3F5F


Conserved Protein Domain Family
Sulfotransfer_2

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pfam03567: Sulfotransfer_2 
Sulfotransferase family
This family includes a variety of sulfotransferase enzymes. Chondroitin 6-sulfotransferase catalyzes the transfer of sulfate to position 6 of the N-acetylgalactosamine residue of chondroitin. This family also includes Heparan sulfate 2-O-sulfotransferase (HS2ST) and Heparan sulfate 6-sulfotransferase (HS6ST). Heparan sulfate (HS) is a co-receptor for a number of growth factors, morphogens, and adhesion proteins. HS biosynthetic modifications may determine the strength and outcome of HS-ligand interactions. Mice that lack HS2ST undergo developmental failure only after midgestation,the most dramatic effect being the complete failure of kidney development. Heparan sulphate 6- O -sulfotransferase (HS6ST) catalyzes the transfer of sulphate from adenosine 3'-phosphate, 5'-phosphosulphate to the 6th position of the N -sulphoglucosamine residue in heparan sulphate.
Statistics
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PSSM-Id: 397568
Aligned: 67 rows
Threshold Bit Score: 98.652
Threshold Setting Gi: 68052988
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3F5F_A       373 EDDVVIIYNRVPKTASTSFTNIAYDLCAknRYhvlhintTKNNPVMS-LQdqvrfvknvtsWKEMKPGFYhGHVSYLDFA 451
O45177       112 SPRYDISLCLIPKVVSTIGTAAICYIQDpeAF-------TKNNRTIS-TE-----------MYGGRF-CE--NNELKSFK 169 Caenorhabditis ...
CAP23026     106 SPRYGISLCLLPKVLSTTGTATICYLEDpdKF-------AADNRTIS--T-----------ETYITRFC--ERNEMKSYN 163 Caenorhabditis ...
O45581        64 APDKKLISCTLRKSMSQLAENIMCLLYDeqQY-------FANSQSLN-DT-----------WK-DERKCE-HDRSYLNP- 121 Caenorhabditis ...
Q5FC32        62 APRNKIIMCGIRKSMSLLSTNIMCLLNNvdPF-------FANNDALN-ED-----------WK-VERSCQ-RNHSFYFP- 119 Caenorhabditis ...
Q9GS12        57 SPENKLVACEIRKSMSQLTTNLMCLLYNetQF-------VADKNTLN-DT-----------WE-APRHCM-QEHSFTNF- 114 Caenorhabditis ...
O45376        21 APKNNIIACGIRNSFFHITQNLMCLVYNetQY-------LADKRSFN-DP-----------WTSSSRDCA-SEKSFFDP- 79  Caenorhabditis ...
Q7YXB5       112 SPRYNLSTCVVQKSMSTVMTSMFCYLRDekKF-------VGNHRELL-KD-----------WK-IVRFCM-FKNEFRNLG 170 Caenorhabditis ...
Q18078       110 APDYKMAHCVVHKSMSTVITGIWCYLFNrnRF-------VRVDKQMNmSE-----------WD-KESLCR-GDNTFRHLK 169 Caenorhabditis ...
XP_002644401 113 APQYKMVNCVVQKSMSTMMTGAMCYLYNetQY-------EKSGRSFD-DE-----------FS-GR-LCK-NQNEFSSVN 170 Caenorhabditis ...
3F5F_A       452 KFGvk-------kkPIYINVIRDPIERLVSYYYFLRFGDDYrpglrr------rkqgdkKTFDECVaaggsDCApEKLW- 517
O45177       170 MVQrsln-----snfdNIIFTRNPYDRFISGFTEKCVNNTDtnichgcg--tdircflqKEYRRLI-----R-M-SMLF- 234 Caenorhabditis ...
CAP23026     164 MVKhylnd-----nfenIIVTRNPYDRFISGFTEKCVNDLeddychgcg--admrcflqKEYRRLM-----R-M-SMLF- 228 Caenorhabditis ...
O45581       122 -SEtllnd----tdtvRFAFIRDPFQRFISFYLDKCVreqkcyncg-----nnmtcvlkNFYWGLK-----K-V-QRRWd 184 Caenorhabditis ...
Q5FC32       120 -PSellnd----sntvRLAFIRDPFQRFVSFYLDKCVnsnmcqscg-----tnmtcvvdKIYTGLR-----K-I-QTNWn 182 Caenorhabditis ...
Q9GS12       115 -SDdlknd----tdtvKFAFIRDPIRRFLSFYLNnksecydcg--------sdmrcvveRIYNGLW-----N-I-QNDRn 174 Caenorhabditis ...
O45376        80 -SEsvqnd----kdtvRFAILKDPFQRFVTLYLNKCVeknecydcg-----sdmrcvvkKLYNSLA-----E-I-QNNTn 142 Caenorhabditis ...
Q7YXB5       171 GVFkkfkippapnnWTHIMMVRHPFERFVSGFVDKCYRKPviqkycngc-grnltcfmeTELKRMG-----QQV-ESGK- 242 Caenorhabditis ...
Q18078       170 SLQkkyna-semtgWSLSMITRDPIDRFISGYVDRCIRVAegpspcngc-dknmtcfilSEYERFK-----KQA-HKGV- 240 Caenorhabditis ...
XP_002644401 171 SVRdafnisyvkhdWTFSMVTRNPIDRFVSGYVDRCVRLALknetqcngcglnmtcfieTEYKRLM-----EIS-YKRK- 243 Caenorhabditis ...
3F5F_A       518 ---LQIPFfcgHssecWNV---GSrwaleQAKyNLINEYFLVGVTEELEDFIMLLEAALPRffrgatELyrtgKKSH--- 588
O45177       235 ---PVYTGadtH----FAPqtwYC-----DMK-NNIKNSTVIQYSSTGTEKIKMIDNLLTVfknrnvPEenlnEVREels 301 Caenorhabditis ...
CAP23026     229 ---PVYTVadtH----FAPqtwYC-----DMR-NTLKNSTIVRFSLQGIEKVKMIDDMLNVfrrrkvPErqldEIREqls 295 Caenorhabditis ...
O45581       185 g-rEQPEYveiH----AAPlswNC-----DFY-KDLSKWQLIPIGSDKTERSSAITQTEKIlrkqrvNEtlvdMVVDgmk 253 Caenorhabditis ...
Q5FC32       183 gtvPFTDRmilH----TATyswNC-----DFR-KDFSKWEFIYIEPEKHERIRAINHLSSVmkkqgvNEtvigRFQNdmk 252 Caenorhabditis ...
Q9GS12       175 m-tFILme--aH----AAPlswNC-----GFN-EGVSKWELLMMGSDLDERTSSTTKLAKIlrkqgvRHelveSIEKdil 241 Caenorhabditis ...
O45376       143 t-tLVIGDietE----AAPiswNC-----NFH-EGIEKWKLMRMSSDLEKRISAAAVLLERlreqgvKQavfmRIHNdiv 211 Caenorhabditis ...
Q7YXB5       243 ---FQRTYedrH----FFPqswRC-----NLH-QYFSNFTFILYSSSHNFSITS--QLFPIfrqhsvPQssldFIETsls 307 Caenorhabditis ...
Q18078       241 ---LTNTFedrH----FYPqnwRC-----DIK-TMRNKYEFIRYSSDASKELME--DLFKIarrqgiPEkeleYIENelt 305 Caenorhabditis ...
XP_002644401 244 ---THRTMedaH----FFPqvwHC-----GLN-EEFEFFEFIQYSGNAEDKMVP--QLQDLlerqnvPEksieFIKNeli 308 Caenorhabditis ...
3F5F_A       589 -----LRKTTEKKLptaatiAKLQQSEIWKMENEFYEFALEQFQF 628
O45177       302 k-gktQHSTSGTSLrlkyekLIEEDGAIRRALQRIYYYDFLYLGY 345 Caenorhabditis elegans
CAP23026     296 l-gksHHTTTGSSLrehyerLVREDESIRRALHRIYYYDFLYLGY 339 Caenorhabditis briggsae
O45581       254 d-gdtDHSTYKSAHrleaerQIREDPYIREMLHKIYYFDYVVFPF 297 Caenorhabditis elegans
Q5FC32       253 n-geiSYATYKSQKraealrLVQEDPYIRNILHKIYYFDYVLFQL 296 Caenorhabditis elegans
Q9GS12       242 k-getAHSTFKSTNrlaaekQIREDPVVRYFLHKIYFFDYVVFPF 285 Caenorhabditis elegans
O45376       212 y-ndiANTTQTSNKrdeaekQVREDQIVRHFLHKIYLMDYLVFRF 255 Caenorhabditis elegans
Q7YXB5       308 a-grtAHSTVDSKAtsfiekRLNSSPYLMELLVKMFYHDFVLFNF 351 Caenorhabditis elegans
Q18078       306 knrktSHTTAYSPAreffqrRLRESPLLMEYVVRMFYHDFVILNY 350 Caenorhabditis elegans
XP_002644401 309 y-kksSHSTTGTPAkrfyysRLMKSPYLLEFIVKMFYYDFLRFHY 352 Caenorhabditis briggsae
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