Conserved Protein Domain Family
Treacle

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pfam03546: Treacle (This model is not part of the current CDD release)
Treacher Collins syndrome protein Treacle
Statistics
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PSSM-Id: 515656
Aligned: 9 rows
Threshold Bit Score: 181.451
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_021581350  318 T-VTPGKAGPVATQTKVGKPKEESESSSEE---ESDSEEDNPAATA----LLQAKPSEKSPQVRAVST-PAKESPRKGAP 388 
XP_008253480  314 TpAPPRKAGLIAPQAKAGRPEEDSGSSSEA---SSDSEEETPAART----PLQAKPPGKTPQVRAAFA-PAKGSPRKGTL 385 
4_pfamImport    1 AiATPVKAG--ATQAKAGKPEQDSESSSEE---ESSSEGETPAPMA----PLQMKPSGKASQVRAASA-PAKGSPVKGAA 70  
5_pfamImport    1 PpAYPGKTGPAGTQAQVGKQEEDSDSSSE----ESDSDEETPAAQTlttnPSQVKPLGKTPQVTAASA-PAKGSPRKEVP 75  
AAH21514      321 IlATPGKTGPAATQAKAERPEKDSETSSED---DSDSEDEMPVTVN----TPQARTSGKSPRARGTSA-PAKESSQKGAP 392 
6_pfamImport    1 TlAPSGKAGPIATQAKAGKPKEDSESSSEE---ESDSEEEIPAAKA----PLQARLSEKAPQVRAASA-SAKESPRKGAA 72  
3_pfamImport    1 TpALTGKTGPAAAQAKAGRPEEDSESSSE----ESDSEEETPAAKT----PLQ--PSGKTPQVKAASV-PTKESPRKGTT 69  
2_pfamImport    1 TpAPPGRAGPAAARDKVVKPEEGSESSSEEassSSDSEEEAPAAKT----PPQAKPPGKVPGVRATSAaPAKESPRKGAP 76  
NP_001382056  304 IsATPEKTGPITPQAKTGRPQKDMETSSED---DSDSEDEMPVTVT----TPQARPSGKSPQVRGTSA-PAKESSQKGAP 375  Norway rat
XP_021581350  389 PVPPGKTGPAAIQASAGKPEEDSDSSS-EDSDS-ERTPVAMTLTVNPAQAKSLGKNLQMKPASTVVQGPLGKGISPVVPA 466 
XP_008253480  386 PVAPGKTGPAATQAQVGKLEVDSESSS-KESDSdEETPAAMGVTVSPAQVKPSGKNSWVRPAPTVGAGPSGKGTGLAPPG 464 
4_pfamImport   71 PAPPGKTGPGA--APAGKPEEDLQSSSeEESDSgEETPAAKTVTVSTAQAKPSGKTPQVRPTSALGTGPSGKGAILAPPG 148 
5_pfamImport   76 PAYPGKTGPAGTQAQVGKQEEDSDSSS-EESDSdGETPAAQTLTTNPSQVKPLGKTPQVTAASAAAKGSPRKEVPPAYPG 154 
AAH21514      393 AVTPGKARPVA--AQAGKPEAKSSEES--ESDS-GETPAAATLTTSPAKVKPLGKSSQVRPVSTVTPGSSGKGANLPCPG 467 
6_pfamImport   73 PALPGKTGPAAAQAQVGKQEEDSESSS-EESDSeGETPA----AASPAQAKPLGKNPQVRPASTMSVGPSGKGAIPVSPG 147 
3_pfamImport   70 PAPPGKAGPVAAQAKAGRPEEDSESSS-GESDSdGEAPAARPLTSSSAQAKPLGKNSQVRAASTVGMGPSGKGAVPAPPG 148 
2_pfamImport   77 PA------PASRAAQAGQREEDSESSS-EESDAgGQAAAAAPQTSSPALVKPMGQNSHGRAPRALA----GKGAVPALPG 145 
NP_001382056  376 AVTPGKTRPVAAQAQAGKPETRSSEES--ESDS-GETPAAGTLTTSPAKVKPLGKSPQVRPASTANLGSSRKGANPPCLG 452  Norway rat
XP_021581350  467 A--------QVKKVEKASESSS-EESDSEEEAPPATLa-----QAKLSGKTTPVRPASGSAKGhlgkvAAPAPPQKAGPG 532 
XP_008253480  465 KaapaapltQVVKPEDESDSSSeEESDSEGETTPAVSa----tQAKPPGKILQVRPASGPTKGplgkdVAMAPSQKLGPG 540 
4_pfamImport  149 KaapvvpqaQVGKPEEDSESSSeEDSDSEGEAPAAVT-----------------------------------PVQKAGPV 193 
5_pfamImport  155 KtgpagtqaQVGKQEEDSDSSS-EESDSDGETPGAQTlttnssQAKPSGKILQVRPASGPTKGllgkgAAPKPPQKSGPV 233 
AAH21514      468 KvgsaalrvQMVKKEDVSESSS-AELDSDGPGSPA--------KAK----------------------ASLALPQKVRPV 516 
6_pfamImport  148 KagttgplaQVGKKKDPTSSS--EESDSEGEAPMPAAl----tQAKPLGKNPQAKSASGPARGplgkgTVPVAPQKAGPV 221 
3_pfamImport  149 KaastatlvLVGKQEEDSESSS-EESDSEREAPA---------QAKSSGKILQVKSATGPAKG---------PPQKTGPV 209 
2_pfamImport  146 Qa-----------gQQDSGSSS-EDSDSGDSEEEAAT------TAKPSEKVLPARTASGPSTG---------PPQKARPA 198 
NP_001382056  453 KvgsavlkvQTGKEEEDSESSS-EESDSDGAVNAA--------KAKPPGR------------K-----ATPALPRKTGPV 506  Norway rat
XP_021581350  533 VSQVKAERSKEDSESSETSS-DSEEEASAAVTPAQAKPALKTpQTKASPKK-GTPITPVSSKIPPVHVGTPAPWKAGTMT 610 
XP_008253480  541 ATQVKAERAKENSESSEESS-DSVEEAPTATTPAQAKPALKT-QAKASPKK-GTPVTPANTKVAPVRVGTPAPWKAGTAT 617 
4_pfamImport  194 ATQVKAERPKEDSESSEES--ESEEEAPAATTPAQAKPAMKTpQPKASPRK-NTPITPASAKLPPMQVDTPAPWKAGTAT 270 
5_pfamImport  234 AIQVKAEKSKDDSESSEESS-DSEEEAPAAVTPAQAKPELKMpQTKASPSK-SILLTPTSAKGAPVRVGTPAPWKAGTVA 311 
AAH21514      517 ATQVKTDRGKGHSGSSEESS-DSEEEAAPAASAAQAKPALEK-QMKASSRK-GTPASATGA-------STSSHCKAGAVT 586 
6_pfamImport  222 ATQVKAESSKEDSESSEESS-GSEDEAPAAMPPAQAKPALKT-QTKASPRKgGTPGTLTSAKVTP--VGSQAPKKGA--- 294 
3_pfamImport  210 ATQIKVERSKEDSESSEDES-ESEEEVAAAVTPAQAKPAMKTpQTKASPTK-GSPVTPASAKVPAARVGTPAPWKAEAVT 287 
2_pfamImport  199 ATQVKAER----SESSEESStDSEEEAPAAAAAAQAKPAVKTpQTKASPRK-GGPVTPASAKAAPVRVGTPAPWKAGa-- 271 
NP_001382056  507 ATQVKTDKGKDHAESSEEST-DSEEEAAPAASAAQAKPAPIK-QMKASPRK-GTAASTTGA-------SASSPRKAGTKT 576  Norway rat
XP_021581350  611 S---SSSPAVAWSTQKPEEDSSSSSEEES---EEEgkSACVAAVAqvkSVGKGLQARAAlvptkapsgQGTAPAPPRKTG 684 
XP_008253480  618 SpatASSPAVAWGARRPQEVSSSSEESES---EEE--TAPAATVT---SVGKGLQAKAA---------PATTPLLPGKMG 680 
4_pfamImport  271 SpacTASPATARGAQRPQEESSSSEGSESeeeEEE--TAPVATAGpakSVGKNLQGKAAsapakapsgPGTAPVPPGKVG 348 
5_pfamImport  312 S---ASSSAVPRGAQRPKDNSSSSEEESE---GKE--ATPAAAVAqakSLGKGLRGQAAsaptmgpsgQGATPVPPGKTR 383 
AAH21514      587 SsasLSSPALAKGTQRSDVDSSSESESEG--------AAPSTPRVqgkSGGKGLQGKAAl-------gQGVAPVHTQKTG 651 
6_pfamImport  295 ----ASSPAVARSVQRPEKDSSSSEESDSe--EEE--TAPVAAVGlakSTGKGLQVKAAsaps------tgpsVLPGKMG 360 
3_pfamImport  288 SpacASSPAVARGTQRPEQDSSSSEESES---EEE--KAPAVAVGqakSVRKNPPAKAAsaptkgpsgQGNAPLLPGKAG 362 
2_pfamImport  272 ---tTASPATAKAAQRPEADSSSSETSESe-eEEE--EAPPAA--------------AA--------------------- 310 
NP_001382056  577 SsasLSSLALPKGTQKPDVDSSSEWESEG--------AAPGTTGVqgkSGGKGLQGRAAs-------gQGVAPLHAQKTG 641  Norway rat
XP_021581350  685 PSVsQVRAQDSEDSESSEEESDS--EEEAATPAPVKALGNTVQAKASPAPIRASSAKG-TSAPGKVLTAVAPAKQGSPAK 761 
XP_008253480  681 PAV-QIKAKAHEDSESSEEESDS--AQAASTPAQVQASARTPQTKASAAATKASSAEGvTSPPGKVVAAAAQAKQGSPAK 757 
4_pfamImport  349 LAAaQVKTETYEDSESSEEESDSeeAPAAVSPAQPYPWPRLPPAKEMIPPLRLTFSQG------------VQAKLVSPAK 416 
5_pfamImport  384 PTVaQVRAEAHESSESSEEESDDseVGAVVTPAQAKAPGKTPQAKANPASTKASTDKEaAWTPAKL-------------- 449 
AAH21514      652 PS---VKAMAQEDSESLEEDSSS--EEEDETPAQATPLGRLPQAKANPPPTKTPPA----SASGKAVA--------APTK 714 
6_pfamImport  361 PAVtQVKTETQEDSESSEEDSDS--EAAAPAPAQVKASVKTPLAKANPAATRVSSAKGaTSAPGKGVTTAAQAKQGSTAK 438 
3_pfamImport  363 PAVaQVKAEMHDDSESSEEESDS--EEVAATPAQVKPSVKTPQTKASPASARAALAPGpSSAVRKVVTAAAQAKQGSPAK 440 
2_pfamImport  311 --------------------------------GRMKNSVTAPQTKATPAVPRVASAKVaASAPGKGAPAGAQATLGSPAK 358 
NP_001382056  642 PSGaQVKATAQEDSESSEEESSS--EEEDETPAQVMALGRLPPAKANPPPTKTPLA----SASGKAAAVV------PPPK 709  Norway rat
XP_021581350  762 GKPSARTPQNSTVtmkgqasvvttGKAVAGAAQTQKGSVGRAEEEDSESSEEESDSEEEEvaPAQAKPLeNKLQQVRNAS 841 
XP_008253480  758 VKLPVRAPQNSAL-----------GKAVATTGPAQKGPVGRPQEEDSESSEESSDSEEEA--PAQVKPL-GKTPQVRAAS 823 
4_pfamImport  417 VKPPMRTPQSSAIlvqgqvsvpavGKAVAVAAPAKTGAVRGPQEEDSGSSEEESDSEEEA--PAQAKPS-RKAPQVKAAS 493 
5_pfamImport  450 GKSPVRAPKNSTIsargqasvpasGKAVTAAAQSQKGPTQESEEKDLESSEESSESEEEL--PTQAKPS-GKTLQVRAAT 526 
AAH21514      715 GKPPV---PNSTVsargqrsvpaaGKAGAPATQAQKGPVAGTGEDSESSSKEESDSEEET--PAQIKPV-GKTSQVRAAS 788 
6_pfamImport  439 AKTPARTLQNSALsvrgqasmqsvGKAG---------------EEDSESSEEESDSEEEV--PAQAKPL-GKTPQVKAAS 500 
3_pfamImport  441 VKPPARTPQSSAIsvrgqvsvlagGKADAAAARAQPGPVRGSQEDSESSSEEDSDSEGAApvPAQAKPP-GKTPQLRTAS 519 
2_pfamImport  359 VRPPARTPQGRPGagkgpgavpavGKAATTAAP-QPGPVGGA-EDDSESSDGDSDSEEAA--PAQAKPT-RKTPQVRAAS 433 
NP_001382056  710 GKAPASTVQNSTIsargqravpatGKAGAPATQAQKGPMAGTGEDSESSSEEESDSEEET--PAQVKPV-GKTSQVRAAS 786  Norway rat
XP_021581350  842 GPAK 845 
XP_008253480  824 APAK 827 
4_pfamImport  494 ASTK 497 
5_pfamImport  527 APAK 530 
AAH21514      789 APAK 792 
6_pfamImport  501 TPAK 504 
3_pfamImport  520 APTK 523 
2_pfamImport  434 APSK 437 
NP_001382056  787 APVK 790  Norway rat
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