5YHI


Conserved Protein Domain Family
MOSC
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pfam03473: MOSC (This model is not part of the current CDD release)
MOSC domain
The MOSC (MOCO sulfurase C-terminal) domain is a superfamily of beta-strand-rich domains identified in the molybdenum cofactor sulfurase and several other proteins from both prokaryotes and eukaryotes. These MOSC domains contain an absolutely conserved cysteine and occur either as stand-alone forms, or fused to other domains such as NifS-like catalytic domain in Molybdenum cofactor sulfurase. The MOSC domain is predicted to be a sulfur-carrier domain that receives sulfur abstracted by the pyridoxal phosphate-dependent NifS-like enzymes, on its conserved cysteine, and delivers it for the formation of diverse sulfur-metal clusters.
Links
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Statistics
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PSSM-Id: 515608
Aligned: 299 rows
Threshold Bit Score: 47.1313
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
5YHI_A         52 EKKVHGGPDRALCHYPREHYLYWAREF--------PEqa--eLFVAPAFGENLSTDGlTESNVYMGDIF---RWG---EA 115 Escherichia co...
Q8MYE6        199 IHQVSLCDGSQTNILSESSIVELNNRIsetrksngEeq--rsPLTWERFRPNILVS--AGDKSFEEDTWekiNIS---GL 271 Dictyostelium ...
Q55D22        203 EYKNSLSNSCQIMFLSKSSIDDLNKRVeknriengESikdkpSLKYDRFRPNLIING---TTPFQEDHWksiEIEnksET 279 Dictyostelium ...
XP_003216077  189 TDEVAYAEGSPILLISEASLDDLNSRLe-------------eKVSITNFRPNIFVTG---CAPFEEDSWsqiLIG---NV 249
XP_005043255  100 TDEVAYPDCSPVLMISEASMDDLNTRLek-------------kAKIQNFRPNIYVT---DCSAFEEDTWedvLIG---DV 160
NP_001014389  194 DDEVAYPDAAPVMLMTEASVGDLNSRLdk-------------dLSVFQFRPSIVVS---DCEAFTEDTWdhiRIG---EV 254
EHA99387      171 GYQVPYPDASPVLLHTEASLVDLNTRLgk-------------kVKMEHFRPNIVVGG---CDAFEEDTWedlVIG---DV 231
17_pfamImport   1 NGNSIYHDFSPYNMLSEESIQDVTKRLdkn-----------enFSVKNFRPNFLISG---CSPHDENLWthyKIG---SA 63 
EEC19993      105 TIPVAFHDTSTIHMLSVASLKDFNSKLpeg----------nvEITERSFRPSFLIEG---CDAYAEDHWirvRLG---DA 168
XP_047279573   16 NFQVAYPDYCPLLIMTDASLVDLNTRMek-------------kMKMENFRPNIVVTG---CDAFEEDTWdelLIG---SV 76  human

5YHI_A        116 -----L-IQVSQPRSPCYKLNYHFD----------ISD-----IAQLMQn-----------TGK-VG-WLYSVI-APGK- 159 Escherichia co...
Q8MYE6        272 -----VlKKLSAGCPRCKLTTVDYDagv----lnpYDDneplrTLETFRkf---------dSGLlFGaEFIQEFeNEANg 333 Dictyostelium ...
Q55D22        280 ttttiE-LKIADGNARCPVVTIDQDmgv----ldpYNDdeplrTLKTFRkvdc----vigqKVL-FG--TYAVT-NPKDl 346 Dictyostelium ...
XP_003216077  250 -----Q-MKGILPCPRCIFTTIDPNtgim--hkkePLK-----TLKRYRkyasteqhsyksFPP-FG-CLYGIE-KTGM- 312
XP_005043255  161 -----E-MKGTVCCGRCILTTVNPDtgiid-rkepLETlksyrLCDPSErhi------yktSPL-FG-KYFAVN-KTGT- 223
NP_001014389  255 -----E-LKRVIGCGRCLFTTVDPEtgvfs-rkepLDTlktyrMTDPKQk----------tSPI-LG-QYYTVR-KTGV- 313
EHA99387      232 -----E-LKRVMSCPRCILTTVDPDtgild-rkepLQTlksyrLCDPSVkhl------yqsSPL-FG-VYFMVE-KIGV- 294
17_pfamImport  64 -----E-FNFAKHCHRCMLTTIDMDtgimrkneepLKTlrtfrLCKPEEkei------ygtSPI-LG-VDLGIT-KTGS- 127
EEC19993      169 -----E-IAFVERCSRCVLTTVDPNtgtk--amepLKT-----LRTYRVdrskfgrkkykmQPL-FG--VCQYLvKDGN- 231
XP_047279573   77 -----E-VKKVMACPRCILTTVDPDtgvid-rkqpLDTlksyrLCDPSErel------yklSPL-FG-IYYSVE-KIGS- 139 human

5YHI_A        160 ---VSADAPLE 167 Escherichia coli K-12
Q8MYE6        334 s-eISVGDIIN 343 Dictyostelium discoideum
Q55D22        347 gkfIYVGDKIN 357 Dictyostelium discoideum AX4
XP_003216077  313 ---LAVGDPVY 320
XP_005043255  224 ---IQVGDPVY 231
NP_001014389  314 ---LHVGEPVY 321
EHA99387      295 ---LRVGDPVY 302
17_pfamImport 128 ---VSVGDVVY 135
EEC19993      232 ---VRVGDDIY 239
XP_047279573  140 ---LRVGDPVY 147 human
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