Conserved Protein Domain Family
Paxillin
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pfam03535: Paxillin (This model is not part of the current CDD release)
Paxillin family
Paxillin is a multi-domain protein that localises in cultured cells primarily to sites of cell adhesion to the extracellular matrix (ECM) called focal adhesions. The family here represents the N-terminal regions with the proline-rich part as well as the Paxillin part. Focal adhesions form a structural link between the ECM and the actin cytoskeleton and are also important sites of signal transduction; their components propagate signals arising from the activation of integrins following their engagement with ECM proteins, such as fibronectin, collagen and laminin. Importantly, focal adhesion proteins including paxillin also serve as a point of convergence for signals resulting from stimulation of various classes of growth factor receptor.
Links
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Statistics
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PSSM-Id: 515648
Aligned: 12 rows
Threshold Bit Score: 325.687
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_005987233   5 DALLADLESTTSHISKRPVFLPEETPYSYPTGGNTYQEIAVPppvpppPSSEALNGTVIDPANQWQPPVSRYSPPQ--PQ 82 
5_pfamImport   1 DALLADLESTTSHISKRPLFLSDEAAYSFPVGGQAQQDICSP------PISSEPNGLDETEVNLHFREFLGVGQHQ--HY 72 
9_pfamImport   1 DALLADLESTTSHISKCSLFLSDEAAYSLPVGGQDQKGISS-------PPERSLNGVDDSE------------------- 54 
8_pfamImport   1 NALLADLESTTSHISKHPLFLSEEAAYSFPVRGQTQQDVCSPsqvpptPSDQALNGVEEIEVNAFHYCYF---------- 70 
6_pfamImport   1 DALLADLESTTSHISKRPVFLSEETPYSIPTGGLSYQEVCAPppvpppPSADALNGSSRVEASHSHHSSQQVRETS--K- 77 
XP_003445713   5 DALLADLESTTSHISKRPVFLPDETPYSIPTGGQPYQDVTLPppvpppPSAEALNGSLRDQPDSHHSSQQ---------- 74 
4_pfamImport   1 DALLADLESTTSHISKRPVFLPDETPYSIPTGGQSFQDVSTPpplpppPSAEALNGTLTDRPNSHLSCQL---------- 70 
NP_598676      5 DALLADLESTTSHISKRPVFLSEEPPYSYPTGNHTYQEIAVPppvpppPSSEALNGTVLDPLDQWQPSGSRYAHQQ--PP 82 
XP_047285206   3 DALLADLESTTSHISKRPVFLSEETPYSYPTGNHTYQEIAVPppvpppPSSEALNGTILDPLDQWQPSSSRFIHQQ--PQ 80  human
XP_007490399   5 DALLADLESTTSHISKRPMFLSEETPYSYPTGNHTYQEIAVPppvpppPSSEALNGTVLDPPDQWQSGGPRYIHQQsqPQ 84  gray short-tail...
P49024         5 DALLADLESTTSHISKRPVFLTEETPYSYPTGNHTYQEIAVPppvpppPSSEALNGTVIDPLDQWQPSVSRYGHQQ--PQ 82  chicken
XP_056715221   5 dalladlESTTSHISKRPVFLSEETSYSYPTGNHTYQEITIPppvpppPSSEALNGTVTDPLDQWQPSISRNIHQQ--PQ 82  tarantolino

XP_005987233  83 --SqnfsPSVKNSSPSIIRETVSPPAAq-TGEEEHVYSFPNKQKPTD--PSSSAMSSSLGSNLSELDRLLQELNCVQHNP 157
5_pfamImport  73 lpS----SLSPAQKSPWSRESSSPSQP--VCEEDHVYSFPNKQKSSD--SSAAAMNSALGSNLSELDRLLLELNAVQQSA 144
9_pfamImport  55 -------SFSSAQKSQWSRESSSPNQP--SGEEDHVYSFPNKQKTSEssSSPAAMNSSLGSNLSELDRLLLELNAVQQST 125
8_pfamImport  71 --TssfqSVSTAQRSPWSRDSSSLGQP--TGGEDHVYSLPNKQKSSD--SSAGAMNS-LGSNLSELDRLLLELNAVQQST 143
6_pfamImport  78 --TrdahSLGSAQKSSWSGDSVGAPSS--HAEEDHVYSFPNKQKPSD--SSSAAMTSALGSNLSDLDRLLLELNAVQQSS 151
XP_003445713  75 -------SLGSAQKSSWSRDSSSSPLS--HIEEDHVYSFPNKQKTSD--SSTTAMTSALGSNLSELDRLLLELNAVQQSS 143
4_pfamImport  71 --------VGSAQKSLWSRDSSSSPLS--HAEEDHVYSFPNKHKTSD--SSSVAMTSGLGSNLSELDRLLLELNAVQKSS 138
NP_598676     83 spLpvysSSAKNSSASNTQDGVGSLCSr-AGEEEHVYSFPNKQKSAE--PSPTVMSSSLGSNLSELDRLLLELNAVQHSP 159
XP_047285206  81 ssSpvygSSAKTSSVSNPQDSVGSPCSr-VGEEEHVYSFPNKQKSAE--PSPTVMSTSLGSNLSELDRLLLELNAVQHNP 157 human
XP_007490399  85 --SpvfgSGAKNPGVPVSRDSLGSPCPrgAGEEEHVYSFPNKQKSAE--PSPT-MSSSLGSNLSELDRLLLELNAVQH-P 158 gray short-tail...
P49024        83 sqSpiysSSAKSSSASVPRDGLSSPSPr-ASEEEHVYSFPNKQKSAE--PSPTMTSTSLGSNLSELDRLLLELNAVQHNP 159 chicken
XP_056715221  83 sqSpvysSSTSVSRECV----ISPTR---ASEEEHVYSFPNKQKSAE--LSPTLMSSSLGNNLSELDRLLLELNAVQHNP 153 tarantolino

XP_005987233 158 PaGFSTEDSNRSPPQPTGLSSQYsTQENGGSLGRKVPPPTKEKPKRNG-SRGIEDVRPSVESLLDQLESSVPTPTPAPAV 236
5_pfamImport 145 P-AFPTEAEEAAPPLPSSSIIHQ-IHENGVSPAGRTAPATLEKPKRGGaGRVMEDARPSVESLLDELESSVPSPIPTPLA 222
9_pfamImport 126 P-AFPT---EVAPPLPASSTIRH-IQENGLSAPGRIPPPTLEKPKHVVaARGIQDARPSVESLLDELESSVPTPIPTPLV 200
8_pfamImport 144 P-AFATE-EEAAPPLPGSSVVHH-VQENGVSTAGKAIPPVVEKPKRSGpTRGIEDVRPSVESLLNELESSVPAPHPTPLV 220
6_pfamImport 152 P-SFPTT-EEAAPPLPSCSITHY---ENGGGPDVRVTPPPQEKPVRNG-TR-TDEARPSVESLLDELESSVPSPSPPGR- 223
XP_003445713 144 P-SFPTT-EEAAPPLPSCSITHY---ENGGTPDILVSPPPQEKPKRNG--R-MEDARPTVESLLDELEGSVPSPSPSTR- 214
4_pfamImport 139 P-SFPTT--EAAPPLPSCSIIHF---ENGGTPEILLSPPSQEKSIRNG-AK-LEESRPTVKSLLDELEGPVPSPSPPAR- 209
NP_598676    160 P-GFPADEAESSPPLPGALSPLYgIPENNTPLGGKAGPLVKEKPKRNG-GRGLEDVRPSVESLLDELESSVPSPVPAITV 237
XP_047285206 158 P-GFPADEANSSPPLPGALSPLYgVPETNSPLGGKAGPLTKEKPKRNG-GRGLEDVRPSVESLLDELESSVPSPVPAITV 235 human
XP_007490399 159 TsGFLADDANQSPPVPGGLSPQYgIPENNSPLGGKATPPVKEKPKRNG-ARGLEDLRPSVESLLDELESSVPSPVPAITV 237 gray short-tail...
P49024       160 PsGFSADEVSRSPSLPNVTGPHYvIPESSSSAGGKAAPPTKEKPKRNG-GRGIEDVRPSVESLLDELESSVPSPVPAITV 238 chicken
XP_056715221 154 PsGYSADETTRNPVLPSGTGSHYgIPENATSLNAKPAAPVKEKPKRNG-GHDIEDVCPSVESLLDELESSVPSPVPAITV 232 tarantolino

XP_005987233 237 SQVDVATPQRGTLSQEQARISASSATRELDELMASLSDFK 276
5_pfamImport 223 APDEQADAPEETPTQQQARMSASSATRELDELMASLSDFK 262
9_pfamImport 201 VSD---DGQAETLSQQQARMSASSATRELDELMASLSDFK 237
8_pfamImport 221 VSDEQTDGQ-ESLSQQQARMSASSATRELDELMASLSDFK 259
6_pfamImport 224 ------HGDADTPAQQQARISASCATRELDELMASLSDFK 257
XP_003445713 215 ------HSDLDTSSQQQARISASCATRELDELMASLSDFK 248
4_pfamImport 210 ------HSDLDTPSQQQTRISASCATRELDELMASLSDFK 243
NP_598676    238 NQGEMSSPQRVTSSQQQTRISASSATRELDELMASLSDFK 277
XP_047285206 236 NQGEMSSPQRVTSTQQQTRISASSATRELDELMASLSDFK 275 human
XP_007490399 238 NQGEMNHPQRVTSSQQQTRISASSATRELDELMASLSDFK 277 gray short-tailed opossum
P49024       239 SQGEVSSPQRVNASQQQTRISASSATRELDELMASLSDFK 278 chicken
XP_056715221 233 NQGEMSSPQRVTSSQQQTRISASSATRELDELMASLSDFK 272 tarantolino
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