6XOL,6XON,5V89,4GBA


Conserved Protein Domain Family
Cullin_binding

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pfam03556: Cullin_binding (This model is not part of the current CDD release)
Cullin binding
This domain binds to cullins and to Rbx-1, components of an E3 ubiquitin ligase complex for neddylation. Neddylation is the process by which the C-terminal glycine of the ubiquitin-like protein Nedd8 is covalently linked to lysine residues in a protein through an isopeptide bond. The structure of this domain is composed entirely of alpha helices.
Statistics
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PSSM-Id: 515662
Aligned: 176 rows
Threshold Bit Score: 82.6427
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6XOL_A       263 KLKAQI-PKMEQELKEpg-rFKDFYQFTFNFAK---NPGQ--KG--LDLEMAIAYWNLVLn--------------gRF-- 317 synthetic const...
Q4CTL1       116 AMRSHV-DEIDEVLHKdpdqFRKFYRFIFGWVRspeTTARslGElgMNIATAVELWQMLFpe--------------yKt- 179 Trypanosoma cruzi
Q4Q0J0       118 aahdAI-VDLNNTIRSneekRSKFYQFLYNWCLkgnDASD-------RVDSAKELWSCFFsaspvsl--tveearrKFta 187 Leishmania major
Q38A65       115 ALRNHV-ETLDGALRGdvtkFRHFYRFIYKWVQsplTMERnmGQvgMSIETAVELWRMLFph--------------yRe- 178 Trypanosoma brucei
XP_024397731  70 HLQAKLlda---------rnFSVFYRFVFFMCR---DPGQ--KN--ISVSTAIAGWRLALtg--------------rFr- 118
XP_003562629  62 KLMSVLeldd-------arhFSTFYDFVFFISR---ENGQ--KN--ITIQKAVAAWRIVLng--------------rFr- 112
VDC68396      71 KLMSRLdlmas----vdfseFTRFYDFVFFMCR---ENGQ--KS--ITVAKAITAWKLVLag--------------rFr- 124
XP_004232218  70 KLRLNLead--------fseFSRFYDFVFFVFR---ENGQ--KN--ITISKAVTGWKIVLag--------------rFr- 119
XP_003063786  79 hplsaLfRSLLGELatdaqkFAAFYHFVFFVAR---ERGQ--RN--LSVAAALEGWRFLLad--------------gRf- 136
XP_001421529  12 RCVECV-ETGDDDA-------EARYEFCYAVMR---ERGA--RH--CSREAATACWRETFarerdattrdamddgeGGar 76 
6XOL_A       318 ----KFLDLWNKF-LlEHHk----------Rs----IPKDTWNLLLDFS--Tmi-aDDMSNYDEEGAWPVLIDDFVEF 373 synthetic construct
Q4CTL1       180 ---fLKMNDWITF-CtTKEi----------Fhr-eaISRDLWEQLLEFTslT-----RYDTYDVNDAWPSAIDDFVEY 237 Trypanosoma cruzi
Q4Q0J0       188 yvcfPRINQWLDF-ItMLGekatesksgrvAveqsgVSFDTWTQLLLFAr-----fDNYDAYDDEDSWPVTMDDFVVY 259 Leishmania major
Q38A65       179 ---fKRLDDWITFcMsKKLfp-------hgI-----ISRDLWEQLLEFTfvT-----DYSKYDVSDAWPSAMDDFVEY 236 Trypanosoma brucei
XP_024397731 119 -----LLDQWCAF-VqVHQr---------hA-----VSEDTWRQVLEFSrsVh---eDLSNYDVEGAWPVLVDEFVEN 173
XP_003562629 113 -----LLDRWCNF-VeKYQr---------hN-----ISEDAWQQLLAFSrcVn---eDLEGYDPKGAWPVVIDDFVEH 167
VDC68396     125 -----LLNRWCDF-TeKNQr---------hN-----ISEDTWQQVLAFSrcVh---eNLEGYDSEGAWPVLIDEFVEH 179
XP_004232218 120 -----LLDHWCDF-VeKKQr---------yN-----ISEDTWQQVLAFSraVh---eNLEGYDREGAWPVLIDDFVEH 174
XP_003063786 137 ----aLLAQWCEF-VgGARad-------akG-----ISEDTWCQVLDFAhaVnq-aGGLDGYDPHGAWPVLVDEFVDW 196
XP_001421529  77 ananDVVDAFVSY-VrDRRdv--------tV-----ITADAWSQAYQFVrrAralgGDLRWYDENEAWPSLFDEFVEC 140
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