1I6A,5Z49,3HFU,6M5F,8H3V,2FYI,5FHK,2F6G,3HHF,4XWS,5Z72,2F7B,7XBE,7YHJ,2ESN,7V5V


Conserved Protein Domain Family
LysR_substrate
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pfam03466: LysR_substrate (This model is not part of the current CDD release)
LysR substrate binding domain
The structure of this domain is known and is similar to the periplasmic binding proteins. This domain binds a variety of ligands that caries in size and structure, such as amino acids, sugar phosphates, organic acids, metal cations, flavonoids, C6-ring carboxylic acids, H2O2, HOCl, homocysteine, NADPH, ATP, sulphate, muropeptides, acetate, salicylate, citrate, phenol- and quinolone derivatives, acetylserines, fatty acid CoA, shikimate, chorismate, homocysteine, indole-3-acetic acid, Na(I), c-di-GMP, ppGpp and hydrogen peroxide.
Links
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Statistics
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PSSM-Id: 515602
Aligned: 299 rows
Threshold Bit Score: 60.3845
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1I6A_A   4 SGPLHIGLiPTVG---PYLLPHIIPMLHQTFPkLEMYLHEAQTHQLLAQLDSGKLDAVILALVK--ESEAFIEVPLFDEP 78  Escherichia coli
Q9I4J0  97 VGELYLGLaDNLAtlpQARFGDALARFQRRDQdVQLNLFVNSPTELELAVIEGELDLAISYFSR--SRPSLEYRPLYREE 174 Pseudomonas aeruginosa
Q9I6Z9 104 RGELNIGIiNNLVtlpQMRITHALSALKGQGPqVRINIGMTTPNEIELGVLDGHLHVGVVPLIS--PLSGLEYLPLYDEH 181 Pseudomonas aeruginos...
Q9I6K1 101 REALHLGCvDGVIgqhCLPLPLAIRLFRQRAPeVLLKLHTRRPDELEHAVLEERLQLAVGAFHH--RLSGLYYQPLFREE 178 Pseudomonas aeruginosa
Q9I3S2  95 RGTLNLGVlDSTVsdpALPLAEVIGAFSREHPaVHLHLLVQSPYELQLSVLENRQDLAIGAFSS--RMNGLVYQPLYREQ 172 Pseudomonas aeruginosa
P77171 100 NDVVRVGAlPTAA---LGILPSVIGQFHQQQKeTTLQVATMSNPMILAGLKTGEIDIGIGRMSDpeLMTGLNYELLFLES 176 Escherichia coli K-12
Q9I1R1 103 LGRVTVGAiPALA---SSLLTRTIATLKQSHPrLSMSIQVDTSDVLVQALQQDQLDVVLGRIPSgaRTDDLVFDSLGEEE 179 Pseudomonas aeruginosa
Q9I113  96 GSRVLLGTsPASA---PSLVPRALRAFLGRYPgAQVELLEGTMNGLLERLEKRQLDVVVGRLDNyaPRASLRCEVLYSEA 172 Pseudomonas aeruginosa
Q9KPI4  88 NTLLRMDCsETLV---AGYLGQTMGQHRKQDPhWVITTNHTP--RIVENVQSGKATLGFCAGYLp-ANHGLLTFHLGDEP 161 Vibrio cholerae O1 bi...
Q9I5C3  84 RGRLRIGAvNTAQ---TGLLPEVLKRLAEQAPhIEPQVVPGVSLHLLDQVDAAELDLAILIRPPfnLPRGLSAQRVERQP 160 Pseudomonas aeruginosa

1I6A_A  79 MLLAIYEDhPWAN---REAVPMADLageKLLMLEDGHC--LRDQAMGFCFEAGADE-DTHFRATSLETLRNMVAAGSGIT 152 Escherichia coli
Q9I4J0 175 IGVFCGDRhPLFA---EAQPTLERIaacDWVM----HGflPENLVL------PLRPsRSRATAYHMEAVAHAVLAGTHLG 241 Pseudomonas aeruginosa
Q9I6Z9 182 AQLYCSRGhALFEr-aDGDIAVDEVlaaDAVA----PS--YRLPAE--AQARHQEL-NNSASASDREGMAFLILTGNFIG 251 Pseudomonas aeruginos...
Q9I6K1 179 QNLYCGSAhPFFAradDEPTlg-----eICAA---DYV--GRGYMAENHRPHDLRF-NQGTDAYTMEAIATLVFSGTYIG 247 Pseudomonas aeruginosa
Q9I3S2 173 HWLYCSDRhPLFD---GRRI-PADLitqQRMV---GRG--YWSQAE--LARHGFKH-SA-GTVESMEAQLILILSGGYIG 239 Pseudomonas aeruginosa
P77171 177 LKLVVRPNhPLLQ---E-NVTLSRVlewPVVVSPEGTA--PRQHSDALVQSQGCKIpSGCIETLSASLSRQLTVEYDYVW 250 Escherichia coli K-12
Q9I1R1 180 LCVVVGAQnPLSQ---ARKLDWGELqelTWVLQQHPSP--MRGIVNQAFHNARIDLpSSIVETTSIMTLLSLLQQTDMIG 254 Pseudomonas aeruginosa
Q9I113 173 IVVMARPGhPLAQ---AAALDWEDVrryDWIVWPPGSP--IRSKLDMALTQGGRQPpAYRLESSSMLANIELLRGSDMLS 247 Pseudomonas aeruginosa
Q9KPI4 162 FTVI--SQaPLHA---L-PS--------ELITNDLANP--ANTYQAAMLHKQGI---RPAMEMDSYTAAAQLALGGMLPA 222 Vibrio cholerae O1 bi...
Q9I5C3 161 FVLIAPPQc-------TATDALELLrtqPFIRYDHVSF--GGRLVGDFLEAQQLRP-RQVMELDEIDAIARMVENGLGVA 230 Pseudomonas aeruginosa

1I6A_A 153 LLPALAVpPER-KRDGVVYLPAIKP-EPR-RTIGLVYRPGSpLRSRYEQLAEAIRARMD 208 Escherichia coli
Q9I4J0 242 YLPTHYAeAWI-ERGRMR-ALLPER-LSYpVEHSMIVYAGRpLSEAARAFIDDLLQVHG 297 Pseudomonas aeruginosa
Q9I6Z9 252 YLPSHYAaDWV-AAGMLR-PLLPER-FHYaIALTIVTRKGRrPNLVLERFLEAV--AVS 305 Pseudomonas aeruginosa PAO1
Q9I6K1 248 YLPTHYAaTWV-AEGRMRAIRPRQL-AYD-SEFHCITRQGHeERPTLTLFLRSLFEAQK 303 Pseudomonas aeruginosa
Q9I3S2 240 YLPEHYAhPWV-EQGRLRALLPATF-GYQ-APFSLILRRGRsREPLIQAFRDQLRTQMS 295 Pseudomonas aeruginosa
P77171 251 FVPSGAVkDDL-RHATLVALPVPGH-GAG-EPIGILTRVDAtFSSGCQLMINAIRKSMP 306 Escherichia coli K-12
Q9I1R1 255 ITPRSVIeDYP-GKHLLAILPIQL--EPRlPPYGLITRRNRvHSSAMQTFMASVHAEQA 310 Pseudomonas aeruginosa
Q9I113 248 IGSARVV-EHL-AGLGLVARLALEI-PGE-GAVGMCWRDEPhRDRASEDLLACLREGAA 302 Pseudomonas aeruginosa
Q9KPI4 223 LVPRSIVsTLK-IEPQHC-FDFAELaDLT-RPIHICLRASRyRSSRVQALITALHDAVP 278 Vibrio cholerae O1 biovar El Tor str. N16961
Q9I5C3 231 LLPRAG--LWLrEPARVRVIELGAL-EFQ-RELVMVSRSGSaQDDLVGEFRRALLAETA 285 Pseudomonas aeruginosa
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