Conserved Protein Domain Family
Smg4_UPF3

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pfam03467: Smg4_UPF3 
Smg-4/UPF3 family
This family contains proteins that are involved in nonsense mediated mRNA decay. A process that is triggered by premature stop codons in mRNA. The family includes Smg-4 and UPF3.
Statistics
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PSSM-Id: 397505
Aligned: 90 rows
Threshold Bit Score: 107.375
Threshold Setting Gi: 124447720
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
KIS71801     125 KSKVVIRRLPPNLPAHVFWKAVSpwirdsadcqaltttaqtssapaqpgaetseahtSdsrsaatssastSPTPTVDYKQ 204 Ustilago maydis...
A0CWM3        13 SFKVHIRRLPPLLREEEFYATIQ-----------------------------------------------EYLNDIVMKY 45  Paramecium tetr...
XP_011271494  66 GFKVVVRLLPPNLKAEEFWSKVE----------------------------------Dy-----------VTAQNILDKY 100 Wickerhamomyces...
XP_001382558  45 NVKVVLRLLPPTLDENGFYDQLSa---------------------------------Fy----------dVNSPNITSKY 81  Scheffersomyces...
CCE65625      65 GFKLVLQSLPPALTETEFWDAVKs--------------------------------vVnd--------tnEYQINLNSFY 104 Tetrapisispora ...
Q756Q0       117 GHKLVVRLLPPNLTEDEFYRTLCp--------------------------------hLps--------eqFFEKTTRDRY 156 Eremothecium go...
CAR22151      64 QYKLVLRQLPPNLMEEQFFDTVSa--------------------------------aVgs---------dFLQQHVEDRY 102 Lachancea therm...
XP_003681278  64 GVKLVLRLLPPDLSQDQFLETIKp---------------------------------Evg---------eFSDCGVLEWY 101 Torulaspora del...
P48412        85 GFKLVIRLLPPNLTADEFFAILRdnn-----------------------------ndDgdk------qdiQGKLKYSDWC 129 Saccharomyces c...
CCK72464     113 GFRVVMRLLPPNLTFEELCTTLKt--------------------------------eIts--------dfVSVYRISDIY 152 Kazachstania na...
KIS71801     205 FVAGKLKtDTNKQNKHARAYVRFLDAQMLVQFYKAFDGHIFRD-SRGNESIAIVEFAPYQKVvvsTPrtgtrggpraAKL 283 Ustilago maydis...
A0CWM3        46 YVKGK---LKEQEKIDSRCYLFFNCDAAMSRFIQGYKK-VFCD-EKGIYYQPDIGKALLQNQqdhLR----------NKP 110 Paramecium tetr...
XP_011271494 101 YVQGKYSnKPFKLPTYSRAYIQFEDPQIVDQFVAKYKEVTFEDdKE--SMIPTFAMALFSKMpenEKsp-------sKKP 171 Wickerhamomyces...
XP_001382558  82 YVKGSYPaKPFEAPIYSRAYITFHTSDDVVFFMSSVNGKPFVEpETEDSFTPLVERAIFNKMpakDGk---------EES 152 Scheffersomyces...
CCE65625     105 FVQGKLSdKPFHDPVYSRSYIMFKDMENLRKFALKIQDVTFTD-ANNDSSVASIKISPYNRSynsALekk----kpaANK 179 Tetrapisispora ...
Q756Q0       157 YVPGHYSrKPFKLPTYSRCYLIFYDLAALQTVGRILQNMTFVD-DHDNATVPKLFLSPYVKKmrnLGghm----qiqDQK 231 Eremothecium go...
CAR22151     103 FFKGHFSrKPFKLPTYSRAYMTFNEAEKLQFFAKSVSAVTFVD-DTNNSMVPTVTLSPYLKKlrtEEskg-----lrKTK 176 Lachancea therm...
XP_003681278 102 YVRGHYPqKLSTRPVYSRCYLIFESTESLAEFTKKVQPIKFVD-DKDNATNVVTRVSTYVKRfvpNTvd------psPVS 174 Torulaspora del...
P48412       130 FFEGHYSsKVFKNSTYSRCNFLFDNLSDLEKCANFIKTCKFID-NKDNITIPDMKLSPYVKKftqTS----------KKD 198 Saccharomyces c...
CCK72464     153 YVQGHYSvKAFNEPIFSRCYFHFDDMENLKAFVMKLQGIMLVD-DRDNAVKPTIKLTPYAKKlsdTNpng----fgkSKT 227 Kazachstania na...
KIS71801     284 DAQQGTIDKDAD-YQCFLERLSKADDQ-VQRSEGELLASlldskg--------------------keketEARRLAGKVT 341 Ustilago maydis...
A0CWM3       111 KPLEGEYQKTEL-YKRFLKFLEEEQLQqQEMENAQTQQLkeepi----------------------npedKPKKFEKVKT 167 Paramecium tetr...
XP_011271494 172 DSKPKHTLQDLLsYKNFLKFYNGEIERpQSFLISEKNDKrae-------------------------kraAKKAEKKAEK 226 Wickerhamomyces...
XP_001382558 153 ITEKSSVEGSEL-FQEFVKFLNGETKEyNIVQLVKLNKRrare-----------------------klknERKKEKKAAK 208 Scheffersomyces...
CCE65625     180 KVLEGTIKDDPL-FKAFVQSMKimaesdqymyseinl-------------------fkplkkeldkqkqvNEAILKQTEK 239 Tetrapisispora ...
Q756Q0       232 LKLEGTLDKDPI-FQIFTKSLQlleenkgeyqykdlh------------------ilnplekelkkrrevDGSIKKQVHD 292 Eremothecium go...
CAR22151     177 DLIEGTIEQDRT-FQTFLKSLDllenhkqeyqyadls------------------vimplekalrrkleeEARVKAQGEK 237 Lachancea therm...
XP_003681278 175 AALEGTITEDPL-FLTFMKSLKileekksdysfadvs------------------ilkplekevakqkavESEIQRKTEN 235 Torulaspora del...
P48412       199 AALVGTIEEDEI-FKTFMNSMKqlnendeysfqdfsv-------------------lkslekefsksielENKIAERTER 258 Saccharomyces c...
CCK72464     228 FVLEGSLEETKL-FKNFMKSLK----------YIEKTQEagdegslfnlldgsisllkplekelakkkkaEAAVKRKTEN 296 Kazachstania na...
KIS71801     342 PLLL------HLREQKM 352 Ustilago maydis 521
A0CWM3       168 HIIM------ELEKEYQ 178 Paramecium tetraurelia
XP_011271494 227 KVEK--------KNEKG 235 Wickerhamomyces ciferrii
XP_001382558 209 AAEA------KIAKLKD 219 Scheffersomyces stipitis CBS 6054
CCE65625     240 ALVEla---gAVESEKK 253 Tetrapisispora phaffii CBS 4417
Q756Q0       293 AMIElageiesedkkkk 309 Eremothecium gossypii
CAR22151     238 AMIAla--------gQV 246 Lachancea thermotolerans CBS 6340
XP_003681278 236 ALIAlt-----gDSGKK 247 Torulaspora delbrueckii
P48412       259 VLTElvgtgdKVKNKNK 275 Saccharomyces cerevisiae S288C
CCK72464     297 ALTEla---gSIAGNNK 310 Kazachstania naganishii CBS 8797
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