3TW8


Conserved Protein Domain Family
dDENN

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pfam03455: dDENN 
dDENN domain
This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.
Statistics
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PSSM-Id: 397494
Aligned: 153 rows
Threshold Bit Score: 34.1298
Threshold Setting Gi: 0
Created: 20-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3TW8_A       336 FCEESFVKH-RSSVMKQFLETAINLQLFKQFIDGRLaKL--NAgr--gfSDVFEEE 386
EEB15446     803 FQVNDFIKHsTSTISQTFLNWFTKTSLFQGFIHERI-N----QvpedvsVKLFNKR 853 human body louse
XP_003242325 792 FQKQFFIDAgINTAHRNFLEWFTETAMFTTFLNNKM-HSniDK------KDVFECR 840 pea aphid
XP_015740417 406 FQERAFCKAiTSKTNRRFVKKFVKTNMFSLFIEDAE-K----Sri--pqEAYFQQK 454 Japanese quail
XP_016159740 406 FQERAFCKAvGSRSCRRLLKRFVRTNMFSLFIEEAE-R----Sri--pqEAYFQRK 454 Collared flycatcher
XP_007664968 404 FQERSFCKAlRSKTSRRFLKKFVKTQMFSLFIQEAE-K----Sqs--lpAGYFQQk 452 platypus
XP_004769823 506 FQERAFYKAlNSKTIRRFVKKFVKTQLFSLFIQEAE-K----Sqt--psAGYFQRK 554 domestic ferret
XP_027777814 223 FQERSFCKAvSSKTNRRFVKKFVKTQLFSLFIQEAE-K----Skn--ppAGYFQQK 271 yellow-bellied marmot
XP_005987654 406 FQERPFRKAiSSKLIRKFLKAFIPTQMFQLFIQEAQ-T----Rtt--sqEGFFEKK 454 coelacanth
KAE8623295   217 FQEKAFLKAiHSKTIRRFLKCFVKTQMFSIFI-EAQ-Q----Nks--tqNVYFQQK 264 tropical clawed frog
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