3B5I


Conserved Protein Domain Family
Methyltransf_7

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pfam03492: Methyltransf_7 
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SAM dependent carboxyl methyltransferase
This family of plant methyltransferases contains enzymes that act on a variety of substrates including salicylic acid, jasmonic acid and 7-Methylxanthine. Caffeine is synthesized through sequential three-step methylation of xanthine derivatives at positions 7-N, 3-N, and 1-N. The protein 7-methylxanthine methyltransferase (designated as CaMXMT) catalyzes the second step to produce theobromine.
Statistics
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PSSM-Id: 397525
Aligned: 112 rows
Threshold Bit Score: 189.302
Threshold Setting Gi: 325079700
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3B5I_B        38 ETLEN-VHLNSsaSP--PPFTAVDLGCSSGANTVHIIDFIVKHISKRFdAAGID-------PPEFTAFFSDLPSNDFNTL 107 thale cress
XP_002284898  44 EAIAQkLDVKCfsSN---PFRLADLGCSVGPNTFISMQHIVEAVERKYlEQGLKs-----qIPEFQVFFNDHVANDFNTL 115 wine grape
XP_006364073  36 daiirklnikIilSSs-NTLRIAELGCSVGPNTFSAMQYIVEALKDKYlLYQDQvinftnnIPEFQIFFNDHVTNDFNIL 114 potato
XP_006364075  36 eaiienLDIKNmlSSs-NKFYITDLGCSIGPNTFNSMQHVVQVVKDKYhDN----------ILEFQVFFNDHFNNDFNTL 104 potato
Q9C9W8        42 klvlEkLNAKTliSSdsNTFRIADLGCATGPNTFFLVDNIIKSIETSLrKSNSS-------KPEFLVFFNDLPQNDFNTL 114 thale cress
XP_002526004  50 aitkkldvrsLlaTSs-NTIRVADLGCAVGPNTFTCMQNIVNVVKEKYrSQCPTse----iLPDFQVFFNDKTSNDFNTL 124 castor bean
CBI33593      40 eaVWEkLDTNFs-----TLFNIADLGCSVGPNTFIVVENIIESVKLKYpSPNPNs-----eGIEFQVFFNDLASNDFNTL 109 wine grape
Q9XI57        30 neinarLDITNhsFS---SFTIADFGCSSGPNTVIAVDIIIQALYHKFtSSLPNt-----tTPQFQVFFNDVSHTDFNAL 101 thale cress
XP_004232014  36 aelieqeldvgiiNSvcSLFCVADFGCSVGGNTYLAVQNIIKAVENKYkSSELDqenpqlqVPEFLVFFNDLVQNDFNTL 115 tomato
EEF29862      21 dgivdhFDIEDtsSS---QFTIADLGCSTGPNTFVSMENIIQGITQTYkIKGYSt------LPEFQVYFNDHISNDFNTL 91  castor bean
3B5I_B       108 FQLL-PP-LVsntcmeeclaadgnrsYFVAGVPGSFYRRLFPARTIDFFHSAFSLHWLSQVPESVtdRRSAAYNRGRVFI 185 thale cress
XP_002284898 116 FASLpTE-RR----------------YFACGVPGSFHGRLFPESSIHFMFSSHAIHWLSKVPEELldKNSPAWNRGRIHY 178 wine grape
XP_006364073 115 FRSLpFD-RS----------------YYAYGIPGSFYGRLFPSRSIHFVHSSSGINWLSKIPKELvdEKSPAWNKGLIHY 177 potato
XP_006364075 105 FRSLpVD-RS----------------YYASGVPGSFHGRLFPSRSIHFAHSSCAIHWLSKCPKELldEKSLAWNKGLIHY 167 potato
Q9C9W8       115 FTSLpQD-RS----------------YLAVGVPGSFYGRVLPQSSVHIVVTMGATHWLSSVPKEVldKSSKAWNKGKVHY 177 thale cress
XP_002526004 125 FTSLpLE-RE----------------YFAAGVPGSFYQRLFPESSLHVVQCHYAIFWLSKVPDELqdKDSPAWNKGKIHY 187 castor bean
CBI33593     110 YRSLpRD-RE----------------YAASIVPGSFHGRLFPKSSLHFIHSSYTLHWLSKVPKELldKNSPAWNKGRISY 172 wine grape
Q9XI57       102 FALLpPQ-RP----------------YFVAGVPGSFYGNLFPKAHLNLAYSSCALCWLSDLPSELtdTSSPAYNRGRIHY 164 thale cress
XP_004232014 116 FNYIhGNkPN----------------YFTTGIPGSFYGRIFPKAFLHFAHSSMSLLYLSRIPEEVldRNSAAWNKGRIHY 179 tomato
EEF29862      92 FLNLpSN-RN----------------YFACGVPGTFHGRLFPRASLNFVYSAFAMQWLSKAPEELndLNSEVCNRGRIHY 154 castor bean
3B5I_B       186 --HGAGE-KTTTAYKRQFQADLAEFLRARAAEVKRGGAMFLVC--LGRtSV-DPTDQGgAgLLfGTHFQDAWDDLVREGL 259 thale cress
XP_002284898 179 --TSAPD-EVSHAYAAQFDHDMEIFLSARAKELVVGGIIVLTM--AALpNG-IPASRIpSgVM-FDLLGASLMDMTKAGL 251 wine grape
XP_006364073 178 --VGASNvEVVNAYFAQFEKDMEVFFNVRAEEIVQGGMMVLITafSGYiRL-------------MRFFGSSLMDLVNEGK 242 potato
XP_006364075 168 --VGASNvEVMNAYVAQFEKDMEMFFNARAEEIVPGGMMVLLSpfSGYrY--------------LNFFGSTLMDLVNEGM 231 potato
Q9C9W8       178 --SNAAD-EVVKAYRDQFGRDMEKFLEARATEIVSGGLLVVGM--CGIpKG-MPFSNLaDsIM-YTSMADVLTQMHSEGL 250 thale cress
XP_002526004 188 --ASAPD-EVLRAYANQWAHDFDSFLNARAKEIVPGGLLIVIM--PSVpDG-MPYSELaNgIF-FNLLASILLDMAKRGL 260 castor bean
CBI33593     173 --GSAPN-EVVQAYSAQFAKDMGSFLKARAQELVHGGLMALII--PCLpVD-TSPSECpLiAV-MDLLGDSLMDMARMGL 245 wine grape
Q9XI57       165 --TGASA-EVAQAYSSQYKKDIKLFLHARSQELAENGLMALIV--PGVpDGfLDCQEAsTgSE-FDLLGSCLMDMAKEGI 238 thale cress
XP_004232014 180 ssSGAAK-EVEAAYADQFRKDIQAFLDARAQELVPGGLMTIIT--LTIlDG-VLPSDSpMaIN-FTILGSCLQDMANMGI 254 tomato
EEF29862     155 --ANAPA-EVCEAYATQYAADMASFLAARAEEVAPGGLMAFII--PGRpDG-TLASEYsLgQV-FHIVEFCLLDMANEGI 227 castor bean
3B5I_B       260 VAAEKRDGFNIPVYAPSLQDFKEVVDANGSFAIDKLVVykgGsplvvnepDDASeVGRAFA-SSCRSVAGVLVEAHIGEE 338 thale cress
XP_002284898 252 INEAQVDSFNLPVYAPSQEQMTDLVKRNGCFTIERMELvyr------askLVAPiTGKECG-MHLRAGMEGMIAKHFGSG 324 wine grape
XP_006364073 243 LDESLVDSFNLPLYYPSPQEMTKVVEKNGLFSIERMELini------ksnLVDEaDAKTLM-TSLRSSIEGVIISHFGSK 315 potato
XP_006364075 232 LDESLVNSFNVPVYFPSIEDMTKVVEKNNSFSIEKIELtyp------kskLVDEaDAKTLI-INLTAVLQQLFINHFGNK 304 potato
Q9C9W8       251 ISEEQVDTFNIPIYSATPEEVTVLVVKNGCFTVESMEL---MdptawlkrPTNVeDVRHWM-VCIKATMGSLFINHFGEH 326 thale cress
XP_002526004 261 IREEEVDGFNMPIYAAPPGEFVAGVEKNGHFNIEEIGLtnpa----pwltDDVHvDMIEFL-RHIRAAWEGMFIKHFPPN 335 castor bean
CBI33593     246 ISEAKVDSFNFPKYYPTQHELKTLIERNGYFSIDRTEPlaq------sttHARDlNFQIFI-SHTRAAWEGVIKMHFGSD 318 wine grape
Q9XI57       239 IEEEEVNSFNLPIYYTTPKELEDIIRSNGELKIDKMETlgs------mdaQDTMpDLESRV-LYLRAVLEGLVRTHFGHQ 311 thale cress
XP_004232014 255 MSEEKLDSFNLPYYYTSPMEFETLIKTHGCFDIIRFEKlpt-------plRQVViDVQTAV-LSVRVVTEQLFQQHFGND 326 tomato
EEF29862     228 VSKEKLDLFNLPLYSPSIEELKKLIEKNGKFSIAKLEA--------------HEeDTKIPPsGYCRAGFESIVKKHFGSE 293 castor bean
3B5I_B       339 LSNKLFSRVESRATShakdvLVNLq--FFHIVASLS 372 thale cress
XP_002284898 325 IIDELFDTFSKKSVEfshqlESSTr-eGAQLFAALR 359 wine grape
XP_006364073 316 IAEEACARTILKSEEisewmKVNNe-kPSILFVALK 350 potato
XP_006364075 305 ITEETFTRTILKSEEisawmKINYe-kACQLFVALK 339 potato
Q9C9W8       327 LLDDVFDRLTAKLVGlte-kiESSyreKVMLFFALQ 361 thale cress
XP_002526004 336 IVDEIFDQLTIRLPEvfe-smERAykdKIQAHYVLQ 370 castor bean
CBI33593     319 IIDGLFDRFMKKVLKfspliSRHSskqIAEIFVLLK 354 wine grape
Q9XI57       312 ILDDLFDRYALKLAHssfilQPQTh-kSIMIFALLS 346 thale cress
XP_004232014 327 ITEELFQRYTEKLDShp-llKDDKyrtDASYFVFLK 361 tomato
EEF29862     294 IIEELFERYKRKHAEmyhivAADFv--SLSVFVLLK 327 castor bean
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