6BE0


Conserved Protein Domain Family
Acetyltransf_14

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pfam03421: Acetyltransf_14 
YopJ Serine/Threonine acetyltransferase
The Yersinia effector YopJ inhibits the innate immune response by blocking MAP kinase and NFkappaB signaling pathways. YopJ is a serine/threonine acetyltransferase which regulates signalling pathways by blocking phosphorylation. Specifically, YopJ has been shown to block phosphorylation of active site residues. It has also been shown that YopJ acetyltransferase is activated by eukaryotic host cell inositol hexakisphosphate. This family was previously incorrectly annotated in Pfam as being a peptidase family.
Statistics
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PSSM-Id: 397475
Aligned: 10 rows
Threshold Bit Score: 175.272
Threshold Setting Gi: 81506739
Created: 11-May-2020
Updated: 7-Aug-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6BE0_A          41 EALTRIVERLESEIIDGSWIHISYEET-DLEMMPFLVAQANKKYPELNLKFV--------MSVHELVSSIKETRMEGVES 111
jgi:Marme_2777 145 SDLHDYAQHAISCIKTGESGGYEMNKF-DKKLLPLIAEAENKRTLGLNLHVF--------KSTQECTDALHQMEAKTNST 215 Marinomonas m...
jgi:Aave_2166   85 SDLRAYAEAALTAAKIGS--TSDMTDL-DVQNKQYLADAYNTRFPDLKLICH--------DSAQAFFSDFMTSEKPVWR- 152 Acidovorax ci...
Q8Y164          86 PEFISYAETTLHNLASHTQPSVMETNL-DIRHLDTIVQSY--RYNNLNLQAF--------NSREAFVASLVEGQGSGRAE 154 Ralstonia sol...
P55555          42 SSLMEYGRQVARHLSANVQPDEKILSL-DIRNLPLLAASYNRRYPDLDLRHM--------DSPARFFDALNDRSSDGAWR 112 Sinorhizobium...
jgi:Aave_2708   91 SSIVKYGERTLKMLAANKQPDEALLKL-DIKNLPALASVYNRRYPGLNIQHF--------DSPIDFLQSLSEQTTSVVSQ 161 Acidovorax ci...
Q87GH0          21 EQLSSYIDLMDDAIRQGKQLPKDTAAAnDIALMDDFIAIANQKKEGLNAHFF--------RSPLDMVNYVKSLIPSEDTT 92  Vibrio paraha...
Q8ZMI3          40 EALTCIVERLESEIIDGSWIHISYEET-DLEMMPFLVAQANKKYPELNLKFV--------MSVHELVSSIKETRMEGVES 110 Salmonella en...
Q9RI13          26 EELKNIITQLETDISDGSWFHKNYSRM-DVEVMPALVIQANNKYPEMNLNLV--------TSPLDLSIEIKNVIENGVRS 96  Yersinia pestis
Q8Y2L4          91 ESMRQYLAELKTAAHADPNLRVETPGHrDAEFLDLLVAVENARHPKLALSAHtislntlnTTNPAAVASLARNLETSMRS 170 Ralstonia sol...
6BE0_A         112 AR----FLVNMGSsg---iHISVVDFRVM-D--GKTSVILFEPAacsaf------gpalaL----RTKAALEREQLPDCY 171
jgi:Marme_2777 216 RKpnhvRIVYPPAsgvspnHHAALDVKFTpK--NPPSIVGFEPA----------------TfensVMLEHSLRYSMPHAK 277 Marinomonas m...
jgi:Aave_2166  153 ------SLVQLSPhs---lHHVAIDVRLQ-D--GKRTAVVLEPAigygmrs---dgkitmLagyePLGRNIQKYLGENGD 217 Acidovorax ci...
Q8Y164         155 R-----GVVR-DYpn---lHHFAADVRHHeD--GRTTVIILEPAsagn---------qenLpgytELASALRYNLGSQCR 214 Ralstonia sol...
P55555         113 ------AVVRLADge---qHHVAADVRTRaG--AAPTIIVMEGAnfy-----------tfVasyfKLRGDSFRQLGTQAK 170 Sinorhizobium...
jgi:Aave_2708  162 R-----AVLRLERdg---eHHVAADVRRRpN--GEASVIVLEPArll-----------tfVtghtQLRRQALSQLGENAK 220 Acidovorax ci...
Q87GH0          93 AR----FVVNMGSgg---iHCIAVDCAIK-N--GKCSLIGIDPVtmnsl------gasmlA----IRLQSVCKRELPETS 152 Vibrio paraha...
Q8ZMI3         111 AR----FLVNMGSsg---iHISVVDFRVM-D--GKTSVILFEPAacsaf------gpallAl---RTKAALEREQLPDCY 171 Salmonella en...
Q9RI13          97 SR----FIINMGEgg---iHFSVIDYKHI-N--GKTSLILFEPAnfnsm------gpamlAi---RTKTAIERYQLPDCH 157 Yersinia pestis
Q8Y2L4         171 REpw-hAVVDIGG------HAMALSVRHHpEqpKQISMIVVNSAgehlsvpewnlmatllAghlnHKLEQAGDPKGVRIV 243 Ralstonia sol...
6BE0_A         172 FAMVELDIQRSSSECGIFSLAlAKKLQLE-FMNLVKIHE 209
jgi:Marme_2777 278 LNVVNPDIQKSDWDCAMFSLNhALKAHKHeDGYVEKLHQ 316 Marinomonas mediterranea MMB-1
jgi:Aave_2166  218 MAVVQLGAQKSHYDCIIFSLNlALCAYQR-DDVIDGLHE 255 Acidovorax citrulli AAC00-1
Q8Y164         215 MVVIEAEAQKSLSDCVAFALDfALAAYQErRTTFDQWHE 253 Ralstonia solanacearum
P55555         171 WAFIEVGAQKSAADCVMFGVQfALAAYRE-LPTFDAWHD 208 Sinorhizobium fredii NGR234
jgi:Aave_2708  221 FAFIQVGAQKSAADCLMFDLHfALHAHQH-SSLFDQWHD 258 Acidovorax citrulli AAC00-1
Q87GH0         153 LVIMETDMQRSQGECLMFSLFlVKKMHKE-CDEFQSLHD 190 Vibrio parahaemolyticus
Q8ZMI3         172 FAMVELDIQRSSSECGIFSLAlAKKLQLE-FMNLVKIHE 209 Salmonella enterica subsp. enterica serovar Typhimurium
Q9RI13         158 FSMVEMDIQRSSSECGIFSFAlAKKLYIE-RDSLLKIHE 195 Yersinia pestis
Q8Y2L4         244 LHCLNTGIQKTNHGGAIFALS-AVKAMPG-DEDIGKLHA 280 Ralstonia solanacearum
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