 Streptomyces s...
WP_020938975  143 VPYLMAVHHr------vRA--AEATPAWLLPLVAPMVSAAVGPLLvphlppgqpretLLLACFalFGLSLLATLLMLPLV 214 Streptomyces c...
O88074        156 VPYLMAVRHr------vEP--GQASPVWLLPLVAPMVSAAVGPLLvphlpagqpretLLLACVamFGMSLFATLVTLPVV 227 Streptomyces c...
Q828E8        161 VPYLMVTRHr------iEP--GRATPVWLLPLVAPMVSAALGPLLvphlpagqpretLLLACVamFGLSLLGTLMMLPMI 232 Streptomyces a...
18_pfamImport 125 IPYLMVVRHr------pAP--GTASPVWLLPLVAPMVSAAVGPALvpelppgqwrtaLLLACYamFGLSSLATLTLLPLV 196
WP_012936319  138 VPLRMLRHPe------rRL--DTVFATWLLPVVPPMVSATTGAALiahlpagqprllLLLGCWamLGASLLAVAATIALV 209 Conexibacter w...
22_pfamImport 124 IPARHLL-GrsgdpagpDR--PEPFGGWLMSVVPPMVSASAAAVLagafdepgarraLLVIGIaaFVFSLVLAAPIVVSV 200
7EN0_A        383 YQRLPTNEALPMELHPVYSMFIATPSAASLAWAAIYGSFDAVARtF-------------FFmalfLY----------MSL 439 stiff brome
WP_014136929  215 LGGLLHGKLPALVLTPSLFLVLGPLGQSTTAVHQFADALPLALP-GagpgaaaaarglaGAygvaVMgfallwlavaLAA 293 Kitasatospora
WP_015032418  224 FGRLVTGGPLPLALTPTLFLVLGPLGQSTTAANKFADVAPGVLP-Apyahg---fasfaVLygvpVMgfallwlglaGAM 299 Streptomyces
WP_358944384  234 FGRLITAGPLPLALTPSLFLVLGPLGQSATAVTHLADAAPGAVP-Apypqg---ltafaVLygvpVLgfallwlalaGAM 309 Streptomyces s...
WP_020938975  215 FARVIGSGPLPLALTPALFLVLGPLGQSTTAVGLIADRADGVVP-Apydhg---lgvfaVLygvpVMgfallwlalaAVH 290 Streptomyces c...
O88074        228 FGRLLTGGPLPLALTPSLFLVLGPLGQSTTAVGKFADVAPGVVP-Gpyaeg---favfaVLygvpVTgfalmwlalaAAH 303 Streptomyces c...
Q828E8        233 FARLITTGPLPLVLTPTLLLVLGPLGQSTTAVGKFADFAPGVVP-Apydqg---fgvlaVLygvpVMgfallwlglaVAL 308 Streptomyces a...
18_pfamImport 197 LGRLLHHGPLPLALTPTLFLVLGPLGQSTTAVGQLADVAPDAVG-Pvyasa---fgafaVLygvpVMgfallwlalsAAM 272
WP_012936319  210 WRRLAAHGCGPARMVPTLFIVLGPLGQSITAACLLAAAAPAATG-Aawags---agalaLVyglpVLgfalawlavaVTI 285 Conexibacter w...
22_pfamImport 201 IGSLVTRGTGPTGLAPTWWIVLGPLGQSVTAACLLAHVATGVTG-Aatagv---lgalaHDyalaVWaaaviwivvaTAI 276
7EN0_A        440 VVrinffrgfrFSIAWWSYTFPMTTASLATVKYAeavpCFLSRALALSLSLMSTTM 495 stiff brome
WP_014136929  294 NLralr-aempFAMTWWAFTFPVGTLVTGATALArhtgFGGFTALAAALYLLLLAA 348 Kitasatospora
WP_015032418  300 VLrarr-qgmgFAMTFWAFTFPVGTCVTGAEGLAqhtgLAAFRWLAIGLYVCLVAA 354 Streptomyces
WP_358944384  310 IVralr-rgmgFSLAWWALTFPVGTCATGARGLArltgLVALDVLAVALYALLLAA 364 Streptomyces scabiei
WP_020938975  291 VVrarr-rgmgFSMTWWAFTFPVGTCVTGAAALArhtgLAVYEGLAVGLYALLVAA 345 Streptomyces collinus
O88074        304 VVrarr-agmrFSMTWWSFTFPVGTCVTGAEALAretgLVVYDGLTVALYALLVAA 358 Streptomyces coelicolor
Q828E8        309 VVrarr-rgmgFALTWWAFTFPVGTCVTGAEALArhtgLAAFDGLAVALYAGLVAA 363 Streptomyces avermitilis
18_pfamImport 273 VAralr-rgmtFTMTWWGFTFPVGTCVTGAAGLArhtgLTAFTWLAVALYALLVTA 327
WP_012936319  286 TWrtar-rglpFAPTWWSFIFPIGTCVTGASELAvrtgAAPLDWLAIALFALLLTA 340 Conexibacter woesei
22_pfamImport 277 TArsvr-rglpFGLTWWSFTFPLGTFVTGSSALAattgHTMFAVIADAGFVALFLA 331
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