Conserved Protein Domain Family
SLC12

?
pfam03522: SLC12 
Solute carrier family 12
Statistics
?
PSSM-Id: 397542
Aligned: 66 rows
Threshold Bit Score: 382.356
Threshold Setting Gi: 0
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
?
Aligned Rows:
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
CAP36148      700 RSCLVDFANNITKGSSLLVCGQVVPY-----DPSDRVHTVIrklDDVVSIWMRKRHLKAFYRAVANSSFRKGAQSLIQLT 774  Caenorhabditi...
EKC27450      617 RPELVDFVYSLTNKISLMVCGNIVEG-----PQSDNLKHLRgmrPKEAYHWLHNRRVKAFYSVTTAPDFRCGVQNLLQNV 691  Pacific oyster
XP_009029757  691 RVPLVDFCSSITKNIGLMIAGHVVLT-----PVQYKLMDLRq-sVQKAHLWLNKQKIKSFYSVVAADNLRRGVQAMLQAI 764  Helobdella ro...
EKC33789      758 RPALIDFASSITKKQSLLITGHVFTG-----EMSDHVKNLR---SHGAYKWFESRKIKAFYNAVVTPTLRIGTQVLLQAL 829  Pacific oyster
EDO41391      585 RPNLTYIVSQITKNVGLMVCGQVNVG-----SLCQ---------VKSEKDWLRERKIRAFHTVCSAASLRDGVQSLLQTA 650  starlet sea a...
XP_014340414  563 RPSLIDLAHAFTKNVGLLICGHVHLG-----PLRQTLK-EMsvnQVRYQRWLIQQKKKAFYSGVCSEDFRQGVQYLIQAA 636  coelacanth
XP_023822140  664 RPALVDFVGCFTKHISLMICGDIIMEqdrktRP-----NNT---TDVLVKWLNKRKVRSFYTPFTGDNLRTGAHHLLQAS 735  Japanese medaka
XP_004085035  656 RPALVDFVGCFTKNISLMICGDIIME-----KDRKTRPDNT---TDVMVKWLNKRKVRAFYTPFTGDNLRTGAHYLLQAS 727  Japanese medaka
XP_006011463  517 RPALVDFVGTFTKNVSLMICGHINMG-----SRSCVEN------SEGQIEWLNNRKVSSFYTSIEAEDLRVGARNLMQAS 585  coelacanth
XP_002934326  755 RPALVDFVSSVTKNTSLMICGNVAID-----SDKITD-------SEGQLRWLNTRKVISFYSMIYEKTLGAGAKNLMQVS 822  tropical claw...
CAP36148      775 GIAKMKPNIVLVGFKSNWymggpTEQNL--NEMNEYFGTIQDVFDWNMAVCVLRnGGVGLDFS-EAM------------- 838  Caenorhabditi...
EKC27450      692 GIGKLRPNILIMGFMSRW-----NDPEVnkNEVDEYVHVVHDAFDLEYGVGILR-LKEGLYCE----------------- 748  Pacific oyster
XP_009029757  765 GLGKLRPNVMLLGFKSNW-----NDCSP--EEVQDYFNIINDAFDLHYGVGILR-LQSGLDFS-NLH------------- 822  Helobdella ro...
EKC33789      830 GIGKLRPNTLFLGYKSNW-----RKSEP--EDLEDYFNIIEDAFDLKYGVGILR-IPEGLDIN-KIP------------- 887  Pacific oyster
EDO41391      651 GLGKLKPNTLVIGFKRNW-----MRAPH--SEVEEYVNIINDAFELNYGVAILR-VREEFDIDdlddgddwm-------- 714  starlet sea a...
XP_014340414  637 GLGRMRPNTLVAGFKADW-----TTCGV--RAVENYVNIIHDAFDFQYGVIIVR-IKEGLDIStHEI------------- 695  coelacanth
XP_023822140  736 GLGKLKPNTLVLGFKANW-----RDSAP--ETIEDYINTIYDSFDSNYCLCILR-MMDGLDVT-ADLdfkvndgfepdep 806  Japanese medaka
XP_004085035  728 GLGKLKPDTLILGFKANW-----RNSTP--ESIDDYINSIYDTFDFNYCLCILR-MMDGLDVT-ADL------------- 785  Japanese medaka
XP_006011463  586 GLGKLKPNTIFMGFKRNW-----NQDCP--QNLESYIGIIHDAFDYSYGVCLLR-MKGGLDIS-KRV------------- 643  coelacanth
XP_002934326  823 GLGRLKPNTLVLGYKSNW-----QSDSV--QNLEEYVGIIHDAFDCQFAVCILR-INDGLDVS-QKV------------- 880  tropical claw...
CAP36148      839 ---------------RNLNLVEsssKINVPNIENQekvEkstngnlspetvhliekdetarteksaddassrlsyrgsfr 903  Caenorhabditi...
EKC27450          --------------------------------------------------------------------------------      Pacific oyster
XP_009029757  823 ---------------KKEGTTNsdsFSKLATPTTAtvgGlggdddddd-------------------------------e 856  Helobdella ro...
EKC33789      888 ---------------DESETNDdddDDSDREEHYDdsdEeedengdktkqhgsshpderkvs---ggsynfreaskgavg 949  Pacific oyster
EDO41391      715 ------------------------------------------------------------------------------ed 716  starlet sea a...
XP_014340414  696 ---------------QGthsqekshavgkeattetqteddgs---------------------peaeksserdpstphgh 739  coelacanth
XP_023822140  807 eepvehddqhsndedPDA-------------------------------------------------------------- 824  Japanese medaka
XP_004085035  786 ---------------DYQvndgf--------------------------------------------------------- 793  Japanese medaka
XP_006011463  644 ---------------QAAHgevnpv------------------------------------------------------- 653  coelacanth
XP_002934326  881 ---------------QGQvn------------------------------------------------------------ 885  tropical claw...
CAP36148      904 smemfqrINAFYINASISINETYGseenpddd----------------------------dhdhdddDDDVGDSGADDDD 955  Caenorhabditi...
EKC27450      749 -----------ETNANESLPVNDSv------------------------------------------HHKADPEDDEEEK 775  Pacific oyster
XP_009029757  857 fdfherkNREESPNKNEKLGLMGI-------------------------------------------------NNNNSNN 887  Helobdella ro...
EKC33789      950 piklkrlNTVEEGTENPAFDPDAP-----------------------------------------------NGNTKGVRP 982  Pacific oyster
EDO41391      717 ddelynkSQTSRGKESLSVRMDPDsgssdksrsrnvrifhtpptslkhfpgdertpptslkhvpgdeQTSQVRFSSEPSS 796  starlet sea a...
XP_014340414  740 kkidereSERKSRRSRPLLWKAIE-------------------------------------------NWRPIRAFTAAGQ 776  coelacanth
XP_023822140  825 -----------------------------------------------------------------------DMSDEDNSD 833  Japanese medaka
XP_004085035  794 --eadepEEPVEDQDPQSNQEDTDadm----------------------------------------------sdEGKSD 825  Japanese medaka
XP_006011463  654 -fegdkeENSSQENSQDSLQT-------------------------------------------------------ITDE 677  coelacanth
XP_002934326  886 --------------------------------------------------------------------laFQDSDNEAFS 897  tropical claw...
CAP36148      956 ERPNKDDDVelgvmdhqdtekrhfslrrrgsrrhtveqKALLSSI-QRFQRKIKKGVIDVWWLYDDGGLTLLIPHLLSIP 1034 Caenorhabditi...
EKC27450      776 RPSSPSSPTmlrrsstssndsdeaddngndvnvelglgKAIQENFkNRFAKKQKRGTIDVWWLFDDGGLTLLLPYILSTK 855  Pacific oyster
XP_009029757  888 NNNNDDDGCencda----------------------------tggvRYFRSKQSRGFIDVWWLFDDGGLTLLIPYLLSTK 939  Helobdella ro...
EKC33789      983 KLRTMLSSMsta-------------------------------tlsSRFQ-EVQYGTIDVWWLFDDGGLTLLIPYILSKR 1030 Pacific oyster
EDO41391      797 TLRS------------------------------------------VTFKGKQ-KGTVDVWWLFDDGGLTILIPYLLTLH 833  starlet sea a...
XP_014340414  777 KMAev----------------------------------------rSHFQKKQGTGTIDVWWLFDDGGLTLLIPYLLTTK 816  coelacanth
XP_023822140  834 QIK-------------------------------------------TVFQNDQGKKTIDVYWIADDGGLTLLVPYLLTRR 870  Japanese medaka
XP_004085035  826 QIN-------------------------------------------TVFQNDQGKKTIDVYWIADDGGLTLLVPYLLTRR 862  Japanese medaka
XP_006011463  678 QAS-------------------------------------------TIFQDKQGKKSIDIYWLSDDGGLTLLIPYLLSRQ 714  coelacanth
XP_002934326  898 DKEDEKeph--------------------------spvPEILSQTnTEFQGRQGKKSIHVYWLSDDGGLTLLIPYLLKRR 951  tropical claw...
CAP36148     1035 KSYlEGARLRIFTIS--TSSRTMEQEQRGMAALLSKFRIDYSDVYVIADIGKKPRQETMATWQSVIDPFTAPDGSCpm-- 1110 Caenorhabditi...
EKC27450      856 QYW-RNCPLRVFAAG--TKRGEIDREQRQMATLLSRFRIQCEKMTILSDIGKSPSEESMKNFDKLLEGWMLDEENGesae 932  Pacific oyster
XP_009029757  940 KLW-KNCQLRVYIAG--SKATELDREQRQMANLLSKFRIEYSSLVVLPDIGKKPSEQSITDFSKLISKWTINKQLKeteq 1016 Helobdella ro...
EKC33789     1031 KIW-KNCKLRIFCAG--TKKGNQYQDEVRMSSLLTKFRIEYSQLTVIPDMWKKPTLTMYKDFESLIHQHRLRPHESpddy 1107 Pacific oyster
EDO41391      834 SLW-KGCRLRIFTPG----SSNIKNNEIRMANLLKKFRIDFSSIEVVHGIDKAPSNKSVQDFRRLP-------------- 894  starlet sea a...
XP_014340414  817 QQW-KECTIRVFTGGkiNTM---DENKRIMANLLSKFRIDFSDIVIIGDINMKPGKDSVRDFDDLIEPFRLHEEDFdket 892  coelacanth
XP_023822140  871 KRW-HRCKVRIFIVG--DEQ-NEEEGRKEMIALLKRFRLDVNDVIVMTDSEKRPQAKSLTRFVDSIAPFRLYDEQQegvs 946  Japanese medaka
XP_004085035  863 KHW-RRCKVRVFLVG--DEQ-NEEEQRKEMTLLLNRFRLNVKEIIIMTDSEKRPQAKCLTRFVDSVAPFRLFDEQQegvs 938  Japanese medaka
XP_006011463  715 KRW-SQCKVRVFVTGelNNM---DEERKAMISLLSKFRLGFHDVIVIPDSNKKPEPENMKAFEDLVAPFRLHDGLKdesa 790  coelacanth
XP_002934326  952 RRW-SQCKVKVFIR---CRTEKAEEEKKEMQSLLEKFRLGFQEVVVLTNADQKPHCRNMKVFEDLIAPYNLSTRQRtsee 1027 tropical claw...
CAP36148     1111 ---------gmTTKS--ELSAQRDKTYRQLRAGELLQEHSIKADLIVMTLPVPRKGMVSSSLYLSWLEVMTRNL-PPILL 1178 Caenorhabditi...
EKC27450      933 k------fpwkVTEE--QKLFLKDKTKRNVRLRELLMEHSKDAALIVMTLPVPRKNTCPAGLYMAWIETLTKDL-PPILL 1003 Pacific oyster
XP_009029757 1017 t------hpwkITEA--ELVAQNAKNYRHLRLKELLKQHSSDSKFIVMTLPIPRRGICSFGLYMAWLDTLTSDL-PPFLL 1087 Helobdella ro...
EKC33789     1108 --------pwkISDA--DLLANKQKIYRNIKLKEQLLIHSPEASLIVLTLPVPKREACPAALFMAWLEMISSGM-PPLLF 1176 Pacific oyster
EDO41391      895 -----------IKEEldEGVQLDKRILRQIRIGELLRQHSKDARLIVMTLPVPKPTLMSPLMYMSWLEVLSADL-PPVFL 962  starlet sea a...
XP_014340414  893 vekmrtaepwkITDD--ELEMFREKTQRQIRLNELLQQHSSSANLIVMSLPVARKGAVSNTLYMAWLETLSKDL-PPLLL 969  coelacanth
XP_023822140  947 vqelrqnapwkISDK--EFEVFRLKSERKIRLNEIIRKNSQHTALVLVSLPVPHRD-CPSSLYMAWLDTLTYGLhCPAVL 1023 Japanese medaka
XP_004085035  939 vqdlrqsapwkISDK--EFEVFRQKSERMIRLNEIIRKNSQHTALVLVSLPVPNRD-CPSALYMAWLDTLTYGLhCPAVL 1015 Japanese medaka
XP_006011463  791 vqelrkacpwkISDQ--EYNRQKKKSQRQVHLNEILRQNSQEAALIVMSLPVAKKDACPSTLYMAWLETLSRGLnCPIIL 868  coelacanth
XP_002934326 1028 ae----ipscgITEK--DLVHYMAKSERYVRMNEILKENSQDAALIAISLPIVSRDTCPSSLYMAWLASLSRDLnPPIVF 1101 tropical claw...
CAP36148     1179 VRGNQQSVLTFYS 1191 Caenorhabditis briggsae
EKC27450     1004 LRGNQSSVLTFYS 1016 Pacific oyster
XP_009029757 1088 LRGNQENVLTFYS 1100 Helobdella robusta
EKC33789     1177 LRGNQENVLTYYS 1189 Pacific oyster
EDO41391      963 IRGNQTSVLTFYC 975  starlet sea anemone
XP_014340414  970 IRGNHQSVLTFYS 982  coelacanth
XP_023822140 1024 IRGNQQNVLTFYC 1036 Japanese medaka
XP_004085035 1016 IRGNQKNVMTLYC 1028 Japanese medaka
XP_006011463  869 IRGNQQDVLTFYC 881  coelacanth
XP_002934326 1102 IRGNQQDALTVYC 1114 tropical clawed frog
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap