3B5I


Conserved Protein Domain Family
Methyltransf_7

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pfam03492: Methyltransf_7 (This model is not part of the current CDD release)
SAM dependent carboxyl methyltransferase
This family of plant methyltransferases contains enzymes that act on a variety of substrates including salicylic acid, jasmonic acid and 7-Methylxanthine. Caffeine is synthesised through sequential three-step methylation of xanthine derivatives at positions 7-N, 3-N, and 1-N. The protein 7-methylxanthine methyltransferase (designated as CaMXMT) catalyzes the second step to produce theobromine.
Statistics
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PSSM-Id: 515622
Aligned: 102 rows
Threshold Bit Score: 195.872
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3B5I_A         38 ETLEN-VHLNSSaSP--PPFTAVDLGCSSGANTVHIIDFIVKHIsKRFdA-AGID------PPEFTAFFSDLPSNDFNTL 107 thale cress
Q9XI57         30 neinarLDITNHsFS---SFTIADFGCSSGPNTVIAVDIIIQALyHKFtSsLPNTt-----TPQFQVFFNDVSHTDFNAL 101 thale cress
XP_004232014   36 aelieqeldvgIiNSvcSLFCVADFGCSVGGNTYLAVQNIIKAVeNKYkSsELDQenpqlqVPEFLVFFNDLVQNDFNTL 115
EEF29862       21 dgivdhFDIEDTsSS---QFTIADLGCSTGPNTFVSMENIIQGItQTYkIkGYST------LPEFQVYFNDHISNDFNTL 91 
XP_002284898   44 EAIAQkLDVKCFsSN---PFRLADLGCSVGPNTFISMQHIVEAVeRKYlEqGLKSq-----IPEFQVFFNDHVANDFNTL 115
12_pfamImport   1 ----------IIlSSs-NTLRIAELGCSVGPNTFSAMQYIVEALkDKYlLyQDQVinftnnIPEFQIFFNDHVTNDFNIL 69 
11_pfamImport   1 ------LDIKNMlSSs-NKFYITDLGCSIGPNTFNSMQHVVQVVkDKYhDn----------ILEFQVFFNDHFNNDFNTL 63 
Q9C9W8         42 klvlEkLNAKTLiSSdsNTFRIADLGCATGPNTFFLVDNIIKSIeTSLrKsNSS-------KPEFLVFFNDLPQNDFNTL 114 thale cress
XP_002526004   50 aitkkldvrsLLaTSs-NTIRVADLGCAVGPNTFTCMQNIVNVVkEKYrSqCPTSe----iLPDFQVFFNDKTSNDFNTL 124
CBI33593       40 eaVWEkLDTNFs-----TLFNIADLGCSVGPNTFIVVENIIESVkLKYpSpNPNSe-----GIEFQVFFNDLASNDFNTL 109
3B5I_A        108 FQLL-PP-LVsntcmeeclaadgnrsYFVAGVPGSFYRRLFPARTIDFFHSAFSLHWLSQVPESVtdRRSAAYNRGRVFI 185 thale cress
Q9XI57        102 FALLpPQ-RP----------------YFVAGVPGSFYGNLFPKAHLNLAYSSCALCWLSDLPSELtdTSSPAYNRGRIHY 164 thale cress
XP_004232014  116 FNYIhGNkPN----------------YFTTGIPGSFYGRIFPKAFLHFAHSSMSLLYLSRIPEEVldRNSAAWNKGRIHY 179
EEF29862       92 FLNLpSN-RN----------------YFACGVPGTFHGRLFPRASLNFVYSAFAMQWLSKAPEELndLNSEVCNRGRIHY 154
XP_002284898  116 FASLpTE-RR----------------YFACGVPGSFHGRLFPESSIHFMFSSHAIHWLSKVPEELldKNSPAWNRGRIHY 178
12_pfamImport  70 FRSLpFD-RS----------------YYAYGIPGSFYGRLFPSRSIHFVHSSSGINWLSKIPKELvdEKSPAWNKGLIHY 132
11_pfamImport  64 FRSLpVD-RS----------------YYASGVPGSFHGRLFPSRSIHFAHSSCAIHWLSKCPKELldEKSLAWNKGLIHY 126
Q9C9W8        115 FTSLpQD-RS----------------YLAVGVPGSFYGRVLPQSSVHIVVTMGATHWLSSVPKEVldKSSKAWNKGKVHY 177 thale cress
XP_002526004  125 FTSLpLE-RE----------------YFAAGVPGSFYQRLFPESSLHVVQCHYAIFWLSKVPDELqdKDSPAWNKGKIHY 187
CBI33593      110 YRSLpRD-RE----------------YAASIVPGSFHGRLFPKSSLHFIHSSYTLHWLSKVPKELldKNSPAWNKGRISY 172
3B5I_A        186 --HGAG-EKTTTAYKRQFQADLAEFLRARAAEVKRGGAMFLVC--LGR-TSVDPTdQGGAgLLFgTHFQDAWDDLVREGL 259 thale cress
Q9XI57        165 --TGASa-EVAQAYSSQYKKDIKLFLHARSQELAENGLMALIV--PGVpDGFLDCqEASTgSEF-DLLGSCLMDMAKEGI 238 thale cress
XP_004232014  180 ssSGAAk-EVEAAYADQFRKDIQAFLDARAQELVPGGLMTIIT--LTIlDG-VLPsDSPMaINF-TILGSCLQDMANMGI 254
EEF29862      155 --ANAPa-EVCEAYATQYAADMASFLAARAEEVAPGGLMAFII--PGRpDG-TLAsEYSLgQVF-HIVEFCLLDMANEGI 227
XP_002284898  179 --TSAPd-EVSHAYAAQFDHDMEIFLSARAKELVVGGIIVLTM--AALpNG-IPAsRIPSgVMF-DLLGASLMDMTKAGL 251
12_pfamImport 133 --VGASnVEVVNAYFAQFEKDMEVFFNVRAEEIVQGGMMVLITafSGYiRL------------M-RFFGSSLMDLVNEGK 197
11_pfamImport 127 --VGASnVEVMNAYVAQFEKDMEMFFNARAEEIVPGGMMVLLSpfSGYrY-------------L-NFFGSTLMDLVNEGM 190
Q9C9W8        178 --SNAAd-EVVKAYRDQFGRDMEKFLEARATEIVSGGLLVVGM--CGIpKG-MPFsNLADsIMY-TSMADVLTQMHSEGL 250 thale cress
XP_002526004  188 --ASAPd-EVLRAYANQWAHDFDSFLNARAKEIVPGGLLIVIM--PSVpDG-MPYsELANgIFF-NLLASILLDMAKRGL 260
CBI33593      173 --GSAPn-EVVQAYSAQFAKDMGSFLKARAQELVHGGLMALII--PCLpVD-TSPsECPLiAVM-DLLGDSLMDMARMGL 245
3B5I_A        260 VAAEKRDGFNIPVYAPSLQDFKEVVDANGSFAIDKLVVykggsPlvv--nepDDASeVGRAFA-SSCRSVAGVLVEAHIG 336 thale cress
Q9XI57        239 IEEEEVNSFNLPIYYTTPKELEDIIRSNGELKIDKMETlgs--------mdaQDTMpDLESRV-LYLRAVLEGLVRTHFG 309 thale cress
XP_004232014  255 MSEEKLDSFNLPYYYTSPMEFETLIKTHGCFDIIRFEKlpt---------plRQVViDVQTAV-LSVRVVTEQLFQQHFG 324
EEF29862      228 VSKEKLDLFNLPLYSPSIEELKKLIEKNGKFSIAKLEA----------------HEeDTKIPPsGYCRAGFESIVKKHFG 291
XP_002284898  252 INEAQVDSFNLPVYAPSQEQMTDLVKRNGCFTIERMELvyr--------askLVAPiTGKECG-MHLRAGMEGMIAKHFG 322
12_pfamImport 198 LDESLVDSFNLPLYYPSPQEMTKVVEKNGLFSIERMELini--------ksnLVDEaDAKTLM-TSLRSSIEGVIISHFG 268
11_pfamImport 191 LDESLVNSFNVPVYFPSIEDMTKVVEKNNSFSIEKIELtyp--------kskLVDEaDAKTLI-INLTAVLQQLFINHFG 261
Q9C9W8        251 ISEEQVDTFNIPIYSATPEEVTVLVVKNGCFTVESMEL-----MdptawlkrPTNVeDVRHWM-VCIKATMGSLFINHFG 324 thale cress
XP_002526004  261 IREEEVDGFNMPIYAAPPGEFVAGVEKNGHFNIEEIGLtnpa------pwltDDVHvDMIEFL-RHIRAAWEGMFIKHFP 333
CBI33593      246 ISEAKVDSFNFPKYYPTQHELKTLIERNGYFSIDRTEPlaq--------sttHARDlNFQIFI-SHTRAAWEGVIKMHFG 316
3B5I_A        337 EELSNKLFSRVESRATShAK--DVlVN-LQFFHIVASLS 372 thale cress
Q9XI57        310 HQILDDLFDRYALKLAHsSFilQP-QThK-SIMIFALLS 346 thale cress
XP_004232014  325 NDITEELFQRYTEKLDShPLl-KD-DKyRTDASYFVFLK 361
EEF29862      292 SEIIEELFERYKRKHAEmYHivAA-DFv--SLSVFVLLK 327
XP_002284898  323 SGIIDELFDTFSKKSVEfSHqlES-STrE-GAQLFAALR 359
12_pfamImport 269 SKIAEEACARTILKSEEiSEwmKV-NNeK-PSILFVALK 305
11_pfamImport 262 NKITEETFTRTILKSEEiSAwmKI-NYeK-ACQLFVALK 298
Q9C9W8        325 EHLLDDVFDRLTAKLVGlTEk-iE-SSyREKVMLFFALQ 361 thale cress
XP_002526004  334 PNIVDEIFDQLTIRLPEvFEs-mE-RAyKDKIQAHYVLQ 370
CBI33593      317 SDIIDGLFDRFMKKVLKfSPliSR-HSsKQIAEIFVLLK 354
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