Conserved Protein Domain Family
dDENN
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pfam03455: dDENN (This model is not part of the current CDD release)
dDENN domain
This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.
Links
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Statistics
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PSSM-Id: 515592
Aligned: 126 rows
Threshold Bit Score: 32.6026
Created: 13-Feb-2025
Updated: 28-Apr-2025
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_004969033   400 FNSQAF--LKKrsratNQPVEsMSMI-MQFLETQGFLDYLERCNSA------EeNANNLLDKL 453 
ERN00342       401 FNTQAF--LKKrsrltSQPQE--PMI-VQFLDSQGFIDYIERCYNS------DdSVTNLLDKL 452 
XP_010318603   397 FNSQAF--LKKrsrstNQPPD--SMI-SQFLESQGFLDYLERGLGS------EeNNNNLLDKL 448 
XP_001340162   556 FDKASF--LSD-----QPEPY-LPFL-SRFLETQMFASFIDSKILChddedkE-HTLRVFDSR 608 
EFX89893       107 FDKTTF--LSD-----QPGPH-LRFM-SCFLESQMFANFIDAKVLAnyg-qyS-HSVRVLDAR 158 
XP_002423771   502 FDKATF--LSD-----QATHH-LPFL-SQFLETQMFASFIDSKILAtfn-eiD-PNLRVFDKR 553 
EFN90041        15 FDKTTF--LSY-----QSTQH-LPFIySRFLKTQMFASLVDSKVMStws-elD-FNIKVFVQR 67  
26_pfamImport    1 FDKATF--LSD-----QQQQH-LPFL-SRFIETQMFATLIDNKILSnwd-rtE-TNLRIFDRR 52  
Q54VP0        1236 FNNEEY--IKS-----KAVAS-RPFI-SMFIKTQAFIYFLEQH---------SwPTKNLFDYL 1280 Dictyostelium discoideum AX4
XP_020438632  1047 FNKQEFirCRS-----NGSAS-DKFY-STLVETQAFSYFLDQH---------NwPKKNLFDYL 1093
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